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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 13-99606708-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=13&pos=99606708&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "13",
"pos": 99606708,
"ref": "C",
"alt": "T",
"effect": "synonymous_variant",
"transcript": "NM_206808.5",
"consequences": [
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLYBL",
"gene_hgnc_id": 18355,
"hgvs_c": "c.13C>T",
"hgvs_p": "p.Leu5Leu",
"transcript": "NM_206808.5",
"protein_id": "NP_996531.1",
"transcript_support_level": null,
"aa_start": 5,
"aa_end": null,
"aa_length": 340,
"cds_start": 13,
"cds_end": null,
"cds_length": 1023,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000339105.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_206808.5"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLYBL",
"gene_hgnc_id": 18355,
"hgvs_c": "c.13C>T",
"hgvs_p": "p.Leu5Leu",
"transcript": "ENST00000339105.9",
"protein_id": "ENSP00000342991.4",
"transcript_support_level": 1,
"aa_start": 5,
"aa_end": null,
"aa_length": 340,
"cds_start": 13,
"cds_end": null,
"cds_length": 1023,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_206808.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000339105.9"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLYBL",
"gene_hgnc_id": 18355,
"hgvs_c": "c.13C>T",
"hgvs_p": "p.Leu5Leu",
"transcript": "ENST00000933047.1",
"protein_id": "ENSP00000603106.1",
"transcript_support_level": null,
"aa_start": 5,
"aa_end": null,
"aa_length": 383,
"cds_start": 13,
"cds_end": null,
"cds_length": 1152,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000933047.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLYBL",
"gene_hgnc_id": 18355,
"hgvs_c": "c.13C>T",
"hgvs_p": "p.Leu5Leu",
"transcript": "ENST00000898531.1",
"protein_id": "ENSP00000568590.1",
"transcript_support_level": null,
"aa_start": 5,
"aa_end": null,
"aa_length": 351,
"cds_start": 13,
"cds_end": null,
"cds_length": 1056,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000898531.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLYBL",
"gene_hgnc_id": 18355,
"hgvs_c": "c.13C>T",
"hgvs_p": "p.Leu5Leu",
"transcript": "ENST00000898532.1",
"protein_id": "ENSP00000568591.1",
"transcript_support_level": null,
"aa_start": 5,
"aa_end": null,
"aa_length": 351,
"cds_start": 13,
"cds_end": null,
"cds_length": 1056,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000898532.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLYBL",
"gene_hgnc_id": 18355,
"hgvs_c": "c.13C>T",
"hgvs_p": "p.Leu5Leu",
"transcript": "ENST00000898526.1",
"protein_id": "ENSP00000568585.1",
"transcript_support_level": null,
"aa_start": 5,
"aa_end": null,
"aa_length": 347,
"cds_start": 13,
"cds_end": null,
"cds_length": 1044,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000898526.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLYBL",
"gene_hgnc_id": 18355,
"hgvs_c": "c.13C>T",
"hgvs_p": "p.Leu5Leu",
"transcript": "ENST00000898527.1",
"protein_id": "ENSP00000568586.1",
"transcript_support_level": null,
"aa_start": 5,
"aa_end": null,
"aa_length": 347,
"cds_start": 13,
"cds_end": null,
"cds_length": 1044,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000898527.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLYBL",
"gene_hgnc_id": 18355,
"hgvs_c": "c.13C>T",
"hgvs_p": "p.Leu5Leu",
"transcript": "ENST00000933045.1",
"protein_id": "ENSP00000603104.1",
"transcript_support_level": null,
"aa_start": 5,
"aa_end": null,
"aa_length": 347,
"cds_start": 13,
"cds_end": null,
"cds_length": 1044,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000933045.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLYBL",
"gene_hgnc_id": 18355,
"hgvs_c": "c.13C>T",
"hgvs_p": "p.Leu5Leu",
"transcript": "ENST00000933046.1",
"protein_id": "ENSP00000603105.1",
"transcript_support_level": null,
"aa_start": 5,
"aa_end": null,
"aa_length": 347,
"cds_start": 13,
"cds_end": null,
"cds_length": 1044,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000933046.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLYBL",
"gene_hgnc_id": 18355,
"hgvs_c": "c.13C>T",
"hgvs_p": "p.Leu5Leu",
"transcript": "NM_001393356.1",
"protein_id": "NP_001380285.1",
"transcript_support_level": null,
"aa_start": 5,
"aa_end": null,
"aa_length": 340,
"cds_start": 13,
"cds_end": null,
"cds_length": 1023,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001393356.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLYBL",
"gene_hgnc_id": 18355,
"hgvs_c": "c.13C>T",
"hgvs_p": "p.Leu5Leu",
"transcript": "NM_001393357.1",
"protein_id": "NP_001380286.1",
"transcript_support_level": null,
