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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 14-21031035-C-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=14&pos=21031035&ref=C&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "14",
"pos": 21031035,
"ref": "C",
"alt": "G",
"effect": "missense_variant",
"transcript": "NM_173846.5",
"consequences": [
{
"aa_ref": "T",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TPPP2",
"gene_hgnc_id": 19293,
"hgvs_c": "c.197C>G",
"hgvs_p": "p.Thr66Arg",
"transcript": "NM_173846.5",
"protein_id": "NP_776245.2",
"transcript_support_level": null,
"aa_start": 66,
"aa_end": null,
"aa_length": 170,
"cds_start": 197,
"cds_end": null,
"cds_length": 513,
"cdna_start": 354,
"cdna_end": null,
"cdna_length": 1408,
"mane_select": "ENST00000321760.11",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_173846.5"
},
{
"aa_ref": "T",
"aa_alt": "R",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TPPP2",
"gene_hgnc_id": 19293,
"hgvs_c": "c.197C>G",
"hgvs_p": "p.Thr66Arg",
"transcript": "ENST00000321760.11",
"protein_id": "ENSP00000317595.6",
"transcript_support_level": 1,
"aa_start": 66,
"aa_end": null,
"aa_length": 170,
"cds_start": 197,
"cds_end": null,
"cds_length": 513,
"cdna_start": 354,
"cdna_end": null,
"cdna_length": 1408,
"mane_select": "NM_173846.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000321760.11"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TPPP2",
"gene_hgnc_id": 19293,
"hgvs_c": "n.642C>G",
"hgvs_p": null,
"transcript": "ENST00000534434.2",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1696,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000534434.2"
},
{
"aa_ref": "T",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TPPP2",
"gene_hgnc_id": 19293,
"hgvs_c": "c.197C>G",
"hgvs_p": "p.Thr66Arg",
"transcript": "ENST00000530140.6",
"protein_id": "ENSP00000435356.2",
"transcript_support_level": 2,
"aa_start": 66,
"aa_end": null,
"aa_length": 170,
"cds_start": 197,
"cds_end": null,
"cds_length": 513,
"cdna_start": 313,
"cdna_end": null,
"cdna_length": 703,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000530140.6"
},
{
"aa_ref": "T",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TPPP2",
"gene_hgnc_id": 19293,
"hgvs_c": "c.197C>G",
"hgvs_p": "p.Thr66Arg",
"transcript": "ENST00000460647.6",
"protein_id": "ENSP00000427504.2",
"transcript_support_level": 3,
"aa_start": 66,
"aa_end": null,
"aa_length": 137,
"cds_start": 197,
"cds_end": null,
"cds_length": 414,
"cdna_start": 321,
"cdna_end": null,
"cdna_length": 568,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000460647.6"
},
{
"aa_ref": "T",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TPPP2",
"gene_hgnc_id": 19293,
"hgvs_c": "c.197C>G",
"hgvs_p": "p.Thr66Arg",
"transcript": "ENST00000472458.5",
"protein_id": "ENSP00000423171.1",
"transcript_support_level": 3,
"aa_start": 66,
"aa_end": null,
"aa_length": 136,
"cds_start": 197,
"cds_end": null,
"cds_length": 411,
"cdna_start": 300,
"cdna_end": null,
"cdna_length": 514,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000472458.5"
},
{
"aa_ref": "T",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TPPP2",
"gene_hgnc_id": 19293,
"hgvs_c": "c.182C>G",
"hgvs_p": "p.Thr61Arg",
"transcript": "ENST00000481535.5",
"protein_id": "ENSP00000421438.1",
"transcript_support_level": 3,
"aa_start": 61,
"aa_end": null,
"aa_length": 119,
"cds_start": 182,
"cds_end": null,
"cds_length": 360,
"cdna_start": 182,
"cdna_end": null,
"cdna_length": 457,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000481535.5"
},
{
"aa_ref": "T",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TPPP2",
"gene_hgnc_id": 19293,
"hgvs_c": "c.11C>G",
"hgvs_p": "p.Thr4Arg",
"transcript": "ENST00000555751.1",
"protein_id": "ENSP00000451899.1",
"transcript_support_level": 3,
"aa_start": 4,
"aa_end": null,
"aa_length": 62,
"cds_start": 11,
"cds_end": null,
"cds_length": 189,
"cdna_start": 13,
"cdna_end": null,
"cdna_length": 488,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000555751.1"
},
{
"aa_ref": "T",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TPPP2",
"gene_hgnc_id": 19293,
"hgvs_c": "c.197C>G",
"hgvs_p": "p.Thr66Arg",
"transcript": "XM_017020966.2",
"protein_id": "XP_016876455.1",
"transcript_support_level": null,
"aa_start": 66,
"aa_end": null,
"aa_length": 170,
"cds_start": 197,
"cds_end": null,
"cds_length": 513,
"cdna_start": 312,
"cdna_end": null,
"cdna_length": 1366,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017020966.2"
},
{
"aa_ref": "T",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TPPP2",
"gene_hgnc_id": 19293,
"hgvs_c": "c.197C>G",
"hgvs_p": "p.Thr66Arg",
"transcript": "XM_011536416.2",
"protein_id": "XP_011534718.1",
"transcript_support_level": null,
"aa_start": 66,
"aa_end": null,
"aa_length": 157,
"cds_start": 197,
"cds_end": null,
"cds_length": 474,
"cdna_start": 354,
"cdna_end": null,
"cdna_length": 646,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011536416.2"
},
{
"aa_ref": "T",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TPPP2",
"gene_hgnc_id": 19293,
"hgvs_c": "c.197C>G",
"hgvs_p": "p.Thr66Arg",
"transcript": "XM_011536417.3",
