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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 12-55697012-G-C (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=12&pos=55697012&ref=G&alt=C&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "12",
      "pos": 55697012,
      "ref": "G",
      "alt": "C",
      "effect": "missense_variant",
      "transcript": "NM_001410977.1",
      "consequences": [
        {
          "aa_ref": "R",
          "aa_alt": "G",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 25,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ITGA7",
          "gene_hgnc_id": 6143,
          "hgvs_c": "c.1624C>G",
          "hgvs_p": "p.Arg542Gly",
          "transcript": "NM_002206.3",
          "protein_id": "NP_002197.2",
          "transcript_support_level": null,
          "aa_start": 542,
          "aa_end": null,
          "aa_length": 1137,
          "cds_start": 1624,
          "cds_end": null,
          "cds_length": 3414,
          "cdna_start": 1846,
          "cdna_end": null,
          "cdna_length": 4126,
          "mane_select": "ENST00000257879.11",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_002206.3"
        },
        {
          "aa_ref": "R",
          "aa_alt": "G",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 25,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ITGA7",
          "gene_hgnc_id": 6143,
          "hgvs_c": "c.1624C>G",
          "hgvs_p": "p.Arg542Gly",
          "transcript": "ENST00000257879.11",
          "protein_id": "ENSP00000257879.7",
          "transcript_support_level": 1,
          "aa_start": 542,
          "aa_end": null,
          "aa_length": 1137,
          "cds_start": 1624,
          "cds_end": null,
          "cds_length": 3414,
          "cdna_start": 1846,
          "cdna_end": null,
          "cdna_length": 4126,
          "mane_select": "NM_002206.3",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000257879.11"
        },
        {
          "aa_ref": "R",
          "aa_alt": "G",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 25,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ITGA7",
          "gene_hgnc_id": 6143,
          "hgvs_c": "c.1636C>G",
          "hgvs_p": "p.Arg546Gly",
          "transcript": "ENST00000553804.6",
          "protein_id": "ENSP00000452120.1",
          "transcript_support_level": 1,
          "aa_start": 546,
          "aa_end": null,
          "aa_length": 1141,
          "cds_start": 1636,
          "cds_end": null,
          "cds_length": 3426,
          "cdna_start": 1858,
          "cdna_end": null,
          "cdna_length": 4138,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000553804.6"
        },
        {
          "aa_ref": "R",
          "aa_alt": "G",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ITGA7",
          "gene_hgnc_id": 6143,
          "hgvs_c": "c.1756C>G",
          "hgvs_p": "p.Arg586Gly",
          "transcript": "NM_001410977.1",
          "protein_id": "NP_001397906.1",
          "transcript_support_level": null,
          "aa_start": 586,
          "aa_end": null,
          "aa_length": 1181,
          "cds_start": 1756,
          "cds_end": null,
          "cds_length": 3546,
          "cdna_start": 1978,
          "cdna_end": null,
          "cdna_length": 4258,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001410977.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "G",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ITGA7",
          "gene_hgnc_id": 6143,
          "hgvs_c": "c.1756C>G",
          "hgvs_p": "p.Arg586Gly",
          "transcript": "ENST00000555728.5",
          "protein_id": "ENSP00000452387.1",
          "transcript_support_level": 5,
          "aa_start": 586,
          "aa_end": null,
          "aa_length": 1181,
          "cds_start": 1756,
          "cds_end": null,
          "cds_length": 3546,
          "cdna_start": 1785,
          "cdna_end": null,
          "cdna_length": 3930,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000555728.5"
        },
        {
          "aa_ref": "R",
          "aa_alt": "G",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ITGA7",
          "gene_hgnc_id": 6143,
          "hgvs_c": "c.1738C>G",
          "hgvs_p": "p.Arg580Gly",
          "transcript": "ENST00000888141.1",
          "protein_id": "ENSP00000558199.1",
          "transcript_support_level": null,
          "aa_start": 580,
          "aa_end": null,
          "aa_length": 1175,
          "cds_start": 1738,
          "cds_end": null,
          "cds_length": 3528,
          "cdna_start": 1958,
          "cdna_end": null,
          "cdna_length": 4238,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000888141.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "G",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ITGA7",
          "gene_hgnc_id": 6143,
          "hgvs_c": "c.1723C>G",
          "hgvs_p": "p.Arg575Gly",
          "transcript": "ENST00000888137.1",
          "protein_id": "ENSP00000558196.1",
          "transcript_support_level": null,
          "aa_start": 575,
          "aa_end": null,
          "aa_length": 1170,
          "cds_start": 1723,
          "cds_end": null,
          "cds_length": 3513,
          "cdna_start": 1948,
          "cdna_end": null,
          "cdna_length": 4228,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000888137.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "G",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 25,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ITGA7",
          "gene_hgnc_id": 6143,
          "hgvs_c": "c.1657C>G",
          "hgvs_p": "p.Arg553Gly",
          "transcript": "ENST00000888151.1",
          "protein_id": "ENSP00000558210.1",
          "transcript_support_level": null,
          "aa_start": 553,
          "aa_end": null,
          "aa_length": 1148,
          "cds_start": 1657,
          "cds_end": null,
          "cds_length": 3447,
          "cdna_start": 1846,
          "cdna_end": null,
          "cdna_length": 4126,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000888151.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "G",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 25,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ITGA7",
          "gene_hgnc_id": 6143,
          "hgvs_c": "c.1636C>G",
          "hgvs_p": "p.Arg546Gly",
          "transcript": "NM_001144996.2",
          "protein_id": "NP_001138468.1",
          "transcript_support_level": null,
          "aa_start": 546,
          "aa_end": null,
          "aa_length": 1141,
          "cds_start": 1636,
          "cds_end": null,
          "cds_length": 3426,
          "cdna_start": 1858,
          "cdna_end": null,
          "cdna_length": 4138,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001144996.2"
        },
        {
          "aa_ref": "R",
