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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 13-77613943-A-C (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=13&pos=77613943&ref=A&alt=C&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "13",
      "pos": 77613943,
      "ref": "A",
      "alt": "C",
      "effect": "missense_variant",
      "transcript": "ENST00000349847.4",
      "consequences": [
        {
          "aa_ref": "K",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 24,
          "exon_rank_end": null,
          "exon_count": 33,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCEL",
          "gene_hgnc_id": 10573,
          "hgvs_c": "c.1439A>C",
          "hgvs_p": "p.Lys480Thr",
          "transcript": "NM_144777.3",
          "protein_id": "NP_659001.2",
          "transcript_support_level": null,
          "aa_start": 480,
          "aa_end": null,
          "aa_length": 688,
          "cds_start": 1439,
          "cds_end": null,
          "cds_length": 2067,
          "cdna_start": 1577,
          "cdna_end": null,
          "cdna_length": 3194,
          "mane_select": "ENST00000349847.4",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "T",
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 24,
          "exon_rank_end": null,
          "exon_count": 33,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCEL",
          "gene_hgnc_id": 10573,
          "hgvs_c": "c.1439A>C",
          "hgvs_p": "p.Lys480Thr",
          "transcript": "ENST00000349847.4",
          "protein_id": "ENSP00000302579.5",
          "transcript_support_level": 1,
          "aa_start": 480,
          "aa_end": null,
          "aa_length": 688,
          "cds_start": 1439,
          "cds_end": null,
          "cds_length": 2067,
          "cdna_start": 1577,
          "cdna_end": null,
          "cdna_length": 3194,
          "mane_select": "NM_144777.3",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 23,
          "exon_rank_end": null,
          "exon_count": 32,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCEL",
          "gene_hgnc_id": 10573,
          "hgvs_c": "c.1379A>C",
          "hgvs_p": "p.Lys460Thr",
          "transcript": "ENST00000377246.7",
          "protein_id": "ENSP00000366454.3",
          "transcript_support_level": 1,
          "aa_start": 460,
          "aa_end": null,
          "aa_length": 668,
          "cds_start": 1379,
          "cds_end": null,
          "cds_length": 2007,
          "cdna_start": 1464,
          "cdna_end": null,
          "cdna_length": 3081,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 23,
          "exon_rank_end": null,
          "exon_count": 32,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCEL",
          "gene_hgnc_id": 10573,
          "hgvs_c": "c.1379A>C",
          "hgvs_p": "p.Lys460Thr",
          "transcript": "NM_003843.4",
          "protein_id": "NP_003834.3",
          "transcript_support_level": null,
          "aa_start": 460,
          "aa_end": null,
          "aa_length": 668,
          "cds_start": 1379,
          "cds_end": null,
          "cds_length": 2007,
          "cdna_start": 1517,
          "cdna_end": null,
          "cdna_length": 3134,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 22,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCEL",
          "gene_hgnc_id": 10573,
          "hgvs_c": "c.1313A>C",
          "hgvs_p": "p.Lys438Thr",
          "transcript": "NM_001160706.2",
          "protein_id": "NP_001154178.1",
          "transcript_support_level": null,
          "aa_start": 438,
          "aa_end": null,
          "aa_length": 646,
          "cds_start": 1313,
          "cds_end": null,
          "cds_length": 1941,
          "cdna_start": 1451,
          "cdna_end": null,
          "cdna_length": 3068,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 22,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCEL",
          "gene_hgnc_id": 10573,
          "hgvs_c": "c.1313A>C",
          "hgvs_p": "p.Lys438Thr",
          "transcript": "ENST00000535157.5",
          "protein_id": "ENSP00000437895.1",
          "transcript_support_level": 2,
          "aa_start": 438,
          "aa_end": null,
          "aa_length": 646,
          "cds_start": 1313,
          "cds_end": null,
          "cds_length": 1941,
          "cdna_start": 1483,
          "cdna_end": null,
          "cdna_length": 3096,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 24,
          "exon_rank_end": null,
          "exon_count": 33,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCEL",
          "gene_hgnc_id": 10573,
          "hgvs_c": "c.1436A>C",
          "hgvs_p": "p.Lys479Thr",
          "transcript": "XM_011535281.2",
          "protein_id": "XP_011533583.1",
          "transcript_support_level": null,
          "aa_start": 479,
          "aa_end": null,
          "aa_length": 687,
          "cds_start": 1436,
          "cds_end": null,
          "cds_length": 2064,
          "cdna_start": 1574,
          "cdna_end": null,
          "cdna_length": 3191,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 24,
          "exon_rank_end": null,
          "exon_count": 33,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCEL",
          "gene_hgnc_id": 10573,
          "hgvs_c": "c.1436A>C",
          "hgvs_p": "p.Lys479Thr",
          "transcript": "XM_011535282.2",
          "protein_id": "XP_011533584.1",
          "transcript_support_level": null,
          "aa_start": 479,
          "aa_end": null,
          "aa_length": 687,
          "cds_start": 1436,
          "cds_end": null,
          "cds_length": 2064,
          "cdna_start": 1574,
          "cdna_end": null,
          "cdna_length": 3191,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 24,
          "exon_rank_end": null,
          "exon_count": 33,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCEL",
          "gene_hgnc_id": 10573,
          "hgvs_c": "c.1436A>C",
          "hgvs_p": "p.Lys479Thr",
          "transcript": "XM_011535283.2",
          "protein_id": "XP_011533585.1",
          "transcript_support_level": null,
          "aa_start": 479,
          "aa_end": null,
          "aa_length": 687,
          "cds_start": 1436,
          "cds_end": null,
          "cds_length": 2064,
          "cdna_start": 1574,
          "cdna_end": null,
          "cdna_length": 3191,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 24,
          "exon_rank_end": null,
          "exon_count": 33,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCEL",
          "gene_hgnc_id": 10573,
