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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 13-27548420-C-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=13&pos=27548420&ref=C&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "13",
      "pos": 27548420,
      "ref": "C",
      "alt": "T",
      "effect": "missense_variant",
      "transcript": "NM_153371.4",
      "consequences": [
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LNX2",
          "gene_hgnc_id": 20421,
          "hgvs_c": "c.1988G>A",
          "hgvs_p": "p.Ser663Asn",
          "transcript": "NM_153371.4",
          "protein_id": "NP_699202.1",
          "transcript_support_level": null,
          "aa_start": 663,
          "aa_end": null,
          "aa_length": 690,
          "cds_start": 1988,
          "cds_end": null,
          "cds_length": 2073,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000316334.5",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_153371.4"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LNX2",
          "gene_hgnc_id": 20421,
          "hgvs_c": "c.1988G>A",
          "hgvs_p": "p.Ser663Asn",
          "transcript": "ENST00000316334.5",
          "protein_id": "ENSP00000325929.3",
          "transcript_support_level": 1,
          "aa_start": 663,
          "aa_end": null,
          "aa_length": 690,
          "cds_start": 1988,
          "cds_end": null,
          "cds_length": 2073,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_153371.4",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000316334.5"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LNX2",
          "gene_hgnc_id": 20421,
          "hgvs_c": "c.1988G>A",
          "hgvs_p": "p.Ser663Asn",
          "transcript": "ENST00000649248.1",
          "protein_id": "ENSP00000497224.1",
          "transcript_support_level": null,
          "aa_start": 663,
          "aa_end": null,
          "aa_length": 690,
          "cds_start": 1988,
          "cds_end": null,
          "cds_length": 2073,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000649248.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LNX2",
          "gene_hgnc_id": 20421,
          "hgvs_c": "c.1988G>A",
          "hgvs_p": "p.Ser663Asn",
          "transcript": "ENST00000869675.1",
          "protein_id": "ENSP00000539734.1",
          "transcript_support_level": null,
          "aa_start": 663,
          "aa_end": null,
          "aa_length": 690,
          "cds_start": 1988,
          "cds_end": null,
          "cds_length": 2073,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000869675.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LNX2",
          "gene_hgnc_id": 20421,
          "hgvs_c": "c.1988G>A",
          "hgvs_p": "p.Ser663Asn",
          "transcript": "ENST00000869676.1",
          "protein_id": "ENSP00000539735.1",
          "transcript_support_level": null,
          "aa_start": 663,
          "aa_end": null,
          "aa_length": 690,
          "cds_start": 1988,
          "cds_end": null,
          "cds_length": 2073,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000869676.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LNX2",
          "gene_hgnc_id": 20421,
          "hgvs_c": "c.1988G>A",
          "hgvs_p": "p.Ser663Asn",
          "transcript": "ENST00000869677.1",
          "protein_id": "ENSP00000539736.1",
          "transcript_support_level": null,
          "aa_start": 663,
          "aa_end": null,
          "aa_length": 690,
          "cds_start": 1988,
          "cds_end": null,
          "cds_length": 2073,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000869677.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LNX2",
          "gene_hgnc_id": 20421,
          "hgvs_c": "c.1988G>A",
          "hgvs_p": "p.Ser663Asn",
          "transcript": "ENST00000869681.1",
          "protein_id": "ENSP00000539740.1",
          "transcript_support_level": null,
          "aa_start": 663,
          "aa_end": null,
          "aa_length": 690,
          "cds_start": 1988,
          "cds_end": null,
          "cds_length": 2073,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000869681.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LNX2",
          "gene_hgnc_id": 20421,
          "hgvs_c": "c.1988G>A",
          "hgvs_p": "p.Ser663Asn",
          "transcript": "ENST00000869683.1",
          "protein_id": "ENSP00000539742.1",
          "transcript_support_level": null,
          "aa_start": 663,
          "aa_end": null,
          "aa_length": 690,
          "cds_start": 1988,
          "cds_end": null,
          "cds_length": 2073,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000869683.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LNX2",
          "gene_hgnc_id": 20421,
          "hgvs_c": "c.1988G>A",
          "hgvs_p": "p.Ser663Asn",
          "transcript": "ENST00000952571.1",
          "protein_id": "ENSP00000622630.1",
          "transcript_support_level": null,
          "aa_start": 663,
          "aa_end": null,
          "aa_length": 690,
          "cds_start": 1988,
          "cds_end": null,
