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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 13-50012697-C-G (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=13&pos=50012697&ref=C&alt=G&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 1,
          "criteria": [
            "PM2",
            "BP4"
          ],
          "effects": [
            "missense_variant"
          ],
          "gene_symbol": "TRIM13",
          "hgnc_id": 9976,
          "hgvs_c": "c.766C>G",
          "hgvs_p": "p.Gln256Glu",
          "inheritance_mode": "AD",
          "pathogenic_score": 2,
          "score": 1,
          "transcript": "NM_001007278.3",
          "verdict": "Uncertain_significance"
        },
        {
          "benign_score": 1,
          "criteria": [
            "PM2",
            "BP4"
          ],
          "effects": [
            "intron_variant"
          ],
          "gene_symbol": "DLEU2",
          "hgnc_id": 13748,
          "hgvs_c": "n.1314+14510G>C",
          "hgvs_p": null,
          "inheritance_mode": "",
          "pathogenic_score": 2,
          "score": 1,
          "transcript": "ENST00000621282.4",
          "verdict": "Uncertain_significance"
        }
      ],
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PM2,BP4",
      "acmg_score": 1,
      "allele_count_reference_population": 1,
      "alphamissense_prediction": null,
      "alphamissense_score": 0.2134,
      "alt": "G",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": "Benign",
      "bayesdelnoaf_score": -0.3,
      "chr": "13",
      "clinvar_classification": "Uncertain significance",
      "clinvar_disease": "not specified",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "US:1",
      "computational_prediction_selected": "Benign",
      "computational_score_selected": 0.3620823621749878,
      "computational_source_selected": "MetaRNN",
      "consequences": [
        {
          "aa_alt": "E",
          "aa_end": null,
          "aa_length": 407,
          "aa_ref": "Q",
          "aa_start": 253,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 7255,
          "cdna_start": 1485,
          "cds_end": null,
          "cds_length": 1224,
          "cds_start": 757,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 2,
          "exon_rank": 2,
          "exon_rank_end": null,
          "feature": "NM_213590.3",
          "gene_hgnc_id": 9976,
          "gene_symbol": "TRIM13",
          "hgvs_c": "c.757C>G",
          "hgvs_p": "p.Gln253Glu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000378182.4",
          "protein_coding": true,
          "protein_id": "NP_998755.1",
          "strand": true,
          "transcript": "NM_213590.3",
          "transcript_support_level": null
        },
        {
          "aa_alt": "E",
          "aa_end": null,
          "aa_length": 407,
          "aa_ref": "Q",
          "aa_start": 253,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 7255,
          "cdna_start": 1485,
          "cds_end": null,
          "cds_length": 1224,
          "cds_start": 757,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 2,
          "exon_rank": 2,
          "exon_rank_end": null,
          "feature": "ENST00000378182.4",
          "gene_hgnc_id": 9976,
          "gene_symbol": "TRIM13",
          "hgvs_c": "c.757C>G",
          "hgvs_p": "p.Gln253Glu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_213590.3",
          "protein_coding": true,
          "protein_id": "ENSP00000367424.3",
          "strand": true,
          "transcript": "ENST00000378182.4",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "E",
          "aa_end": null,
          "aa_length": 410,
          "aa_ref": "Q",
          "aa_start": 256,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1637,
          "cdna_start": 1154,
          "cds_end": null,
          "cds_length": 1233,
          "cds_start": 766,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 4,
          "exon_rank": 4,
          "exon_rank_end": null,
          "feature": "ENST00000356017.8",
          "gene_hgnc_id": 9976,
          "gene_symbol": "TRIM13",
          "hgvs_c": "c.766C>G",
          "hgvs_p": "p.Gln256Glu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000348299.4",
          "strand": true,
          "transcript": "ENST00000356017.8",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "E",
          "aa_end": null,
          "aa_length": 407,
          "aa_ref": "Q",
          "aa_start": 253,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2607,
          "cdna_start": 973,
          "cds_end": null,
          "cds_length": 1224,
          "cds_start": 757,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 3,
          "exon_rank": 3,
          "exon_rank_end": null,
          "feature": "ENST00000420995.6",
          "gene_hgnc_id": 9976,
          "gene_symbol": "TRIM13",
          "hgvs_c": "c.757C>G",
          "hgvs_p": "p.Gln253Glu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000412943.2",
          "strand": true,
          "transcript": "ENST00000420995.6",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "E",
