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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 12-908031-C-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=12&pos=908031&ref=C&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 21,
          "criteria": [
            "BP4_Strong",
            "BP6_Very_Strong",
            "BP7",
            "BA1"
          ],
          "effects": [
            "synonymous_variant"
          ],
          "gene_symbol": "WNK1",
          "hgnc_id": 14540,
          "hgvs_c": "c.7608C>T",
          "hgvs_p": "p.Tyr2536Tyr",
          "inheritance_mode": "AR,AD",
          "pathogenic_score": 0,
          "score": -21,
          "transcript": "NM_001184985.2",
          "verdict": "Benign"
        }
      ],
      "acmg_classification": "Benign",
      "acmg_criteria": "BP4_Strong,BP6_Very_Strong,BP7,BA1",
      "acmg_score": -21,
      "allele_count_reference_population": 1610593,
      "alphamissense_prediction": null,
      "alphamissense_score": null,
      "alt": "T",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": "Benign",
      "bayesdelnoaf_score": -0.65,
      "chr": "12",
      "clinvar_classification": "Benign",
      "clinvar_disease": " hereditary sensory and autonomic, type 2A,Neuropathy,Pseudohypoaldosteronism type 2C,not provided,not specified",
      "clinvar_review_status": "criteria provided, multiple submitters, no conflicts",
      "clinvar_submissions_summary": "B:7",
      "computational_prediction_selected": "Benign",
      "computational_score_selected": -0.6499999761581421,
      "computational_source_selected": "BayesDel_noAF",
      "consequences": [
        {
          "aa_alt": "Y",
          "aa_end": null,
          "aa_length": 2634,
          "aa_ref": "Y",
          "aa_start": 2528,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 11552,
          "cdna_start": 8571,
          "cds_end": null,
          "cds_length": 7905,
          "cds_start": 7584,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 28,
          "exon_rank": 27,
          "exon_rank_end": null,
          "feature": "NM_213655.5",
          "gene_hgnc_id": 14540,
          "gene_symbol": "WNK1",
          "hgvs_c": "c.7584C>T",
          "hgvs_p": "p.Tyr2528Tyr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": "ENST00000340908.9",
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_998820.3",
          "strand": true,
          "transcript": "NM_213655.5",
          "transcript_support_level": null
        },
        {
          "aa_alt": "Y",
          "aa_end": null,
          "aa_length": 2634,
          "aa_ref": "Y",
          "aa_start": 2528,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 11552,
          "cdna_start": 8571,
          "cds_end": null,
          "cds_length": 7905,
          "cds_start": 7584,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 28,
          "exon_rank": 27,
          "exon_rank_end": null,
          "feature": "ENST00000340908.9",
          "gene_hgnc_id": 14540,
          "gene_symbol": "WNK1",
          "hgvs_c": "c.7584C>T",
          "hgvs_p": "p.Tyr2528Tyr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": "NM_213655.5",
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000341292.5",
          "strand": true,
          "transcript": "ENST00000340908.9",
          "transcript_support_level": 5
        },
        {
          "aa_alt": "Y",
          "aa_end": null,
          "aa_length": 2382,
          "aa_ref": "Y",
          "aa_start": 2276,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 10796,
          "cdna_start": 7815,
          "cds_end": null,
          "cds_length": 7149,
          "cds_start": 6828,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 28,
          "exon_rank": 27,
          "exon_rank_end": null,
          "feature": "NM_018979.4",
          "gene_hgnc_id": 14540,
          "gene_symbol": "WNK1",
          "hgvs_c": "c.6828C>T",
          "hgvs_p": "p.Tyr2276Tyr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000315939.11",
          "protein_coding": true,
          "protein_id": "NP_061852.3",
          "strand": true,
          "transcript": "NM_018979.4",
          "transcript_support_level": null
        },
        {
          "aa_alt": "Y",
          "aa_end": null,
          "aa_length": 2382,
          "aa_ref": "Y",
          "aa_start": 2276,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 10796,
          "cdna_start": 7815,
          "cds_end": null,
          "cds_length": 7149,
          "cds_start": 6828,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 28,
          "exon_rank": 27,
          "exon_rank_end": null,
          "feature": "ENST00000315939.11",
          "gene_hgnc_id": 14540,
          "gene_symbol": "WNK1",
          "hgvs_c": "c.6828C>T",
          "hgvs_p": "p.Tyr2276Tyr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_018979.4",
          "protein_coding": true,
          "protein_id": "ENSP00000313059.6",
          "strand": true,
          "transcript": "ENST00000315939.11",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "Y",
          "aa_end": null,
          "aa_length": 2833,
          "aa_ref": "Y",
          "aa_start": 2727,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 11804,
          "cdna_start": 8824,
          "cds_end": null,
          "cds_length": 8502,