"protein_id": "XP_011534719.1",
"transcript_support_level": null,
"aa_start": 66,
"aa_end": null,
"aa_length": 124,
"cds_start": 197,
"cds_end": null,
"cds_length": 375,
"cdna_start": 354,
"cdna_end": null,
"cdna_length": 980,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011536417.3"
},
{
"aa_ref": "T",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TPPP2",
"gene_hgnc_id": 19293,
"hgvs_c": "c.197C>G",
"hgvs_p": "p.Thr66Arg",
"transcript": "XM_011536418.2",
"protein_id": "XP_011534720.1",
"transcript_support_level": null,
"aa_start": 66,
"aa_end": null,
"aa_length": 124,
"cds_start": 197,
"cds_end": null,
"cds_length": 375,
"cdna_start": 354,
"cdna_end": null,
"cdna_length": 756,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011536418.2"
},
{
"aa_ref": "T",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TPPP2",
"gene_hgnc_id": 19293,
"hgvs_c": "c.197C>G",
"hgvs_p": "p.Thr66Arg",
"transcript": "XM_011536420.3",
"protein_id": "XP_011534722.1",
"transcript_support_level": null,
"aa_start": 66,
"aa_end": null,
"aa_length": 124,
"cds_start": 197,
"cds_end": null,
"cds_length": 375,
"cdna_start": 354,
"cdna_end": null,
"cdna_length": 846,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011536420.3"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NDRG2",
"gene_hgnc_id": 14460,
"hgvs_c": "c.-6-7714G>C",
"hgvs_p": null,
"transcript": "ENST00000876704.1",
"protein_id": "ENSP00000546763.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 371,
"cds_start": null,
"cds_end": null,
"cds_length": 1116,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2001,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876704.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NDRG2",
"gene_hgnc_id": 14460,
"hgvs_c": "c.-6-7714G>C",
"hgvs_p": null,
"transcript": "ENST00000876707.1",
"protein_id": "ENSP00000546766.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 371,
"cds_start": null,
"cds_end": null,
"cds_length": 1116,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2058,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876707.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NDRG2",
"gene_hgnc_id": 14460,
"hgvs_c": "c.-6-7714G>C",
"hgvs_p": null,
"transcript": "ENST00000876710.1",
"protein_id": "ENSP00000546769.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 371,
"cds_start": null,
"cds_end": null,
"cds_length": 1116,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1973,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876710.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NDRG2",
"gene_hgnc_id": 14460,
"hgvs_c": "c.-73-6939G>C",
"hgvs_p": null,
"transcript": "ENST00000949233.1",
"protein_id": "ENSP00000619292.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 371,
"cds_start": null,
"cds_end": null,
"cds_length": 1116,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2120,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000949233.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NDRG2",
"gene_hgnc_id": 14460,
"hgvs_c": "c.-6-7714G>C",
"hgvs_p": null,
"transcript": "ENST00000949235.1",
"protein_id": "ENSP00000619294.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 371,
"cds_start": null,
"cds_end": null,
"cds_length": 1116,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2092,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000949235.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NDRG2",
"gene_hgnc_id": 14460,
"hgvs_c": "c.-73-6939G>C",
"hgvs_p": null,
"transcript": "ENST00000949236.1",
"protein_id": "ENSP00000619295.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 371,
"cds_start": null,
"cds_end": null,
"cds_length": 1116,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2115,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000949236.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NDRG2",
"gene_hgnc_id": 14460,
"hgvs_c": "c.25-7714G>C",
"hgvs_p": null,
"transcript": "NM_001282211.2",
"protein_id": "NP_001269140.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 367,
"cds_start": null,
"cds_end": null,
"cds_length": 1104,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1949,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001282211.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NDRG2",
"gene_hgnc_id": 14460,
"hgvs_c": "c.25-7714G>C",
"hgvs_p": null,
"transcript": "ENST00000403829.7",
"protein_id": "ENSP00000385889.3",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 367,
"cds_start": null,
"cds_end": null,
"cds_length": 1104,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1500,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000403829.7"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NDRG2",
"gene_hgnc_id": 14460,
"hgvs_c": "c.-6-7714G>C",
"hgvs_p": null,
"transcript": "ENST00000876703.1",
"protein_id": "ENSP00000546762.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 357,
"cds_start": null,
"cds_end": null,
"cds_length": 1074,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1982,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876703.1"
},
{
"aa_ref": null,
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}
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}