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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 14-102870243-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=14&pos=102870243&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "14",
"pos": 102870243,
"ref": "G",
"alt": "T",
"effect": "missense_variant",
"transcript": "NM_003300.4",
"consequences": [
{
"aa_ref": "Q",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRAF3",
"gene_hgnc_id": 12033,
"hgvs_c": "c.42G>T",
"hgvs_p": "p.Gln14His",
"transcript": "NM_145725.3",
"protein_id": "NP_663777.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 568,
"cds_start": 42,
"cds_end": null,
"cds_length": 1707,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000392745.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_145725.3"
},
{
"aa_ref": "Q",
"aa_alt": "H",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRAF3",
"gene_hgnc_id": 12033,
"hgvs_c": "c.42G>T",
"hgvs_p": "p.Gln14His",
"transcript": "ENST00000392745.8",
"protein_id": "ENSP00000376500.3",
"transcript_support_level": 1,
"aa_start": 14,
"aa_end": null,
"aa_length": 568,
"cds_start": 42,
"cds_end": null,
"cds_length": 1707,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_145725.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000392745.8"
},
{
"aa_ref": "Q",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRAF3",
"gene_hgnc_id": 12033,
"hgvs_c": "c.42G>T",
"hgvs_p": "p.Gln14His",
"transcript": "ENST00000560371.5",
"protein_id": "ENSP00000454207.1",
"transcript_support_level": 1,
"aa_start": 14,
"aa_end": null,
"aa_length": 568,
"cds_start": 42,
"cds_end": null,
"cds_length": 1707,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000560371.5"
},
{
"aa_ref": "Q",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRAF3",
"gene_hgnc_id": 12033,
"hgvs_c": "c.42G>T",
"hgvs_p": "p.Gln14His",
"transcript": "ENST00000351691.10",
"protein_id": "ENSP00000332468.5",
"transcript_support_level": 1,
"aa_start": 14,
"aa_end": null,
"aa_length": 543,
"cds_start": 42,
"cds_end": null,
"cds_length": 1632,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000351691.10"
},
{
"aa_ref": "Q",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRAF3",
"gene_hgnc_id": 12033,
"hgvs_c": "c.42G>T",
"hgvs_p": "p.Gln14His",
"transcript": "NM_003300.4",
"protein_id": "NP_003291.2",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 568,
"cds_start": 42,
"cds_end": null,
"cds_length": 1707,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_003300.4"
},
{
"aa_ref": "Q",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRAF3",
"gene_hgnc_id": 12033,
"hgvs_c": "c.42G>T",
"hgvs_p": "p.Gln14His",
"transcript": "ENST00000699894.1",
"protein_id": "ENSP00000514678.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 568,
"cds_start": 42,
"cds_end": null,
"cds_length": 1707,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000699894.1"
},
{
"aa_ref": "Q",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRAF3",
"gene_hgnc_id": 12033,
"hgvs_c": "c.42G>T",
"hgvs_p": "p.Gln14His",
"transcript": "ENST00000860916.1",
"protein_id": "ENSP00000530975.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 568,
"cds_start": 42,
"cds_end": null,
"cds_length": 1707,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000860916.1"
},
{
"aa_ref": "Q",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRAF3",
"gene_hgnc_id": 12033,
"hgvs_c": "c.42G>T",
"hgvs_p": "p.Gln14His",
"transcript": "ENST00000860917.1",
"protein_id": "ENSP00000530976.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 568,
"cds_start": 42,
"cds_end": null,
"cds_length": 1707,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000860917.1"
},
{
"aa_ref": "Q",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRAF3",
"gene_hgnc_id": 12033,
"hgvs_c": "c.42G>T",
"hgvs_p": "p.Gln14His",
"transcript": "ENST00000860918.1",
"protein_id": "ENSP00000530977.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 568,
"cds_start": 42,
"cds_end": null,
"cds_length": 1707,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000860918.1"
},
{
"aa_ref": "Q",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRAF3",
"gene_hgnc_id": 12033,
"hgvs_c": "c.42G>T",
"hgvs_p": "p.Gln14His",
"transcript": "ENST00000860919.1",
"protein_id": "ENSP00000530978.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 568,
"cds_start": 42,
"cds_end": null,
"cds_length": 1707,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000860919.1"
},
{
"aa_ref": "Q",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRAF3",
"gene_hgnc_id": 12033,
"hgvs_c": "c.42G>T",
