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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 12-57256482-G-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=12&pos=57256482&ref=G&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 0,
          "criteria": [
            "PM2",
            "PP3_Moderate"
          ],
          "effects": [
            "missense_variant"
          ],
          "gene_symbol": "R3HDM2",
          "hgnc_id": 29167,
          "hgvs_c": "c.2635C>T",
          "hgvs_p": "p.Pro879Ser",
          "inheritance_mode": "",
          "pathogenic_score": 4,
          "score": 4,
          "transcript": "NM_001351204.2",
          "verdict": "Uncertain_significance"
        },
        {
          "benign_score": 0,
          "criteria": [
            "PM2",
            "PP3_Moderate"
          ],
          "effects": [
            "non_coding_transcript_exon_variant"
          ],
          "gene_symbol": "ENSG00000258830",
          "hgnc_id": null,
          "hgvs_c": "n.*1529C>T",
          "hgvs_p": null,
          "inheritance_mode": "",
          "pathogenic_score": 4,
          "score": 4,
          "transcript": "ENST00000548184.1",
          "verdict": "Uncertain_significance"
        },
        {
          "benign_score": 0,
          "criteria": [
            "PM2",
            "PP3_Moderate"
          ],
          "effects": [
            "intron_variant"
          ],
          "gene_symbol": "ENSG00000295078",
          "hgnc_id": null,
          "hgvs_c": "n.808+16267G>A",
          "hgvs_p": null,
          "inheritance_mode": "",
          "pathogenic_score": 4,
          "score": 4,
          "transcript": "ENST00000727836.1",
          "verdict": "Uncertain_significance"
        }
      ],
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PM2,PP3_Moderate",
      "acmg_score": 4,
      "allele_count_reference_population": 5,
      "alphamissense_prediction": null,
      "alphamissense_score": 0.917,
      "alt": "A",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": "Pathogenic",
      "bayesdelnoaf_score": 0.21,
      "chr": "12",
      "clinvar_classification": "Uncertain significance",
      "clinvar_disease": "not specified",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "US:1",
      "computational_prediction_selected": "Pathogenic",
      "computational_score_selected": 0.8941010236740112,
      "computational_source_selected": "MetaRNN",
      "consequences": [
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 990,
          "aa_ref": "P",
          "aa_start": 827,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4411,
          "cdna_start": 2908,
          "cds_end": null,
          "cds_length": 2973,
          "cds_start": 2479,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 24,
          "exon_rank": 22,
          "exon_rank_end": null,
          "feature": "NM_001394031.1",
          "gene_hgnc_id": 29167,
          "gene_symbol": "R3HDM2",
          "hgvs_c": "c.2479C>T",
          "hgvs_p": "p.Pro827Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000402412.6",
          "protein_coding": true,
          "protein_id": "NP_001380960.1",
          "strand": false,
          "transcript": "NM_001394031.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 990,
          "aa_ref": "P",
          "aa_start": 827,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 4411,
          "cdna_start": 2908,
          "cds_end": null,
          "cds_length": 2973,
          "cds_start": 2479,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 24,
          "exon_rank": 22,
          "exon_rank_end": null,
          "feature": "ENST00000402412.6",
          "gene_hgnc_id": 29167,
          "gene_symbol": "R3HDM2",
          "hgvs_c": "c.2479C>T",
          "hgvs_p": "p.Pro827Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_001394031.1",
          "protein_coding": true,
          "protein_id": "ENSP00000385839.1",
          "strand": false,
          "transcript": "ENST00000402412.6",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 976,
          "aa_ref": "P",
          "aa_start": 813,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4331,
          "cdna_start": 2828,
          "cds_end": null,
          "cds_length": 2931,
          "cds_start": 2437,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 24,
          "exon_rank": 22,
          "exon_rank_end": null,
          "feature": "ENST00000347140.7",
          "gene_hgnc_id": 29167,
          "gene_symbol": "R3HDM2",
          "hgvs_c": "c.2437C>T",
          "hgvs_p": "p.Pro813Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000317903.6",
          "strand": false,
          "transcript": "ENST00000347140.7",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "retained_intron",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3778,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_count": 14,
