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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 14-33321403-A-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=14&pos=33321403&ref=A&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "14",
"pos": 33321403,
"ref": "A",
"alt": "C",
"effect": "intron_variant",
"transcript": "ENST00000356141.9",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "NPAS3",
"gene_hgnc_id": 19311,
"hgvs_c": "c.386-45783A>C",
"hgvs_p": null,
"transcript": "NM_001164749.2",
"protein_id": "NP_001158221.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 933,
"cds_start": -4,
"cds_end": null,
"cds_length": 2802,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6304,
"mane_select": "ENST00000356141.9",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "NPAS3",
"gene_hgnc_id": 19311,
"hgvs_c": "c.386-45783A>C",
"hgvs_p": null,
"transcript": "ENST00000356141.9",
"protein_id": "ENSP00000348460.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 933,
"cds_start": -4,
"cds_end": null,
"cds_length": 2802,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6304,
"mane_select": "NM_001164749.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "NPAS3",
"gene_hgnc_id": 19311,
"hgvs_c": "c.347-45783A>C",
"hgvs_p": null,
"transcript": "ENST00000357798.9",
"protein_id": "ENSP00000350446.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 920,
"cds_start": -4,
"cds_end": null,
"cds_length": 2763,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2763,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "NPAS3",
"gene_hgnc_id": 19311,
"hgvs_c": "c.296-45783A>C",
"hgvs_p": null,
"transcript": "ENST00000548645.5",
"protein_id": "ENSP00000448916.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 903,
"cds_start": -4,
"cds_end": null,
"cds_length": 2712,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2926,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "NPAS3",
"gene_hgnc_id": 19311,
"hgvs_c": "c.296-45789A>C",
"hgvs_p": null,
"transcript": "ENST00000346562.6",
"protein_id": "ENSP00000319610.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 901,
"cds_start": -4,
"cds_end": null,
"cds_length": 2706,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5847,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NPAS3",
"gene_hgnc_id": 19311,
"hgvs_c": "c.215-45783A>C",
"hgvs_p": null,
"transcript": "ENST00000551008.6",
"protein_id": "ENSP00000447213.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 200,
"cds_start": -4,
"cds_end": null,
"cds_length": 603,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1002,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NPAS3",
"gene_hgnc_id": 19311,
"hgvs_c": "c.80-45789A>C",
"hgvs_p": null,
"transcript": "ENST00000547068.5",
"protein_id": "ENSP00000449542.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 153,
"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 2531,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "NPAS3",
"gene_hgnc_id": 19311,
"hgvs_c": "c.407-45789A>C",
"hgvs_p": null,
"transcript": "ENST00000551492.5",
"protein_id": "ENSP00000450392.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 938,
"cds_start": -4,
"cds_end": null,
"cds_length": 2817,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2817,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "NPAS3",
"gene_hgnc_id": 19311,
"hgvs_c": "c.404-45783A>C",
"hgvs_p": null,
"transcript": "ENST00000551634.6",
"protein_id": "ENSP00000448373.2",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 934,
"cds_start": -4,
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"cds_length": 2805,
"cdna_start": null,
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"cdna_length": 3255,
"mane_select": null,
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"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 12,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "NPAS3",
"gene_hgnc_id": 19311,
"hgvs_c": "c.347-45783A>C",
"hgvs_p": null,
"transcript": "NM_173159.3",
"protein_id": "NP_775182.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"intron_rank": 3,
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"gene_symbol": "NPAS3",
"gene_hgnc_id": 19311,
"hgvs_c": "c.347-45789A>C",
"hgvs_p": null,
"transcript": "NM_001394988.1",
"protein_id": "NP_001381917.1",
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},
{
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],
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"gene_symbol": "NPAS3",
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},
{
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],
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"gene_symbol": "NPAS3",
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"hgvs_c": "c.296-45789A>C",
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"transcript": "NM_022123.3",
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},
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],
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"gene_symbol": "NPAS3",
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"hgvs_c": "c.296-45783A>C",
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},
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],
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"transcript": "ENST00000546849.1",
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},
{
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],
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"gene_symbol": "NPAS3",
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],
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},
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],
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"hgvs_c": "n.237-45783A>C",
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],
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},
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],
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"gene_symbol": "NPAS3",
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}