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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 13-77613943-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=13&pos=77613943&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "13",
"pos": 77613943,
"ref": "A",
"alt": "G",
"effect": "missense_variant",
"transcript": "NM_144777.3",
"consequences": [
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 24,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SCEL",
"gene_hgnc_id": 10573,
"hgvs_c": "c.1439A>G",
"hgvs_p": "p.Lys480Arg",
"transcript": "NM_144777.3",
"protein_id": "NP_659001.2",
"transcript_support_level": null,
"aa_start": 480,
"aa_end": null,
"aa_length": 688,
"cds_start": 1439,
"cds_end": null,
"cds_length": 2067,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000349847.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_144777.3"
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 24,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SCEL",
"gene_hgnc_id": 10573,
"hgvs_c": "c.1439A>G",
"hgvs_p": "p.Lys480Arg",
"transcript": "ENST00000349847.4",
"protein_id": "ENSP00000302579.5",
"transcript_support_level": 1,
"aa_start": 480,
"aa_end": null,
"aa_length": 688,
"cds_start": 1439,
"cds_end": null,
"cds_length": 2067,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_144777.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000349847.4"
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SCEL",
"gene_hgnc_id": 10573,
"hgvs_c": "c.1379A>G",
"hgvs_p": "p.Lys460Arg",
"transcript": "ENST00000377246.7",
"protein_id": "ENSP00000366454.3",
"transcript_support_level": 1,
"aa_start": 460,
"aa_end": null,
"aa_length": 668,
"cds_start": 1379,
"cds_end": null,
"cds_length": 2007,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000377246.7"
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 24,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SCEL",
"gene_hgnc_id": 10573,
"hgvs_c": "c.1436A>G",
"hgvs_p": "p.Lys479Arg",
"transcript": "ENST00000856158.1",
"protein_id": "ENSP00000526217.1",
"transcript_support_level": null,
"aa_start": 479,
"aa_end": null,
"aa_length": 687,
"cds_start": 1436,
"cds_end": null,
"cds_length": 2064,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856158.1"
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 24,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SCEL",
"gene_hgnc_id": 10573,
"hgvs_c": "c.1436A>G",
"hgvs_p": "p.Lys479Arg",
"transcript": "ENST00000856162.1",
"protein_id": "ENSP00000526221.1",
"transcript_support_level": null,
"aa_start": 479,
"aa_end": null,
"aa_length": 687,
"cds_start": 1436,
"cds_end": null,
"cds_length": 2064,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856162.1"
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 24,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SCEL",
"gene_hgnc_id": 10573,
"hgvs_c": "c.1433A>G",
"hgvs_p": "p.Lys478Arg",
"transcript": "ENST00000965443.1",
"protein_id": "ENSP00000635502.1",
"transcript_support_level": null,
"aa_start": 478,
"aa_end": null,
"aa_length": 686,
"cds_start": 1433,
"cds_end": null,
"cds_length": 2061,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000965443.1"
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SCEL",
"gene_hgnc_id": 10573,
"hgvs_c": "c.1379A>G",
"hgvs_p": "p.Lys460Arg",
"transcript": "ENST00000965440.1",
"protein_id": "ENSP00000635499.1",
"transcript_support_level": null,
"aa_start": 460,
"aa_end": null,
"aa_length": 681,
"cds_start": 1379,
"cds_end": null,
"cds_length": 2046,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000965440.1"
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SCEL",
"gene_hgnc_id": 10573,
"hgvs_c": "c.1400A>G",
"hgvs_p": "p.Lys467Arg",
"transcript": "ENST00000856139.1",
"protein_id": "ENSP00000526198.1",
"transcript_support_level": null,
"aa_start": 467,
"aa_end": null,
"aa_length": 675,
"cds_start": 1400,
"cds_end": null,
"cds_length": 2028,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856139.1"
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SCEL",
"gene_hgnc_id": 10573,
"hgvs_c": "c.1379A>G",
"hgvs_p": "p.Lys460Arg",
"transcript": "NM_003843.4",
"protein_id": "NP_003834.3",
"transcript_support_level": null,
"aa_start": 460,
"aa_end": null,
"aa_length": 668,
"cds_start": 1379,
"cds_end": null,
"cds_length": 2007,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_003843.4"
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SCEL",
"gene_hgnc_id": 10573,
"hgvs_c": "c.1379A>G",
"hgvs_p": "p.Lys460Arg",
"transcript": "ENST00000856144.1",
"protein_id": "ENSP00000526203.1",
"transcript_support_level": null,
"aa_start": 460,
"aa_end": null,
"aa_length": 668,
"cds_start": 1379,
"cds_end": null,
"cds_length": 2007,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856144.1"
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SCEL",
"gene_hgnc_id": 10573,