          "aa_alt": "G",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 25,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ITGA7",
          "gene_hgnc_id": 6143,
          "hgvs_c": "c.1636C>G",
          "hgvs_p": "p.Arg546Gly",
          "transcript": "ENST00000888150.1",
          "protein_id": "ENSP00000558209.1",
          "transcript_support_level": null,
          "aa_start": 546,
          "aa_end": null,
          "aa_length": 1140,
          "cds_start": 1636,
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          "cdna_start": 1828,
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          "cdna_length": 4105,
          "mane_select": null,
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          "biotype": "protein_coding",
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        },
        {
          "aa_ref": "R",
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          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 25,
          "intron_rank": null,
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          "gene_symbol": "ITGA7",
          "gene_hgnc_id": 6143,
          "hgvs_c": "c.1624C>G",
          "hgvs_p": "p.Arg542Gly",
          "transcript": "ENST00000945417.1",
          "protein_id": "ENSP00000615476.1",
          "transcript_support_level": null,
          "aa_start": 542,
          "aa_end": null,
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          "cds_start": 1624,
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          "cdna_start": 1844,
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          "cdna_length": 4115,
          "mane_select": null,
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          "biotype": "protein_coding",
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        },
        {
          "aa_ref": "R",
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          "canonical": false,
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          "strand": false,
          "consequences": [
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          ],
          "exon_rank": 12,
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          "intron_rank": null,
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          "gene_symbol": "ITGA7",
          "gene_hgnc_id": 6143,
          "hgvs_c": "c.1618C>G",
          "hgvs_p": "p.Arg540Gly",
          "transcript": "NM_001414029.1",
          "protein_id": "NP_001400958.1",
          "transcript_support_level": null,
          "aa_start": 540,
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          "cds_start": 1618,
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          "cdna_start": 1840,
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          "mane_select": null,
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          "biotype": "protein_coding",
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        },
        {
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 12,
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          "intron_rank": null,
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          "gene_symbol": "ITGA7",
          "gene_hgnc_id": 6143,
          "hgvs_c": "c.1618C>G",
          "hgvs_p": "p.Arg540Gly",
          "transcript": "ENST00000888129.1",
          "protein_id": "ENSP00000558189.1",
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          "cds_start": 1618,
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          "cdna_start": 1871,
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          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000888129.1"
        },
        {
          "aa_ref": "R",
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
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          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 25,
          "intron_rank": null,
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          "gene_symbol": "ITGA7",
          "gene_hgnc_id": 6143,
          "hgvs_c": "c.1612C>G",
          "hgvs_p": "p.Arg538Gly",
          "transcript": "ENST00000888135.1",
          "protein_id": "ENSP00000558193.1",
          "transcript_support_level": null,
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          "cds_start": 1612,
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        {
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          "gene_symbol": "ITGA7",
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          "hgvs_c": "c.1606C>G",
          "hgvs_p": "p.Arg536Gly",
          "transcript": "NM_001374465.1",
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          "aa_end": null,
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          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "NM_001374465.1"
        },
        {
          "aa_ref": "R",
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          "canonical": false,
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          "consequences": [
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          "intron_rank": null,
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          "gene_symbol": "ITGA7",
          "gene_hgnc_id": 6143,
          "hgvs_c": "c.1606C>G",
          "hgvs_p": "p.Arg536Gly",
          "transcript": "ENST00000347027.10",
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        {
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          "intron_rank": null,
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          "gene_symbol": "ITGA7",
          "gene_hgnc_id": 6143,
          "hgvs_c": "c.1624C>G",
          "hgvs_p": "p.Arg542Gly",
          "transcript": "ENST00000888145.1",
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        {
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          "gene_symbol": "ITGA7",
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          "gene_symbol": "ITGA7",
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          "transcript": "ENST00000945415.1",
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          "mane_select": null,
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          "biotype": "protein_coding",
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        },
        {
          "aa_ref": "R",
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          "strand": false,
          "consequences": [
            "missense_variant"
          ],
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          "exon_rank_end": null,
          "exon_count": 25,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ITGA7",
          "gene_hgnc_id": 6143,
          "hgvs_c": "c.1594C>G",
          "hgvs_p": "p.Arg532Gly",
          "transcript": "ENST00000912204.1",
          "protein_id": "ENSP00000582263.1",
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}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.