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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 13-46343334-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=13&pos=46343334&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "13",
"pos": 46343334,
"ref": "G",
"alt": "A",
"effect": "3_prime_UTR_variant",
"transcript": "ENST00000429979.6",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RUBCNL",
"gene_hgnc_id": 20420,
"hgvs_c": "c.*51C>T",
"hgvs_p": null,
"transcript": "NM_025113.5",
"protein_id": "NP_079389.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 662,
"cds_start": -4,
"cds_end": null,
"cds_length": 1989,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 11050,
"mane_select": "ENST00000429979.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RUBCNL",
"gene_hgnc_id": 20420,
"hgvs_c": "c.*51C>T",
"hgvs_p": null,
"transcript": "ENST00000429979.6",
"protein_id": "ENSP00000396935.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 662,
"cds_start": -4,
"cds_end": null,
"cds_length": 1989,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 11050,
"mane_select": "NM_025113.5",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RUBCNL",
"gene_hgnc_id": 20420,
"hgvs_c": "c.*51C>T",
"hgvs_p": null,
"transcript": "ENST00000378784.8",
"protein_id": "ENSP00000368061.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 595,
"cds_start": -4,
"cds_end": null,
"cds_length": 1788,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2361,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RUBCNL",
"gene_hgnc_id": 20420,
"hgvs_c": "c.*51C>T",
"hgvs_p": null,
"transcript": "ENST00000378797.6",
"protein_id": "ENSP00000368074.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 447,
"cds_start": -4,
"cds_end": null,
"cds_length": 1344,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3206,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RUBCNL",
"gene_hgnc_id": 20420,
"hgvs_c": "c.1886C>T",
"hgvs_p": "p.Pro629Leu",
"transcript": "NM_001286762.3",
"protein_id": "NP_001273691.1",
"transcript_support_level": null,
"aa_start": 629,
"aa_end": null,
"aa_length": 635,
"cds_start": 1886,
"cds_end": null,
"cds_length": 1908,
"cdna_start": 2127,
"cdna_end": null,
"cdna_length": 3722,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RUBCNL",
"gene_hgnc_id": 20420,
"hgvs_c": "c.1886C>T",
"hgvs_p": "p.Pro629Leu",
"transcript": "ENST00000378787.7",
"protein_id": "ENSP00000368064.3",
"transcript_support_level": 2,
"aa_start": 629,
"aa_end": null,
"aa_length": 635,
"cds_start": 1886,
"cds_end": null,
"cds_length": 1908,
"cdna_start": 2361,
"cdna_end": null,
"cdna_length": 2731,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RUBCNL",
"gene_hgnc_id": 20420,
"hgvs_c": "c.1886C>T",
"hgvs_p": "p.Pro629Leu",
"transcript": "ENST00000417405.2",
"protein_id": "ENSP00000402357.2",
"transcript_support_level": 3,
"aa_start": 629,
"aa_end": null,
"aa_length": 635,
"cds_start": 1886,
"cds_end": null,
"cds_length": 1908,
"cdna_start": 2325,
"cdna_end": null,
"cdna_length": 2613,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RUBCNL",
"gene_hgnc_id": 20420,
"hgvs_c": "n.*1391C>T",
"hgvs_p": null,
"transcript": "ENST00000441284.6",
"protein_id": "ENSP00000412507.2",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3954,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RUBCNL",
"gene_hgnc_id": 20420,
"hgvs_c": "n.1366C>T",
"hgvs_p": null,
"transcript": "ENST00000487195.5",
"protein_id": null,
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1736,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RUBCNL",
"gene_hgnc_id": 20420,
"hgvs_c": "n.*1516C>T",
"hgvs_p": null,
"transcript": "ENST00000675291.1",
"protein_id": "ENSP00000502306.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3061,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RUBCNL",
"gene_hgnc_id": 20420,
"hgvs_c": "n.382C>T",
"hgvs_p": null,
"transcript": "ENST00000675678.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 635,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RUBCNL",
"gene_hgnc_id": 20420,
"hgvs_c": "n.*701C>T",
"hgvs_p": null,
"transcript": "ENST00000676063.1",
"protein_id": "ENSP00000501621.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
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"cdna_length": 4066,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RUBCNL",
"gene_hgnc_id": 20420,
"hgvs_c": "n.*1545C>T",
"hgvs_p": null,
"transcript": "ENST00000676084.1",
"protein_id": "ENSP00000502430.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
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"cds_length": null,
"cdna_start": null,
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"cdna_length": 3762,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RUBCNL",
"gene_hgnc_id": 20420,
"hgvs_c": "c.*51C>T",
"hgvs_p": null,
"transcript": "NM_001286761.2",
"protein_id": "NP_001273690.1",
"transcript_support_level": null,
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"cds_start": -4,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RUBCNL",
"gene_hgnc_id": 20420,
"hgvs_c": "c.*51C>T",
"hgvs_p": null,
"transcript": "NM_001349772.2",
"protein_id": "NP_001336701.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 662,
"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 3876,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RUBCNL",
"gene_hgnc_id": 20420,
"hgvs_c": "c.*51C>T",
"hgvs_p": null,
"transcript": "ENST00000389908.7",
"protein_id": "ENSP00000374558.3",
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RUBCNL",
"gene_hgnc_id": 20420,
"hgvs_c": "c.*51C>T",
"hgvs_p": null,
"transcript": "ENST00000676114.1",
"protein_id": "ENSP00000502252.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 662,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RUBCNL",
"gene_hgnc_id": 20420,
"hgvs_c": "c.*51C>T",
"hgvs_p": null,
"transcript": "ENST00000676307.1",
"protein_id": "ENSP00000502015.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 662,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RUBCNL",
"gene_hgnc_id": 20420,
"hgvs_c": "c.*51C>T",
"hgvs_p": null,
"transcript": "NM_001286763.3",
"protein_id": "NP_001273692.1",
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"cdna_start": null,
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"feature": null
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RUBCNL",
"gene_hgnc_id": 20420,
"hgvs_c": "c.*51C>T",
"hgvs_p": null,
"transcript": "ENST00000675585.1",
"protein_id": "ENSP00000502011.1",
"transcript_support_level": null,
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"aa_end": null,
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"cds_start": -4,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
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"gene_symbol": "RUBCNL",
"gene_hgnc_id": 20420,
"hgvs_c": "c.*51C>T",
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"transcript": "NM_001286764.3",
"protein_id": "NP_001273693.1",
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"aa_start": null,
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"aa_length": 527,
"cds_start": -4,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RUBCNL",
"gene_hgnc_id": 20420,
"hgvs_c": "c.*51C>T",
"hgvs_p": null,
"transcript": "ENST00000631139.2",
"protein_id": "ENSP00000485932.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 527,
"cds_start": -4,
"cds_end": null,
"cds_length": 1584,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1948,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RUBCNL",
"gene_hgnc_id": 20420,
"hgvs_c": "c.*51C>T",
"hgvs_p": null,
"transcript": "ENST00000676051.1",
"protein_id": "ENSP00000501843.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 527,
"cds_start": -4,
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}