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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 13-113190934-C-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=13&pos=113190934&ref=C&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "13",
"pos": 113190934,
"ref": "C",
"alt": "G",
"effect": "synonymous_variant",
"transcript": "NM_001320656.2",
"consequences": [
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PCID2",
"gene_hgnc_id": 25653,
"hgvs_c": "c.405G>C",
"hgvs_p": "p.Gly135Gly",
"transcript": "NM_001127202.4",
"protein_id": "NP_001120674.1",
"transcript_support_level": null,
"aa_start": 135,
"aa_end": null,
"aa_length": 399,
"cds_start": 405,
"cds_end": null,
"cds_length": 1200,
"cdna_start": 440,
"cdna_end": null,
"cdna_length": 1897,
"mane_select": "ENST00000337344.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001127202.4"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PCID2",
"gene_hgnc_id": 25653,
"hgvs_c": "c.405G>C",
"hgvs_p": "p.Gly135Gly",
"transcript": "ENST00000337344.9",
"protein_id": "ENSP00000337405.4",
"transcript_support_level": 2,
"aa_start": 135,
"aa_end": null,
"aa_length": 399,
"cds_start": 405,
"cds_end": null,
"cds_length": 1200,
"cdna_start": 440,
"cdna_end": null,
"cdna_length": 1897,
"mane_select": "NM_001127202.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000337344.9"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PCID2",
"gene_hgnc_id": 25653,
"hgvs_c": "c.405G>C",
"hgvs_p": "p.Gly135Gly",
"transcript": "ENST00000375477.5",
"protein_id": "ENSP00000364626.1",
"transcript_support_level": 1,
"aa_start": 135,
"aa_end": null,
"aa_length": 399,
"cds_start": 405,
"cds_end": null,
"cds_length": 1200,
"cdna_start": 437,
"cdna_end": null,
"cdna_length": 1654,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000375477.5"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PCID2",
"gene_hgnc_id": 25653,
"hgvs_c": "c.405G>C",
"hgvs_p": "p.Gly135Gly",
"transcript": "ENST00000375479.6",
"protein_id": "ENSP00000364628.2",
"transcript_support_level": 2,
"aa_start": 135,
"aa_end": null,
"aa_length": 399,
"cds_start": 405,
"cds_end": null,
"cds_length": 1200,
"cdna_start": 486,
"cdna_end": null,
"cdna_length": 1671,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000375479.6"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PCID2",
"gene_hgnc_id": 25653,
"hgvs_c": "c.399G>C",
"hgvs_p": "p.Gly133Gly",
"transcript": "ENST00000375457.2",
"protein_id": "ENSP00000364606.2",
"transcript_support_level": 1,
"aa_start": 133,
"aa_end": null,
"aa_length": 397,
"cds_start": 399,
"cds_end": null,
"cds_length": 1194,
"cdna_start": 996,
"cdna_end": null,
"cdna_length": 2372,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000375457.2"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PCID2",
"gene_hgnc_id": 25653,
"hgvs_c": "c.399G>C",
"hgvs_p": "p.Gly133Gly",
"transcript": "ENST00000375459.5",
"protein_id": "ENSP00000364608.1",
"transcript_support_level": 2,
"aa_start": 133,
"aa_end": null,
"aa_length": 397,
"cds_start": 399,
"cds_end": null,
"cds_length": 1194,
"cdna_start": 452,
"cdna_end": null,
"cdna_length": 1668,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000375459.5"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PCID2",
"gene_hgnc_id": 25653,
"hgvs_c": "c.567G>C",
"hgvs_p": "p.Gly189Gly",
"transcript": "NM_001320656.2",
"protein_id": "NP_001307585.1",
"transcript_support_level": null,
"aa_start": 189,
"aa_end": null,
"aa_length": 453,
"cds_start": 567,
"cds_end": null,
"cds_length": 1362,
