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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 14-21081734-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=14&pos=21081734&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "14",
"pos": 21081734,
"ref": "G",
"alt": "C",
"effect": "missense_variant",
"transcript": "NM_018071.5",
"consequences": [
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF40",
"gene_hgnc_id": 25516,
"hgvs_c": "c.2866G>C",
"hgvs_p": "p.Val956Leu",
"transcript": "NM_018071.5",
"protein_id": "NP_060541.3",
"transcript_support_level": null,
"aa_start": 956,
"aa_end": null,
"aa_length": 1519,
"cds_start": 2866,
"cds_end": null,
"cds_length": 4560,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000298694.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_018071.5"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF40",
"gene_hgnc_id": 25516,
"hgvs_c": "c.2866G>C",
"hgvs_p": "p.Val956Leu",
"transcript": "ENST00000298694.9",
"protein_id": "ENSP00000298694.4",
"transcript_support_level": 2,
"aa_start": 956,
"aa_end": null,
"aa_length": 1519,
"cds_start": 2866,
"cds_end": null,
"cds_length": 4560,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_018071.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000298694.9"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF40",
"gene_hgnc_id": 25516,
"hgvs_c": "n.*1030G>C",
"hgvs_p": null,
"transcript": "ENST00000553709.5",
"protein_id": "ENSP00000452283.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000553709.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF40",
"gene_hgnc_id": 25516,
"hgvs_c": "n.346G>C",
"hgvs_p": null,
"transcript": "ENST00000554514.1",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000554514.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF40",
"gene_hgnc_id": 25516,
"hgvs_c": "n.*1190G>C",
"hgvs_p": null,
"transcript": "ENST00000556399.5",
"protein_id": "ENSP00000451655.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000556399.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF40",
"gene_hgnc_id": 25516,
"hgvs_c": "n.*1030G>C",
"hgvs_p": null,
"transcript": "ENST00000553709.5",
"protein_id": "ENSP00000452283.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000553709.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF40",
"gene_hgnc_id": 25516,
"hgvs_c": "n.*1190G>C",
"hgvs_p": null,
"transcript": "ENST00000556399.5",
"protein_id": "ENSP00000451655.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000556399.5"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF40",
"gene_hgnc_id": 25516,
"hgvs_c": "c.2866G>C",
"hgvs_p": "p.Val956Leu",
"transcript": "ENST00000918639.1",
"protein_id": "ENSP00000588698.1",
"transcript_support_level": null,
"aa_start": 956,
"aa_end": null,
"aa_length": 1546,
"cds_start": 2866,
"cds_end": null,
"cds_length": 4641,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000918639.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF40",
"gene_hgnc_id": 25516,
"hgvs_c": "c.2866G>C",
"hgvs_p": "p.Val956Leu",
"transcript": "ENST00000950137.1",
"protein_id": "ENSP00000620196.1",
"transcript_support_level": null,
"aa_start": 956,
"aa_end": null,
"aa_length": 1542,
"cds_start": 2866,
"cds_end": null,
"cds_length": 4629,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000950137.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF40",
"gene_hgnc_id": 25516,
"hgvs_c": "c.2896G>C",
"hgvs_p": "p.Val966Leu",
"transcript": "ENST00000918633.1",
"protein_id": "ENSP00000588692.1",
"transcript_support_level": null,
"aa_start": 966,
"aa_end": null,
"aa_length": 1529,
"cds_start": 2896,
"cds_end": null,
"cds_length": 4590,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000918633.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF40",
"gene_hgnc_id": 25516,
"hgvs_c": "c.2866G>C",
"hgvs_p": "p.Val956Leu",
"transcript": "ENST00000877989.1",
"protein_id": "ENSP00000548048.1",
"transcript_support_level": null,
"aa_start": 956,
"aa_end": null,
"aa_length": 1524,
"cds_start": 2866,
"cds_end": null,
"cds_length": 4575,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000877989.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF40",
"gene_hgnc_id": 25516,
"hgvs_c": "c.2866G>C",
"hgvs_p": "p.Val956Leu",