          "exon_rank": 12,
          "exon_rank_end": null,
          "feature": "ENST00000393811.6",
          "gene_hgnc_id": 29167,
          "gene_symbol": "R3HDM2",
          "hgvs_c": "n.2273C>T",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": null,
          "strand": false,
          "transcript": "ENST00000393811.6",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "nonsense_mediated_decay",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 2107,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_count": 15,
          "exon_rank": 12,
          "exon_rank_end": null,
          "feature": "ENST00000548184.1",
          "gene_hgnc_id": null,
          "gene_symbol": "ENSG00000258830",
          "hgvs_c": "n.*1529C>T",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": "ENSP00000477227.1",
          "strand": false,
          "transcript": "ENST00000548184.1",
          "transcript_support_level": 2
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "nonsense_mediated_decay",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 2107,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_count": 15,
          "exon_rank": 12,
          "exon_rank_end": null,
          "feature": "ENST00000548184.1",
          "gene_hgnc_id": null,
          "gene_symbol": "ENSG00000258830",
          "hgvs_c": "n.*1529C>T",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": "ENSP00000477227.1",
          "strand": false,
          "transcript": "ENST00000548184.1",
          "transcript_support_level": 2
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 1042,
          "aa_ref": "P",
          "aa_start": 879,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4567,
          "cdna_start": 3064,
          "cds_end": null,
          "cds_length": 3129,
          "cds_start": 2635,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 26,
          "exon_rank": 24,
          "exon_rank_end": null,
          "feature": "NM_001351204.2",
          "gene_hgnc_id": 29167,
          "gene_symbol": "R3HDM2",
          "hgvs_c": "c.2635C>T",
          "hgvs_p": "p.Pro879Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001338133.1",
          "strand": false,
          "transcript": "NM_001351204.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 1042,
          "aa_ref": "P",
          "aa_start": 879,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4461,
          "cdna_start": 2958,
          "cds_end": null,
          "cds_length": 3129,
          "cds_start": 2635,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 25,
          "exon_rank": 23,
          "exon_rank_end": null,
          "feature": "NM_001351205.2",
          "gene_hgnc_id": 29167,
          "gene_symbol": "R3HDM2",
          "hgvs_c": "c.2635C>T",
          "hgvs_p": "p.Pro879Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001338134.1",
          "strand": false,
          "transcript": "NM_001351205.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 1042,
          "aa_ref": "P",
          "aa_start": 879,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4562,
          "cdna_start": 3059,
          "cds_end": null,
          "cds_length": 3129,
          "cds_start": 2635,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 25,
          "exon_rank": 23,
          "exon_rank_end": null,
          "feature": "NM_001351206.2",
          "gene_hgnc_id": 29167,
          "gene_symbol": "R3HDM2",
          "hgvs_c": "c.2635C>T",
          "hgvs_p": "p.Pro879Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001338135.1",
          "strand": false,
          "transcript": "NM_001351206.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 1032,
          "aa_ref": "P",
          "aa_start": 869,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4638,
          "cdna_start": 3135,
          "cds_end": null,
          "cds_length": 3099,
          "cds_start": 2605,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 27,
          "exon_rank": 25,
          "exon_rank_end": null,
          "feature": "NM_001351207.2",
          "gene_hgnc_id": 29167,
          "gene_symbol": "R3HDM2",
          "hgvs_c": "c.2605C>T",
          "hgvs_p": "p.Pro869Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001338136.1",
          "strand": false,
          "transcript": "NM_001351207.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 1024,
          "aa_ref": "P",
          "aa_start": 861,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4589,
          "cdna_start": 3086,
          "cds_end": null,
          "cds_length": 3075,
          "cds_start": 2581,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 24,
          "exon_rank": 22,
          "exon_rank_end": null,
          "feature": "NM_001351208.2",
          "gene_hgnc_id": 29167,
          "gene_symbol": "R3HDM2",
          "hgvs_c": "c.2581C>T",
          "hgvs_p": "p.Pro861Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001338137.1",