          "cds_length": 2073,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000952571.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LNX2",
          "gene_hgnc_id": 20421,
          "hgvs_c": "c.1847G>A",
          "hgvs_p": "p.Ser616Asn",
          "transcript": "ENST00000869678.1",
          "protein_id": "ENSP00000539737.1",
          "transcript_support_level": null,
          "aa_start": 616,
          "aa_end": null,
          "aa_length": 643,
          "cds_start": 1847,
          "cds_end": null,
          "cds_length": 1932,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000869678.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LNX2",
          "gene_hgnc_id": 20421,
          "hgvs_c": "c.1847G>A",
          "hgvs_p": "p.Ser616Asn",
          "transcript": "ENST00000869680.1",
          "protein_id": "ENSP00000539739.1",
          "transcript_support_level": null,
          "aa_start": 616,
          "aa_end": null,
          "aa_length": 643,
          "cds_start": 1847,
          "cds_end": null,
          "cds_length": 1932,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000869680.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LNX2",
          "gene_hgnc_id": 20421,
          "hgvs_c": "c.1844G>A",
          "hgvs_p": "p.Ser615Asn",
          "transcript": "ENST00000940589.1",
          "protein_id": "ENSP00000610648.1",
          "transcript_support_level": null,
          "aa_start": 615,
          "aa_end": null,
          "aa_length": 642,
          "cds_start": 1844,
          "cds_end": null,
          "cds_length": 1929,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000940589.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LNX2",
          "gene_hgnc_id": 20421,
          "hgvs_c": "c.1619G>A",
          "hgvs_p": "p.Ser540Asn",
          "transcript": "ENST00000869679.1",
          "protein_id": "ENSP00000539738.1",
          "transcript_support_level": null,
          "aa_start": 540,
          "aa_end": null,
          "aa_length": 567,
          "cds_start": 1619,
          "cds_end": null,
          "cds_length": 1704,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000869679.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LNX2",
          "gene_hgnc_id": 20421,
          "hgvs_c": "c.1619G>A",
          "hgvs_p": "p.Ser540Asn",
          "transcript": "ENST00000869682.1",
          "protein_id": "ENSP00000539741.1",
          "transcript_support_level": null,
          "aa_start": 540,
          "aa_end": null,
          "aa_length": 567,
          "cds_start": 1619,
          "cds_end": null,
          "cds_length": 1704,
          "cdna_start": null,
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          "mane_select": null,
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          "biotype": "protein_coding",
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        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LNX2",
          "gene_hgnc_id": 20421,
          "hgvs_c": "c.1619G>A",
          "hgvs_p": "p.Ser540Asn",
          "transcript": "ENST00000952572.1",
          "protein_id": "ENSP00000622631.1",
          "transcript_support_level": null,
          "aa_start": 540,
          "aa_end": null,
          "aa_length": 567,
          "cds_start": 1619,
          "cds_end": null,
          "cds_length": 1704,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000952572.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LNX2",
          "gene_hgnc_id": 20421,
          "hgvs_c": "c.1475G>A",
          "hgvs_p": "p.Ser492Asn",
          "transcript": "ENST00000952573.1",
          "protein_id": "ENSP00000622632.1",
          "transcript_support_level": null,
          "aa_start": 492,
          "aa_end": null,
          "aa_length": 519,
          "cds_start": 1475,
          "cds_end": null,
          "cds_length": 1560,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000952573.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LNX2",
          "gene_hgnc_id": 20421,
          "hgvs_c": "c.1988G>A",
          "hgvs_p": "p.Ser663Asn",
          "transcript": "XM_017020434.2",
          "protein_id": "XP_016875923.1",
          "transcript_support_level": null,
          "aa_start": 663,
          "aa_end": null,
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          "cds_start": 1988,
          "cds_end": null,
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          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_017020434.2"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LNX2",
          "gene_hgnc_id": 20421,
          "hgvs_c": "c.1988G>A",
          "hgvs_p": "p.Ser663Asn",
          "transcript": "XM_047430145.1",
          "protein_id": "XP_047286101.1",
          "transcript_support_level": null,
          "aa_start": 663,
          "aa_end": null,
          "aa_length": 690,
          "cds_start": 1988,
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          "cds_length": 2073,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047430145.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LNX2",
          "gene_hgnc_id": 20421,