"transcript": "ENST00000877993.1",
"protein_id": "ENSP00000548052.1",
"transcript_support_level": null,
"aa_start": 956,
"aa_end": null,
"aa_length": 1523,
"cds_start": 2866,
"cds_end": null,
"cds_length": 4572,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000877993.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF40",
"gene_hgnc_id": 25516,
"hgvs_c": "c.2866G>C",
"hgvs_p": "p.Val956Leu",
"transcript": "ENST00000877998.1",
"protein_id": "ENSP00000548057.1",
"transcript_support_level": null,
"aa_start": 956,
"aa_end": null,
"aa_length": 1519,
"cds_start": 2866,
"cds_end": null,
"cds_length": 4560,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000877998.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF40",
"gene_hgnc_id": 25516,
"hgvs_c": "c.2863G>C",
"hgvs_p": "p.Val955Leu",
"transcript": "ENST00000918636.1",
"protein_id": "ENSP00000588695.1",
"transcript_support_level": null,
"aa_start": 955,
"aa_end": null,
"aa_length": 1518,
"cds_start": 2863,
"cds_end": null,
"cds_length": 4557,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000918636.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF40",
"gene_hgnc_id": 25516,
"hgvs_c": "c.2863G>C",
"hgvs_p": "p.Val955Leu",
"transcript": "ENST00000950138.1",
"protein_id": "ENSP00000620197.1",
"transcript_support_level": null,
"aa_start": 955,
"aa_end": null,
"aa_length": 1518,
"cds_start": 2863,
"cds_end": null,
"cds_length": 4557,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000950138.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF40",
"gene_hgnc_id": 25516,
"hgvs_c": "c.2863G>C",
"hgvs_p": "p.Val955Leu",
"transcript": "ENST00000950140.1",
"protein_id": "ENSP00000620199.1",
"transcript_support_level": null,
"aa_start": 955,
"aa_end": null,
"aa_length": 1518,
"cds_start": 2863,
"cds_end": null,
"cds_length": 4557,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000950140.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF40",
"gene_hgnc_id": 25516,
"hgvs_c": "c.2866G>C",
"hgvs_p": "p.Val956Leu",
"transcript": "ENST00000950139.1",
"protein_id": "ENSP00000620198.1",
"transcript_support_level": null,
"aa_start": 956,
"aa_end": null,
"aa_length": 1505,
"cds_start": 2866,
"cds_end": null,
"cds_length": 4518,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000950139.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF40",
"gene_hgnc_id": 25516,
"hgvs_c": "c.2776G>C",
"hgvs_p": "p.Val926Leu",
"transcript": "ENST00000918632.1",
"protein_id": "ENSP00000588691.1",
"transcript_support_level": null,
"aa_start": 926,
"aa_end": null,
"aa_length": 1489,
"cds_start": 2776,
"cds_end": null,
"cds_length": 4470,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000918632.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF40",
"gene_hgnc_id": 25516,
"hgvs_c": "c.2866G>C",
"hgvs_p": "p.Val956Leu",
"transcript": "ENST00000950135.1",
"protein_id": "ENSP00000620194.1",
"transcript_support_level": null,
"aa_start": 956,
"aa_end": null,
"aa_length": 1484,
"cds_start": 2866,
"cds_end": null,
"cds_length": 4455,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000950135.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF40",
"gene_hgnc_id": 25516,
"hgvs_c": "c.2896G>C",
"hgvs_p": "p.Val966Leu",
"transcript": "ENST00000918635.1",
"protein_id": "ENSP00000588694.1",
"transcript_support_level": null,
"aa_start": 966,
"aa_end": null,
"aa_length": 1481,
"cds_start": 2896,
"cds_end": null,
"cds_length": 4446,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000918635.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF40",
"gene_hgnc_id": 25516,
"hgvs_c": "c.2749G>C",
"hgvs_p": "p.Val917Leu",
"transcript": "ENST00000918637.1",
"protein_id": "ENSP00000588696.1",
"transcript_support_level": null,
"aa_start": 917,
"aa_end": null,
"aa_length": 1480,
"cds_start": 2749,
"cds_end": null,
"cds_length": 4443,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000918637.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF40",
"gene_hgnc_id": 25516,
"hgvs_c": "c.2866G>C",
"hgvs_p": "p.Val956Leu",
"transcript": "ENST00000918630.1",
"protein_id": "ENSP00000588689.1",
"transcript_support_level": null,
"aa_start": 956,
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}
],
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}