          "aa_end": null,
          "aa_length": 407,
          "aa_ref": "Q",
          "aa_start": 253,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1489,
          "cdna_start": 1018,
          "cds_end": null,
          "cds_length": 1224,
          "cds_start": 757,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 3,
          "exon_rank": 3,
          "exon_rank_end": null,
          "feature": "ENST00000457662.2",
          "gene_hgnc_id": 9976,
          "gene_symbol": "TRIM13",
          "hgvs_c": "c.757C>G",
          "hgvs_p": "p.Gln253Glu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000399206.2",
          "strand": true,
          "transcript": "ENST00000457662.2",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "pseudogene",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3068,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 14,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000621282.4",
          "gene_hgnc_id": 13748,
          "gene_symbol": "DLEU2",
          "hgvs_c": "n.1314+14510G>C",
          "hgvs_p": null,
          "intron_rank": 10,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": null,
          "strand": false,
          "transcript": "ENST00000621282.4",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "E",
          "aa_end": null,
          "aa_length": 410,
          "aa_ref": "Q",
          "aa_start": 256,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6919,
          "cdna_start": 1149,
          "cds_end": null,
          "cds_length": 1233,
          "cds_start": 766,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 4,
          "exon_rank": 4,
          "exon_rank_end": null,
          "feature": "NM_001007278.3",
          "gene_hgnc_id": 9976,
          "gene_symbol": "TRIM13",
          "hgvs_c": "c.766C>G",
          "hgvs_p": "p.Gln256Glu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001007279.1",
          "strand": true,
          "transcript": "NM_001007278.3",
          "transcript_support_level": null
        },
        {
          "aa_alt": "E",
          "aa_end": null,
          "aa_length": 407,
          "aa_ref": "Q",
          "aa_start": 253,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6720,
          "cdna_start": 950,
          "cds_end": null,
          "cds_length": 1224,
          "cds_start": 757,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 3,
          "exon_rank": 3,
          "exon_rank_end": null,
          "feature": "NM_005798.5",
          "gene_hgnc_id": 9976,
          "gene_symbol": "TRIM13",
          "hgvs_c": "c.757C>G",
          "hgvs_p": "p.Gln253Glu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_005789.2",
          "strand": true,
          "transcript": "NM_005798.5",
          "transcript_support_level": null
        },
        {
          "aa_alt": "E",
          "aa_end": null,
          "aa_length": 407,
          "aa_ref": "Q",
          "aa_start": 253,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6805,
          "cdna_start": 1035,
          "cds_end": null,
          "cds_length": 1224,
          "cds_start": 757,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 3,
          "exon_rank": 3,
          "exon_rank_end": null,
          "feature": "NM_052811.4",
          "gene_hgnc_id": 9976,
          "gene_symbol": "TRIM13",
          "hgvs_c": "c.757C>G",
          "hgvs_p": "p.Gln253Glu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_434698.1",
          "strand": true,
          "transcript": "NM_052811.4",
          "transcript_support_level": null
        },
        {
          "aa_alt": "E",
          "aa_end": null,
          "aa_length": 407,
          "aa_ref": "Q",
          "aa_start": 253,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2966,
          "cdna_start": 1350,
          "cds_end": null,
          "cds_length": 1224,
          "cds_start": 757,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 3,
          "exon_rank": 3,
          "exon_rank_end": null,
          "feature": "ENST00000870403.1",
          "gene_hgnc_id": 9976,
          "gene_symbol": "TRIM13",
          "hgvs_c": "c.757C>G",
          "hgvs_p": "p.Gln253Glu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000540462.1",
          "strand": true,
          "transcript": "ENST00000870403.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "E",
          "aa_end": null,
          "aa_length": 407,
          "aa_ref": "Q",
          "aa_start": 253,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1420,
          "cdna_start": 947,
          "cds_end": null,
          "cds_length": 1224,
          "cds_start": 757,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 3,
          "exon_rank": 3,
          "exon_rank_end": null,
          "feature": "ENST00000870404.1",
          "gene_hgnc_id": 9976,
          "gene_symbol": "TRIM13",
          "hgvs_c": "c.757C>G",
          "hgvs_p": "p.Gln253Glu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000540463.1",
          "strand": true,
