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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 13-46084577-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=13&pos=46084577&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "13",
"pos": 46084577,
"ref": "A",
"alt": "G",
"effect": "intron_variant",
"transcript": "ENST00000181383.10",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "CPB2",
"gene_hgnc_id": 2300,
"hgvs_c": "c.151-234T>C",
"hgvs_p": null,
"transcript": "NM_001872.5",
"protein_id": "NP_001863.3",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 423,
"cds_start": -4,
"cds_end": null,
"cds_length": 1272,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1724,
"mane_select": "ENST00000181383.10",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "CPB2",
"gene_hgnc_id": 2300,
"hgvs_c": "c.151-234T>C",
"hgvs_p": null,
"transcript": "ENST00000181383.10",
"protein_id": "ENSP00000181383.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 423,
"cds_start": -4,
"cds_end": null,
"cds_length": 1272,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1724,
"mane_select": "NM_001872.5",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "CPB2",
"gene_hgnc_id": 2300,
"hgvs_c": "c.151-234T>C",
"hgvs_p": null,
"transcript": "NM_001278541.2",
"protein_id": "NP_001265470.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 386,
"cds_start": -4,
"cds_end": null,
"cds_length": 1161,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1613,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "CPB2",
"gene_hgnc_id": 2300,
"hgvs_c": "c.151-234T>C",
"hgvs_p": null,
"transcript": "ENST00000439329.5",
"protein_id": "ENSP00000400714.3",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 386,
"cds_start": -4,
"cds_end": null,
"cds_length": 1161,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1577,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "CPB2",
"gene_hgnc_id": 2300,
"hgvs_c": "c.151-234T>C",
"hgvs_p": null,
"transcript": "ENST00000674625.1",
"protein_id": "ENSP00000502808.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 207,
"cds_start": -4,
"cds_end": null,
"cds_length": 624,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5585,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "CPB2-AS1",
"gene_hgnc_id": 39898,
"hgvs_c": "n.152-10276A>G",
"hgvs_p": null,
"transcript": "ENST00000415033.4",
"protein_id": null,
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4078,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "CPB2-AS1",
"gene_hgnc_id": 39898,
"hgvs_c": "n.166-10276A>G",
"hgvs_p": null,
"transcript": "ENST00000606243.7",
"protein_id": null,
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3790,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "CPB2-AS1",
"gene_hgnc_id": 39898,
"hgvs_c": "n.169-10276A>G",
"hgvs_p": null,
"transcript": "ENST00000606351.6",
"protein_id": null,
"transcript_support_level": 4,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 839,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "CPB2-AS1",
"gene_hgnc_id": 39898,
"hgvs_c": "n.169-10276A>G",
"hgvs_p": null,
"transcript": "ENST00000606991.6",
"protein_id": null,
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3509,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "CPB2-AS1",
"gene_hgnc_id": 39898,
"hgvs_c": "n.127-10276A>G",
"hgvs_p": null,
"transcript": "ENST00000624622.2",
"protein_id": null,
"transcript_support_level": 6,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
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"cds_length": null,
"cdna_start": null,
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"cdna_length": 3977,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 1,
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"gene_symbol": "CPB2-AS1",
"gene_hgnc_id": 39898,
"hgvs_c": "n.127-10276A>G",
"hgvs_p": null,
"transcript": "ENST00000658197.1",
"protein_id": null,
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"aa_start": null,
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},
{
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"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 2,
"intron_rank": 1,
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"gene_symbol": "CPB2-AS1",
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"hgvs_c": "n.172-10276A>G",
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"transcript": "ENST00000659168.2",
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},
{
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"strand": true,
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],
"exon_rank": null,
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"exon_count": 4,
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"gene_symbol": "CPB2-AS1",
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"hgvs_c": "n.161-10276A>G",
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},
{
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"strand": true,
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],
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"gene_symbol": "CPB2-AS1",
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"transcript": "ENST00000663015.1",
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},
{
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],
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"gene_symbol": "CPB2-AS1",
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},
{
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"strand": true,
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],
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"exon_count": 5,
"intron_rank": 1,
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"gene_symbol": "CPB2-AS1",
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"hgvs_c": "n.127-10276A>G",
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},
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],
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},
{
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"strand": true,
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],
"exon_rank": null,
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"intron_rank": 1,
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"gene_symbol": "CPB2-AS1",
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"hgvs_c": "n.126-10276A>G",
"hgvs_p": null,
"transcript": "ENST00000667034.1",
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},
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"strand": true,
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],
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"exon_count": 5,
"intron_rank": 1,
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"gene_symbol": "CPB2-AS1",
"gene_hgnc_id": 39898,
"hgvs_c": "n.90-10276A>G",
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"transcript": "ENST00000667409.1",
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},
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],
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],
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"hgvs_c": "n.126-10276A>G",
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},
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],
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"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "CPB2",
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"hgvs_c": "n.151-234T>C",
"hgvs_p": null,
"transcript": "ENST00000675730.1",
"protein_id": "ENSP00000502038.1",
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"feature": null
},
{
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"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 2,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "CPB2-AS1",
"gene_hgnc_id": 39898,
"hgvs_c": "n.152-28607A>G",
"hgvs_p": null,
"transcript": "ENST00000839803.1",
"protein_id": null,
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},
{
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"protein_coding": false,
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"consequences": [
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],
"exon_rank": null,
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{
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}
],
"message": null
}