          "strand": false,
          "transcript": "NM_001351208.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 1022,
          "aa_ref": "P",
          "aa_start": 861,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4217,
          "cdna_start": 2723,
          "cds_end": null,
          "cds_length": 3069,
          "cds_start": 2581,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 25,
          "exon_rank": 23,
          "exon_rank_end": null,
          "feature": "ENST00000945082.1",
          "gene_hgnc_id": 29167,
          "gene_symbol": "R3HDM2",
          "hgvs_c": "c.2581C>T",
          "hgvs_p": "p.Pro861Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000615141.1",
          "strand": false,
          "transcript": "ENST00000945082.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 1010,
          "aa_ref": "P",
          "aa_start": 847,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4471,
          "cdna_start": 2968,
          "cds_end": null,
          "cds_length": 3033,
          "cds_start": 2539,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 25,
          "exon_rank": 23,
          "exon_rank_end": null,
          "feature": "NM_001330121.2",
          "gene_hgnc_id": 29167,
          "gene_symbol": "R3HDM2",
          "hgvs_c": "c.2539C>T",
          "hgvs_p": "p.Pro847Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001317050.1",
          "strand": false,
          "transcript": "NM_001330121.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 1010,
          "aa_ref": "P",
          "aa_start": 847,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4466,
          "cdna_start": 2963,
          "cds_end": null,
          "cds_length": 3033,
          "cds_start": 2539,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 24,
          "exon_rank": 22,
          "exon_rank_end": null,
          "feature": "NM_001330122.2",
          "gene_hgnc_id": 29167,
          "gene_symbol": "R3HDM2",
          "hgvs_c": "c.2539C>T",
          "hgvs_p": "p.Pro847Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001317051.1",
          "strand": false,
          "transcript": "NM_001330122.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 1010,
          "aa_ref": "P",
          "aa_start": 847,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3347,
          "cdna_start": 2836,
          "cds_end": null,
          "cds_length": 3033,
          "cds_start": 2539,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 24,
          "exon_rank": 22,
          "exon_rank_end": null,
          "feature": "ENST00000403821.6",
          "gene_hgnc_id": 29167,
          "gene_symbol": "R3HDM2",
          "hgvs_c": "c.2539C>T",
          "hgvs_p": "p.Pro847Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000385169.2",
          "strand": false,
          "transcript": "ENST00000403821.6",
          "transcript_support_level": 5
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 1008,
          "aa_ref": "P",
          "aa_start": 845,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4460,
          "cdna_start": 2957,
          "cds_end": null,
          "cds_length": 3027,
          "cds_start": 2533,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 24,
          "exon_rank": 22,
          "exon_rank_end": null,
          "feature": "NM_001351209.2",
          "gene_hgnc_id": 29167,
          "gene_symbol": "R3HDM2",
          "hgvs_c": "c.2533C>T",
          "hgvs_p": "p.Pro845Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001338138.1",
          "strand": false,
          "transcript": "NM_001351209.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 1008,
          "aa_ref": "P",
          "aa_start": 845,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4515,
          "cdna_start": 3015,
          "cds_end": null,
          "cds_length": 3027,
          "cds_start": 2533,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 26,
          "exon_rank": 24,
          "exon_rank_end": null,
          "feature": "ENST00000878714.1",
          "gene_hgnc_id": 29167,
          "gene_symbol": "R3HDM2",
          "hgvs_c": "c.2533C>T",
          "hgvs_p": "p.Pro845Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000548773.1",
          "strand": false,
          "transcript": "ENST00000878714.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 1008,
          "aa_ref": "P",
          "aa_start": 847,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4220,
          "cdna_start": 2725,
          "cds_end": null,
          "cds_length": 3027,
          "cds_start": 2539,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 25,
          "exon_rank": 23,
          "exon_rank_end": null,
          "feature": "ENST00000878715.1",
          "gene_hgnc_id": 29167,
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}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.