          "cds_start": 8181,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 31,
          "exon_rank": 30,
          "exon_rank_end": null,
          "feature": "ENST00000530271.6",
          "gene_hgnc_id": 14540,
          "gene_symbol": "WNK1",
          "hgvs_c": "c.8181C>T",
          "hgvs_p": "p.Tyr2727Tyr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000433548.3",
          "strand": true,
          "transcript": "ENST00000530271.6",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "Y",
          "aa_end": null,
          "aa_length": 2134,
          "aa_ref": "Y",
          "aa_start": 2028,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 9886,
          "cdna_start": 7057,
          "cds_end": null,
          "cds_length": 6405,
          "cds_start": 6084,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 26,
          "exon_rank": 25,
          "exon_rank_end": null,
          "feature": "ENST00000535572.5",
          "gene_hgnc_id": 14540,
          "gene_symbol": "WNK1",
          "hgvs_c": "c.6084C>T",
          "hgvs_p": "p.Tyr2028Tyr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000441972.1",
          "strand": true,
          "transcript": "ENST00000535572.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "retained_intron",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 874,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_count": 2,
          "exon_rank": 1,
          "exon_rank_end": null,
          "feature": "ENST00000540885.1",
          "gene_hgnc_id": 14540,
          "gene_symbol": "WNK1",
          "hgvs_c": "n.312C>T",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": null,
          "strand": true,
          "transcript": "ENST00000540885.1",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "Y",
          "aa_end": null,
          "aa_length": 2642,
          "aa_ref": "Y",
          "aa_start": 2536,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 11576,
          "cdna_start": 8595,
          "cds_end": null,
          "cds_length": 7929,
          "cds_start": 7608,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 28,
          "exon_rank": 27,
          "exon_rank_end": null,
          "feature": "NM_001184985.2",
          "gene_hgnc_id": 14540,
          "gene_symbol": "WNK1",
          "hgvs_c": "c.7608C>T",
          "hgvs_p": "p.Tyr2536Tyr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001171914.1",
          "strand": true,
          "transcript": "NM_001184985.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "Y",
          "aa_end": null,
          "aa_length": 2642,
          "aa_ref": "Y",
          "aa_start": 2536,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 11232,
          "cdna_start": 8251,
          "cds_end": null,
          "cds_length": 7929,
          "cds_start": 7608,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 28,
          "exon_rank": 27,
          "exon_rank_end": null,
          "feature": "ENST00000537687.5",
          "gene_hgnc_id": 14540,
          "gene_symbol": "WNK1",
          "hgvs_c": "c.7608C>T",
          "hgvs_p": "p.Tyr2536Tyr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000444465.1",
          "strand": true,
          "transcript": "ENST00000537687.5",
          "transcript_support_level": 5
        },
        {
          "aa_alt": "Y",
          "aa_end": null,
          "aa_length": 2381,
          "aa_ref": "Y",
          "aa_start": 2275,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 10773,
          "cdna_start": 7794,
          "cds_end": null,
          "cds_length": 7146,
          "cds_start": 6825,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 28,
          "exon_rank": 27,
          "exon_rank_end": null,
          "feature": "ENST00000899151.1",
          "gene_hgnc_id": 14540,
          "gene_symbol": "WNK1",
          "hgvs_c": "c.6825C>T",
          "hgvs_p": "p.Tyr2275Tyr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000569210.1",
          "strand": true,
          "transcript": "ENST00000899151.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "Y",
          "aa_end": null,
          "aa_length": 2354,
          "aa_ref": "Y",
          "aa_start": 2248,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 10701,
          "cdna_start": 7720,
          "cds_end": null,
          "cds_length": 7065,
          "cds_start": 6744,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 27,
          "exon_rank": 26,
          "exon_rank_end": null,
          "feature": "ENST00000928791.1",
          "gene_hgnc_id": 14540,
          "gene_symbol": "WNK1",
          "hgvs_c": "c.6744C>T",
          "hgvs_p": "p.Tyr2248Tyr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000598850.1",
          "strand": true,
          "transcript": "ENST00000928791.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "Y",
          "aa_end": null,
          "aa_length": 2228,
          "aa_ref": "Y",
          "aa_start": 2122,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 7746,
          "cdna_start": 6797,
          "cds_end": null,
          "cds_length": 6687,
          "cds_start": 6366,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 27,
          "exon_rank": 26,
          "exon_rank_end": null,
          "feature": "ENST00000899157.1",
          "gene_hgnc_id": 14540,
          "gene_symbol": "WNK1",
          "hgvs_c": "c.6366C>T",