          "transcript": "ENST00000870404.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "E",
          "aa_end": null,
          "aa_length": 407,
          "aa_ref": "Q",
          "aa_start": 253,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2065,
          "cdna_start": 1593,
          "cds_end": null,
          "cds_length": 1224,
          "cds_start": 757,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 3,
          "exon_rank": 3,
          "exon_rank_end": null,
          "feature": "ENST00000870405.1",
          "gene_hgnc_id": 9976,
          "gene_symbol": "TRIM13",
          "hgvs_c": "c.757C>G",
          "hgvs_p": "p.Gln253Glu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000540464.1",
          "strand": true,
          "transcript": "ENST00000870405.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "E",
          "aa_end": null,
          "aa_length": 407,
          "aa_ref": "Q",
          "aa_start": 253,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1443,
          "cdna_start": 964,
          "cds_end": null,
          "cds_length": 1224,
          "cds_start": 757,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 3,
          "exon_rank": 3,
          "exon_rank_end": null,
          "feature": "ENST00000923738.1",
          "gene_hgnc_id": 9976,
          "gene_symbol": "TRIM13",
          "hgvs_c": "c.757C>G",
          "hgvs_p": "p.Gln253Glu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000593797.1",
          "strand": true,
          "transcript": "ENST00000923738.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "E",
          "aa_end": null,
          "aa_length": 407,
          "aa_ref": "Q",
          "aa_start": 253,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2533,
          "cdna_start": 888,
          "cds_end": null,
          "cds_length": 1224,
          "cds_start": 757,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 3,
          "exon_rank": 3,
          "exon_rank_end": null,
          "feature": "ENST00000944732.1",
          "gene_hgnc_id": 9976,
          "gene_symbol": "TRIM13",
          "hgvs_c": "c.757C>G",
          "hgvs_p": "p.Gln253Glu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000614791.1",
          "strand": true,
          "transcript": "ENST00000944732.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "E",
          "aa_end": null,
          "aa_length": 265,
          "aa_ref": "Q",
          "aa_start": 253,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1251,
          "cdna_start": 1208,
          "cds_end": null,
          "cds_length": 800,
          "cds_start": 757,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 3,
          "exon_rank": 3,
          "exon_rank_end": null,
          "feature": "ENST00000378183.8",
          "gene_hgnc_id": 9976,
          "gene_symbol": "TRIM13",
          "hgvs_c": "c.757C>G",
          "hgvs_p": "p.Gln253Glu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000367425.4",
          "strand": true,
          "transcript": "ENST00000378183.8",
          "transcript_support_level": 2
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "pseudogene",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 403,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 3,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000474805.5",
          "gene_hgnc_id": 9976,
          "gene_symbol": "TRIM13",
          "hgvs_c": "n.136-7517C>G",
          "hgvs_p": null,
          "intron_rank": 2,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": null,
          "strand": true,
          "transcript": "ENST00000474805.5",
          "transcript_support_level": 5
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "pseudogene",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 478,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 3,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000478111.5",
          "gene_hgnc_id": 9976,
          "gene_symbol": "TRIM13",
          "hgvs_c": "n.211-7517C>G",
          "hgvs_p": null,
          "intron_rank": 2,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": null,
          "strand": true,
          "transcript": "ENST00000478111.5",
          "transcript_support_level": 2
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "pseudogene",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1333,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 7,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000651713.2",
          "gene_hgnc_id": 13748,
          "gene_symbol": "DLEU2",
          "hgvs_c": "n.533+14510G>C",
          "hgvs_p": null,
          "intron_rank": 3,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": null,
          "strand": false,
          "transcript": "ENST00000651713.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "pseudogene",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1187,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 8,
          "exon_rank": null,
          "exon_rank_end": null,
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For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.