"hgvs_c": "c.1376A>G",
"hgvs_p": "p.Lys459Arg",
"transcript": "ENST00000856183.1",
"protein_id": "ENSP00000526242.1",
"transcript_support_level": null,
"aa_start": 459,
"aa_end": null,
"aa_length": 667,
"cds_start": 1376,
"cds_end": null,
"cds_length": 2004,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856183.1"
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SCEL",
"gene_hgnc_id": 10573,
"hgvs_c": "c.1373A>G",
"hgvs_p": "p.Lys458Arg",
"transcript": "ENST00000856156.1",
"protein_id": "ENSP00000526215.1",
"transcript_support_level": null,
"aa_start": 458,
"aa_end": null,
"aa_length": 666,
"cds_start": 1373,
"cds_end": null,
"cds_length": 2001,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856156.1"
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SCEL",
"gene_hgnc_id": 10573,
"hgvs_c": "c.1370A>G",
"hgvs_p": "p.Lys457Arg",
"transcript": "ENST00000856170.1",
"protein_id": "ENSP00000526229.1",
"transcript_support_level": null,
"aa_start": 457,
"aa_end": null,
"aa_length": 665,
"cds_start": 1370,
"cds_end": null,
"cds_length": 1998,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856170.1"
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SCEL",
"gene_hgnc_id": 10573,
"hgvs_c": "c.1367A>G",
"hgvs_p": "p.Lys456Arg",
"transcript": "ENST00000965414.1",
"protein_id": "ENSP00000635473.1",
"transcript_support_level": null,
"aa_start": 456,
"aa_end": null,
"aa_length": 664,
"cds_start": 1367,
"cds_end": null,
"cds_length": 1995,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000965414.1"
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SCEL",
"gene_hgnc_id": 10573,
"hgvs_c": "c.1367A>G",
"hgvs_p": "p.Lys456Arg",
"transcript": "ENST00000965424.1",
"protein_id": "ENSP00000635483.1",
"transcript_support_level": null,
"aa_start": 456,
"aa_end": null,
"aa_length": 664,
"cds_start": 1367,
"cds_end": null,
"cds_length": 1995,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000965424.1"
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SCEL",
"gene_hgnc_id": 10573,
"hgvs_c": "c.1367A>G",
"hgvs_p": "p.Lys456Arg",
"transcript": "ENST00000965431.1",
"protein_id": "ENSP00000635490.1",
"transcript_support_level": null,
"aa_start": 456,
"aa_end": null,
"aa_length": 664,
"cds_start": 1367,
"cds_end": null,
"cds_length": 1995,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000965431.1"
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SCEL",
"gene_hgnc_id": 10573,
"hgvs_c": "c.1367A>G",
"hgvs_p": "p.Lys456Arg",
"transcript": "ENST00000965441.1",
"protein_id": "ENSP00000635500.1",
"transcript_support_level": null,
"aa_start": 456,
"aa_end": null,
"aa_length": 664,
"cds_start": 1367,
"cds_end": null,
"cds_length": 1995,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000965441.1"
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SCEL",
"gene_hgnc_id": 10573,
"hgvs_c": "c.1331A>G",
"hgvs_p": "p.Lys444Arg",
"transcript": "ENST00000856188.1",
"protein_id": "ENSP00000526247.1",
"transcript_support_level": null,
"aa_start": 444,
"aa_end": null,
"aa_length": 652,
"cds_start": 1331,
"cds_end": null,
"cds_length": 1959,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856188.1"
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 24,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SCEL",
"gene_hgnc_id": 10573,
"hgvs_c": "c.1439A>G",
"hgvs_p": "p.Lys480Arg",
"transcript": "ENST00000856137.1",
"protein_id": "ENSP00000526196.1",
"transcript_support_level": null,
"aa_start": 480,
"aa_end": null,
"aa_length": 649,
"cds_start": 1439,
"cds_end": null,
"cds_length": 1950,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856137.1"
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SCEL",
"gene_hgnc_id": 10573,
"hgvs_c": "c.1319A>G",
"hgvs_p": "p.Lys440Arg",
"transcript": "ENST00000856173.1",
"protein_id": "ENSP00000526232.1",
"transcript_support_level": null,
"aa_start": 440,
"aa_end": null,
"aa_length": 648,
"cds_start": 1319,
"cds_end": null,
"cds_length": 1947,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856173.1"
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SCEL",
"gene_hgnc_id": 10573,
"hgvs_c": "c.1316A>G",
"hgvs_p": "p.Lys439Arg",
"transcript": "ENST00000856160.1",
"protein_id": "ENSP00000526219.1",
"transcript_support_level": null,
"aa_start": 439,
"aa_end": null,
"aa_length": 647,
"cds_start": 1316,
"cds_end": null,
"cds_length": 1944,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856160.1"
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SCEL",
"gene_hgnc_id": 10573,
"hgvs_c": "c.1313A>G",
"hgvs_p": "p.Lys438Arg",
"transcript": "NM_001160706.2",
"protein_id": "NP_001154178.1",
"transcript_support_level": null,
"aa_start": 438,
"aa_end": null,
"aa_length": 646,
"cds_start": 1313,
"cds_end": null,
"cds_length": 1941,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001160706.2"
},
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