          "hgvs_c": "c.1988G>A",
          "hgvs_p": "p.Ser663Asn",
          "transcript": "XM_047430147.1",
          "protein_id": "XP_047286103.1",
          "transcript_support_level": null,
          "aa_start": 663,
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          "aa_length": 690,
          "cds_start": 1988,
          "cds_end": null,
          "cds_length": 2073,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047430147.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LNX2",
          "gene_hgnc_id": 20421,
          "hgvs_c": "c.1988G>A",
          "hgvs_p": "p.Ser663Asn",
          "transcript": "XM_047430148.1",
          "protein_id": "XP_047286104.1",
          "transcript_support_level": null,
          "aa_start": 663,
          "aa_end": null,
          "aa_length": 690,
          "cds_start": 1988,
          "cds_end": null,
          "cds_length": 2073,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047430148.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
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          "exon_count": 10,
          "intron_rank": null,
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          "gene_symbol": "LNX2",
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          "hgvs_c": "c.1988G>A",
          "hgvs_p": "p.Ser663Asn",
          "transcript": "XM_047430149.1",
          "protein_id": "XP_047286105.1",
          "transcript_support_level": null,
          "aa_start": 663,
          "aa_end": null,
          "aa_length": 690,
          "cds_start": 1988,
          "cds_end": null,
          "cds_length": 2073,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047430149.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LNX2",
          "gene_hgnc_id": 20421,
          "hgvs_c": "c.1988G>A",
          "hgvs_p": "p.Ser663Asn",
          "transcript": "XM_047430150.1",
          "protein_id": "XP_047286106.1",
          "transcript_support_level": null,
          "aa_start": 663,
          "aa_end": null,
          "aa_length": 690,
          "cds_start": 1988,
          "cds_end": null,
          "cds_length": 2073,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047430150.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LNX2",
          "gene_hgnc_id": 20421,
          "hgvs_c": "c.1619G>A",
          "hgvs_p": "p.Ser540Asn",
          "transcript": "XM_011534995.3",
          "protein_id": "XP_011533297.1",
          "transcript_support_level": null,
          "aa_start": 540,
          "aa_end": null,
          "aa_length": 567,
          "cds_start": 1619,
          "cds_end": null,
          "cds_length": 1704,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_011534995.3"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
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          "gene_symbol": "LNX2",
          "gene_hgnc_id": 20421,
          "hgvs_c": "c.1619G>A",
          "hgvs_p": "p.Ser540Asn",
          "transcript": "XM_047430151.1",
          "protein_id": "XP_047286107.1",
          "transcript_support_level": null,
          "aa_start": 540,
          "aa_end": null,
          "aa_length": 567,
          "cds_start": 1619,
          "cds_end": null,
          "cds_length": 1704,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047430151.1"
        }
      ],
      "gene_symbol": "LNX2",
      "gene_hgnc_id": 20421,
      "dbsnp": "rs151176870",
      "frequency_reference_population": 0.000010532812,
      "hom_count_reference_population": 0,
      "allele_count_reference_population": 17,
      "gnomad_exomes_af": 0.00000957721,
      "gnomad_genomes_af": 0.0000197109,
      "gnomad_exomes_ac": 14,
      "gnomad_genomes_ac": 3,
      "gnomad_exomes_homalt": 0,
      "gnomad_genomes_homalt": 0,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": 0.3443729877471924,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": 0.191,
      "revel_prediction": "Benign",
      "alphamissense_score": 0.3083,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": -0.34,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": 7.905,
      "phylop100way_prediction": "Pathogenic",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": 1,
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PM2,BP4",
      "acmg_by_gene": [
        {
          "score": 1,
          "benign_score": 1,
          "pathogenic_score": 2,
          "criteria": [
            "PM2",
            "BP4"
          ],
          "verdict": "Uncertain_significance",
          "transcript": "NM_153371.4",
          "gene_symbol": "LNX2",
          "hgnc_id": 20421,
          "effects": [
            "missense_variant"
          ],
          "inheritance_mode": "AR",
          "hgvs_c": "c.1988G>A",
          "hgvs_p": "p.Ser663Asn"
        }
      ],
      "clinvar_disease": "not specified",
      "clinvar_classification": "Uncertain significance",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "US:1",
      "phenotype_combined": "not specified",
      "pathogenicity_classification_combined": "Uncertain significance",
      "custom_annotations": null
    }
  ],
  "message": null
}