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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 12-52054373-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=12&pos=52054373&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "12",
"pos": 52054373,
"ref": "G",
"alt": "A",
"effect": "synonymous_variant",
"transcript": "NM_001202234.2",
"consequences": [
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR4A1",
"gene_hgnc_id": 7980,
"hgvs_c": "c.45G>A",
"hgvs_p": "p.Pro15Pro",
"transcript": "NM_173157.3",
"protein_id": "NP_775180.1",
"transcript_support_level": null,
"aa_start": 15,
"aa_end": null,
"aa_length": 598,
"cds_start": 45,
"cds_end": null,
"cds_length": 1797,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000394825.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_173157.3"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR4A1",
"gene_hgnc_id": 7980,
"hgvs_c": "c.45G>A",
"hgvs_p": "p.Pro15Pro",
"transcript": "ENST00000394825.6",
"protein_id": "ENSP00000378302.1",
"transcript_support_level": 1,
"aa_start": 15,
"aa_end": null,
"aa_length": 598,
"cds_start": 45,
"cds_end": null,
"cds_length": 1797,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_173157.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000394825.6"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR4A1",
"gene_hgnc_id": 7980,
"hgvs_c": "c.45G>A",
"hgvs_p": "p.Pro15Pro",
"transcript": "ENST00000243050.5",
"protein_id": "ENSP00000243050.1",
"transcript_support_level": 1,
"aa_start": 15,
"aa_end": null,
"aa_length": 598,
"cds_start": 45,
"cds_end": null,
"cds_length": 1797,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000243050.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR4A1",
"gene_hgnc_id": 7980,
"hgvs_c": "n.232G>A",
"hgvs_p": null,
"transcript": "ENST00000478250.1",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000478250.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR4A1",
"gene_hgnc_id": 7980,
"hgvs_c": "n.534G>A",
"hgvs_p": null,
"transcript": "ENST00000549102.1",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000549102.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR4A1",
"gene_hgnc_id": 7980,
"hgvs_c": "n.956G>A",
"hgvs_p": null,
"transcript": "ENST00000550557.1",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000550557.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR4A1",
"gene_hgnc_id": 7980,
"hgvs_c": "c.207G>A",
"hgvs_p": "p.Pro69Pro",
"transcript": "NM_001202234.2",
"protein_id": "NP_001189163.1",
"transcript_support_level": null,
"aa_start": 69,
"aa_end": null,
"aa_length": 652,
"cds_start": 207,
"cds_end": null,
"cds_length": 1959,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001202234.2"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR4A1",
"gene_hgnc_id": 7980,
"hgvs_c": "c.207G>A",
"hgvs_p": "p.Pro69Pro",
"transcript": "ENST00000545748.5",
"protein_id": "ENSP00000440864.1",
"transcript_support_level": 2,
"aa_start": 69,
"aa_end": null,
"aa_length": 652,
"cds_start": 207,
"cds_end": null,
"cds_length": 1959,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000545748.5"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR4A1",
"gene_hgnc_id": 7980,
"hgvs_c": "c.84G>A",
"hgvs_p": "p.Pro28Pro",
"transcript": "NM_001202233.2",
"protein_id": "NP_001189162.1",
"transcript_support_level": null,
"aa_start": 28,
"aa_end": null,
"aa_length": 611,
"cds_start": 84,
"cds_end": null,
"cds_length": 1836,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001202233.2"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR4A1",
"gene_hgnc_id": 7980,
"hgvs_c": "c.84G>A",
"hgvs_p": "p.Pro28Pro",
"transcript": "ENST00000360284.7",
"protein_id": "ENSP00000353427.3",
"transcript_support_level": 2,
"aa_start": 28,
"aa_end": null,
"aa_length": 611,
"cds_start": 84,
"cds_end": null,
"cds_length": 1836,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000360284.7"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR4A1",
"gene_hgnc_id": 7980,
"hgvs_c": "c.84G>A",
"hgvs_p": "p.Pro28Pro",
"transcript": "ENST00000550082.5",
"protein_id": "ENSP00000449539.1",
"transcript_support_level": 5,
"aa_start": 28,
"aa_end": null,
"aa_length": 611,
"cds_start": 84,
"cds_end": null,
"cds_length": 1836,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000550082.5"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR4A1",
"gene_hgnc_id": 7980,
