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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 13-31139080-T-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=13&pos=31139080&ref=T&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "13",
"pos": 31139080,
"ref": "T",
"alt": "A",
"effect": "missense_variant",
"transcript": "NM_001286504.1",
"consequences": [
{
"aa_ref": "T",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HSPH1",
"gene_hgnc_id": 16969,
"hgvs_c": "c.2008A>T",
"hgvs_p": "p.Thr670Ser",
"transcript": "NM_006644.4",
"protein_id": "NP_006635.2",
"transcript_support_level": null,
"aa_start": 670,
"aa_end": null,
"aa_length": 858,
"cds_start": 2008,
"cds_end": null,
"cds_length": 2577,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000320027.10",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_006644.4"
},
{
"aa_ref": "T",
"aa_alt": "S",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HSPH1",
"gene_hgnc_id": 16969,
"hgvs_c": "c.2008A>T",
"hgvs_p": "p.Thr670Ser",
"transcript": "ENST00000320027.10",
"protein_id": "ENSP00000318687.5",
"transcript_support_level": 1,
"aa_start": 670,
"aa_end": null,
"aa_length": 858,
"cds_start": 2008,
"cds_end": null,
"cds_length": 2577,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_006644.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000320027.10"
},
{
"aa_ref": "T",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HSPH1",
"gene_hgnc_id": 16969,
"hgvs_c": "c.2014A>T",
"hgvs_p": "p.Thr672Ser",
"transcript": "ENST00000630972.2",
"protein_id": "ENSP00000487365.1",
"transcript_support_level": 1,
"aa_start": 672,
"aa_end": null,
"aa_length": 860,
"cds_start": 2014,
"cds_end": null,
"cds_length": 2583,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000630972.2"
},
{
"aa_ref": "T",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HSPH1",
"gene_hgnc_id": 16969,
"hgvs_c": "c.1876A>T",
"hgvs_p": "p.Thr626Ser",
"transcript": "ENST00000380405.7",
"protein_id": "ENSP00000369768.4",
"transcript_support_level": 1,
"aa_start": 626,
"aa_end": null,
"aa_length": 814,
"cds_start": 1876,
"cds_end": null,
"cds_length": 2445,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000380405.7"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HSPH1",
"gene_hgnc_id": 16969,
"hgvs_c": "n.*1536A>T",
"hgvs_p": null,
"transcript": "ENST00000602786.5",
"protein_id": "ENSP00000473512.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000602786.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": false,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HSPH1",
"gene_hgnc_id": 16969,
"hgvs_c": "n.*1536A>T",
"hgvs_p": null,
"transcript": "ENST00000602786.5",
"protein_id": "ENSP00000473512.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000602786.5"
},
{
"aa_ref": "T",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HSPH1",
"gene_hgnc_id": 16969,
"hgvs_c": "c.2014A>T",
"hgvs_p": "p.Thr672Ser",
"transcript": "NM_001286504.1",
"protein_id": "NP_001273433.1",
"transcript_support_level": null,
"aa_start": 672,
"aa_end": null,
"aa_length": 860,
"cds_start": 2014,
"cds_end": null,
"cds_length": 2583,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001286504.1"
},
{
"aa_ref": "T",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HSPH1",
"gene_hgnc_id": 16969,
"hgvs_c": "c.2008A>T",
"hgvs_p": "p.Thr670Ser",
"transcript": "ENST00000853999.1",
"protein_id": "ENSP00000524058.1",
"transcript_support_level": null,
"aa_start": 670,
"aa_end": null,
"aa_length": 858,
"cds_start": 2008,
"cds_end": null,
"cds_length": 2577,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000853999.1"
},
{
"aa_ref": "T",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HSPH1",
"gene_hgnc_id": 16969,
"hgvs_c": "c.2008A>T",
"hgvs_p": "p.Thr670Ser",
"transcript": "ENST00000936549.1",
"protein_id": "ENSP00000606608.1",
"transcript_support_level": null,
"aa_start": 670,
"aa_end": null,
"aa_length": 858,
"cds_start": 2008,
"cds_end": null,
"cds_length": 2577,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000936549.1"
},
{
"aa_ref": "T",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HSPH1",
"gene_hgnc_id": 16969,
"hgvs_c": "c.2008A>T",
"hgvs_p": "p.Thr670Ser",
"transcript": "NM_001349704.2",
"protein_id": "NP_001336633.1",
"transcript_support_level": null,
"aa_start": 670,
"aa_end": null,
"aa_length": 851,
"cds_start": 2008,
"cds_end": null,
"cds_length": 2556,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001349704.2"
},
{
"aa_ref": "T",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HSPH1",
"gene_hgnc_id": 16969,
"hgvs_c": "c.1933A>T",
"hgvs_p": "p.Thr645Ser",
"transcript": "ENST00000954004.1",
"protein_id": "ENSP00000624063.1",
"transcript_support_level": null,
"aa_start": 645,
"aa_end": null,
"aa_length": 833,
"cds_start": 1933,
"cds_end": null,
