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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 12-62484182-G-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=12&pos=62484182&ref=G&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 0,
          "criteria": [
            "PM2",
            "PP3"
          ],
          "effects": [
            "missense_variant"
          ],
          "gene_symbol": "MON2",
          "hgnc_id": 29177,
          "hgvs_c": "c.124G>A",
          "hgvs_p": "p.Gly42Arg",
          "inheritance_mode": "AD",
          "pathogenic_score": 3,
          "score": 3,
          "transcript": "NM_015026.3",
          "verdict": "Uncertain_significance"
        },
        {
          "benign_score": 0,
          "criteria": [
            "PM2",
            "PP3"
          ],
          "effects": [
            "intron_variant"
          ],
          "gene_symbol": "MON2-AS1",
          "hgnc_id": 56698,
          "hgvs_c": "n.164+587C>T",
          "hgvs_p": null,
          "inheritance_mode": "",
          "pathogenic_score": 3,
          "score": 3,
          "transcript": "ENST00000551713.1",
          "verdict": "Uncertain_significance"
        }
      ],
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PM2,PP3",
      "acmg_score": 3,
      "allele_count_reference_population": 0,
      "alphamissense_prediction": null,
      "alphamissense_score": 0.9986,
      "alt": "A",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": "Pathogenic",
      "bayesdelnoaf_score": 0.2,
      "chr": "12",
      "clinvar_classification": "Uncertain significance",
      "clinvar_disease": "not specified",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "US:1",
      "computational_prediction_selected": "Pathogenic",
      "computational_score_selected": 0.7986477613449097,
      "computational_source_selected": "MetaRNN",
      "consequences": [
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 1717,
          "aa_ref": "G",
          "aa_start": 42,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 13263,
          "cdna_start": 506,
          "cds_end": null,
          "cds_length": 5154,
          "cds_start": 124,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 35,
          "exon_rank": 2,
          "exon_rank_end": null,
          "feature": "NM_015026.3",
          "gene_hgnc_id": 29177,
          "gene_symbol": "MON2",
          "hgvs_c": "c.124G>A",
          "hgvs_p": "p.Gly42Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000393630.8",
          "protein_coding": true,
          "protein_id": "NP_055841.2",
          "strand": true,
          "transcript": "NM_015026.3",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 1717,
          "aa_ref": "G",
          "aa_start": 42,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 13263,
          "cdna_start": 506,
          "cds_end": null,
          "cds_length": 5154,
          "cds_start": 124,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 35,
          "exon_rank": 2,
          "exon_rank_end": null,
          "feature": "ENST00000393630.8",
          "gene_hgnc_id": 29177,
          "gene_symbol": "MON2",
          "hgvs_c": "c.124G>A",
          "hgvs_p": "p.Gly42Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_015026.3",
          "protein_coding": true,
          "protein_id": "ENSP00000377250.4",
          "strand": true,
          "transcript": "ENST00000393630.8",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 1711,
          "aa_ref": "G",
          "aa_start": 42,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5612,
          "cdna_start": 484,
          "cds_end": null,
          "cds_length": 5136,
          "cds_start": 124,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 34,
          "exon_rank": 2,
          "exon_rank_end": null,
          "feature": "ENST00000393629.6",
          "gene_hgnc_id": 29177,
          "gene_symbol": "MON2",
          "hgvs_c": "c.124G>A",
          "hgvs_p": "p.Gly42Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000377249.2",
          "strand": true,
          "transcript": "ENST00000393629.6",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 1688,
          "aa_ref": "G",
          "aa_start": 42,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5543,
          "cdna_start": 484,
          "cds_end": null,
          "cds_length": 5067,
          "cds_start": 124,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 34,
          "exon_rank": 2,
          "exon_rank_end": null,
          "feature": "ENST00000552738.5",
          "gene_hgnc_id": 29177,
          "gene_symbol": "MON2",
          "hgvs_c": "c.124G>A",
          "hgvs_p": "p.Gly42Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000449215.1",
          "strand": true,
          "transcript": "ENST00000552738.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 1675,
          "aa_ref": "G",
          "aa_start": 42,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6130,
          "cdna_start": 510,
          "cds_end": null,
          "cds_length": 5028,
          "cds_start": 124,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 36,
          "exon_rank": 2,
          "exon_rank_end": null,
          "feature": "ENST00000546600.5",
          "gene_hgnc_id": 29177,
          "gene_symbol": "MON2",
          "hgvs_c": "c.124G>A",
          "hgvs_p": "p.Gly42Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000447407.1",
          "strand": true,
          "transcript": "ENST00000546600.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "nonsense_mediated_decay",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5708,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_count": 36,
          "exon_rank": 3,
          "exon_rank_end": null,
          "feature": "ENST00000547095.5",
          "gene_hgnc_id": 29177,
          "gene_symbol": "MON2",
          "hgvs_c": "n.*70G>A",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": "ENSP00000446626.1",
          "strand": true,
          "transcript": "ENST00000547095.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "nonsense_mediated_decay",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5708,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_count": 36,
          "exon_rank": 3,
          "exon_rank_end": null,
          "feature": "ENST00000547095.5",
          "gene_hgnc_id": 29177,
          "gene_symbol": "MON2",
          "hgvs_c": "n.*70G>A",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": "ENSP00000446626.1",
          "strand": true,
          "transcript": "ENST00000547095.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "pseudogene",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1689,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 5,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000549378.5",
          "gene_hgnc_id": 29177,
          "gene_symbol": "MON2",
          "hgvs_c": "n.476-14737G>A",
          "hgvs_p": null,
          "intron_rank": 1,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": null,
          "strand": true,
