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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 13-26681059-A-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=13&pos=26681059&ref=A&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "13",
"pos": 26681059,
"ref": "A",
"alt": "C",
"effect": "missense_variant",
"transcript": "NM_006646.6",
"consequences": [
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WASF3",
"gene_hgnc_id": 12734,
"hgvs_c": "c.722A>C",
"hgvs_p": "p.His241Pro",
"transcript": "NM_006646.6",
"protein_id": "NP_006637.2",
"transcript_support_level": null,
"aa_start": 241,
"aa_end": null,
"aa_length": 502,
"cds_start": 722,
"cds_end": null,
"cds_length": 1509,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000335327.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_006646.6"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WASF3",
"gene_hgnc_id": 12734,
"hgvs_c": "c.722A>C",
"hgvs_p": "p.His241Pro",
"transcript": "ENST00000335327.6",
"protein_id": "ENSP00000335055.5",
"transcript_support_level": 1,
"aa_start": 241,
"aa_end": null,
"aa_length": 502,
"cds_start": 722,
"cds_end": null,
"cds_length": 1509,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_006646.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000335327.6"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WASF3",
"gene_hgnc_id": 12734,
"hgvs_c": "c.713A>C",
"hgvs_p": "p.His238Pro",
"transcript": "ENST00000361042.8",
"protein_id": "ENSP00000354325.4",
"transcript_support_level": 1,
"aa_start": 238,
"aa_end": null,
"aa_length": 499,
"cds_start": 713,
"cds_end": null,
"cds_length": 1500,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000361042.8"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WASF3",
"gene_hgnc_id": 12734,
"hgvs_c": "c.755A>C",
"hgvs_p": "p.His252Pro",
"transcript": "ENST00000887339.1",
"protein_id": "ENSP00000557398.1",
"transcript_support_level": null,
"aa_start": 252,
"aa_end": null,
"aa_length": 513,
"cds_start": 755,
"cds_end": null,
"cds_length": 1542,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000887339.1"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WASF3",
"gene_hgnc_id": 12734,
"hgvs_c": "c.722A>C",
"hgvs_p": "p.His241Pro",
"transcript": "ENST00000887337.1",
"protein_id": "ENSP00000557396.1",
"transcript_support_level": null,
"aa_start": 241,
"aa_end": null,
"aa_length": 502,
"cds_start": 722,
"cds_end": null,
"cds_length": 1509,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000887337.1"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WASF3",
"gene_hgnc_id": 12734,
"hgvs_c": "c.722A>C",
"hgvs_p": "p.His241Pro",
"transcript": "ENST00000916503.1",
"protein_id": "ENSP00000586562.1",
"transcript_support_level": null,
"aa_start": 241,
"aa_end": null,
"aa_length": 502,
"cds_start": 722,
"cds_end": null,
"cds_length": 1509,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000916503.1"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WASF3",
"gene_hgnc_id": 12734,
"hgvs_c": "c.722A>C",
"hgvs_p": "p.His241Pro",
"transcript": "ENST00000916504.1",
"protein_id": "ENSP00000586563.1",
"transcript_support_level": null,
"aa_start": 241,
"aa_end": null,
"aa_length": 502,
"cds_start": 722,
"cds_end": null,
"cds_length": 1509,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000916504.1"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WASF3",
"gene_hgnc_id": 12734,
"hgvs_c": "c.722A>C",
"hgvs_p": "p.His241Pro",
"transcript": "ENST00000916505.1",
"protein_id": "ENSP00000586564.1",
"transcript_support_level": null,
"aa_start": 241,
"aa_end": null,
"aa_length": 502,
"cds_start": 722,
"cds_end": null,
"cds_length": 1509,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000916505.1"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WASF3",
"gene_hgnc_id": 12734,
"hgvs_c": "c.722A>C",
"hgvs_p": "p.His241Pro",
"transcript": "ENST00000916506.1",
"protein_id": "ENSP00000586565.1",
"transcript_support_level": null,
"aa_start": 241,
"aa_end": null,
"aa_length": 502,
"cds_start": 722,
"cds_end": null,
"cds_length": 1509,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000916506.1"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WASF3",
"gene_hgnc_id": 12734,
"hgvs_c": "c.713A>C",
"hgvs_p": "p.His238Pro",
"transcript": "NM_001291965.1",
"protein_id": "NP_001278894.1",
"transcript_support_level": null,
"aa_start": 238,
"aa_end": null,
"aa_length": 499,
"cds_start": 713,
"cds_end": null,
"cds_length": 1500,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001291965.1"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WASF3",
"gene_hgnc_id": 12734,
"hgvs_c": "c.713A>C",
"hgvs_p": "p.His238Pro",
"transcript": "ENST00000887335.1",
"protein_id": "ENSP00000557394.1",
"transcript_support_level": null,
"aa_start": 238,
"aa_end": null,