          "hgvs_p": "p.Tyr2122Tyr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000569216.1",
          "strand": true,
          "transcript": "ENST00000899157.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "Y",
          "aa_end": null,
          "aa_length": 2136,
          "aa_ref": "Y",
          "aa_start": 2030,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 10057,
          "cdna_start": 7077,
          "cds_end": null,
          "cds_length": 6411,
          "cds_start": 6090,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 26,
          "exon_rank": 25,
          "exon_rank_end": null,
          "feature": "ENST00000899150.1",
          "gene_hgnc_id": 14540,
          "gene_symbol": "WNK1",
          "hgvs_c": "c.6090C>T",
          "hgvs_p": "p.Tyr2030Tyr",
          "intron_rank": null,
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          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000569209.1",
          "strand": true,
          "transcript": "ENST00000899150.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "Y",
          "aa_end": null,
          "aa_length": 2135,
          "aa_ref": "Y",
          "aa_start": 2029,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 9845,
          "cdna_start": 7074,
          "cds_end": null,
          "cds_length": 6408,
          "cds_start": 6087,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 26,
          "exon_rank": 25,
          "exon_rank_end": null,
          "feature": "ENST00000899152.1",
          "gene_hgnc_id": 14540,
          "gene_symbol": "WNK1",
          "hgvs_c": "c.6087C>T",
          "hgvs_p": "p.Tyr2029Tyr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000569211.1",
          "strand": true,
          "transcript": "ENST00000899152.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "Y",
          "aa_end": null,
          "aa_length": 2135,
          "aa_ref": "Y",
          "aa_start": 2029,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 7844,
          "cdna_start": 6895,
          "cds_end": null,
          "cds_length": 6408,
          "cds_start": 6087,
          "consequences": [
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          ],
          "exon_count": 26,
          "exon_rank": 25,
          "exon_rank_end": null,
          "feature": "ENST00000899156.1",
          "gene_hgnc_id": 14540,
          "gene_symbol": "WNK1",
          "hgvs_c": "c.6087C>T",
          "hgvs_p": "p.Tyr2029Tyr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000569215.1",
          "strand": true,
          "transcript": "ENST00000899156.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "Y",
          "aa_end": null,
          "aa_length": 2134,
          "aa_ref": "Y",
          "aa_start": 2028,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 10052,
          "cdna_start": 7071,
          "cds_end": null,
          "cds_length": 6405,
          "cds_start": 6084,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 26,
          "exon_rank": 25,
          "exon_rank_end": null,
          "feature": "NM_014823.3",
          "gene_hgnc_id": 14540,
          "gene_symbol": "WNK1",
          "hgvs_c": "c.6084C>T",
          "hgvs_p": "p.Tyr2028Tyr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_055638.2",
          "strand": true,
          "transcript": "NM_014823.3",
          "transcript_support_level": null
        },
        {
          "aa_alt": "Y",
          "aa_end": null,
          "aa_length": 2107,
          "aa_ref": "Y",
          "aa_start": 2001,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 7982,
          "cdna_start": 7033,
          "cds_end": null,
          "cds_length": 6324,
          "cds_start": 6003,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 25,
          "exon_rank": 24,
          "exon_rank_end": null,
          "feature": "ENST00000899153.1",
          "gene_hgnc_id": 14540,
          "gene_symbol": "WNK1",
          "hgvs_c": "c.6003C>T",
          "hgvs_p": "p.Tyr2001Tyr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000569212.1",
          "strand": true,
          "transcript": "ENST00000899153.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "Y",
          "aa_end": null,
          "aa_length": 2107,
          "aa_ref": "Y",
          "aa_start": 2001,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 7928,
          "cdna_start": 6979,
          "cds_end": null,
          "cds_length": 6324,
          "cds_start": 6003,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 25,
          "exon_rank": 24,
          "exon_rank_end": null,
          "feature": "ENST00000899154.1",
          "gene_hgnc_id": 14540,
          "gene_symbol": "WNK1",
          "hgvs_c": "c.6003C>T",
          "hgvs_p": "p.Tyr2001Tyr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000569213.1",
          "strand": true,
          "transcript": "ENST00000899154.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "Y",
          "aa_end": null,
          "aa_length": 2106,
          "aa_ref": "Y",
          "aa_start": 2000,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 7921,
          "cdna_start": 6972,
          "cds_end": null,
          "cds_length": 6321,
          "cds_start": 6000,
          "consequences": [
            "synonymous_variant"
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}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.