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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 14-35266761-A-G (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=14&pos=35266761&ref=A&alt=G&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 13,
          "criteria": [
            "BP4_Strong",
            "BP6",
            "BA1"
          ],
          "effects": [
            "missense_variant"
          ],
          "gene_symbol": "PRORP",
          "hgnc_id": 19958,
          "hgvs_c": "c.1310A>G",
          "hgvs_p": "p.Asn437Ser",
          "inheritance_mode": "AR",
          "pathogenic_score": 0,
          "score": -13,
          "transcript": "NM_014672.4",
          "verdict": "Benign"
        },
        {
          "benign_score": 13,
          "criteria": [
            "BP4_Strong",
            "BP6",
            "BA1"
          ],
          "effects": [
            "non_coding_transcript_exon_variant"
          ],
          "gene_symbol": "ENSG00000258790",
          "hgnc_id": null,
          "hgvs_c": "n.1310A>G",
          "hgvs_p": null,
          "inheritance_mode": "",
          "pathogenic_score": 0,
          "score": -13,
          "transcript": "ENST00000557565.1",
          "verdict": "Benign"
        },
        {
          "benign_score": 13,
          "criteria": [
            "BP4_Strong",
            "BP6",
            "BA1"
          ],
          "effects": [
            "non_coding_transcript_exon_variant"
          ],
          "gene_symbol": "PRORP-PSMA6",
          "hgnc_id": null,
          "hgvs_c": "n.1818A>G",
          "hgvs_p": null,
          "inheritance_mode": "",
          "pathogenic_score": 0,
          "score": -13,
          "transcript": "NR_182666.1",
          "verdict": "Benign"
        }
      ],
      "acmg_classification": "Benign",
      "acmg_criteria": "BP4_Strong,BP6,BA1",
      "acmg_score": -13,
      "allele_count_reference_population": 245934,
      "alphamissense_prediction": null,
      "alphamissense_score": 0.1236,
      "alt": "G",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": "Benign",
      "bayesdelnoaf_score": -0.55,
      "chr": "14",
      "clinvar_classification": "Benign",
      "clinvar_disease": "PRORP-related disorder",
      "clinvar_review_status": "no assertion criteria provided",
      "clinvar_submissions_summary": "null",
      "computational_prediction_selected": "Benign",
      "computational_score_selected": 0.0016128122806549072,
      "computational_source_selected": "MetaRNN",
      "consequences": [
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 583,
          "aa_ref": "N",
          "aa_start": 437,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6186,
          "cdna_start": 1688,
          "cds_end": null,
          "cds_length": 1752,
          "cds_start": 1310,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 8,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "NM_014672.4",
          "gene_hgnc_id": 19958,
          "gene_symbol": "PRORP",
          "hgvs_c": "c.1310A>G",
          "hgvs_p": "p.Asn437Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000534898.9",
          "protein_coding": true,
          "protein_id": "NP_055487.2",
          "strand": true,
          "transcript": "NM_014672.4",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 583,
          "aa_ref": "N",
          "aa_start": 437,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 6186,
          "cdna_start": 1688,
          "cds_end": null,
          "cds_length": 1752,
          "cds_start": 1310,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 8,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "ENST00000534898.9",
          "gene_hgnc_id": 19958,
          "gene_symbol": "PRORP",
          "hgvs_c": "c.1310A>G",
          "hgvs_p": "p.Asn437Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_014672.4",
          "protein_coding": true,
          "protein_id": "ENSP00000440915.2",
          "strand": true,
          "transcript": "ENST00000534898.9",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 211,
          "aa_ref": "N",
          "aa_start": 65,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1406,
          "cdna_start": 513,
          "cds_end": null,
          "cds_length": 636,
          "cds_start": 194,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 7,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000605870.5",
          "gene_hgnc_id": 19958,
          "gene_symbol": "PRORP",
          "hgvs_c": "c.194A>G",
          "hgvs_p": "p.Asn65Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000474299.1",
          "strand": true,
          "transcript": "ENST00000605870.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "nonsense_mediated_decay",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 3857,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_count": 15,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "ENST00000557565.1",
          "gene_hgnc_id": null,
          "gene_symbol": "ENSG00000258790",
          "hgvs_c": "n.1310A>G",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": "ENSP00000454657.1",
          "strand": true,
          "transcript": "ENST00000557565.1",
          "transcript_support_level": 2
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 583,
          "aa_ref": "N",
          "aa_start": 437,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2759,
          "cdna_start": 1818,
          "cds_end": null,
          "cds_length": 1752,
          "cds_start": 1310,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 8,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "NM_001414503.1",
          "gene_hgnc_id": 19958,
          "gene_symbol": "PRORP",
          "hgvs_c": "c.1310A>G",
          "hgvs_p": "p.Asn437Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001401432.1",
          "strand": true,
          "transcript": "NM_001414503.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 583,
          "aa_ref": "N",
          "aa_start": 437,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5393,
          "cdna_start": 1859,
          "cds_end": null,
          "cds_length": 1752,
          "cds_start": 1310,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 8,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "ENST00000887494.1",
          "gene_hgnc_id": 19958,
          "gene_symbol": "PRORP",
          "hgvs_c": "c.1310A>G",
          "hgvs_p": "p.Asn437Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000557553.1",
          "strand": true,
          "transcript": "ENST00000887494.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 583,
          "aa_ref": "N",
          "aa_start": 437,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2745,
          "cdna_start": 1804,
          "cds_end": null,
          "cds_length": 1752,
          "cds_start": 1310,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 8,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "ENST00000887498.1",
          "gene_hgnc_id": 19958,
          "gene_symbol": "PRORP",
          "hgvs_c": "c.1310A>G",
          "hgvs_p": "p.Asn437Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000557557.1",
          "strand": true,
          "transcript": "ENST00000887498.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 583,
          "aa_ref": "N",
