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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 12-82380120-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=12&pos=82380120&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "12",
"pos": 82380120,
"ref": "T",
"alt": "C",
"effect": "intron_variant",
"transcript": "NM_032230.3",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "METTL25",
"gene_hgnc_id": 26228,
"hgvs_c": "c.260-6683T>C",
"hgvs_p": null,
"transcript": "NM_032230.3",
"protein_id": "NP_115606.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 603,
"cds_start": null,
"cds_end": null,
"cds_length": 1812,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000248306.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_032230.3"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "METTL25",
"gene_hgnc_id": 26228,
"hgvs_c": "c.260-6683T>C",
"hgvs_p": null,
"transcript": "ENST00000248306.8",
"protein_id": "ENSP00000248306.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 603,
"cds_start": null,
"cds_end": null,
"cds_length": 1812,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_032230.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000248306.8"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "METTL25",
"gene_hgnc_id": 26228,
"hgvs_c": "c.260-6683T>C",
"hgvs_p": null,
"transcript": "ENST00000548200.5",
"protein_id": "ENSP00000446878.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 238,
"cds_start": null,
"cds_end": null,
"cds_length": 717,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000548200.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "METTL25",
"gene_hgnc_id": 26228,
"hgvs_c": "n.297-6683T>C",
"hgvs_p": null,
"transcript": "ENST00000547357.5",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "pseudogene",
"feature": "ENST00000547357.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "METTL25",
"gene_hgnc_id": 26228,
"hgvs_c": "c.104-6683T>C",
"hgvs_p": null,
"transcript": "NM_001347934.2",
"protein_id": "NP_001334863.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 551,
"cds_start": null,
"cds_end": null,
"cds_length": 1656,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001347934.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "METTL25",
"gene_hgnc_id": 26228,
"hgvs_c": "c.260-9696T>C",
"hgvs_p": null,
"transcript": "ENST00000872357.1",
"protein_id": "ENSP00000542416.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 548,
"cds_start": null,
"cds_end": null,
"cds_length": 1647,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000872357.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "METTL25",
"gene_hgnc_id": 26228,
"hgvs_c": "c.-2-6683T>C",
"hgvs_p": null,
"transcript": "NM_001319675.2",
"protein_id": "NP_001306604.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 516,
"cds_start": null,
"cds_end": null,
"cds_length": 1551,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001319675.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "METTL25",
"gene_hgnc_id": 26228,
"hgvs_c": "c.259+21296T>C",
"hgvs_p": null,
"transcript": "ENST00000872358.1",
"protein_id": "ENSP00000542417.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 263,
"cds_start": null,
"cds_end": null,
"cds_length": 792,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000872358.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "METTL25",
"gene_hgnc_id": 26228,
"hgvs_c": "c.259+21296T>C",
"hgvs_p": null,
"transcript": "ENST00000872359.1",
"protein_id": "ENSP00000542418.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 207,
"cds_start": null,
"cds_end": null,
"cds_length": 624,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000872359.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "METTL25",
"gene_hgnc_id": 26228,
"hgvs_c": "c.351+21204T>C",
"hgvs_p": null,
"transcript": "ENST00000935491.1",
"protein_id": "ENSP00000605550.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 196,
"cds_start": null,
"cds_end": null,
"cds_length": 591,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000935491.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "METTL25",
"gene_hgnc_id": 26228,
"hgvs_c": "c.134-6683T>C",
"hgvs_p": null,
"transcript": "ENST00000550058.1",
"protein_id": "ENSP00000450317.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 187,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000550058.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 1,
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"gene_symbol": "METTL25",
"gene_hgnc_id": 26228,
"hgvs_c": "c.104-6683T>C",
"hgvs_p": null,
"transcript": "XM_047429658.1",
"protein_id": "XP_047285614.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 551,
"cds_start": null,
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"cdna_start": null,
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"biotype": "protein_coding",
"feature": "XM_047429658.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "METTL25",
"gene_hgnc_id": 26228,
"hgvs_c": "c.260-9696T>C",
"hgvs_p": null,
"transcript": "XM_011538827.4",
"protein_id": "XP_011537129.1",
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"cdna_start": null,
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 1,
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"gene_symbol": "METTL25",
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"hgvs_c": "c.260-6683T>C",
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"transcript": "XM_011538828.4",
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},
{
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"strand": true,
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"intron_variant"
],
"exon_rank": null,
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"exon_count": 10,
"intron_rank": 1,
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"gene_symbol": "METTL25",
"gene_hgnc_id": 26228,
"hgvs_c": "c.260-6683T>C",
"hgvs_p": null,
"transcript": "XM_011538829.4",
"protein_id": "XP_011537131.1",
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "XM_011538829.4"
},
{
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],
"exon_rank": null,
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"intron_rank": 1,
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"gene_symbol": "METTL25",
"gene_hgnc_id": 26228,
"hgvs_c": "c.260-6683T>C",
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"transcript": "XM_047429659.1",
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},
{
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"protein_coding": true,
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],
"exon_rank": null,
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"exon_count": 7,
"intron_rank": 1,
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"gene_symbol": "METTL25",
"gene_hgnc_id": 26228,
"hgvs_c": "c.260-6683T>C",
"hgvs_p": null,
"transcript": "XM_005269186.6",
"protein_id": "XP_005269243.2",
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"biotype": "protein_coding",
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "METTL25",
"gene_hgnc_id": 26228,
"hgvs_c": "c.260-9696T>C",
"hgvs_p": null,
"transcript": "XM_047429660.1",
"protein_id": "XP_047285616.1",
"transcript_support_level": null,
"aa_start": null,
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 1,
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"gene_symbol": "METTL25",
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"hgvs_c": "c.-2-6683T>C",
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"transcript": "XM_047429661.1",
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},
{
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"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
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"exon_count": 2,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "METTL25",
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"hgvs_c": "n.389-6683T>C",
"hgvs_p": null,
"transcript": "ENST00000547985.1",
"protein_id": null,
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"feature": "ENST00000547985.1"
},
{
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"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"intron_rank": 1,
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"gene_symbol": "METTL25",
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"hgvs_c": "n.298-6683T>C",
"hgvs_p": null,
"transcript": "ENST00000548569.5",
"protein_id": null,
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"cds_start": null,
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"mane_plus": null,
"biotype": "pseudogene",
"feature": "ENST00000548569.5"
},
{
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"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "METTL25",
"gene_hgnc_id": 26228,
"hgvs_c": "n.284+5810T>C",
"hgvs_p": null,
"transcript": "ENST00000551722.1",
"protein_id": null,
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "pseudogene",
"feature": "ENST00000551722.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "METTL25",
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}