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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 12-56346433-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=12&pos=56346433&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "12",
"pos": 56346433,
"ref": "G",
"alt": "A",
"effect": "intron_variant",
"transcript": "ENST00000314128.9",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 21,
"intron_rank_end": null,
"gene_symbol": "STAT2",
"gene_hgnc_id": 11363,
"hgvs_c": "c.2044+9C>T",
"hgvs_p": null,
"transcript": "NM_005419.4",
"protein_id": "NP_005410.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 851,
"cds_start": -4,
"cds_end": null,
"cds_length": 2556,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4405,
"mane_select": "ENST00000314128.9",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 21,
"intron_rank_end": null,
"gene_symbol": "STAT2",
"gene_hgnc_id": 11363,
"hgvs_c": "c.2044+9C>T",
"hgvs_p": null,
"transcript": "ENST00000314128.9",
"protein_id": "ENSP00000315768.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 851,
"cds_start": -4,
"cds_end": null,
"cds_length": 2556,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4405,
"mane_select": "NM_005419.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "STAT2",
"gene_hgnc_id": 11363,
"hgvs_c": "n.974+9C>T",
"hgvs_p": null,
"transcript": "ENST00000556539.5",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3278,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 21,
"intron_rank_end": null,
"gene_symbol": "STAT2",
"gene_hgnc_id": 11363,
"hgvs_c": "c.2032+9C>T",
"hgvs_p": null,
"transcript": "NM_198332.2",
"protein_id": "NP_938146.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 847,
"cds_start": -4,
"cds_end": null,
"cds_length": 2544,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4393,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 21,
"intron_rank_end": null,
"gene_symbol": "STAT2",
"gene_hgnc_id": 11363,
"hgvs_c": "c.2032+9C>T",
"hgvs_p": null,
"transcript": "ENST00000557235.5",
"protein_id": "ENSP00000450751.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 847,
"cds_start": -4,
"cds_end": null,
"cds_length": 2544,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3073,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 20,
"intron_rank_end": null,
"gene_symbol": "STAT2",
"gene_hgnc_id": 11363,
"hgvs_c": "c.2023+9C>T",
"hgvs_p": null,
"transcript": "NM_001385114.1",
"protein_id": "NP_001372043.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 844,
"cds_start": -4,
"cds_end": null,
"cds_length": 2535,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4384,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 20,
"intron_rank_end": null,
"gene_symbol": "STAT2",
"gene_hgnc_id": 11363,
"hgvs_c": "c.2011+9C>T",
"hgvs_p": null,
"transcript": "NM_001385110.1",
"protein_id": "NP_001372039.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 840,
"cds_start": -4,
"cds_end": null,
"cds_length": 2523,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4372,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 21,
"intron_rank_end": null,
"gene_symbol": "STAT2",
"gene_hgnc_id": 11363,
"hgvs_c": "c.2002+9C>T",
"hgvs_p": null,
"transcript": "NM_001385115.1",
"protein_id": "NP_001372044.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 837,
"cds_start": -4,
"cds_end": null,
"cds_length": 2514,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4363,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 20,
"intron_rank_end": null,
"gene_symbol": "STAT2",
"gene_hgnc_id": 11363,
"hgvs_c": "c.1945+9C>T",
"hgvs_p": null,
"transcript": "NM_001385111.1",
"protein_id": "NP_001372040.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 818,
"cds_start": -4,
"cds_end": null,
"cds_length": 2457,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4306,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 20,
"intron_rank_end": null,
"gene_symbol": "STAT2",
"gene_hgnc_id": 11363,
"hgvs_c": "c.1945+9C>T",
"hgvs_p": null,
"transcript": "ENST00000651915.1",
"protein_id": "ENSP00000498876.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 818,
"cds_start": -4,
"cds_end": null,
"cds_length": 2457,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4319,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 21,
"intron_rank_end": null,
"gene_symbol": "STAT2",
"gene_hgnc_id": 11363,
"hgvs_c": "c.2044+9C>T",
"hgvs_p": null,
"transcript": "NM_001385113.1",
"protein_id": "NP_001372042.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 807,
"cds_start": -4,
"cds_end": null,
"cds_length": 2424,
"cdna_start": null,
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"cdna_length": 4398,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "STAT2",
"gene_hgnc_id": 11363,
"hgvs_c": "c.1912+9C>T",
"hgvs_p": null,
"transcript": "ENST00000698186.1",
"protein_id": "ENSP00000513598.1",
"transcript_support_level": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 21,
"intron_rank_end": null,
"gene_symbol": "STAT2",
"gene_hgnc_id": 11363,
"hgvs_c": "c.2044+9C>T",
"hgvs_p": null,
"transcript": "ENST00000698193.1",
"protein_id": "ENSP00000513600.1",
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"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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},
{
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 3,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "STAT2",
"gene_hgnc_id": 11363,
"hgvs_c": "n.1634+9C>T",
"hgvs_p": null,
"transcript": "ENST00000555488.2",
"protein_id": null,
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"aa_start": null,
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},
{
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"strand": false,
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],
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"exon_count": 22,
"intron_rank": 19,
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"gene_symbol": "STAT2",
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"hgvs_c": "n.2816+9C>T",
"hgvs_p": null,
"transcript": "ENST00000556140.6",
"protein_id": null,
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"aa_start": null,
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"cds_start": -4,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
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],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "STAT2",
"gene_hgnc_id": 11363,
"hgvs_c": "n.*1478+9C>T",
"hgvs_p": null,
"transcript": "ENST00000650805.1",
"protein_id": "ENSP00000498710.1",
"transcript_support_level": null,
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},
{
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],
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"intron_rank": 19,
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"gene_symbol": "STAT2",
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"hgvs_c": "n.2697+9C>T",
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"transcript": "ENST00000651078.1",
"protein_id": null,
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"feature": null
},
{
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"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 21,
"intron_rank_end": null,
"gene_symbol": "STAT2",
"gene_hgnc_id": 11363,
"hgvs_c": "n.*1718+9C>T",
"hgvs_p": null,
"transcript": "ENST00000651301.1",
"protein_id": "ENSP00000498470.1",
"transcript_support_level": null,
"aa_start": null,
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"mane_select": null,
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"feature": null
},
{
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"protein_coding": false,
"strand": false,
"consequences": [
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],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "STAT2",
"gene_hgnc_id": 11363,
"hgvs_c": "n.779+9C>T",
"hgvs_p": null,
"transcript": "ENST00000651339.1",
"protein_id": null,
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},
{
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"protein_coding": false,
"strand": false,
"consequences": [
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],
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"exon_count": 21,
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"gene_symbol": "STAT2",
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},
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"consequences": [
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],
"exon_rank": null,
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"intron_rank_end": null,
"gene_symbol": "STAT2",
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"hgvs_c": "n.2484+9C>T",
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"transcript": "ENST00000651934.1",
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},
{
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"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 19,
"intron_rank": 16,
"intron_rank_end": null,
"gene_symbol": "STAT2",
"gene_hgnc_id": 11363,
"hgvs_c": "n.2159+9C>T",
"hgvs_p": null,
"transcript": "ENST00000651967.1",
"protein_id": null,
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"aa_start": null,
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"cds_start": -4,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 20,
"intron_rank_end": null,
"gene_symbol": "STAT2",
"gene_hgnc_id": 11363,
"hgvs_c": "n.2562+9C>T",
"hgvs_p": null,
"transcript": "ENST00000652091.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
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"aa_length": null,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
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