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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 14-33800515-C-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=14&pos=33800515&ref=C&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "14",
"pos": 33800515,
"ref": "C",
"alt": "G",
"effect": "synonymous_variant",
"transcript": "ENST00000356141.9",
"consequences": [
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NPAS3",
"gene_hgnc_id": 19311,
"hgvs_c": "c.2208C>G",
"hgvs_p": "p.Thr736Thr",
"transcript": "NM_001164749.2",
"protein_id": "NP_001158221.1",
"transcript_support_level": null,
"aa_start": 736,
"aa_end": null,
"aa_length": 933,
"cds_start": 2208,
"cds_end": null,
"cds_length": 2802,
"cdna_start": 2646,
"cdna_end": null,
"cdna_length": 6304,
"mane_select": "ENST00000356141.9",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NPAS3",
"gene_hgnc_id": 19311,
"hgvs_c": "c.2208C>G",
"hgvs_p": "p.Thr736Thr",
"transcript": "ENST00000356141.9",
"protein_id": "ENSP00000348460.4",
"transcript_support_level": 1,
"aa_start": 736,
"aa_end": null,
"aa_length": 933,
"cds_start": 2208,
"cds_end": null,
"cds_length": 2802,
"cdna_start": 2646,
"cdna_end": null,
"cdna_length": 6304,
"mane_select": "NM_001164749.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NPAS3",
"gene_hgnc_id": 19311,
"hgvs_c": "c.2169C>G",
"hgvs_p": "p.Thr723Thr",
"transcript": "ENST00000357798.9",
"protein_id": "ENSP00000350446.5",
"transcript_support_level": 1,
"aa_start": 723,
"aa_end": null,
"aa_length": 920,
"cds_start": 2169,
"cds_end": null,
"cds_length": 2763,
"cdna_start": 2169,
"cdna_end": null,
"cdna_length": 2763,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NPAS3",
"gene_hgnc_id": 19311,
"hgvs_c": "c.2118C>G",
"hgvs_p": "p.Thr706Thr",
"transcript": "ENST00000548645.5",
"protein_id": "ENSP00000448916.1",
"transcript_support_level": 1,
"aa_start": 706,
"aa_end": null,
"aa_length": 903,
"cds_start": 2118,
"cds_end": null,
"cds_length": 2712,
"cdna_start": 2163,
"cdna_end": null,
"cdna_length": 2926,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NPAS3",
"gene_hgnc_id": 19311,
"hgvs_c": "c.2112C>G",
"hgvs_p": "p.Thr704Thr",
"transcript": "ENST00000346562.6",
"protein_id": "ENSP00000319610.5",
"transcript_support_level": 1,
"aa_start": 704,
"aa_end": null,
"aa_length": 901,
"cds_start": 2112,
"cds_end": null,
"cds_length": 2706,
"cdna_start": 2186,
"cdna_end": null,
"cdna_length": 5847,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NPAS3",
"gene_hgnc_id": 19311,
"hgvs_c": "c.2223C>G",
"hgvs_p": "p.Thr741Thr",
"transcript": "ENST00000551492.5",
"protein_id": "ENSP00000450392.1",
"transcript_support_level": 5,
"aa_start": 741,
"aa_end": null,
"aa_length": 938,
"cds_start": 2223,
"cds_end": null,
"cds_length": 2817,
"cdna_start": 2223,
"cdna_end": null,
"cdna_length": 2817,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NPAS3",
"gene_hgnc_id": 19311,
"hgvs_c": "c.2217C>G",
"hgvs_p": "p.Thr739Thr",
"transcript": "ENST00000551634.6",
"protein_id": "ENSP00000448373.2",
"transcript_support_level": 5,
"aa_start": 739,
"aa_end": null,
"aa_length": 934,
"cds_start": 2217,
"cds_end": null,
"cds_length": 2805,
"cdna_start": 2667,
"cdna_end": null,
"cdna_length": 3255,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NPAS3",
"gene_hgnc_id": 19311,
"hgvs_c": "c.2169C>G",
"hgvs_p": "p.Thr723Thr",
"transcript": "NM_173159.3",
"protein_id": "NP_775182.1",
"transcript_support_level": null,
"aa_start": 723,
"aa_end": null,
"aa_length": 920,
"cds_start": 2169,
"cds_end": null,
"cds_length": 2763,
"cdna_start": 2607,
"cdna_end": null,
"cdna_length": 6265,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NPAS3",
"gene_hgnc_id": 19311,
"hgvs_c": "c.2163C>G",
"hgvs_p": "p.Thr721Thr",
"transcript": "NM_001394988.1",
"protein_id": "NP_001381917.1",
"transcript_support_level": null,
"aa_start": 721,
"aa_end": null,
"aa_length": 918,
"cds_start": 2163,
"cds_end": null,
"cds_length": 2757,
"cdna_start": 2601,
"cdna_end": null,
"cdna_length": 6259,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NPAS3",
"gene_hgnc_id": 19311,
"hgvs_c": "c.2118C>G",
"hgvs_p": "p.Thr706Thr",
"transcript": "NM_001165893.2",
"protein_id": "NP_001159365.1",
"transcript_support_level": null,
"aa_start": 706,
"aa_end": null,
"aa_length": 903,
"cds_start": 2118,
"cds_end": null,
"cds_length": 2712,
"cdna_start": 2556,
"cdna_end": null,
"cdna_length": 6214,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NPAS3",
"gene_hgnc_id": 19311,
"hgvs_c": "c.2112C>G",
"hgvs_p": "p.Thr704Thr",
"transcript": "NM_022123.3",
"protein_id": "NP_071406.1",
"transcript_support_level": null,
"aa_start": 704,
"aa_end": null,
"aa_length": 901,
"cds_start": 2112,
"cds_end": null,
"cds_length": 2706,
"cdna_start": 2550,
"cdna_end": null,
"cdna_length": 6208,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NPAS3",
