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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 14-45109775-A-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=14&pos=45109775&ref=A&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "14",
      "pos": 45109775,
      "ref": "A",
      "alt": "T",
      "effect": "missense_variant",
      "transcript": "NM_017922.4",
      "consequences": [
        {
          "aa_ref": "I",
          "aa_alt": "F",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PRPF39",
          "gene_hgnc_id": 20314,
          "hgvs_c": "c.1171A>T",
          "hgvs_p": "p.Ile391Phe",
          "transcript": "NM_017922.4",
          "protein_id": "NP_060392.3",
          "transcript_support_level": null,
          "aa_start": 391,
          "aa_end": null,
          "aa_length": 669,
          "cds_start": 1171,
          "cds_end": null,
          "cds_length": 2010,
          "cdna_start": 1324,
          "cdna_end": null,
          "cdna_length": 3532,
          "mane_select": "ENST00000355765.11",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_017922.4"
        },
        {
          "aa_ref": "I",
          "aa_alt": "F",
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PRPF39",
          "gene_hgnc_id": 20314,
          "hgvs_c": "c.1171A>T",
          "hgvs_p": "p.Ile391Phe",
          "transcript": "ENST00000355765.11",
          "protein_id": "ENSP00000348010.6",
          "transcript_support_level": 1,
          "aa_start": 391,
          "aa_end": null,
          "aa_length": 669,
          "cds_start": 1171,
          "cds_end": null,
          "cds_length": 2010,
          "cdna_start": 1324,
          "cdna_end": null,
          "cdna_length": 3532,
          "mane_select": "NM_017922.4",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000355765.11"
        },
        {
          "aa_ref": "I",
          "aa_alt": "F",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PRPF39",
          "gene_hgnc_id": 20314,
          "hgvs_c": "c.1171A>T",
          "hgvs_p": "p.Ile391Phe",
          "transcript": "ENST00000931178.1",
          "protein_id": "ENSP00000601237.1",
          "transcript_support_level": null,
          "aa_start": 391,
          "aa_end": null,
          "aa_length": 669,
          "cds_start": 1171,
          "cds_end": null,
          "cds_length": 2010,
          "cdna_start": 1228,
          "cdna_end": null,
          "cdna_length": 2752,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000931178.1"
        },
        {
          "aa_ref": "I",
          "aa_alt": "F",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PRPF39",
          "gene_hgnc_id": 20314,
          "hgvs_c": "c.1171A>T",
          "hgvs_p": "p.Ile391Phe",
          "transcript": "ENST00000905876.1",
          "protein_id": "ENSP00000575935.1",
          "transcript_support_level": null,
          "aa_start": 391,
          "aa_end": null,
          "aa_length": 668,
          "cds_start": 1171,
          "cds_end": null,
          "cds_length": 2007,
          "cdna_start": 1278,
          "cdna_end": null,
          "cdna_length": 2792,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000905876.1"
        },
        {
          "aa_ref": "I",
          "aa_alt": "F",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PRPF39",
          "gene_hgnc_id": 20314,
          "hgvs_c": "c.1171A>T",
          "hgvs_p": "p.Ile391Phe",
          "transcript": "ENST00000961952.1",
          "protein_id": "ENSP00000632011.1",
          "transcript_support_level": null,
          "aa_start": 391,
          "aa_end": null,
          "aa_length": 651,
          "cds_start": 1171,
          "cds_end": null,
          "cds_length": 1956,
          "cdna_start": 1316,
          "cdna_end": null,
          "cdna_length": 2787,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000961952.1"
        },
        {
          "aa_ref": "I",
          "aa_alt": "F",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PRPF39",
          "gene_hgnc_id": 20314,
          "hgvs_c": "c.1063A>T",
          "hgvs_p": "p.Ile355Phe",
          "transcript": "ENST00000931176.1",
          "protein_id": "ENSP00000601235.1",
          "transcript_support_level": null,
          "aa_start": 355,
          "aa_end": null,
          "aa_length": 633,
          "cds_start": 1063,
          "cds_end": null,
          "cds_length": 1902,
          "cdna_start": 1211,
          "cdna_end": null,
          "cdna_length": 2738,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000931176.1"
        },
        {
          "aa_ref": "I",
          "aa_alt": "F",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PRPF39",
          "gene_hgnc_id": 20314,
          "hgvs_c": "c.1027A>T",
          "hgvs_p": "p.Ile343Phe",
          "transcript": "ENST00000905874.1",
          "protein_id": "ENSP00000575933.1",
          "transcript_support_level": null,
          "aa_start": 343,
          "aa_end": null,
          "aa_length": 621,
          "cds_start": 1027,
          "cds_end": null,
          "cds_length": 1866,
          "cdna_start": 1189,
          "cdna_end": null,
          "cdna_length": 2716,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000905874.1"
        },
        {
          "aa_ref": "I",
          "aa_alt": "F",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PRPF39",
          "gene_hgnc_id": 20314,
          "hgvs_c": "c.1003A>T",
          "hgvs_p": "p.Ile335Phe",
          "transcript": "ENST00000961951.1",
          "protein_id": "ENSP00000632010.1",
          "transcript_support_level": null,
          "aa_start": 335,
          "aa_end": null,
          "aa_length": 613,
          "cds_start": 1003,
          "cds_end": null,
          "cds_length": 1842,
          "cdna_start": 1149,
          "cdna_end": null,
          "cdna_length": 2674,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000961951.1"
        },
        {
          "aa_ref": "I",
          "aa_alt": "F",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PRPF39",
