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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 13-32403003-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=13&pos=32403003&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "13",
"pos": 32403003,
"ref": "T",
"alt": "C",
"effect": "missense_variant",
"transcript": "NM_001353627.2",
"consequences": [
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "N4BP2L1",
"gene_hgnc_id": 25037,
"hgvs_c": "c.671A>G",
"hgvs_p": "p.His224Arg",
"transcript": "NM_052818.3",
"protein_id": "NP_438169.2",
"transcript_support_level": null,
"aa_start": 224,
"aa_end": null,
"aa_length": 243,
"cds_start": 671,
"cds_end": null,
"cds_length": 732,
"cdna_start": 719,
"cdna_end": null,
"cdna_length": 2999,
"mane_select": "ENST00000380130.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_052818.3"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "N4BP2L1",
"gene_hgnc_id": 25037,
"hgvs_c": "c.671A>G",
"hgvs_p": "p.His224Arg",
"transcript": "ENST00000380130.7",
"protein_id": "ENSP00000369473.2",
"transcript_support_level": 1,
"aa_start": 224,
"aa_end": null,
"aa_length": 243,
"cds_start": 671,
"cds_end": null,
"cds_length": 732,
"cdna_start": 719,
"cdna_end": null,
"cdna_length": 2999,
"mane_select": "NM_052818.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000380130.7"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "N4BP2L1",
"gene_hgnc_id": 25037,
"hgvs_c": "c.671A>G",
"hgvs_p": "p.His224Arg",
"transcript": "ENST00000380133.6",
"protein_id": "ENSP00000369476.2",
"transcript_support_level": 1,
"aa_start": 224,
"aa_end": null,
"aa_length": 243,
"cds_start": 671,
"cds_end": null,
"cds_length": 732,
"cdna_start": 722,
"cdna_end": null,
"cdna_length": 903,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000380133.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "N4BP2L1",
"gene_hgnc_id": 25037,
"hgvs_c": "c.*141A>G",
"hgvs_p": null,
"transcript": "ENST00000380139.8",
"protein_id": "ENSP00000369484.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 173,
"cds_start": null,
"cds_end": null,
"cds_length": 522,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2994,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000380139.8"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "N4BP2L1",
"gene_hgnc_id": 25037,
"hgvs_c": "c.947A>G",
"hgvs_p": "p.His316Arg",
"transcript": "NM_001353627.2",
"protein_id": "NP_001340556.1",
"transcript_support_level": null,
"aa_start": 316,
"aa_end": null,
"aa_length": 335,
"cds_start": 947,
"cds_end": null,
"cds_length": 1008,
"cdna_start": 995,
"cdna_end": null,
"cdna_length": 3275,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001353627.2"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "N4BP2L1",
"gene_hgnc_id": 25037,
"hgvs_c": "c.713A>G",
"hgvs_p": "p.His238Arg",
"transcript": "NM_001353629.2",
"protein_id": "NP_001340558.1",
"transcript_support_level": null,
"aa_start": 238,
"aa_end": null,
"aa_length": 257,
"cds_start": 713,
"cds_end": null,
"cds_length": 774,
"cdna_start": 1201,
"cdna_end": null,
"cdna_length": 3481,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001353629.2"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "N4BP2L1",
"gene_hgnc_id": 25037,
"hgvs_c": "c.671A>G",
"hgvs_p": "p.His224Arg",
"transcript": "NM_001286459.2",
"protein_id": "NP_001273388.1",
"transcript_support_level": null,
"aa_start": 224,
"aa_end": null,
"aa_length": 243,
"cds_start": 671,
"cds_end": null,
"cds_length": 732,
"cdna_start": 719,
"cdna_end": null,
"cdna_length": 1993,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001286459.2"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "N4BP2L1",
"gene_hgnc_id": 25037,
"hgvs_c": "c.668A>G",
"hgvs_p": "p.His223Arg",
"transcript": "ENST00000970430.1",
"protein_id": "ENSP00000640489.1",
"transcript_support_level": null,
"aa_start": 223,
"aa_end": null,
"aa_length": 242,
"cds_start": 668,
"cds_end": null,
"cds_length": 729,
"cdna_start": 695,
"cdna_end": null,
"cdna_length": 1566,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000970430.1"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "N4BP2L1",
"gene_hgnc_id": 25037,
"hgvs_c": "c.593A>G",
"hgvs_p": "p.His198Arg",
"transcript": "ENST00000970429.1",
"protein_id": "ENSP00000640488.1",
"transcript_support_level": null,
"aa_start": 198,
"aa_end": null,
"aa_length": 217,
"cds_start": 593,
"cds_end": null,
"cds_length": 654,
"cdna_start": 641,
"cdna_end": null,
"cdna_length": 1905,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000970429.1"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "N4BP2L1",
"gene_hgnc_id": 25037,
"hgvs_c": "c.503A>G",
"hgvs_p": "p.His168Arg",
"transcript": "NM_001353633.2",
"protein_id": "NP_001340562.1",
"transcript_support_level": null,
"aa_start": 168,
"aa_end": null,
"aa_length": 187,
"cds_start": 503,
"cds_end": null,
"cds_length": 564,
"cdna_start": 790,
"cdna_end": null,
"cdna_length": 3070,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001353633.2"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "N4BP2L1",
"gene_hgnc_id": 25037,
"hgvs_c": "c.353A>G",