"aa_start": 5,
"aa_end": null,
"aa_length": 340,
"cds_start": 13,
"cds_end": null,
"cds_length": 1023,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001393357.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLYBL",
"gene_hgnc_id": 18355,
"hgvs_c": "c.13C>T",
"hgvs_p": "p.Leu5Leu",
"transcript": "NM_001393358.1",
"protein_id": "NP_001380287.1",
"transcript_support_level": null,
"aa_start": 5,
"aa_end": null,
"aa_length": 340,
"cds_start": 13,
"cds_end": null,
"cds_length": 1023,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001393358.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLYBL",
"gene_hgnc_id": 18355,
"hgvs_c": "c.13C>T",
"hgvs_p": "p.Leu5Leu",
"transcript": "NM_001393359.2",
"protein_id": "NP_001380288.1",
"transcript_support_level": null,
"aa_start": 5,
"aa_end": null,
"aa_length": 340,
"cds_start": 13,
"cds_end": null,
"cds_length": 1023,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001393359.2"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLYBL",
"gene_hgnc_id": 18355,
"hgvs_c": "c.13C>T",
"hgvs_p": "p.Leu5Leu",
"transcript": "ENST00000376355.7",
"protein_id": "ENSP00000365533.4",
"transcript_support_level": 2,
"aa_start": 5,
"aa_end": null,
"aa_length": 340,
"cds_start": 13,
"cds_end": null,
"cds_length": 1023,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000376355.7"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLYBL",
"gene_hgnc_id": 18355,
"hgvs_c": "c.13C>T",
"hgvs_p": "p.Leu5Leu",
"transcript": "ENST00000898520.1",
"protein_id": "ENSP00000568579.1",
"transcript_support_level": null,
"aa_start": 5,
"aa_end": null,
"aa_length": 340,
"cds_start": 13,
"cds_end": null,
"cds_length": 1023,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000898520.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLYBL",
"gene_hgnc_id": 18355,
"hgvs_c": "c.13C>T",
"hgvs_p": "p.Leu5Leu",
"transcript": "ENST00000898521.1",
"protein_id": "ENSP00000568580.1",
"transcript_support_level": null,
"aa_start": 5,
"aa_end": null,
"aa_length": 340,
"cds_start": 13,
"cds_end": null,
"cds_length": 1023,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000898521.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLYBL",
"gene_hgnc_id": 18355,
"hgvs_c": "c.13C>T",
"hgvs_p": "p.Leu5Leu",
"transcript": "ENST00000898523.1",
"protein_id": "ENSP00000568582.1",
"transcript_support_level": null,
"aa_start": 5,
"aa_end": null,
"aa_length": 340,
"cds_start": 13,
"cds_end": null,
"cds_length": 1023,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000898523.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLYBL",
"gene_hgnc_id": 18355,
"hgvs_c": "c.13C>T",
"hgvs_p": "p.Leu5Leu",
"transcript": "ENST00000898524.1",
"protein_id": "ENSP00000568583.1",
"transcript_support_level": null,
"aa_start": 5,
"aa_end": null,
"aa_length": 340,
"cds_start": 13,
"cds_end": null,
"cds_length": 1023,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000898524.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLYBL",
"gene_hgnc_id": 18355,
"hgvs_c": "c.13C>T",
"hgvs_p": "p.Leu5Leu",
"transcript": "ENST00000898528.1",
"protein_id": "ENSP00000568587.1",
"transcript_support_level": null,
"aa_start": 5,
"aa_end": null,
"aa_length": 340,
"cds_start": 13,
"cds_end": null,
"cds_length": 1023,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000898528.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLYBL",
"gene_hgnc_id": 18355,
"hgvs_c": "c.13C>T",
"hgvs_p": "p.Leu5Leu",
"transcript": "ENST00000943589.1",
"protein_id": "ENSP00000613648.1",
"transcript_support_level": null,
"aa_start": 5,
"aa_end": null,
"aa_length": 340,
"cds_start": 13,
"cds_end": null,
"cds_length": 1023,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000943589.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLYBL",
"gene_hgnc_id": 18355,
"hgvs_c": "c.13C>T",
"hgvs_p": "p.Leu5Leu",
"transcript": "ENST00000943590.1",
"protein_id": "ENSP00000613649.1",
"transcript_support_level": null,
"aa_start": 5,
"aa_end": null,
"aa_length": 317,
"cds_start": 13,
"cds_end": null,
"cds_length": 954,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000943590.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLYBL",
"gene_hgnc_id": 18355,
"hgvs_c": "c.13C>T",
"hgvs_p": "p.Leu5Leu",
"transcript": "ENST00000943591.1",
"protein_id": "ENSP00000613650.1",
"transcript_support_level": null,
"aa_start": 5,
"aa_end": null,
"aa_length": 317,
"cds_start": 13,
"cds_end": null,
"cds_length": 954,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
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{
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}
],
"message": null
}