          "aa_start": 437,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 7212,
          "cdna_start": 2714,
          "cds_end": null,
          "cds_length": 1752,
          "cds_start": 1310,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 7,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000928184.1",
          "gene_hgnc_id": 19958,
          "gene_symbol": "PRORP",
          "hgvs_c": "c.1310A>G",
          "hgvs_p": "p.Asn437Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000598243.1",
          "strand": true,
          "transcript": "ENST00000928184.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 571,
          "aa_ref": "N",
          "aa_start": 437,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2580,
          "cdna_start": 1678,
          "cds_end": null,
          "cds_length": 1716,
          "cds_start": 1310,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 8,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "ENST00000947894.1",
          "gene_hgnc_id": 19958,
          "gene_symbol": "PRORP",
          "hgvs_c": "c.1310A>G",
          "hgvs_p": "p.Asn437Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000617953.1",
          "strand": true,
          "transcript": "ENST00000947894.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 567,
          "aa_ref": "N",
          "aa_start": 421,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6138,
          "cdna_start": 1640,
          "cds_end": null,
          "cds_length": 1704,
          "cds_start": 1262,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 7,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "NM_001256678.2",
          "gene_hgnc_id": 19958,
          "gene_symbol": "PRORP",
          "hgvs_c": "c.1262A>G",
          "hgvs_p": "p.Asn421Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001243607.1",
          "strand": true,
          "transcript": "NM_001256678.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 567,
          "aa_ref": "N",
          "aa_start": 421,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6118,
          "cdna_start": 1628,
          "cds_end": null,
          "cds_length": 1704,
          "cds_start": 1262,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 7,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000250377.11",
          "gene_hgnc_id": 19958,
          "gene_symbol": "PRORP",
          "hgvs_c": "c.1262A>G",
          "hgvs_p": "p.Asn421Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000250377.8",
          "strand": true,
          "transcript": "ENST00000250377.11",
          "transcript_support_level": 2
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 567,
          "aa_ref": "N",
          "aa_start": 421,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2232,
          "cdna_start": 1686,
          "cds_end": null,
          "cds_length": 1704,
          "cds_start": 1262,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 7,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000603544.5",
          "gene_hgnc_id": 19958,
          "gene_symbol": "PRORP",
          "hgvs_c": "c.1262A>G",
          "hgvs_p": "p.Asn421Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000473856.1",
          "strand": true,
          "transcript": "ENST00000603544.5",
          "transcript_support_level": 5
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 567,
          "aa_ref": "N",
          "aa_start": 421,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2907,
          "cdna_start": 1966,
          "cds_end": null,
          "cds_length": 1704,
          "cds_start": 1262,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 6,
          "exon_rank": 4,
          "exon_rank_end": null,
          "feature": "ENST00000887496.1",
          "gene_hgnc_id": 19958,
          "gene_symbol": "PRORP",
          "hgvs_c": "c.1262A>G",
          "hgvs_p": "p.Asn421Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000557555.1",
          "strand": true,
          "transcript": "ENST00000887496.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 564,
          "aa_ref": "N",
          "aa_start": 437,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2188,
          "cdna_start": 1678,
          "cds_end": null,
          "cds_length": 1695,
          "cds_start": 1310,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 8,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "ENST00000887499.1",
          "gene_hgnc_id": 19958,
          "gene_symbol": "PRORP",
          "hgvs_c": "c.1310A>G",
          "hgvs_p": "p.Asn437Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000557558.1",
          "strand": true,
          "transcript": "ENST00000887499.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 547,
          "aa_ref": "N",
          "aa_start": 401,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2768,
          "cdna_start": 1596,
          "cds_end": null,
          "cds_length": 1644,
          "cds_start": 1202,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 7,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000887495.1",
          "gene_hgnc_id": 19958,
          "gene_symbol": "PRORP",
          "hgvs_c": "c.1202A>G",
          "hgvs_p": "p.Asn401Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000557554.1",
          "strand": true,
          "transcript": "ENST00000887495.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 531,
          "aa_ref": "N",
          "aa_start": 385,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2479,
          "cdna_start": 1542,
          "cds_end": null,
          "cds_length": 1596,
          "cds_start": 1154,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 6,
          "exon_rank": 4,
          "exon_rank_end": null,
          "feature": "ENST00000887497.1",
          "gene_hgnc_id": 19958,
          "gene_symbol": "PRORP",
          "hgvs_c": "c.1154A>G",
          "hgvs_p": "p.Asn385Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000557556.1",
          "strand": true,
          "transcript": "ENST00000887497.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 488,
          "aa_ref": "N",
          "aa_start": 342,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5633,
          "cdna_start": 1135,
          "cds_end": null,
          "cds_length": 1467,
          "cds_start": 1025,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 8,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "NM_001256679.2",
          "gene_hgnc_id": 19958,
          "gene_symbol": "PRORP",
          "hgvs_c": "c.1025A>G",
          "hgvs_p": "p.Asn342Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001243608.1",
          "strand": true,
          "transcript": "NM_001256679.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 488,
          "aa_ref": "N",
          "aa_start": 342,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1706,
          "cdna_start": 1140,
          "cds_end": null,
          "cds_length": 1467,
          "cds_start": 1025,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 8,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "ENST00000604948.5",
          "gene_hgnc_id": 19958,
          "gene_symbol": "PRORP",
          "hgvs_c": "c.1025A>G",
          "hgvs_p": "p.Asn342Ser",
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}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.