          "transcript": "ENST00000549378.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "pseudogene",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 848,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 2,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000551713.1",
          "gene_hgnc_id": 56698,
          "gene_symbol": "MON2-AS1",
          "hgvs_c": "n.164+587C>T",
          "hgvs_p": null,
          "intron_rank": 1,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": null,
          "strand": false,
          "transcript": "ENST00000551713.1",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 1718,
          "aa_ref": "G",
          "aa_start": 42,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 10382,
          "cdna_start": 515,
          "cds_end": null,
          "cds_length": 5157,
          "cds_start": 124,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 36,
          "exon_rank": 2,
          "exon_rank_end": null,
          "feature": "ENST00000641654.1",
          "gene_hgnc_id": 29177,
          "gene_symbol": "MON2",
          "hgvs_c": "c.124G>A",
          "hgvs_p": "p.Gly42Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000493462.1",
          "strand": true,
          "transcript": "ENST00000641654.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 1711,
          "aa_ref": "G",
          "aa_start": 42,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 13245,
          "cdna_start": 506,
          "cds_end": null,
          "cds_length": 5136,
          "cds_start": 124,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 34,
          "exon_rank": 2,
          "exon_rank_end": null,
          "feature": "NM_001278470.2",
          "gene_hgnc_id": 29177,
          "gene_symbol": "MON2",
          "hgvs_c": "c.124G>A",
          "hgvs_p": "p.Gly42Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001265399.1",
          "strand": true,
          "transcript": "NM_001278470.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 1694,
          "aa_ref": "G",
          "aa_start": 42,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6002,
          "cdna_start": 518,
          "cds_end": null,
          "cds_length": 5085,
          "cds_start": 124,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 35,
          "exon_rank": 2,
          "exon_rank_end": null,
          "feature": "ENST00000953602.1",
          "gene_hgnc_id": 29177,
          "gene_symbol": "MON2",
          "hgvs_c": "c.124G>A",
          "hgvs_p": "p.Gly42Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000623661.1",
          "strand": true,
          "transcript": "ENST00000953602.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 1688,
          "aa_ref": "G",
          "aa_start": 42,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 13176,
          "cdna_start": 506,
          "cds_end": null,
          "cds_length": 5067,
          "cds_start": 124,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 34,
          "exon_rank": 2,
          "exon_rank_end": null,
          "feature": "NM_001278471.2",
          "gene_hgnc_id": 29177,
          "gene_symbol": "MON2",
          "hgvs_c": "c.124G>A",
          "hgvs_p": "p.Gly42Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001265400.1",
          "strand": true,
          "transcript": "NM_001278471.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 1683,
          "aa_ref": "G",
          "aa_start": 42,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5965,
          "cdna_start": 512,
          "cds_end": null,
          "cds_length": 5052,
          "cds_start": 124,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 34,
          "exon_rank": 2,
          "exon_rank_end": null,
          "feature": "ENST00000953603.1",
          "gene_hgnc_id": 29177,
          "gene_symbol": "MON2",
          "hgvs_c": "c.124G>A",
          "hgvs_p": "p.Gly42Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000623662.1",
          "strand": true,
          "transcript": "ENST00000953603.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 1677,
          "aa_ref": "G",
          "aa_start": 42,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5967,
          "cdna_start": 533,
          "cds_end": null,
          "cds_length": 5034,
          "cds_start": 124,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 33,
          "exon_rank": 2,
          "exon_rank_end": null,
          "feature": "ENST00000854043.1",
          "gene_hgnc_id": 29177,
          "gene_symbol": "MON2",
          "hgvs_c": "c.124G>A",
          "hgvs_p": "p.Gly42Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000524102.1",
          "strand": true,
          "transcript": "ENST00000854043.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 1675,
          "aa_ref": "G",
          "aa_start": 42,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 13324,
          "cdna_start": 506,
          "cds_end": null,
          "cds_length": 5028,
          "cds_start": 124,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 36,
          "exon_rank": 2,
          "exon_rank_end": null,
          "feature": "NM_001278469.3",
          "gene_hgnc_id": 29177,
          "gene_symbol": "MON2",
          "hgvs_c": "c.124G>A",
          "hgvs_p": "p.Gly42Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001265398.1",
          "strand": true,
          "transcript": "NM_001278469.3",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 1668,
          "aa_ref": "G",
          "aa_start": 42,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5919,
          "cdna_start": 507,
          "cds_end": null,
          "cds_length": 5007,
          "cds_start": 124,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 33,
          "exon_rank": 2,
          "exon_rank_end": null,
          "feature": "ENST00000914365.1",
          "gene_hgnc_id": 29177,
          "gene_symbol": "MON2",
          "hgvs_c": "c.124G>A",
          "hgvs_p": "p.Gly42Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000584424.1",
          "strand": true,
          "transcript": "ENST00000914365.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 1646,
          "aa_ref": "G",
          "aa_start": 42,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5891,
          "cdna_start": 510,
          "cds_end": null,
          "cds_length": 4941,
          "cds_start": 124,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 33,
          "exon_rank": 2,
          "exon_rank_end": null,
          "feature": "ENST00000854042.1",
          "gene_hgnc_id": 29177,
          "gene_symbol": "MON2",
          "hgvs_c": "c.124G>A",
          "hgvs_p": "p.Gly42Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000524101.1",
          "strand": true,
          "transcript": "ENST00000854042.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 1633,
          "aa_ref": "G",
          "aa_start": 42,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6693,
          "cdna_start": 505,
          "cds_end": null,
          "cds_length": 4902,
          "cds_start": 124,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 33,
          "exon_rank": 2,
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For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.