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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 12-9076800-C-G (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=12&pos=9076800&ref=C&alt=G&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 0,
          "criteria": [
            "PM2"
          ],
          "effects": [
            "missense_variant"
          ],
          "gene_symbol": "A2M",
          "hgnc_id": 7,
          "hgvs_c": "c.3488G>C",
          "hgvs_p": "p.Arg1163Thr",
          "inheritance_mode": "Unknown",
          "pathogenic_score": 2,
          "score": 2,
          "transcript": "NM_000014.6",
          "verdict": "Uncertain_significance"
        },
        {
          "benign_score": 0,
          "criteria": [
            "PM2"
          ],
          "effects": [
            "intron_variant"
          ],
          "gene_symbol": "KLRG1",
          "hgnc_id": 6380,
          "hgvs_c": "c.*33+18634C>G",
          "hgvs_p": null,
          "inheritance_mode": "AR",
          "pathogenic_score": 2,
          "score": 2,
          "transcript": "XM_017018684.2",
          "verdict": "Uncertain_significance"
        }
      ],
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PM2",
      "acmg_score": 2,
      "allele_count_reference_population": 0,
      "alphamissense_prediction": "Benign",
      "alphamissense_score": 0.1148,
      "alt": "G",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": "Benign",
      "bayesdelnoaf_score": -0.48,
      "chr": "12",
      "clinvar_classification": "Uncertain significance",
      "clinvar_disease": "not specified",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "US:1",
      "computational_prediction_selected": "Uncertain_significance",
      "computational_score_selected": 0.5217900276184082,
      "computational_source_selected": "MetaRNN",
      "consequences": [
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 1474,
          "aa_ref": "R",
          "aa_start": 1163,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4610,
          "cdna_start": 3558,
          "cds_end": null,
          "cds_length": 4425,
          "cds_start": 3488,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 36,
          "exon_rank": 28,
          "exon_rank_end": null,
          "feature": "NM_000014.6",
          "gene_hgnc_id": 7,
          "gene_symbol": "A2M",
          "hgvs_c": "c.3488G>C",
          "hgvs_p": "p.Arg1163Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000318602.12",
          "protein_coding": true,
          "protein_id": "NP_000005.3",
          "strand": false,
          "transcript": "NM_000014.6",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 1474,
          "aa_ref": "R",
          "aa_start": 1163,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 4610,
          "cdna_start": 3558,
          "cds_end": null,
          "cds_length": 4425,
          "cds_start": 3488,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 36,
          "exon_rank": 28,
          "exon_rank_end": null,
          "feature": "ENST00000318602.12",
          "gene_hgnc_id": 7,
          "gene_symbol": "A2M",
          "hgvs_c": "c.3488G>C",
          "hgvs_p": "p.Arg1163Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_000014.6",
          "protein_coding": true,
          "protein_id": "ENSP00000323929.8",
          "strand": false,
          "transcript": "ENST00000318602.12",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 1520,
          "aa_ref": "R",
          "aa_start": 1209,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4742,
          "cdna_start": 3696,
          "cds_end": null,
          "cds_length": 4563,
          "cds_start": 3626,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 37,
          "exon_rank": 29,
          "exon_rank_end": null,
          "feature": "ENST00000891833.1",
          "gene_hgnc_id": 7,
          "gene_symbol": "A2M",
          "hgvs_c": "c.3626G>C",
          "hgvs_p": "p.Arg1209Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000561892.1",
          "strand": false,
          "transcript": "ENST00000891833.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 1501,
          "aa_ref": "R",
          "aa_start": 1163,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4692,
          "cdna_start": 3558,
          "cds_end": null,
          "cds_length": 4506,
          "cds_start": 3488,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 36,
          "exon_rank": 28,
          "exon_rank_end": null,
          "feature": "ENST00000956132.1",
          "gene_hgnc_id": 7,
          "gene_symbol": "A2M",
          "hgvs_c": "c.3488G>C",
          "hgvs_p": "p.Arg1163Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000626191.1",
          "strand": false,
          "transcript": "ENST00000956132.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 1484,
          "aa_ref": "R",
          "aa_start": 1173,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4640,