"aa_length": 499,
"cds_start": 713,
"cds_end": null,
"cds_length": 1500,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000887335.1"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WASF3",
"gene_hgnc_id": 12734,
"hgvs_c": "c.713A>C",
"hgvs_p": "p.His238Pro",
"transcript": "ENST00000887336.1",
"protein_id": "ENSP00000557395.1",
"transcript_support_level": null,
"aa_start": 238,
"aa_end": null,
"aa_length": 499,
"cds_start": 713,
"cds_end": null,
"cds_length": 1500,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000887336.1"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WASF3",
"gene_hgnc_id": 12734,
"hgvs_c": "c.713A>C",
"hgvs_p": "p.His238Pro",
"transcript": "ENST00000887338.1",
"protein_id": "ENSP00000557397.1",
"transcript_support_level": null,
"aa_start": 238,
"aa_end": null,
"aa_length": 499,
"cds_start": 713,
"cds_end": null,
"cds_length": 1500,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000887338.1"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WASF3",
"gene_hgnc_id": 12734,
"hgvs_c": "c.713A>C",
"hgvs_p": "p.His238Pro",
"transcript": "ENST00000887341.1",
"protein_id": "ENSP00000557400.1",
"transcript_support_level": null,
"aa_start": 238,
"aa_end": null,
"aa_length": 499,
"cds_start": 713,
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"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000887341.1"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WASF3",
"gene_hgnc_id": 12734,
"hgvs_c": "c.713A>C",
"hgvs_p": "p.His238Pro",
"transcript": "ENST00000887342.1",
"protein_id": "ENSP00000557401.1",
"transcript_support_level": null,
"aa_start": 238,
"aa_end": null,
"aa_length": 499,
"cds_start": 713,
"cds_end": null,
"cds_length": 1500,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000887342.1"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WASF3",
"gene_hgnc_id": 12734,
"hgvs_c": "c.713A>C",
"hgvs_p": "p.His238Pro",
"transcript": "ENST00000916507.1",
"protein_id": "ENSP00000586566.1",
"transcript_support_level": null,
"aa_start": 238,
"aa_end": null,
"aa_length": 499,
"cds_start": 713,
"cds_end": null,
"cds_length": 1500,
"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000916507.1"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WASF3",
"gene_hgnc_id": 12734,
"hgvs_c": "c.713A>C",
"hgvs_p": "p.His238Pro",
"transcript": "ENST00000942982.1",
"protein_id": "ENSP00000613041.1",
"transcript_support_level": null,
"aa_start": 238,
"aa_end": null,
"aa_length": 499,
"cds_start": 713,
"cds_end": null,
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"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000942982.1"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WASF3",
"gene_hgnc_id": 12734,
"hgvs_c": "c.713A>C",
"hgvs_p": "p.His238Pro",
"transcript": "ENST00000942983.1",
"protein_id": "ENSP00000613042.1",
"transcript_support_level": null,
"aa_start": 238,
"aa_end": null,
"aa_length": 499,
"cds_start": 713,
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"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000942983.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WASF3",
"gene_hgnc_id": 12734,
"hgvs_c": "c.428A>C",
"hgvs_p": "p.His143Pro",
"transcript": "ENST00000887340.1",
"protein_id": "ENSP00000557399.1",
"transcript_support_level": null,
"aa_start": 143,
"aa_end": null,
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"cds_start": 428,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000887340.1"
},
{
"aa_ref": "H",
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WASF3",
"gene_hgnc_id": 12734,
"hgvs_c": "c.713A>C",
"hgvs_p": "p.His238Pro",
"transcript": "ENST00000671038.1",
"protein_id": "ENSP00000499292.1",
"transcript_support_level": null,
"aa_start": 238,
"aa_end": null,
"aa_length": 358,
"cds_start": 713,
"cds_end": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000671038.1"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WASF3",
"gene_hgnc_id": 12734,
"hgvs_c": "c.722A>C",
"hgvs_p": "p.His241Pro",
"transcript": "XM_011534889.3",
"protein_id": "XP_011533191.1",
"transcript_support_level": null,
"aa_start": 241,
"aa_end": null,
"aa_length": 502,
"cds_start": 722,
"cds_end": null,
"cds_length": 1509,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011534889.3"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WASF3",
"gene_hgnc_id": 12734,
"hgvs_c": "c.722A>C",
"hgvs_p": "p.His241Pro",
"transcript": "XM_011534890.2",
"protein_id": "XP_011533192.1",
"transcript_support_level": null,
"aa_start": 241,
"aa_end": null,
"aa_length": 502,
"cds_start": 722,
"cds_end": null,
"cds_length": 1509,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011534890.2"
},
{
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],
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}
],
"message": null
}