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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 13-35475441-T-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=13&pos=35475441&ref=T&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "13",
"pos": 35475441,
"ref": "T",
"alt": "G",
"effect": "missense_variant",
"transcript": "NM_005584.5",
"consequences": [
{
"aa_ref": "Q",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 1,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAB21L1",
"gene_hgnc_id": 6757,
"hgvs_c": "c.698A>C",
"hgvs_p": "p.Gln233Pro",
"transcript": "NM_005584.5",
"protein_id": "NP_005575.1",
"transcript_support_level": null,
"aa_start": 233,
"aa_end": null,
"aa_length": 359,
"cds_start": 698,
"cds_end": null,
"cds_length": 1080,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000379919.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_005584.5"
},
{
"aa_ref": "Q",
"aa_alt": "P",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 1,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAB21L1",
"gene_hgnc_id": 6757,
"hgvs_c": "c.698A>C",
"hgvs_p": "p.Gln233Pro",
"transcript": "ENST00000379919.6",
"protein_id": "ENSP00000369251.4",
"transcript_support_level": 6,
"aa_start": 233,
"aa_end": null,
"aa_length": 359,
"cds_start": 698,
"cds_end": null,
"cds_length": 1080,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_005584.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000379919.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 59,
"intron_rank": 41,
"intron_rank_end": null,
"gene_symbol": "NBEA",
"gene_hgnc_id": 7648,
"hgvs_c": "c.6585+2905T>G",
"hgvs_p": null,
"transcript": "NM_001385012.1",
"protein_id": "NP_001371941.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2967,
"cds_start": null,
"cds_end": null,
"cds_length": 8904,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000379939.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001385012.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 59,
"intron_rank": 41,
"intron_rank_end": null,
"gene_symbol": "NBEA",
"gene_hgnc_id": 7648,
"hgvs_c": "c.6585+2905T>G",
"hgvs_p": null,
"transcript": "ENST00000379939.7",
"protein_id": "ENSP00000369271.2",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 2967,
"cds_start": null,
"cds_end": null,
"cds_length": 8904,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001385012.1",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000379939.7"
},
{
"aa_ref": "Q",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAB21L1",
"gene_hgnc_id": 6757,
"hgvs_c": "c.698A>C",
"hgvs_p": "p.Gln233Pro",
"transcript": "ENST00000707125.1",
"protein_id": "ENSP00000516753.1",
"transcript_support_level": null,
"aa_start": 233,
"aa_end": null,
"aa_length": 359,
"cds_start": 698,
"cds_end": null,
"cds_length": 1080,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000707125.1"
},
{
"aa_ref": "Q",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAB21L1",
"gene_hgnc_id": 6757,
"hgvs_c": "c.698A>C",
"hgvs_p": "p.Gln233Pro",
"transcript": "ENST00000951518.1",
"protein_id": "ENSP00000621577.1",
"transcript_support_level": null,
"aa_start": 233,
"aa_end": null,
"aa_length": 359,
"cds_start": 698,
"cds_end": null,
"cds_length": 1080,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000951518.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 58,
"intron_rank": 40,
"intron_rank_end": null,
"gene_symbol": "NBEA",
"gene_hgnc_id": 7648,
"hgvs_c": "c.6576+2905T>G",
"hgvs_p": null,
"transcript": "NM_001379245.1",
"protein_id": "NP_001366174.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2964,
"cds_start": null,
"cds_end": null,
"cds_length": 8895,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001379245.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 58,
"intron_rank": 41,
"intron_rank_end": null,
"gene_symbol": "NBEA",
"gene_hgnc_id": 7648,
"hgvs_c": "c.6585+2905T>G",
"hgvs_p": null,
"transcript": "NM_015678.5",
"protein_id": "NP_056493.3",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2946,
"cds_start": null,
"cds_end": null,
"cds_length": 8841,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_015678.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 58,
"intron_rank": 41,
"intron_rank_end": null,
"gene_symbol": "NBEA",
"gene_hgnc_id": 7648,
"hgvs_c": "c.6585+2905T>G",
"hgvs_p": null,
"transcript": "ENST00000400445.8",
"protein_id": "ENSP00000383295.3",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 2946,
"cds_start": null,
"cds_end": null,
"cds_length": 8841,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000400445.8"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 42,
"intron_rank": 25,
"intron_rank_end": null,
"gene_symbol": "NBEA",
"gene_hgnc_id": 7648,
"hgvs_c": "c.4431+2905T>G",
"hgvs_p": null,
"transcript": "ENST00000688626.1",