"hgvs_c": "c.45G>A",
"hgvs_p": "p.Pro15Pro",
"transcript": "NM_002135.5",
"protein_id": "NP_002126.2",
"transcript_support_level": null,
"aa_start": 15,
"aa_end": null,
"aa_length": 598,
"cds_start": 45,
"cds_end": null,
"cds_length": 1797,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_002135.5"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR4A1",
"gene_hgnc_id": 7980,
"hgvs_c": "c.45G>A",
"hgvs_p": "p.Pro15Pro",
"transcript": "ENST00000394824.2",
"protein_id": "ENSP00000378301.2",
"transcript_support_level": 5,
"aa_start": 15,
"aa_end": null,
"aa_length": 598,
"cds_start": 45,
"cds_end": null,
"cds_length": 1797,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000394824.2"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR4A1",
"gene_hgnc_id": 7980,
"hgvs_c": "c.45G>A",
"hgvs_p": "p.Pro15Pro",
"transcript": "ENST00000875309.1",
"protein_id": "ENSP00000545368.1",
"transcript_support_level": null,
"aa_start": 15,
"aa_end": null,
"aa_length": 598,
"cds_start": 45,
"cds_end": null,
"cds_length": 1797,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000875309.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR4A1",
"gene_hgnc_id": 7980,
"hgvs_c": "c.45G>A",
"hgvs_p": "p.Pro15Pro",
"transcript": "ENST00000875310.1",
"protein_id": "ENSP00000545369.1",
"transcript_support_level": null,
"aa_start": 15,
"aa_end": null,
"aa_length": 598,
"cds_start": 45,
"cds_end": null,
"cds_length": 1797,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000875310.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR4A1",
"gene_hgnc_id": 7980,
"hgvs_c": "c.45G>A",
"hgvs_p": "p.Pro15Pro",
"transcript": "ENST00000875312.1",
"protein_id": "ENSP00000545371.1",
"transcript_support_level": null,
"aa_start": 15,
"aa_end": null,
"aa_length": 598,
"cds_start": 45,
"cds_end": null,
"cds_length": 1797,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000875312.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR4A1",
"gene_hgnc_id": 7980,
"hgvs_c": "c.45G>A",
"hgvs_p": "p.Pro15Pro",
"transcript": "ENST00000875315.1",
"protein_id": "ENSP00000545374.1",
"transcript_support_level": null,
"aa_start": 15,
"aa_end": null,
"aa_length": 598,
"cds_start": 45,
"cds_end": null,
"cds_length": 1797,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000875315.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR4A1",
"gene_hgnc_id": 7980,
"hgvs_c": "c.45G>A",
"hgvs_p": "p.Pro15Pro",
"transcript": "ENST00000875317.1",
"protein_id": "ENSP00000545376.1",
"transcript_support_level": null,
"aa_start": 15,
"aa_end": null,
"aa_length": 598,
"cds_start": 45,
"cds_end": null,
"cds_length": 1797,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000875317.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR4A1",
"gene_hgnc_id": 7980,
"hgvs_c": "c.45G>A",
"hgvs_p": "p.Pro15Pro",
"transcript": "ENST00000875319.1",
"protein_id": "ENSP00000545378.1",
"transcript_support_level": null,
"aa_start": 15,
"aa_end": null,
"aa_length": 598,
"cds_start": 45,
"cds_end": null,
"cds_length": 1797,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000875319.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR4A1",
"gene_hgnc_id": 7980,
"hgvs_c": "c.45G>A",
"hgvs_p": "p.Pro15Pro",
"transcript": "ENST00000875321.1",
"protein_id": "ENSP00000545380.1",
"transcript_support_level": null,
"aa_start": 15,
"aa_end": null,
"aa_length": 598,
"cds_start": 45,
"cds_end": null,
"cds_length": 1797,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000875321.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR4A1",
"gene_hgnc_id": 7980,
"hgvs_c": "c.45G>A",
"hgvs_p": "p.Pro15Pro",
"transcript": "ENST00000875324.1",
"protein_id": "ENSP00000545383.1",
"transcript_support_level": null,
"aa_start": 15,
"aa_end": null,
"aa_length": 598,
"cds_start": 45,
"cds_end": null,
"cds_length": 1797,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000875324.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR4A1",
"gene_hgnc_id": 7980,
"hgvs_c": "c.45G>A",
"hgvs_p": "p.Pro15Pro",
"transcript": "ENST00000914800.1",
"protein_id": "ENSP00000584859.1",
"transcript_support_level": null,
"aa_start": 15,
"aa_end": null,
"aa_length": 598,
"cds_start": 45,
"cds_end": null,
"cds_length": 1797,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000914800.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
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