          "cdna_start": 3588,
          "cds_end": null,
          "cds_length": 4455,
          "cds_start": 3518,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 37,
          "exon_rank": 29,
          "exon_rank_end": null,
          "feature": "ENST00000956134.1",
          "gene_hgnc_id": 7,
          "gene_symbol": "A2M",
          "hgvs_c": "c.3518G>C",
          "hgvs_p": "p.Arg1173Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000626193.1",
          "strand": false,
          "transcript": "ENST00000956134.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 1474,
          "aa_ref": "R",
          "aa_start": 1163,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4659,
          "cdna_start": 3607,
          "cds_end": null,
          "cds_length": 4425,
          "cds_start": 3488,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 37,
          "exon_rank": 29,
          "exon_rank_end": null,
          "feature": "NM_001347423.2",
          "gene_hgnc_id": 7,
          "gene_symbol": "A2M",
          "hgvs_c": "c.3488G>C",
          "hgvs_p": "p.Arg1163Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001334352.2",
          "strand": false,
          "transcript": "NM_001347423.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 1474,
          "aa_ref": "R",
          "aa_start": 1163,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4653,
          "cdna_start": 3601,
          "cds_end": null,
          "cds_length": 4425,
          "cds_start": 3488,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 37,
          "exon_rank": 29,
          "exon_rank_end": null,
          "feature": "ENST00000891824.1",
          "gene_hgnc_id": 7,
          "gene_symbol": "A2M",
          "hgvs_c": "c.3488G>C",
          "hgvs_p": "p.Arg1163Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000561883.1",
          "strand": false,
          "transcript": "ENST00000891824.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 1473,
          "aa_ref": "R",
          "aa_start": 1162,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4607,
          "cdna_start": 3555,
          "cds_end": null,
          "cds_length": 4422,
          "cds_start": 3485,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 36,
          "exon_rank": 28,
          "exon_rank_end": null,
          "feature": "ENST00000891825.1",
          "gene_hgnc_id": 7,
          "gene_symbol": "A2M",
          "hgvs_c": "c.3485G>C",
          "hgvs_p": "p.Arg1162Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000561884.1",
          "strand": false,
          "transcript": "ENST00000891825.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 1471,
          "aa_ref": "R",
          "aa_start": 1160,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4595,
          "cdna_start": 3549,
          "cds_end": null,
          "cds_length": 4416,
          "cds_start": 3479,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 36,
          "exon_rank": 28,
          "exon_rank_end": null,
          "feature": "ENST00000891834.1",
          "gene_hgnc_id": 7,
          "gene_symbol": "A2M",
          "hgvs_c": "c.3479G>C",
          "hgvs_p": "p.Arg1160Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000561893.1",
          "strand": false,
          "transcript": "ENST00000891834.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 1471,
          "aa_ref": "R",
          "aa_start": 1160,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4601,
          "cdna_start": 3549,
          "cds_end": null,
          "cds_length": 4416,
          "cds_start": 3479,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 36,
          "exon_rank": 28,
          "exon_rank_end": null,
          "feature": "ENST00000956135.1",
          "gene_hgnc_id": 7,
          "gene_symbol": "A2M",
          "hgvs_c": "c.3479G>C",
          "hgvs_p": "p.Arg1160Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000626194.1",
          "strand": false,
          "transcript": "ENST00000956135.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 1467,
          "aa_ref": "R",
          "aa_start": 1156,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4589,
          "cdna_start": 3537,
          "cds_end": null,
          "cds_length": 4404,
          "cds_start": 3467,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 36,
          "exon_rank": 28,
          "exon_rank_end": null,
          "feature": "ENST00000891829.1",
          "gene_hgnc_id": 7,
          "gene_symbol": "A2M",
          "hgvs_c": "c.3467G>C",
          "hgvs_p": "p.Arg1156Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000561888.1",
          "strand": false,
          "transcript": "ENST00000891829.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 1461,
          "aa_ref": "R",
          "aa_start": 1150,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4571,
          "cdna_start": 3519,
          "cds_end": null,