"gene_hgnc_id": 19311,
"hgvs_c": "c.2109C>G",
"hgvs_p": "p.Thr703Thr",
"transcript": "NM_001394989.1",
"protein_id": "NP_001381918.1",
"transcript_support_level": null,
"aa_start": 703,
"aa_end": null,
"aa_length": 900,
"cds_start": 2109,
"cds_end": null,
"cds_length": 2703,
"cdna_start": 2547,
"cdna_end": null,
"cdna_length": 6205,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NPAS3",
"gene_hgnc_id": 19311,
"hgvs_c": "c.2367C>G",
"hgvs_p": "p.Thr789Thr",
"transcript": "XM_017021582.2",
"protein_id": "XP_016877071.1",
"transcript_support_level": null,
"aa_start": 789,
"aa_end": null,
"aa_length": 986,
"cds_start": 2367,
"cds_end": null,
"cds_length": 2961,
"cdna_start": 2428,
"cdna_end": null,
"cdna_length": 6086,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NPAS3",
"gene_hgnc_id": 19311,
"hgvs_c": "c.2361C>G",
"hgvs_p": "p.Thr787Thr",
"transcript": "XM_047431678.1",
"protein_id": "XP_047287634.1",
"transcript_support_level": null,
"aa_start": 787,
"aa_end": null,
"aa_length": 984,
"cds_start": 2361,
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"cds_length": 2955,
"cdna_start": 2422,
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"cdna_length": 6080,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NPAS3",
"gene_hgnc_id": 19311,
"hgvs_c": "c.2358C>G",
"hgvs_p": "p.Thr786Thr",
"transcript": "XM_017021583.2",
"protein_id": "XP_016877072.1",
"transcript_support_level": null,
"aa_start": 786,
"aa_end": null,
"aa_length": 983,
"cds_start": 2358,
"cds_end": null,
"cds_length": 2952,
"cdna_start": 2419,
"cdna_end": null,
"cdna_length": 6077,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NPAS3",
"gene_hgnc_id": 19311,
"hgvs_c": "c.2316C>G",
"hgvs_p": "p.Thr772Thr",
"transcript": "XM_005267991.4",
"protein_id": "XP_005268048.2",
"transcript_support_level": null,
"aa_start": 772,
"aa_end": null,
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"cds_start": 2316,
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"cdna_start": 2377,
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"cdna_length": 6035,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NPAS3",
"gene_hgnc_id": 19311,
"hgvs_c": "c.2310C>G",
"hgvs_p": "p.Thr770Thr",
"transcript": "XM_005267992.4",
"protein_id": "XP_005268049.2",
"transcript_support_level": null,
"aa_start": 770,
"aa_end": null,
"aa_length": 967,
"cds_start": 2310,
"cds_end": null,
"cds_length": 2904,
"cdna_start": 2359,
"cdna_end": null,
"cdna_length": 6017,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NPAS3",
"gene_hgnc_id": 19311,
"hgvs_c": "c.2307C>G",
"hgvs_p": "p.Thr769Thr",
"transcript": "XM_011537069.3",
"protein_id": "XP_011535371.2",
"transcript_support_level": null,
"aa_start": 769,
"aa_end": null,
"aa_length": 966,
"cds_start": 2307,
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"cdna_start": 2368,
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"cdna_length": 6026,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NPAS3",
"gene_hgnc_id": 19311,
"hgvs_c": "c.2277C>G",
"hgvs_p": "p.Thr759Thr",
"transcript": "XM_017021584.2",
"protein_id": "XP_016877073.1",
"transcript_support_level": null,
"aa_start": 759,
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"cdna_start": 2338,
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"cdna_length": 5996,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NPAS3",
"gene_hgnc_id": 19311,
"hgvs_c": "c.2259C>G",
"hgvs_p": "p.Thr753Thr",
"transcript": "XM_011537067.3",
"protein_id": "XP_011535369.1",
"transcript_support_level": null,
"aa_start": 753,
"aa_end": null,
"aa_length": 950,
"cds_start": 2259,
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"cdna_start": 2697,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NPAS3",
"gene_hgnc_id": 19311,
"hgvs_c": "c.2226C>G",
"hgvs_p": "p.Thr742Thr",
"transcript": "XM_017021585.2",
"protein_id": "XP_016877074.1",
"transcript_support_level": null,
"aa_start": 742,
"aa_end": null,
"aa_length": 939,
"cds_start": 2226,
"cds_end": null,
"cds_length": 2820,
"cdna_start": 2287,
"cdna_end": null,
"cdna_length": 5945,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NPAS3",
"gene_hgnc_id": 19311,
"hgvs_c": "c.2217C>G",
"hgvs_p": "p.Thr739Thr",
"transcript": "XM_011537071.3",
"protein_id": "XP_011535373.2",
"transcript_support_level": null,
"aa_start": 739,
"aa_end": null,
"aa_length": 936,
"cds_start": 2217,
"cds_end": null,
"cds_length": 2811,
"cdna_start": 2263,
"cdna_end": null,
"cdna_length": 5921,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
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{
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"verdict": "Benign",
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"clinvar_review_status": "",
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}
],
"message": null
}