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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 13-108208804-GA-AG (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=13&pos=108208804&ref=GA&alt=AG&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 0,
          "criteria": [],
          "effects": [
            "missense_variant"
          ],
          "gene_symbol": "LIG4",
          "hgnc_id": 6601,
          "hgvs_c": "c.2500_2501delTCinsCT",
          "hgvs_p": "p.Ser834Leu",
          "inheritance_mode": "AR",
          "pathogenic_score": 0,
          "score": 0,
          "transcript": "NM_001352604.2",
          "verdict": "Uncertain_significance"
        }
      ],
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "",
      "acmg_score": 0,
      "allele_count_reference_population": 0,
      "alphamissense_prediction": null,
      "alphamissense_score": null,
      "alt": "AG",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": null,
      "bayesdelnoaf_score": null,
      "chr": "13",
      "clinvar_classification": "",
      "clinvar_disease": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "computational_prediction_selected": null,
      "computational_score_selected": null,
      "computational_source_selected": null,
      "consequences": [
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 911,
          "aa_ref": "S",
          "aa_start": 822,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3981,
          "cdna_start": 2619,
          "cds_end": null,
          "cds_length": 2736,
          "cds_start": 2464,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 3,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_206937.2",
          "gene_hgnc_id": 6601,
          "gene_symbol": "LIG4",
          "hgvs_c": "c.2464_2465delTCinsCT",
          "hgvs_p": "p.Ser822Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000442234.6",
          "protein_coding": true,
          "protein_id": "NP_996820.1",
          "strand": false,
          "transcript": "NM_206937.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 911,
          "aa_ref": "S",
          "aa_start": 822,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 3981,
          "cdna_start": 2619,
          "cds_end": null,
          "cds_length": 2736,
          "cds_start": 2464,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 3,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000442234.6",
          "gene_hgnc_id": 6601,
          "gene_symbol": "LIG4",
          "hgvs_c": "c.2464_2465delTCinsCT",
          "hgvs_p": "p.Ser822Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_206937.2",
          "protein_coding": true,
          "protein_id": "ENSP00000402030.1",
          "strand": false,
          "transcript": "ENST00000442234.6",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 911,
          "aa_ref": "S",
          "aa_start": 822,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4065,
          "cdna_start": 2700,
          "cds_end": null,
          "cds_length": 2736,
          "cds_start": 2464,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 2,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000405925.2",
          "gene_hgnc_id": 6601,
          "gene_symbol": "LIG4",
          "hgvs_c": "c.2464_2465delTCinsCT",
          "hgvs_p": "p.Ser822Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000385955.1",
          "strand": false,
          "transcript": "ENST00000405925.2",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 923,
          "aa_ref": "S",
          "aa_start": 834,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4005,
          "cdna_start": 2643,
          "cds_end": null,
          "cds_length": 2772,
          "cds_start": 2500,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 3,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_001352604.2",
          "gene_hgnc_id": 6601,
          "gene_symbol": "LIG4",
          "hgvs_c": "c.2500_2501delTCinsCT",
          "hgvs_p": "p.Ser834Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001339533.1",
          "strand": false,
          "transcript": "NM_001352604.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 911,
          "aa_ref": "S",
          "aa_start": 822,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4043,
          "cdna_start": 2681,
          "cds_end": null,
          "cds_length": 2736,
          "cds_start": 2464,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 2,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_001098268.2",
          "gene_hgnc_id": 6601,
          "gene_symbol": "LIG4",
          "hgvs_c": "c.2464_2465delTCinsCT",
          "hgvs_p": "p.Ser822Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001091738.1",
          "strand": false,
          "transcript": "NM_001098268.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 911,
          "aa_ref": "S",
          "aa_start": 822,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4460,
          "cdna_start": 3098,
          "cds_end": null,
          "cds_length": 2736,
          "cds_start": 2464,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 4,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_001352598.2",
          "gene_hgnc_id": 6601,
          "gene_symbol": "LIG4",
          "hgvs_c": "c.2464_2465delTCinsCT",
          "hgvs_p": "p.Ser822Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001339527.1",
          "strand": false,
          "transcript": "NM_001352598.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 911,
          "aa_ref": "S",
          "aa_start": 822,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4484,
          "cdna_start": 3122,
          "cds_end": null,
          "cds_length": 2736,
          "cds_start": 2464,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 4,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_001352599.2",
          "gene_hgnc_id": 6601,
          "gene_symbol": "LIG4",
          "hgvs_c": "c.2464_2465delTCinsCT",
          "hgvs_p": "p.Ser822Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001339528.1",
          "strand": false,
          "transcript": "NM_001352599.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 911,
          "aa_ref": "S",
          "aa_start": 822,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4376,
          "cdna_start": 3014,
          "cds_end": null,
          "cds_length": 2736,
          "cds_start": 2464,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 4,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_001352600.2",
          "gene_hgnc_id": 6601,
          "gene_symbol": "LIG4",
          "hgvs_c": "c.2464_2465delTCinsCT",
          "hgvs_p": "p.Ser822Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001339529.1",
          "strand": false,
          "transcript": "NM_001352600.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 911,
          "aa_ref": "S",
          "aa_start": 822,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4085,
          "cdna_start": 2723,
          "cds_end": null,
