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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 13-101726667-C-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=13&pos=101726667&ref=C&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "13",
"pos": 101726667,
"ref": "C",
"alt": "A",
"effect": "synonymous_variant",
"transcript": "ENST00000376143.5",
"consequences": [
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGF14",
"gene_hgnc_id": 3671,
"hgvs_c": "c.552G>T",
"hgvs_p": "p.Gly184Gly",
"transcript": "NM_004115.4",
"protein_id": "NP_004106.1",
"transcript_support_level": null,
"aa_start": 184,
"aa_end": null,
"aa_length": 247,
"cds_start": 552,
"cds_end": null,
"cds_length": 744,
"cdna_start": 852,
"cdna_end": null,
"cdna_length": 13071,
"mane_select": "ENST00000376143.5",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGF14",
"gene_hgnc_id": 3671,
"hgvs_c": "c.552G>T",
"hgvs_p": "p.Gly184Gly",
"transcript": "ENST00000376143.5",
"protein_id": "ENSP00000365313.4",
"transcript_support_level": 1,
"aa_start": 184,
"aa_end": null,
"aa_length": 247,
"cds_start": 552,
"cds_end": null,
"cds_length": 744,
"cdna_start": 852,
"cdna_end": null,
"cdna_length": 13071,
"mane_select": "NM_004115.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGF14",
"gene_hgnc_id": 3671,
"hgvs_c": "c.567G>T",
"hgvs_p": "p.Gly189Gly",
"transcript": "ENST00000376131.9",
"protein_id": "ENSP00000365301.3",
"transcript_support_level": 1,
"aa_start": 189,
"aa_end": null,
"aa_length": 252,
"cds_start": 567,
"cds_end": null,
"cds_length": 759,
"cdna_start": 937,
"cdna_end": null,
"cdna_length": 13156,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGF14",
"gene_hgnc_id": 3671,
"hgvs_c": "c.567G>T",
"hgvs_p": "p.Gly189Gly",
"transcript": "NM_175929.3",
"protein_id": "NP_787125.1",
"transcript_support_level": null,
"aa_start": 189,
"aa_end": null,
"aa_length": 252,
"cds_start": 567,
"cds_end": null,
"cds_length": 759,
"cdna_start": 937,
"cdna_end": null,
"cdna_length": 13156,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGF14",
"gene_hgnc_id": 3671,
"hgvs_c": "c.456G>T",
"hgvs_p": "p.Gly152Gly",
"transcript": "NM_001321939.2",
"protein_id": "NP_001308868.1",
"transcript_support_level": null,
"aa_start": 152,
"aa_end": null,
"aa_length": 215,
"cds_start": 456,
"cds_end": null,
"cds_length": 648,
"cdna_start": 826,
"cdna_end": null,
"cdna_length": 13045,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGF14",
"gene_hgnc_id": 3671,
"hgvs_c": "c.450G>T",
"hgvs_p": "p.Gly150Gly",
"transcript": "NM_001321945.2",
"protein_id": "NP_001308874.1",
"transcript_support_level": null,
"aa_start": 150,
"aa_end": null,
"aa_length": 213,
"cds_start": 450,
"cds_end": null,
"cds_length": 642,
"cdna_start": 808,
"cdna_end": null,
"cdna_length": 13027,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGF14",
"gene_hgnc_id": 3671,
"hgvs_c": "c.450G>T",
"hgvs_p": "p.Gly150Gly",
"transcript": "NM_001321948.2",
"protein_id": "NP_001308877.1",
"transcript_support_level": null,
"aa_start": 150,
"aa_end": null,
"aa_length": 213,
"cds_start": 450,
"cds_end": null,
"cds_length": 642,
"cdna_start": 804,
"cdna_end": null,
"cdna_length": 13023,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGF14",
"gene_hgnc_id": 3671,
"hgvs_c": "c.450G>T",
"hgvs_p": "p.Gly150Gly",
"transcript": "NM_001379342.1",
"protein_id": "NP_001366271.1",
"transcript_support_level": null,
"aa_start": 150,
"aa_end": null,
"aa_length": 213,
"cds_start": 450,
"cds_end": null,
"cds_length": 642,
"cdna_start": 795,
"cdna_end": null,
"cdna_length": 13014,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGF14",
"gene_hgnc_id": 3671,
"hgvs_c": "c.450G>T",
"hgvs_p": "p.Gly150Gly",
"transcript": "ENST00000418923.3",
"protein_id": "ENSP00000516414.1",
"transcript_support_level": 3,
"aa_start": 150,
"aa_end": null,
"aa_length": 213,
"cds_start": 450,
"cds_end": null,
"cds_length": 642,
"cdna_start": 818,
"cdna_end": null,
"cdna_length": 1922,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGF14",
"gene_hgnc_id": 3671,
"hgvs_c": "c.411G>T",
"hgvs_p": "p.Gly137Gly",
"transcript": "NM_001321947.2",
"protein_id": "NP_001308876.1",
"transcript_support_level": null,
"aa_start": 137,
"aa_end": null,
"aa_length": 200,
"cds_start": 411,
"cds_end": null,
"cds_length": 603,
"cdna_start": 732,
"cdna_end": null,
"cdna_length": 12951,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGF14",
"gene_hgnc_id": 3671,
"hgvs_c": "c.372G>T",
"hgvs_p": "p.Gly124Gly",
"transcript": "NM_001321933.1",
"protein_id": "NP_001308862.1",
"transcript_support_level": null,
"aa_start": 124,
"aa_end": null,
"aa_length": 187,
"cds_start": 372,
"cds_end": null,
"cds_length": 564,
"cdna_start": 812,
"cdna_end": null,