          "hgvs_c": "c.1433A>C",
          "hgvs_p": "p.Lys478Thr",
          "transcript": "XM_011535284.2",
          "protein_id": "XP_011533586.1",
          "transcript_support_level": null,
          "aa_start": 478,
          "aa_end": null,
          "aa_length": 686,
          "cds_start": 1433,
          "cds_end": null,
          "cds_length": 2061,
          "cdna_start": 1571,
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          "cdna_length": 3188,
          "mane_select": null,
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          "biotype": null,
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        },
        {
          "aa_ref": "K",
          "aa_alt": "T",
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          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 23,
          "exon_rank_end": null,
          "exon_count": 32,
          "intron_rank": null,
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          "gene_symbol": "SCEL",
          "gene_hgnc_id": 10573,
          "hgvs_c": "c.1400A>C",
          "hgvs_p": "p.Lys467Thr",
          "transcript": "XM_011535285.3",
          "protein_id": "XP_011533587.1",
          "transcript_support_level": null,
          "aa_start": 467,
          "aa_end": null,
          "aa_length": 675,
          "cds_start": 1400,
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          "cds_length": 2028,
          "cdna_start": 1538,
          "cdna_end": null,
          "cdna_length": 3155,
          "mane_select": null,
          "mane_plus": null,
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          "feature": null
        },
        {
          "aa_ref": "K",
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          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 23,
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          "intron_rank": null,
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          "gene_symbol": "SCEL",
          "gene_hgnc_id": 10573,
          "hgvs_c": "c.1379A>C",
          "hgvs_p": "p.Lys460Thr",
          "transcript": "XM_006719882.2",
          "protein_id": "XP_006719945.1",
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          "cdna_start": 1517,
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        {
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          "protein_coding": true,
          "strand": true,
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          ],
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          "gene_symbol": "SCEL",
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          "hgvs_c": "c.1379A>C",
          "hgvs_p": "p.Lys460Thr",
          "transcript": "XM_011535286.2",
          "protein_id": "XP_011533588.1",
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          "cds_start": 1379,
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        {
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          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 23,
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          "intron_rank": null,
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          "gene_symbol": "SCEL",
          "gene_hgnc_id": 10573,
          "hgvs_c": "c.1376A>C",
          "hgvs_p": "p.Lys459Thr",
          "transcript": "XM_011535287.2",
          "protein_id": "XP_011533589.1",
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        {
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          ],
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        {
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          "gene_symbol": "SCEL",
          "gene_hgnc_id": 10573,
          "hgvs_c": "c.1376A>C",
          "hgvs_p": "p.Lys459Thr",
          "transcript": "XM_047430710.1",
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        {
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          "gene_symbol": "SCEL",
          "gene_hgnc_id": 10573,
          "hgvs_c": "c.1373A>C",
          "hgvs_p": "p.Lys458Thr",
          "transcript": "XM_006719884.2",
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        {
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        {
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        {
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          "gene_symbol": "SCEL",
          "gene_hgnc_id": 10573,
          "hgvs_c": "c.1331A>C",
          "hgvs_p": "p.Lys444Thr",
          "transcript": "XM_011535288.2",
          "protein_id": "XP_011533590.1",
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          "feature": null
        },
        {
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          ],
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          "intron_rank": null,
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          "gene_symbol": "SCEL",
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      "gene_symbol": "SCEL",
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      "hom_count_reference_population": 0,
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      "gnomad_exomes_af": null,
      "gnomad_genomes_af": null,
      "gnomad_exomes_ac": null,
      "gnomad_genomes_ac": null,
      "gnomad_exomes_homalt": null,
      "gnomad_genomes_homalt": null,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": 0.20190590620040894,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": 0.177,
      "revel_prediction": "Benign",
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      "bayesdelnoaf_score": -0.25,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": 1.369,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
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      "acmg_score": 0,
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PM2,BP4_Moderate",
      "acmg_by_gene": [
        {
          "score": 0,
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          "pathogenic_score": 2,
          "criteria": [
            "PM2",
            "BP4_Moderate"
          ],
          "verdict": "Uncertain_significance",
          "transcript": "ENST00000349847.4",
          "gene_symbol": "SCEL",
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          "hgvs_p": "p.Lys480Thr"
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      ],
      "clinvar_disease": "",
      "clinvar_classification": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "phenotype_combined": null,
      "pathogenicity_classification_combined": null,
      "custom_annotations": null
    }
  ],
  "message": null
}