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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 13-46022005-C-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=13&pos=46022005&ref=C&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "13",
"pos": 46022005,
"ref": "C",
"alt": "G",
"effect": "intron_variant",
"transcript": "ENST00000679008.1",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "ZC3H13",
"gene_hgnc_id": 20368,
"hgvs_c": "c.340-1448G>C",
"hgvs_p": null,
"transcript": "NM_001330564.2",
"protein_id": "NP_001317493.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1669,
"cds_start": -4,
"cds_end": null,
"cds_length": 5010,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 8024,
"mane_select": "ENST00000679008.1",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "ZC3H13",
"gene_hgnc_id": 20368,
"hgvs_c": "c.340-1448G>C",
"hgvs_p": null,
"transcript": "ENST00000679008.1",
"protein_id": "ENSP00000503994.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1669,
"cds_start": -4,
"cds_end": null,
"cds_length": 5010,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 8024,
"mane_select": "NM_001330564.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "ZC3H13",
"gene_hgnc_id": 20368,
"hgvs_c": "c.340-1448G>C",
"hgvs_p": null,
"transcript": "ENST00000282007.7",
"protein_id": "ENSP00000282007.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1564,
"cds_start": -4,
"cds_end": null,
"cds_length": 4695,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6412,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "ZC3H13",
"gene_hgnc_id": 20368,
"hgvs_c": "c.340-1448G>C",
"hgvs_p": null,
"transcript": "NM_001382211.1",
"protein_id": "NP_001369140.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1697,
"cds_start": -4,
"cds_end": null,
"cds_length": 5094,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 8108,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "ZC3H13",
"gene_hgnc_id": 20368,
"hgvs_c": "c.340-1448G>C",
"hgvs_p": null,
"transcript": "NM_001382212.1",
"protein_id": "NP_001369141.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1696,
"cds_start": -4,
"cds_end": null,
"cds_length": 5091,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7811,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "ZC3H13",
"gene_hgnc_id": 20368,
"hgvs_c": "c.340-1448G>C",
"hgvs_p": null,
"transcript": "NM_001382213.1",
"protein_id": "NP_001369142.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1696,
"cds_start": -4,
"cds_end": null,
"cds_length": 5091,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 8105,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "ZC3H13",
"gene_hgnc_id": 20368,
"hgvs_c": "c.340-1448G>C",
"hgvs_p": null,
"transcript": "NM_001076788.2",
"protein_id": "NP_001070256.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1669,
"cds_start": -4,
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"cds_length": 5010,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7730,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "ZC3H13",
"gene_hgnc_id": 20368,
"hgvs_c": "c.340-1448G>C",
"hgvs_p": null,
"transcript": "NM_001382206.1",
"protein_id": "NP_001369135.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1669,
"cds_start": -4,
"cds_end": null,
"cds_length": 5010,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7788,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "ZC3H13",
"gene_hgnc_id": 20368,
"hgvs_c": "c.340-1448G>C",
"hgvs_p": null,
"transcript": "NM_001382207.1",
"protein_id": "NP_001369136.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1669,
"cds_start": -4,
"cds_end": null,
"cds_length": 5010,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7727,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "ZC3H13",
"gene_hgnc_id": 20368,
"hgvs_c": "c.340-1448G>C",
"hgvs_p": null,
"transcript": "NM_001382208.1",
"protein_id": "NP_001369137.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
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"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "ZC3H13",
"gene_hgnc_id": 20368,
"hgvs_c": "c.340-1448G>C",
"hgvs_p": null,
"transcript": "NM_001330565.2",
"protein_id": "NP_001317494.1",
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 20,
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"gene_symbol": "ZC3H13",
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"hgvs_c": "c.340-1448G>C",
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"transcript": "NM_001330566.2",
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"feature": null
},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 4,
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"gene_symbol": "ZC3H13",
"gene_hgnc_id": 20368,
"hgvs_c": "c.340-1448G>C",
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"transcript": "NM_001330567.2",
"protein_id": "NP_001317496.1",
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},
{
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"strand": false,
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],
"exon_rank": null,
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"intron_rank": 5,
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"gene_symbol": "ZC3H13",
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"hgvs_c": "c.340-1448G>C",
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"transcript": "NM_001382209.1",
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},
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],
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"gene_symbol": "ZC3H13",
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"hgvs_c": "c.340-1448G>C",
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"transcript": "NM_001382210.1",
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},
{
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],
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"gene_symbol": "ZC3H13",
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"hgvs_c": "c.340-1448G>C",
"hgvs_p": null,
"transcript": "ENST00000242848.8",
"protein_id": "ENSP00000242848.4",
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},
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],
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"gene_symbol": "ZC3H13",
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"hgvs_c": "c.340-1448G>C",
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"transcript": "NM_015070.6",
"protein_id": "NP_055885.3",
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},
{
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],
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"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "ZC3H13",
"gene_hgnc_id": 20368,
"hgvs_c": "c.-162-1448G>C",
"hgvs_p": null,
"transcript": "NM_001382214.1",
"protein_id": "NP_001369143.1",
"transcript_support_level": null,
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"cds_start": -4,
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},
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"strand": false,
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],
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"exon_count": 20,
"intron_rank": 4,
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"gene_symbol": "ZC3H13",
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"hgvs_c": "n.395-1448G>C",
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"transcript": "NR_167893.1",
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},
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],
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"gene_symbol": "ZC3H13",
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"hgvs_c": "c.340-1448G>C",
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"protein_id": "XP_005266359.1",
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},
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],
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"intron_rank": 5,
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"gene_symbol": "ZC3H13",
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},
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"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 20,
"intron_rank": 4,
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"gene_symbol": "ZC3H13",
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"hgvs_c": "c.340-1448G>C",
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"transcript": "XM_005266304.4",
"protein_id": "XP_005266361.1",
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
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"exon_count": 21,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "ZC3H13",
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"hgvs_c": "c.340-1448G>C",
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"transcript": "XM_005266305.4",
"protein_id": "XP_005266362.1",
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}