"cdna_start": 602,
"cdna_end": null,
"cdna_length": 1862,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001320656.2"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PCID2",
"gene_hgnc_id": 25653,
"hgvs_c": "c.567G>C",
"hgvs_p": "p.Gly189Gly",
"transcript": "ENST00000246505.9",
"protein_id": "ENSP00000246505.5",
"transcript_support_level": 2,
"aa_start": 189,
"aa_end": null,
"aa_length": 453,
"cds_start": 567,
"cds_end": null,
"cds_length": 1362,
"cdna_start": 602,
"cdna_end": null,
"cdna_length": 1786,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000246505.9"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PCID2",
"gene_hgnc_id": 25653,
"hgvs_c": "c.567G>C",
"hgvs_p": "p.Gly189Gly",
"transcript": "ENST00000622406.4",
"protein_id": "ENSP00000479494.1",
"transcript_support_level": 5,
"aa_start": 189,
"aa_end": null,
"aa_length": 453,
"cds_start": 567,
"cds_end": null,
"cds_length": 1362,
"cdna_start": 648,
"cdna_end": null,
"cdna_length": 1937,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000622406.4"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PCID2",
"gene_hgnc_id": 25653,
"hgvs_c": "c.567G>C",
"hgvs_p": "p.Gly189Gly",
"transcript": "ENST00000925339.1",
"protein_id": "ENSP00000595398.1",
"transcript_support_level": null,
"aa_start": 189,
"aa_end": null,
"aa_length": 453,
"cds_start": 567,
"cds_end": null,
"cds_length": 1362,
"cdna_start": 623,
"cdna_end": null,
"cdna_length": 2004,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000925339.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PCID2",
"gene_hgnc_id": 25653,
"hgvs_c": "c.405G>C",
"hgvs_p": "p.Gly135Gly",
"transcript": "NM_001320657.2",
"protein_id": "NP_001307586.1",
"transcript_support_level": null,
"aa_start": 135,
"aa_end": null,
"aa_length": 432,
"cds_start": 405,
"cds_end": null,
"cds_length": 1299,
"cdna_start": 440,
"cdna_end": null,
"cdna_length": 1901,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001320657.2"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PCID2",
"gene_hgnc_id": 25653,
"hgvs_c": "c.399G>C",
"hgvs_p": "p.Gly133Gly",
"transcript": "NM_001320660.2",
"protein_id": "NP_001307589.1",
"transcript_support_level": null,
"aa_start": 133,
"aa_end": null,
"aa_length": 430,
"cds_start": 399,
"cds_end": null,
"cds_length": 1293,
"cdna_start": 1015,
"cdna_end": null,
"cdna_length": 2476,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001320660.2"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PCID2",
"gene_hgnc_id": 25653,
"hgvs_c": "c.405G>C",
"hgvs_p": "p.Gly135Gly",
"transcript": "NM_001320659.2",
"protein_id": "NP_001307588.1",
"transcript_support_level": null,
"aa_start": 135,
"aa_end": null,
"aa_length": 410,
"cds_start": 405,
"cds_end": null,
"cds_length": 1233,
"cdna_start": 440,
"cdna_end": null,
"cdna_length": 1736,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001320659.2"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PCID2",
"gene_hgnc_id": 25653,
"hgvs_c": "c.405G>C",
"hgvs_p": "p.Gly135Gly",
"transcript": "NM_001127203.4",
"protein_id": "NP_001120675.1",
"transcript_support_level": null,
"aa_start": 135,
"aa_end": null,
"aa_length": 399,
"cds_start": 405,
"cds_end": null,
"cds_length": 1200,
"cdna_start": 440,
"cdna_end": null,
"cdna_length": 1732,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001127203.4"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PCID2",
"gene_hgnc_id": 25653,
"hgvs_c": "c.405G>C",
"hgvs_p": "p.Gly135Gly",
"transcript": "NM_018386.5",
"protein_id": "NP_060856.2",
