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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 13-98448277-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=13&pos=98448277&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "13",
"pos": 98448277,
"ref": "G",
"alt": "C",
"effect": "missense_variant",
"transcript": "NM_001286839.2",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FARP1",
"gene_hgnc_id": 3591,
"hgvs_c": "c.3098G>C",
"hgvs_p": "p.Arg1033Pro",
"transcript": "NM_005766.4",
"protein_id": "NP_005757.1",
"transcript_support_level": null,
"aa_start": 1033,
"aa_end": null,
"aa_length": 1045,
"cds_start": 3098,
"cds_end": null,
"cds_length": 3138,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000319562.11",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_005766.4"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FARP1",
"gene_hgnc_id": 3591,
"hgvs_c": "c.3098G>C",
"hgvs_p": "p.Arg1033Pro",
"transcript": "ENST00000319562.11",
"protein_id": "ENSP00000322926.6",
"transcript_support_level": 1,
"aa_start": 1033,
"aa_end": null,
"aa_length": 1045,
"cds_start": 3098,
"cds_end": null,
"cds_length": 3138,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_005766.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000319562.11"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FARP1",
"gene_hgnc_id": 3591,
"hgvs_c": "c.3191G>C",
"hgvs_p": "p.Arg1064Pro",
"transcript": "ENST00000595437.5",
"protein_id": "ENSP00000471242.1",
"transcript_support_level": 1,
"aa_start": 1064,
"aa_end": null,
"aa_length": 1076,
"cds_start": 3191,
"cds_end": null,
"cds_length": 3231,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000595437.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STK24",
"gene_hgnc_id": 11403,
"hgvs_c": "c.*4896C>G",
"hgvs_p": null,
"transcript": "NM_001032296.4",
"protein_id": "NP_001027467.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 431,
"cds_start": null,
"cds_end": null,
"cds_length": 1296,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000539966.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001032296.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STK24",
"gene_hgnc_id": 11403,
"hgvs_c": "c.*4896C>G",
"hgvs_p": null,
"transcript": "ENST00000539966.6",
"protein_id": "ENSP00000442539.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 431,
"cds_start": null,
"cds_end": null,
"cds_length": 1296,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001032296.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000539966.6"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FARP1",
"gene_hgnc_id": 3591,
"hgvs_c": "c.3203G>C",
"hgvs_p": "p.Arg1068Pro",
"transcript": "ENST00000871505.1",
"protein_id": "ENSP00000541564.1",
"transcript_support_level": null,
"aa_start": 1068,
"aa_end": null,
"aa_length": 1080,
"cds_start": 3203,
"cds_end": null,
"cds_length": 3243,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000871505.1"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FARP1",
"gene_hgnc_id": 3591,
"hgvs_c": "c.3191G>C",
"hgvs_p": "p.Arg1064Pro",
"transcript": "NM_001286839.2",
"protein_id": "NP_001273768.1",
"transcript_support_level": null,
"aa_start": 1064,
"aa_end": null,
"aa_length": 1076,
"cds_start": 3191,
"cds_end": null,
"cds_length": 3231,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001286839.2"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FARP1",
"gene_hgnc_id": 3591,
"hgvs_c": "c.3191G>C",
"hgvs_p": "p.Arg1064Pro",
"transcript": "ENST00000627049.2",
"protein_id": "ENSP00000486285.1",
"transcript_support_level": 5,
"aa_start": 1064,
"aa_end": null,
"aa_length": 1076,
"cds_start": 3191,
"cds_end": null,
"cds_length": 3231,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000627049.2"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FARP1",
"gene_hgnc_id": 3591,
"hgvs_c": "c.3182G>C",
"hgvs_p": "p.Arg1061Pro",
"transcript": "ENST00000871504.1",
"protein_id": "ENSP00000541563.1",
"transcript_support_level": null,
"aa_start": 1061,
"aa_end": null,
"aa_length": 1073,
"cds_start": 3182,
"cds_end": null,
"cds_length": 3222,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000871504.1"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FARP1",
"gene_hgnc_id": 3591,
"hgvs_c": "c.3182G>C",
"hgvs_p": "p.Arg1061Pro",
"transcript": "ENST00000964193.1",
"protein_id": "ENSP00000634252.1",
"transcript_support_level": null,
"aa_start": 1061,
"aa_end": null,
"aa_length": 1073,
"cds_start": 3182,
"cds_end": null,
"cds_length": 3222,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000964193.1"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FARP1",
"gene_hgnc_id": 3591,
"hgvs_c": "c.3176G>C",
"hgvs_p": "p.Arg1059Pro",
"transcript": "ENST00000922579.1",
"protein_id": "ENSP00000592638.1",
"transcript_support_level": null,