"protein_id": "ENSP00000509239.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2228,
"cds_start": null,
"cds_end": null,
"cds_length": 6687,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000688626.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 41,
"intron_rank": 24,
"intron_rank_end": null,
"gene_symbol": "NBEA",
"gene_hgnc_id": 7648,
"hgvs_c": "c.4335+2905T>G",
"hgvs_p": null,
"transcript": "ENST00000688363.1",
"protein_id": "ENSP00000510178.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2198,
"cds_start": null,
"cds_end": null,
"cds_length": 6597,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000688363.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": 15,
"intron_rank_end": null,
"gene_symbol": "NBEA",
"gene_hgnc_id": 7648,
"hgvs_c": "c.2229+2905T>G",
"hgvs_p": null,
"transcript": "ENST00000629018.4",
"protein_id": "ENSP00000486239.3",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 1494,
"cds_start": null,
"cds_end": null,
"cds_length": 4485,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000629018.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "NBEA",
"gene_hgnc_id": 7648,
"hgvs_c": "c.807+2905T>G",
"hgvs_p": null,
"transcript": "ENST00000686320.1",
"protein_id": "ENSP00000508724.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1020,
"cds_start": null,
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"cds_length": 3063,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000686320.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 19,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "NBEA",
"gene_hgnc_id": 7648,
"hgvs_c": "c.-37+2905T>G",
"hgvs_p": null,
"transcript": "ENST00000685686.1",
"protein_id": "ENSP00000509879.1",
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000685686.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "NBEA",
"gene_hgnc_id": 7648,
"hgvs_c": "c.-37+2905T>G",
"hgvs_p": null,
"transcript": "ENST00000686741.1",
"protein_id": "ENSP00000510596.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 739,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000686741.1"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 18,
"intron_rank": 1,
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"gene_symbol": "NBEA",
"gene_hgnc_id": 7648,
"hgvs_c": "c.-37+2905T>G",
"hgvs_p": null,
"transcript": "ENST00000686952.1",
"protein_id": "ENSP00000509331.1",
"transcript_support_level": null,
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000686952.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "NBEA",
"gene_hgnc_id": 7648,
"hgvs_c": "c.-37+2905T>G",
"hgvs_p": null,
"transcript": "ENST00000689454.1",
"protein_id": "ENSP00000509389.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 739,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000689454.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "NBEA",
"gene_hgnc_id": 7648,
"hgvs_c": "c.-159+2905T>G",
"hgvs_p": null,
"transcript": "ENST00000693262.1",
"protein_id": "ENSP00000509811.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 739,
"cds_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000693262.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "NBEA",
"gene_hgnc_id": 7648,
"hgvs_c": "c.-37+2905T>G",
"hgvs_p": null,
"transcript": "ENST00000688335.1",
"protein_id": "ENSP00000509646.1",
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"cdna_start": null,
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"biotype": "protein_coding",
"feature": "ENST00000688335.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "NBEA",
"gene_hgnc_id": 7648,
"hgvs_c": "c.-37+2905T>G",
"hgvs_p": null,
"transcript": "ENST00000691561.1",
"protein_id": "ENSP00000510517.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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"biotype": "protein_coding",
"feature": "ENST00000691561.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "NBEA",
"gene_hgnc_id": 7648,
"hgvs_c": "c.-163+2905T>G",
"hgvs_p": null,
"transcript": "ENST00000688422.1",
"protein_id": "ENSP00000509488.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 184,
"cds_start": null,
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"cds_length": 555,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000688422.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 59,
"intron_rank": 41,
"intron_rank_end": null,
"gene_symbol": "NBEA",
"gene_hgnc_id": 7648,
"hgvs_c": "c.6585+2905T>G",
"hgvs_p": null,
"transcript": "XM_006719803.4",
"protein_id": "XP_006719866.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2962,
"cds_start": null,
"cds_end": null,
"cds_length": 8889,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_006719803.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
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}