"hgvs_p": "p.Gln14His",
"transcript": "ENST00000860920.1",
"protein_id": "ENSP00000530979.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 568,
"cds_start": 42,
"cds_end": null,
"cds_length": 1707,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000860920.1"
},
{
"aa_ref": "Q",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRAF3",
"gene_hgnc_id": 12033,
"hgvs_c": "c.42G>T",
"hgvs_p": "p.Gln14His",
"transcript": "ENST00000952335.1",
"protein_id": "ENSP00000622394.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 568,
"cds_start": 42,
"cds_end": null,
"cds_length": 1707,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000952335.1"
},
{
"aa_ref": "Q",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRAF3",
"gene_hgnc_id": 12033,
"hgvs_c": "c.42G>T",
"hgvs_p": "p.Gln14His",
"transcript": "ENST00000952336.1",
"protein_id": "ENSP00000622395.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 568,
"cds_start": 42,
"cds_end": null,
"cds_length": 1707,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000952336.1"
},
{
"aa_ref": "Q",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRAF3",
"gene_hgnc_id": 12033,
"hgvs_c": "c.42G>T",
"hgvs_p": "p.Gln14His",
"transcript": "NM_145726.3",
"protein_id": "NP_663778.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 543,
"cds_start": 42,
"cds_end": null,
"cds_length": 1632,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_145726.3"
},
{
"aa_ref": "Q",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRAF3",
"gene_hgnc_id": 12033,
"hgvs_c": "c.42G>T",
"hgvs_p": "p.Gln14His",
"transcript": "ENST00000699893.1",
"protein_id": "ENSP00000514677.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 543,
"cds_start": 42,
"cds_end": null,
"cds_length": 1632,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000699893.1"
},
{
"aa_ref": "Q",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRAF3",
"gene_hgnc_id": 12033,
"hgvs_c": "c.42G>T",
"hgvs_p": "p.Gln14His",
"transcript": "ENST00000860914.1",
"protein_id": "ENSP00000530973.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 543,
"cds_start": 42,
"cds_end": null,
"cds_length": 1632,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000860914.1"
},
{
"aa_ref": "Q",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRAF3",
"gene_hgnc_id": 12033,
"hgvs_c": "c.42G>T",
"hgvs_p": "p.Gln14His",
"transcript": "ENST00000952337.1",
"protein_id": "ENSP00000622396.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 543,
"cds_start": 42,
"cds_end": null,
"cds_length": 1632,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000952337.1"
},
{
"aa_ref": "Q",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRAF3",
"gene_hgnc_id": 12033,
"hgvs_c": "c.42G>T",
"hgvs_p": "p.Gln14His",
"transcript": "ENST00000952338.1",
"protein_id": "ENSP00000622397.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 543,
"cds_start": 42,
"cds_end": null,
"cds_length": 1632,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000952338.1"
},
{
"aa_ref": "Q",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRAF3",
"gene_hgnc_id": 12033,
"hgvs_c": "c.42G>T",
"hgvs_p": "p.Gln14His",
"transcript": "NM_001385143.1",
"protein_id": "NP_001372072.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 541,
"cds_start": 42,
"cds_end": null,
"cds_length": 1626,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001385143.1"
},
{
"aa_ref": "Q",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRAF3",
"gene_hgnc_id": 12033,
"hgvs_c": "c.42G>T",
"hgvs_p": "p.Gln14His",
"transcript": "NM_001385142.1",
"protein_id": "NP_001372071.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 521,
"cds_start": 42,
"cds_end": null,
"cds_length": 1566,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001385142.1"
},
{
"aa_ref": "Q",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRAF3",
"gene_hgnc_id": 12033,
"hgvs_c": "c.42G>T",
"hgvs_p": "p.Gln14His",
"transcript": "ENST00000860915.1",
"protein_id": "ENSP00000530974.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 512,
"cds_start": 42,
"cds_end": null,
"cds_length": 1539,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000860915.1"
},
{
"aa_ref": "Q",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRAF3",
"gene_hgnc_id": 12033,
"hgvs_c": "c.42G>T",
"hgvs_p": "p.Gln14His",
"transcript": "NM_001199427.2",
"protein_id": "NP_001186356.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 485,
"cds_start": 42,
"cds_end": null,
"cds_length": 1458,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001199427.2"
},
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}