"cdna_length": 2980,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGF14",
"gene_hgnc_id": 3671,
"hgvs_c": "c.372G>T",
"hgvs_p": "p.Gly124Gly",
"transcript": "NM_001321938.2",
"protein_id": "NP_001308867.1",
"transcript_support_level": null,
"aa_start": 124,
"aa_end": null,
"aa_length": 187,
"cds_start": 372,
"cds_end": null,
"cds_length": 564,
"cdna_start": 1214,
"cdna_end": null,
"cdna_length": 13433,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGF14",
"gene_hgnc_id": 3671,
"hgvs_c": "c.372G>T",
"hgvs_p": "p.Gly124Gly",
"transcript": "NM_001321940.1",
"protein_id": "NP_001308869.1",
"transcript_support_level": null,
"aa_start": 124,
"aa_end": null,
"aa_length": 187,
"cds_start": 372,
"cds_end": null,
"cds_length": 564,
"cdna_start": 1158,
"cdna_end": null,
"cdna_length": 3326,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGF14",
"gene_hgnc_id": 3671,
"hgvs_c": "c.366G>T",
"hgvs_p": "p.Gly122Gly",
"transcript": "NM_001321941.2",
"protein_id": "NP_001308870.1",
"transcript_support_level": null,
"aa_start": 122,
"aa_end": null,
"aa_length": 185,
"cds_start": 366,
"cds_end": null,
"cds_length": 558,
"cdna_start": 1004,
"cdna_end": null,
"cdna_length": 13223,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGF14",
"gene_hgnc_id": 3671,
"hgvs_c": "c.363G>T",
"hgvs_p": "p.Gly121Gly",
"transcript": "NM_001321932.1",
"protein_id": "NP_001308861.1",
"transcript_support_level": null,
"aa_start": 121,
"aa_end": null,
"aa_length": 184,
"cds_start": 363,
"cds_end": null,
"cds_length": 555,
"cdna_start": 902,
"cdna_end": null,
"cdna_length": 3070,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGF14",
"gene_hgnc_id": 3671,
"hgvs_c": "c.363G>T",
"hgvs_p": "p.Gly121Gly",
"transcript": "NM_001321936.1",
"protein_id": "NP_001308865.1",
"transcript_support_level": null,
"aa_start": 121,
"aa_end": null,
"aa_length": 184,
"cds_start": 363,
"cds_end": null,
"cds_length": 555,
"cdna_start": 755,
"cdna_end": null,
"cdna_length": 2923,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGF14",
"gene_hgnc_id": 3671,
"hgvs_c": "c.363G>T",
"hgvs_p": "p.Gly121Gly",
"transcript": "NM_001321944.1",
"protein_id": "NP_001308873.1",
"transcript_support_level": null,
"aa_start": 121,
"aa_end": null,
"aa_length": 184,
"cds_start": 363,
"cds_end": null,
"cds_length": 555,
"cdna_start": 1250,
"cdna_end": null,
"cdna_length": 3418,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGF14",
"gene_hgnc_id": 3671,
"hgvs_c": "c.300G>T",
"hgvs_p": "p.Gly100Gly",
"transcript": "NM_001321931.1",
"protein_id": "NP_001308860.1",
"transcript_support_level": null,
"aa_start": 100,
"aa_end": null,
"aa_length": 163,
"cds_start": 300,
"cds_end": null,
"cds_length": 492,
"cdna_start": 816,
"cdna_end": null,
"cdna_length": 2984,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGF14",
"gene_hgnc_id": 3671,
"hgvs_c": "c.300G>T",
"hgvs_p": "p.Gly100Gly",
"transcript": "NM_001321934.1",
"protein_id": "NP_001308863.1",
"transcript_support_level": null,
"aa_start": 100,
"aa_end": null,
"aa_length": 163,
"cds_start": 300,
"cds_end": null,
"cds_length": 492,
"cdna_start": 575,
"cdna_end": null,
"cdna_length": 2743,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGF14",
"gene_hgnc_id": 3671,
"hgvs_c": "c.300G>T",
"hgvs_p": "p.Gly100Gly",
"transcript": "NM_001321935.1",
"protein_id": "NP_001308864.1",
"transcript_support_level": null,
"aa_start": 100,
"aa_end": null,
"aa_length": 163,
"cds_start": 300,
"cds_end": null,
"cds_length": 492,
"cdna_start": 428,
"cdna_end": null,
"cdna_length": 2596,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGF14",
"gene_hgnc_id": 3671,
"hgvs_c": "c.300G>T",
"hgvs_p": "p.Gly100Gly",
"transcript": "NM_001321942.1",
"protein_id": "NP_001308871.1",
"transcript_support_level": null,
"aa_start": 100,
"aa_end": null,
"aa_length": 163,
"cds_start": 300,
"cds_end": null,
"cds_length": 492,
"cdna_start": 997,
"cdna_end": null,
"cdna_length": 3165,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGF14",
"gene_hgnc_id": 3671,
"hgvs_c": "c.300G>T",
"hgvs_p": "p.Gly100Gly",
"transcript": "NM_001321943.1",
"protein_id": "NP_001308872.1",
"transcript_support_level": null,
"aa_start": 100,
"aa_end": null,
"aa_length": 163,
"cds_start": 300,
"cds_end": null,
"cds_length": 492,
"cdna_start": 1034,
"cdna_end": null,
"cdna_length": 3202,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGF14",
"gene_hgnc_id": 3671,
"hgvs_c": "c.300G>T",
"hgvs_p": "p.Gly100Gly",
"transcript": "NM_001321946.2",
"protein_id": "NP_001308875.1",
"transcript_support_level": null,
"aa_start": 100,
"aa_end": null,
"aa_length": 163,
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}
],
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}