"cds_length": 2502,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000954004.1"
},
{
"aa_ref": "T",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HSPH1",
"gene_hgnc_id": 16969,
"hgvs_c": "c.1885A>T",
"hgvs_p": "p.Thr629Ser",
"transcript": "ENST00000936550.1",
"protein_id": "ENSP00000606609.1",
"transcript_support_level": null,
"aa_start": 629,
"aa_end": null,
"aa_length": 817,
"cds_start": 1885,
"cds_end": null,
"cds_length": 2454,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000936550.1"
},
{
"aa_ref": "T",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HSPH1",
"gene_hgnc_id": 16969,
"hgvs_c": "c.1876A>T",
"hgvs_p": "p.Thr626Ser",
"transcript": "NM_001286503.2",
"protein_id": "NP_001273432.1",
"transcript_support_level": null,
"aa_start": 626,
"aa_end": null,
"aa_length": 814,
"cds_start": 1876,
"cds_end": null,
"cds_length": 2445,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001286503.2"
},
{
"aa_ref": "T",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HSPH1",
"gene_hgnc_id": 16969,
"hgvs_c": "c.1876A>T",
"hgvs_p": "p.Thr626Ser",
"transcript": "ENST00000954002.1",
"protein_id": "ENSP00000624061.1",
"transcript_support_level": null,
"aa_start": 626,
"aa_end": null,
"aa_length": 814,
"cds_start": 1876,
"cds_end": null,
"cds_length": 2445,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000954002.1"
},
{
"aa_ref": "T",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HSPH1",
"gene_hgnc_id": 16969,
"hgvs_c": "c.1780A>T",
"hgvs_p": "p.Thr594Ser",
"transcript": "NM_001286505.1",
"protein_id": "NP_001273434.1",
"transcript_support_level": null,
"aa_start": 594,
"aa_end": null,
"aa_length": 782,
"cds_start": 1780,
"cds_end": null,
"cds_length": 2349,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001286505.1"
},
{
"aa_ref": "T",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HSPH1",
"gene_hgnc_id": 16969,
"hgvs_c": "c.1780A>T",
"hgvs_p": "p.Thr594Ser",
"transcript": "ENST00000445273.6",
"protein_id": "ENSP00000396090.3",
"transcript_support_level": 2,
"aa_start": 594,
"aa_end": null,
"aa_length": 782,
"cds_start": 1780,
"cds_end": null,
"cds_length": 2349,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000445273.6"
},
{
"aa_ref": "T",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HSPH1",
"gene_hgnc_id": 16969,
"hgvs_c": "c.1774A>T",
"hgvs_p": "p.Thr592Ser",
"transcript": "ENST00000954003.1",
"protein_id": "ENSP00000624062.1",
"transcript_support_level": null,
"aa_start": 592,
"aa_end": null,
"aa_length": 780,
"cds_start": 1774,
"cds_end": null,
"cds_length": 2343,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000954003.1"
},
{
"aa_ref": "T",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HSPH1",
"gene_hgnc_id": 16969,
"hgvs_c": "c.1753A>T",
"hgvs_p": "p.Thr585Ser",
"transcript": "ENST00000954005.1",
"protein_id": "ENSP00000624064.1",
"transcript_support_level": null,
"aa_start": 585,
"aa_end": null,
"aa_length": 773,
"cds_start": 1753,
"cds_end": null,
"cds_length": 2322,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000954005.1"
},
{
"aa_ref": "T",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HSPH1",
"gene_hgnc_id": 16969,
"hgvs_c": "c.1642A>T",
"hgvs_p": "p.Thr548Ser",
"transcript": "ENST00000954006.1",
"protein_id": "ENSP00000624065.1",
"transcript_support_level": null,
"aa_start": 548,
"aa_end": null,
"aa_length": 736,
"cds_start": 1642,
"cds_end": null,
"cds_length": 2211,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000954006.1"
},
{
"aa_ref": "T",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HSPH1",
"gene_hgnc_id": 16969,
"hgvs_c": "c.721A>T",
"hgvs_p": "p.Thr241Ser",
"transcript": "ENST00000936551.1",
"protein_id": "ENSP00000606610.1",
"transcript_support_level": null,
"aa_start": 241,
"aa_end": null,
"aa_length": 429,
"cds_start": 721,
"cds_end": null,
"cds_length": 1290,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000936551.1"
},
{
"aa_ref": "T",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HSPH1",
"gene_hgnc_id": 16969,
"hgvs_c": "c.2014A>T",
"hgvs_p": "p.Thr672Ser",
"transcript": "XM_011534887.4",
"protein_id": "XP_011533189.1",
"transcript_support_level": null,
"aa_start": 672,
"aa_end": null,
"aa_length": 853,
"cds_start": 2014,
"cds_end": null,
"cds_length": 2562,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011534887.4"
},
{
"aa_ref": "T",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HSPH1",
"gene_hgnc_id": 16969,
"hgvs_c": "c.1882A>T",
"hgvs_p": "p.Thr628Ser",
"transcript": "XM_005266236.3",
"protein_id": "XP_005266293.1",
"transcript_support_level": null,
"aa_start": 628,
"aa_end": null,
"aa_length": 816,
"cds_start": 1882,
"cds_end": null,
"cds_length": 2451,
"cdna_start": null,
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}
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}