          "gene_hgnc_id": 20314,
          "hgvs_c": "c.1171A>T",
          "hgvs_p": "p.Ile391Phe",
          "transcript": "ENST00000961950.1",
          "protein_id": "ENSP00000632009.1",
          "transcript_support_level": null,
          "aa_start": 391,
          "aa_end": null,
          "aa_length": 606,
          "cds_start": 1171,
          "cds_end": null,
          "cds_length": 1821,
          "cdna_start": 1321,
          "cdna_end": null,
          "cdna_length": 2657,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000961950.1"
        },
        {
          "aa_ref": "I",
          "aa_alt": "F",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PRPF39",
          "gene_hgnc_id": 20314,
          "hgvs_c": "c.913A>T",
          "hgvs_p": "p.Ile305Phe",
          "transcript": "ENST00000905875.1",
          "protein_id": "ENSP00000575934.1",
          "transcript_support_level": null,
          "aa_start": 305,
          "aa_end": null,
          "aa_length": 583,
          "cds_start": 913,
          "cds_end": null,
          "cds_length": 1752,
          "cdna_start": 1061,
          "cdna_end": null,
          "cdna_length": 2585,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000905875.1"
        },
        {
          "aa_ref": "I",
          "aa_alt": "F",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PRPF39",
          "gene_hgnc_id": 20314,
          "hgvs_c": "c.859A>T",
          "hgvs_p": "p.Ile287Phe",
          "transcript": "ENST00000931177.1",
          "protein_id": "ENSP00000601236.1",
          "transcript_support_level": null,
          "aa_start": 287,
          "aa_end": null,
          "aa_length": 565,
          "cds_start": 859,
          "cds_end": null,
          "cds_length": 1698,
          "cdna_start": 1004,
          "cdna_end": null,
          "cdna_length": 2527,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000931177.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PRPF39",
          "gene_hgnc_id": 20314,
          "hgvs_c": "n.*1047A>T",
          "hgvs_p": null,
          "transcript": "ENST00000424478.5",
          "protein_id": "ENSP00000390867.1",
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3174,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000424478.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PRPF39",
          "gene_hgnc_id": 20314,
          "hgvs_c": "n.1980A>T",
          "hgvs_p": null,
          "transcript": "ENST00000477626.5",
          "protein_id": null,
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3507,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "retained_intron",
          "feature": "ENST00000477626.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PRPF39",
          "gene_hgnc_id": 20314,
          "hgvs_c": "n.*863A>T",
          "hgvs_p": null,
          "transcript": "ENST00000554081.5",
          "protein_id": "ENSP00000451988.1",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3223,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000554081.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PRPF39",
          "gene_hgnc_id": 20314,
          "hgvs_c": "n.*944A>T",
          "hgvs_p": null,
          "transcript": "ENST00000554429.5",
          "protein_id": "ENSP00000451331.1",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2977,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000554429.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PRPF39",
          "gene_hgnc_id": 20314,
          "hgvs_c": "n.*944A>T",
          "hgvs_p": null,
          "transcript": "ENST00000554439.5",
          "protein_id": "ENSP00000451334.1",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2982,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000554439.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PRPF39",
          "gene_hgnc_id": 20314,
          "hgvs_c": "n.44A>T",
          "hgvs_p": null,
          "transcript": "ENST00000554785.1",
          "protein_id": null,
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2121,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "retained_intron",
          "feature": "ENST00000554785.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PRPF39",
          "gene_hgnc_id": 20314,
          "hgvs_c": "n.33A>T",
          "hgvs_p": null,
          "transcript": "ENST00000556718.1",
          "protein_id": null,
          "transcript_support_level": 3,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 499,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "retained_intron",
          "feature": "ENST00000556718.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PRPF39",
          "gene_hgnc_id": 20314,
          "hgvs_c": "n.*264A>T",
          "hgvs_p": null,
          "transcript": "ENST00000557477.1",
          "protein_id": "ENSP00000452516.1",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 724,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000557477.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PRPF39",
          "gene_hgnc_id": 20314,
          "hgvs_c": "n.*1047A>T",
          "hgvs_p": null,
          "transcript": "ENST00000424478.5",
          "protein_id": "ENSP00000390867.1",
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3174,
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      "computational_prediction_selected": "Uncertain_significance",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
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      "acmg_by_gene": [
        {
          "score": 2,
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          "transcript": "NM_017922.4",
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          "hgvs_p": "p.Ile391Phe"
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      "clinvar_disease": "",
      "clinvar_classification": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "phenotype_combined": null,
      "pathogenicity_classification_combined": null,
      "custom_annotations": null
    }
  ],
  "message": null
}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.