"hgvs_p": "p.His118Arg",
"transcript": "ENST00000530622.6",
"protein_id": "ENSP00000435515.2",
"transcript_support_level": 5,
"aa_start": 118,
"aa_end": null,
"aa_length": 137,
"cds_start": 353,
"cds_end": null,
"cds_length": 414,
"cdna_start": 571,
"cdna_end": null,
"cdna_length": 1897,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000530622.6"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "N4BP2L1",
"gene_hgnc_id": 25037,
"hgvs_c": "c.944A>G",
"hgvs_p": "p.His315Arg",
"transcript": "XM_047430761.1",
"protein_id": "XP_047286717.1",
"transcript_support_level": null,
"aa_start": 315,
"aa_end": null,
"aa_length": 334,
"cds_start": 944,
"cds_end": null,
"cds_length": 1005,
"cdna_start": 4868,
"cdna_end": null,
"cdna_length": 7148,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047430761.1"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "N4BP2L1",
"gene_hgnc_id": 25037,
"hgvs_c": "c.713A>G",
"hgvs_p": "p.His238Arg",
"transcript": "XM_017020838.3",
"protein_id": "XP_016876327.1",
"transcript_support_level": null,
"aa_start": 238,
"aa_end": null,
"aa_length": 257,
"cds_start": 713,
"cds_end": null,
"cds_length": 774,
"cdna_start": 1437,
"cdna_end": null,
"cdna_length": 3717,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017020838.3"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "N4BP2L1",
"gene_hgnc_id": 25037,
"hgvs_c": "c.578A>G",
"hgvs_p": "p.His193Arg",
"transcript": "XM_011535303.3",
"protein_id": "XP_011533605.1",
"transcript_support_level": null,
"aa_start": 193,
"aa_end": null,
"aa_length": 212,
"cds_start": 578,
"cds_end": null,
"cds_length": 639,
"cdna_start": 1329,
"cdna_end": null,
"cdna_length": 3609,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011535303.3"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "N4BP2L1",
"gene_hgnc_id": 25037,
"hgvs_c": "c.503A>G",
"hgvs_p": "p.His168Arg",
"transcript": "XM_047430764.1",
"protein_id": "XP_047286720.1",
"transcript_support_level": null,
"aa_start": 168,
"aa_end": null,
"aa_length": 187,
"cds_start": 503,
"cds_end": null,
"cds_length": 564,
"cdna_start": 652,
"cdna_end": null,
"cdna_length": 2932,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047430764.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "N4BP2L1",
"gene_hgnc_id": 25037,
"hgvs_c": "c.*141A>G",
"hgvs_p": null,
"transcript": "NM_001353628.2",
"protein_id": "NP_001340557.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 265,
"cds_start": null,
"cds_end": null,
"cds_length": 798,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3267,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001353628.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "N4BP2L1",
"gene_hgnc_id": 25037,
"hgvs_c": "c.*154A>G",
"hgvs_p": null,
"transcript": "NM_001353630.2",
"protein_id": "NP_001340559.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 204,
"cds_start": null,
"cds_end": null,
"cds_length": 615,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3097,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001353630.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "N4BP2L1",
"gene_hgnc_id": 25037,
"hgvs_c": "c.*210A>G",
"hgvs_p": null,
"transcript": "NM_001353631.2",
"protein_id": "NP_001340560.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 202,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001353631.2"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "N4BP2L1",
"gene_hgnc_id": 25037,
"hgvs_c": "c.*210A>G",
"hgvs_p": null,
"transcript": "NM_001353632.2",
"protein_id": "NP_001340561.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 188,
"cds_start": null,
"cds_end": null,
"cds_length": 567,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3105,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001353632.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "N4BP2L1",
"gene_hgnc_id": 25037,
"hgvs_c": "c.*141A>G",
"hgvs_p": null,
"transcript": "NM_001079691.2",
"protein_id": "NP_001073159.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 173,
"cds_start": null,
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"cdna_start": null,
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"cdna_length": 2991,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001079691.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "N4BP2L1",
"gene_hgnc_id": 25037,
"hgvs_c": "c.*141A>G",
"hgvs_p": null,
"transcript": "ENST00000613078.4",
"protein_id": "ENSP00000483310.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 173,
"cds_start": null,
"cds_end": null,
"cds_length": 522,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2032,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000613078.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "N4BP2L1",
"gene_hgnc_id": 25037,
"hgvs_c": "c.*210A>G",
"hgvs_p": null,
"transcript": "ENST00000635608.1",
"protein_id": "ENSP00000489423.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 165,
"cds_start": null,
"cds_end": null,
"cds_length": 498,
"cdna_start": null,
"cdna_end": null,
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}
],
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}