"transcript_support_level": null,
"aa_start": 135,
"aa_end": null,
"aa_length": 399,
"cds_start": 405,
"cds_end": null,
"cds_length": 1200,
"cdna_start": 440,
"cdna_end": null,
"cdna_length": 1700,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_018386.5"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PCID2",
"gene_hgnc_id": 25653,
"hgvs_c": "c.399G>C",
"hgvs_p": "p.Gly133Gly",
"transcript": "NM_001258213.3",
"protein_id": "NP_001245142.1",
"transcript_support_level": null,
"aa_start": 133,
"aa_end": null,
"aa_length": 397,
"cds_start": 399,
"cds_end": null,
"cds_length": 1194,
"cdna_start": 1015,
"cdna_end": null,
"cdna_length": 2472,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001258213.3"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PCID2",
"gene_hgnc_id": 25653,
"hgvs_c": "c.399G>C",
"hgvs_p": "p.Gly133Gly",
"transcript": "NM_001320655.2",
"protein_id": "NP_001307584.1",
"transcript_support_level": null,
"aa_start": 133,
"aa_end": null,
"aa_length": 397,
"cds_start": 399,
"cds_end": null,
"cds_length": 1194,
"cdna_start": 1015,
"cdna_end": null,
"cdna_length": 2307,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001320655.2"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PCID2",
"gene_hgnc_id": 25653,
"hgvs_c": "c.399G>C",
"hgvs_p": "p.Gly133Gly",
"transcript": "NM_001353092.2",
"protein_id": "NP_001340021.1",
"transcript_support_level": null,
"aa_start": 133,
"aa_end": null,
"aa_length": 397,
"cds_start": 399,
"cds_end": null,
"cds_length": 1194,
"cdna_start": 623,
"cdna_end": null,
"cdna_length": 2080,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001353092.2"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PCID2",
"gene_hgnc_id": 25653,
"hgvs_c": "c.405G>C",
"hgvs_p": "p.Gly135Gly",
"transcript": "ENST00000952597.1",
"protein_id": "ENSP00000622656.1",
"transcript_support_level": null,
"aa_start": 135,
"aa_end": null,
"aa_length": 388,
"cds_start": 405,
"cds_end": null,
"cds_length": 1167,
"cdna_start": 449,
"cdna_end": null,
"cdna_length": 1798,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000952597.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PCID2",
"gene_hgnc_id": 25653,
"hgvs_c": "c.315G>C",
"hgvs_p": "p.Gly105Gly",
"transcript": "ENST00000952598.1",
"protein_id": "ENSP00000622657.1",
"transcript_support_level": null,
"aa_start": 105,
"aa_end": null,
"aa_length": 369,
"cds_start": 315,
"cds_end": null,
"cds_length": 1110,
"cdna_start": 355,
"cdna_end": null,
"cdna_length": 1734,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000952598.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PCID2",
"gene_hgnc_id": 25653,
"hgvs_c": "c.405G>C",
"hgvs_p": "p.Gly135Gly",
"transcript": "ENST00000952599.1",
"protein_id": "ENSP00000622658.1",
"transcript_support_level": null,
"aa_start": 135,
"aa_end": null,
"aa_length": 362,
"cds_start": 405,
"cds_end": null,
"cds_length": 1089,
"cdna_start": 423,
"cdna_end": null,
"cdna_length": 1694,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000952599.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PCID2",
"gene_hgnc_id": 25653,
"hgvs_c": "c.279G>C",
"hgvs_p": "p.Gly93Gly",
"transcript": "NM_001353091.2",
"protein_id": "NP_001340020.1",
"transcript_support_level": null,
"aa_start": 93,
"aa_end": null,
"aa_length": 357,
"cds_start": 279,
"cds_end": null,
"cds_length": 1074,
"cdna_start": 436,
"cdna_end": null,
"cdna_length": 1696,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001353091.2"
},
{
"aa_ref": "G",
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}