          "cds_length": 2736,
          "cds_start": 2464,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 3,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_001352601.2",
          "gene_hgnc_id": 6601,
          "gene_symbol": "LIG4",
          "hgvs_c": "c.2464_2465delTCinsCT",
          "hgvs_p": "p.Ser822Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001339530.1",
          "strand": false,
          "transcript": "NM_001352601.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 911,
          "aa_ref": "S",
          "aa_start": 822,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3977,
          "cdna_start": 2615,
          "cds_end": null,
          "cds_length": 2736,
          "cds_start": 2464,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 3,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_001352602.2",
          "gene_hgnc_id": 6601,
          "gene_symbol": "LIG4",
          "hgvs_c": "c.2464_2465delTCinsCT",
          "hgvs_p": "p.Ser822Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001339531.1",
          "strand": false,
          "transcript": "NM_001352602.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 911,
          "aa_ref": "S",
          "aa_start": 822,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3955,
          "cdna_start": 2593,
          "cds_end": null,
          "cds_length": 2736,
          "cds_start": 2464,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 3,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_001352603.1",
          "gene_hgnc_id": 6601,
          "gene_symbol": "LIG4",
          "hgvs_c": "c.2464_2465delTCinsCT",
          "hgvs_p": "p.Ser822Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001339532.1",
          "strand": false,
          "transcript": "NM_001352603.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 911,
          "aa_ref": "S",
          "aa_start": 822,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4178,
          "cdna_start": 2816,
          "cds_end": null,
          "cds_length": 2736,
          "cds_start": 2464,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 3,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_001379095.1",
          "gene_hgnc_id": 6601,
          "gene_symbol": "LIG4",
          "hgvs_c": "c.2464_2465delTCinsCT",
          "hgvs_p": "p.Ser822Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001366024.1",
          "strand": false,
          "transcript": "NM_001379095.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 911,
          "aa_ref": "S",
          "aa_start": 822,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4100,
          "cdna_start": 2738,
          "cds_end": null,
          "cds_length": 2736,
          "cds_start": 2464,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 2,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_002312.3",
          "gene_hgnc_id": 6601,
          "gene_symbol": "LIG4",
          "hgvs_c": "c.2464_2465delTCinsCT",
          "hgvs_p": "p.Ser822Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_002303.2",
          "strand": false,
          "transcript": "NM_002312.3",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 911,
          "aa_ref": "S",
          "aa_start": 822,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4180,
          "cdna_start": 2815,
          "cds_end": null,
          "cds_length": 2736,
          "cds_start": 2464,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 3,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000611712.4",
          "gene_hgnc_id": 6601,
          "gene_symbol": "LIG4",
          "hgvs_c": "c.2464_2465delTCinsCT",
          "hgvs_p": "p.Ser822Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000484288.1",
          "strand": false,
          "transcript": "ENST00000611712.4",
          "transcript_support_level": 4
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 911,
          "aa_ref": "S",
          "aa_start": 822,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3987,
          "cdna_start": 2831,
          "cds_end": null,
          "cds_length": 2736,
          "cds_start": 2464,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 3,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000685338.1",
          "gene_hgnc_id": 6601,
          "gene_symbol": "LIG4",
          "hgvs_c": "c.2464_2465delTCinsCT",
          "hgvs_p": "p.Ser822Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000510567.1",
          "strand": false,
          "transcript": "ENST00000685338.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 911,
          "aa_ref": "S",
          "aa_start": 822,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4043,
          "cdna_start": 2701,
          "cds_end": null,
          "cds_length": 2736,
          "cds_start": 2464,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 3,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000686095.1",
          "gene_hgnc_id": 6601,
          "gene_symbol": "LIG4",
          "hgvs_c": "c.2464_2465delTCinsCT",
          "hgvs_p": "p.Ser822Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000509942.1",
          "strand": false,
          "transcript": "ENST00000686095.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 911,
          "aa_ref": "S",
          "aa_start": 822,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6142,
          "cdna_start": 5516,
          "cds_end": null,
          "cds_length": 2736,
          "cds_start": 2464,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 3,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000686204.1",
          "gene_hgnc_id": 6601,
          "gene_symbol": "LIG4",
          "hgvs_c": "c.2464_2465delTCinsCT",
          "hgvs_p": "p.Ser822Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000509685.1",
          "strand": false,
          "transcript": "ENST00000686204.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 911,
          "aa_ref": "S",
          "aa_start": 822,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4149,
          "cdna_start": 2807,
          "cds_end": null,
          "cds_length": 2736,
          "cds_start": 2464,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 3,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000686913.1",
          "gene_hgnc_id": 6601,
          "gene_symbol": "LIG4",
          "hgvs_c": "c.2464_2465delTCinsCT",
          "hgvs_p": "p.Ser822Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000509299.1",
          "strand": false,
          "transcript": "ENST00000686913.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 911,
          "aa_ref": "S",
          "aa_start": 822,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3443,
          "cdna_start": 2577,
          "cds_end": null,
          "cds_length": 2736,
          "cds_start": 2464,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 2,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000686926.1",
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}
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