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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 14-24964647-C-CTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=14&pos=24964647&ref=C&alt=CTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "14",
"pos": 24964647,
"ref": "C",
"alt": "CTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG",
"effect": "intron_variant",
"transcript": "ENST00000323944.10",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "STXBP6",
"gene_hgnc_id": 19666,
"hgvs_c": "c.154+9988_154+10017dupCACACACACACACACACACACACACACACA",
"hgvs_p": null,
"transcript": "NM_001394410.1",
"protein_id": "NP_001381339.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 210,
"cds_start": -4,
"cds_end": null,
"cds_length": 633,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4190,
"mane_select": "ENST00000323944.10",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "STXBP6",
"gene_hgnc_id": 19666,
"hgvs_c": "c.154+10017_154+10018insCACACACACACACACACACACACACACACA",
"hgvs_p": null,
"transcript": "ENST00000323944.10",
"protein_id": "ENSP00000324302.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 210,
"cds_start": -4,
"cds_end": null,
"cds_length": 633,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4190,
"mane_select": "NM_001394410.1",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "STXBP6",
"gene_hgnc_id": 19666,
"hgvs_c": "c.154+10017_154+10018insCACACACACACACACACACACACACACACA",
"hgvs_p": null,
"transcript": "ENST00000396700.5",
"protein_id": "ENSP00000379928.1",
"transcript_support_level": 1,
"aa_start": null,
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"cds_start": -4,
"cds_end": null,
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"cdna_start": null,
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"cdna_length": 4021,
"mane_select": null,
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"feature": null
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
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"exon_count": 6,
"intron_rank": 2,
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"gene_symbol": "STXBP6",
"gene_hgnc_id": 19666,
"hgvs_c": "c.154+10017_154+10018insCACACACACACACACACACACACACACACA",
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"transcript": "ENST00000419632.6",
"protein_id": "ENSP00000397212.2",
"transcript_support_level": 1,
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"cds_start": -4,
"cds_end": null,
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"cdna_start": null,
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"cdna_length": 1970,
"mane_select": null,
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
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"exon_count": 6,
"intron_rank": 2,
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"gene_symbol": "STXBP6",
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"hgvs_c": "c.154+10017_154+10018insCACACACACACACACACACACACACACACA",
"hgvs_p": null,
"transcript": "ENST00000546511.5",
"protein_id": "ENSP00000449536.1",
"transcript_support_level": 1,
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"cdna_start": null,
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"mane_select": null,
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},
{
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"consequences": [
"intron_variant"
],
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"exon_count": 7,
"intron_rank": 3,
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"gene_symbol": "STXBP6",
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"hgvs_c": "c.154+9988_154+10017dupCACACACACACACACACACACACACACACA",
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"transcript": "NM_001304476.3",
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},
{
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],
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},
{
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],
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"gene_symbol": "STXBP6",
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"hgvs_c": "c.154+9988_154+10017dupCACACACACACACACACACACACACACACA",
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"transcript": "NM_001351940.3",
"protein_id": "NP_001338869.2",
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{
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