          "cds_length": 4386,
          "cds_start": 3449,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 36,
          "exon_rank": 28,
          "exon_rank_end": null,
          "feature": "ENST00000956133.1",
          "gene_hgnc_id": 7,
          "gene_symbol": "A2M",
          "hgvs_c": "c.3449G>C",
          "hgvs_p": "p.Arg1150Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000626192.1",
          "strand": false,
          "transcript": "ENST00000956133.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 1425,
          "aa_ref": "R",
          "aa_start": 1163,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4459,
          "cdna_start": 3558,
          "cds_end": null,
          "cds_length": 4278,
          "cds_start": 3488,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 36,
          "exon_rank": 28,
          "exon_rank_end": null,
          "feature": "ENST00000891830.1",
          "gene_hgnc_id": 7,
          "gene_symbol": "A2M",
          "hgvs_c": "c.3488G>C",
          "hgvs_p": "p.Arg1163Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000561889.1",
          "strand": false,
          "transcript": "ENST00000891830.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 1420,
          "aa_ref": "R",
          "aa_start": 1109,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4443,
          "cdna_start": 3396,
          "cds_end": null,
          "cds_length": 4263,
          "cds_start": 3326,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 35,
          "exon_rank": 27,
          "exon_rank_end": null,
          "feature": "ENST00000956136.1",
          "gene_hgnc_id": 7,
          "gene_symbol": "A2M",
          "hgvs_c": "c.3326G>C",
          "hgvs_p": "p.Arg1109Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000626195.1",
          "strand": false,
          "transcript": "ENST00000956136.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 1415,
          "aa_ref": "R",
          "aa_start": 1104,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4433,
          "cdna_start": 3381,
          "cds_end": null,
          "cds_length": 4248,
          "cds_start": 3311,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 35,
          "exon_rank": 27,
          "exon_rank_end": null,
          "feature": "ENST00000891826.1",
          "gene_hgnc_id": 7,
          "gene_symbol": "A2M",
          "hgvs_c": "c.3311G>C",
          "hgvs_p": "p.Arg1104Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000561885.1",
          "strand": false,
          "transcript": "ENST00000891826.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 1402,
          "aa_ref": "R",
          "aa_start": 1163,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4390,
          "cdna_start": 3558,
          "cds_end": null,
          "cds_length": 4209,
          "cds_start": 3488,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 36,
          "exon_rank": 28,
          "exon_rank_end": null,
          "feature": "ENST00000891832.1",
          "gene_hgnc_id": 7,
          "gene_symbol": "A2M",
          "hgvs_c": "c.3488G>C",
          "hgvs_p": "p.Arg1163Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000561891.1",
          "strand": false,
          "transcript": "ENST00000891832.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 1398,
          "aa_ref": "R",
          "aa_start": 1087,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4378,
          "cdna_start": 3330,
          "cds_end": null,
          "cds_length": 4197,
          "cds_start": 3260,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 35,
          "exon_rank": 27,
          "exon_rank_end": null,
          "feature": "ENST00000891831.1",
          "gene_hgnc_id": 7,
          "gene_symbol": "A2M",
          "hgvs_c": "c.3260G>C",
          "hgvs_p": "p.Arg1087Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000561890.1",
          "strand": false,
          "transcript": "ENST00000891831.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 1374,
          "aa_ref": "R",
          "aa_start": 1063,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4763,
          "cdna_start": 3711,
          "cds_end": null,
          "cds_length": 4125,
          "cds_start": 3188,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 36,
          "exon_rank": 28,
          "exon_rank_end": null,
          "feature": "NM_001347424.2",
          "gene_hgnc_id": 7,
          "gene_symbol": "A2M",
          "hgvs_c": "c.3188G>C",
          "hgvs_p": "p.Arg1063Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001334353.2",
          "strand": false,
          "transcript": "NM_001347424.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 1342,
          "aa_ref": "R",
          "aa_start": 1031,
          "biotype": "protein_coding",
          "canonical": false,
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For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.