"aa_start": 1059,
"aa_end": null,
"aa_length": 1071,
"cds_start": 3176,
"cds_end": null,
"cds_length": 3216,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000922579.1"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FARP1",
"gene_hgnc_id": 3591,
"hgvs_c": "c.3125G>C",
"hgvs_p": "p.Arg1042Pro",
"transcript": "ENST00000922580.1",
"protein_id": "ENSP00000592639.1",
"transcript_support_level": null,
"aa_start": 1042,
"aa_end": null,
"aa_length": 1054,
"cds_start": 3125,
"cds_end": null,
"cds_length": 3165,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000922580.1"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FARP1",
"gene_hgnc_id": 3591,
"hgvs_c": "c.3125G>C",
"hgvs_p": "p.Arg1042Pro",
"transcript": "ENST00000922581.1",
"protein_id": "ENSP00000592640.1",
"transcript_support_level": null,
"aa_start": 1042,
"aa_end": null,
"aa_length": 1054,
"cds_start": 3125,
"cds_end": null,
"cds_length": 3165,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000922581.1"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FARP1",
"gene_hgnc_id": 3591,
"hgvs_c": "c.3125G>C",
"hgvs_p": "p.Arg1042Pro",
"transcript": "ENST00000964194.1",
"protein_id": "ENSP00000634253.1",
"transcript_support_level": null,
"aa_start": 1042,
"aa_end": null,
"aa_length": 1054,
"cds_start": 3125,
"cds_end": null,
"cds_length": 3165,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000964194.1"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FARP1",
"gene_hgnc_id": 3591,
"hgvs_c": "c.3098G>C",
"hgvs_p": "p.Arg1033Pro",
"transcript": "ENST00000871496.1",
"protein_id": "ENSP00000541555.1",
"transcript_support_level": null,
"aa_start": 1033,
"aa_end": null,
"aa_length": 1045,
"cds_start": 3098,
"cds_end": null,
"cds_length": 3138,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000871496.1"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FARP1",
"gene_hgnc_id": 3591,
"hgvs_c": "c.3098G>C",
"hgvs_p": "p.Arg1033Pro",
"transcript": "ENST00000871497.1",
"protein_id": "ENSP00000541556.1",
"transcript_support_level": null,
"aa_start": 1033,
"aa_end": null,
"aa_length": 1045,
"cds_start": 3098,
"cds_end": null,
"cds_length": 3138,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000871497.1"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FARP1",
"gene_hgnc_id": 3591,
"hgvs_c": "c.3098G>C",
"hgvs_p": "p.Arg1033Pro",
"transcript": "ENST00000871500.1",
"protein_id": "ENSP00000541559.1",
"transcript_support_level": null,
"aa_start": 1033,
"aa_end": null,
"aa_length": 1045,
"cds_start": 3098,
"cds_end": null,
"cds_length": 3138,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000871500.1"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FARP1",
"gene_hgnc_id": 3591,
"hgvs_c": "c.3098G>C",
"hgvs_p": "p.Arg1033Pro",
"transcript": "ENST00000871503.1",
"protein_id": "ENSP00000541562.1",
"transcript_support_level": null,
"aa_start": 1033,
"aa_end": null,
"aa_length": 1045,
"cds_start": 3098,
"cds_end": null,
"cds_length": 3138,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000871503.1"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FARP1",
"gene_hgnc_id": 3591,
"hgvs_c": "c.3098G>C",
"hgvs_p": "p.Arg1033Pro",
"transcript": "ENST00000871506.1",
"protein_id": "ENSP00000541565.1",
"transcript_support_level": null,
"aa_start": 1033,
"aa_end": null,
"aa_length": 1045,
"cds_start": 3098,
"cds_end": null,
"cds_length": 3138,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000871506.1"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FARP1",
"gene_hgnc_id": 3591,
"hgvs_c": "c.3098G>C",
"hgvs_p": "p.Arg1033Pro",
"transcript": "ENST00000922582.1",
"protein_id": "ENSP00000592641.1",
"transcript_support_level": null,
"aa_start": 1033,
"aa_end": null,
"aa_length": 1045,
"cds_start": 3098,
"cds_end": null,
"cds_length": 3138,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000922582.1"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FARP1",
"gene_hgnc_id": 3591,
"hgvs_c": "c.3098G>C",
"hgvs_p": "p.Arg1033Pro",
"transcript": "ENST00000922585.1",
"protein_id": "ENSP00000592644.1",
"transcript_support_level": null,
"aa_start": 1033,
"aa_end": null,
"aa_length": 1045,
"cds_start": 3098,
"cds_end": null,
"cds_length": 3138,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000922585.1"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FARP1",
"gene_hgnc_id": 3591,
"hgvs_c": "c.3098G>C",
"hgvs_p": "p.Arg1033Pro",
"transcript": "ENST00000922586.1",
"protein_id": "ENSP00000592645.1",
"transcript_support_level": null,
"aa_start": 1033,
"aa_end": null,
"aa_length": 1045,
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],
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"clinvar_review_status": "",
"clinvar_submissions_summary": "",
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"custom_annotations": null
}
],
"message": null
}