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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 14-77907858-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=14&pos=77907858&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "14",
"pos": 77907858,
"ref": "T",
"alt": "C",
"effect": "missense_variant",
"transcript": "NM_001366487.2",
"consequences": [
{
"aa_ref": "V",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADCK1",
"gene_hgnc_id": 19038,
"hgvs_c": "c.797T>C",
"hgvs_p": "p.Val266Ala",
"transcript": "NM_020421.4",
"protein_id": "NP_065154.2",
"transcript_support_level": null,
"aa_start": 266,
"aa_end": null,
"aa_length": 523,
"cds_start": 797,
"cds_end": null,
"cds_length": 1572,
"cdna_start": 870,
"cdna_end": null,
"cdna_length": 3268,
"mane_select": "ENST00000238561.10",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_020421.4"
},
{
"aa_ref": "V",
"aa_alt": "A",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADCK1",
"gene_hgnc_id": 19038,
"hgvs_c": "c.797T>C",
"hgvs_p": "p.Val266Ala",
"transcript": "ENST00000238561.10",
"protein_id": "ENSP00000238561.5",
"transcript_support_level": 1,
"aa_start": 266,
"aa_end": null,
"aa_length": 523,
"cds_start": 797,
"cds_end": null,
"cds_length": 1572,
"cdna_start": 870,
"cdna_end": null,
"cdna_length": 3268,
"mane_select": "NM_020421.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000238561.10"
},
{
"aa_ref": "V",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADCK1",
"gene_hgnc_id": 19038,
"hgvs_c": "c.797T>C",
"hgvs_p": "p.Val266Ala",
"transcript": "ENST00000951873.1",
"protein_id": "ENSP00000621932.1",
"transcript_support_level": null,
"aa_start": 266,
"aa_end": null,
"aa_length": 604,
"cds_start": 797,
"cds_end": null,
"cds_length": 1815,
"cdna_start": 888,
"cdna_end": null,
"cdna_length": 2466,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000951873.1"
},
{
"aa_ref": "V",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADCK1",
"gene_hgnc_id": 19038,
"hgvs_c": "c.797T>C",
"hgvs_p": "p.Val266Ala",
"transcript": "NM_001366487.2",
"protein_id": "NP_001353416.1",
"transcript_support_level": null,
"aa_start": 266,
"aa_end": null,
"aa_length": 580,
"cds_start": 797,
"cds_end": null,
"cds_length": 1743,
"cdna_start": 870,
"cdna_end": null,
"cdna_length": 3439,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001366487.2"
},
{
"aa_ref": "V",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADCK1",
"gene_hgnc_id": 19038,
"hgvs_c": "c.797T>C",
"hgvs_p": "p.Val266Ala",
"transcript": "ENST00000951875.1",
"protein_id": "ENSP00000621934.1",
"transcript_support_level": null,
"aa_start": 266,
"aa_end": null,
"aa_length": 580,
"cds_start": 797,
"cds_end": null,
"cds_length": 1743,
"cdna_start": 853,
"cdna_end": null,
"cdna_length": 2360,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000951875.1"
},
{
"aa_ref": "V",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADCK1",
"gene_hgnc_id": 19038,
"hgvs_c": "c.770T>C",
"hgvs_p": "p.Val257Ala",
"transcript": "ENST00000936818.1",
"protein_id": "ENSP00000606877.1",
"transcript_support_level": null,
"aa_start": 257,
"aa_end": null,
"aa_length": 514,
"cds_start": 770,
"cds_end": null,
"cds_length": 1545,
"cdna_start": 853,
"cdna_end": null,
"cdna_length": 2189,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000936818.1"
},
{
"aa_ref": "V",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADCK1",
"gene_hgnc_id": 19038,
"hgvs_c": "c.797T>C",
"hgvs_p": "p.Val266Ala",
"transcript": "ENST00000936824.1",
"protein_id": "ENSP00000606883.1",
"transcript_support_level": null,
"aa_start": 266,
"aa_end": null,
"aa_length": 508,
"cds_start": 797,
"cds_end": null,
"cds_length": 1527,
"cdna_start": 830,
"cdna_end": null,
"cdna_length": 2119,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000936824.1"
},
{
"aa_ref": "V",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADCK1",
"gene_hgnc_id": 19038,
"hgvs_c": "c.722T>C",
"hgvs_p": "p.Val241Ala",
"transcript": "ENST00000936820.1",
"protein_id": "ENSP00000606879.1",
"transcript_support_level": null,
"aa_start": 241,
"aa_end": null,
"aa_length": 498,
"cds_start": 722,
"cds_end": null,
"cds_length": 1497,
"cdna_start": 796,
"cdna_end": null,
"cdna_length": 2132,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000936820.1"
},
{
"aa_ref": "V",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADCK1",
"gene_hgnc_id": 19038,
"hgvs_c": "c.638T>C",
"hgvs_p": "p.Val213Ala",
"transcript": "NM_001366489.2",
"protein_id": "NP_001353418.1",
"transcript_support_level": null,
"aa_start": 213,
"aa_end": null,
"aa_length": 470,
"cds_start": 638,
"cds_end": null,
"cds_length": 1413,
"cdna_start": 711,
"cdna_end": null,
"cdna_length": 3109,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001366489.2"
},
{
"aa_ref": "V",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADCK1",
"gene_hgnc_id": 19038,
"hgvs_c": "c.638T>C",
"hgvs_p": "p.Val213Ala",
"transcript": "ENST00000878181.1",
"protein_id": "ENSP00000548240.1",
"transcript_support_level": null,
"aa_start": 213,
"aa_end": null,
"aa_length": 470,
"cds_start": 638,
"cds_end": null,
"cds_length": 1413,
"cdna_start": 700,
"cdna_end": null,
"cdna_length": 2036,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000878181.1"
},
{
"aa_ref": "V",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADCK1",
"gene_hgnc_id": 19038,
"hgvs_c": "c.638T>C",
"hgvs_p": "p.Val213Ala",
"transcript": "ENST00000878182.1",
"protein_id": "ENSP00000548241.1",
"transcript_support_level": null,
"aa_start": 213,
"aa_end": null,
"aa_length": 470,
"cds_start": 638,
"cds_end": null,
"cds_length": 1413,
"cdna_start": 694,
"cdna_end": null,
"cdna_length": 2029,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000878182.1"
},
{
"aa_ref": "V",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADCK1",
"gene_hgnc_id": 19038,
"hgvs_c": "c.797T>C",
"hgvs_p": "p.Val266Ala",
"transcript": "NM_001366486.2",
"protein_id": "NP_001353415.1",
"transcript_support_level": null,
"aa_start": 266,
"aa_end": null,
"aa_length": 457,
"cds_start": 797,
"cds_end": null,
"cds_length": 1374,
"cdna_start": 870,
"cdna_end": null,
"cdna_length": 3070,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001366486.2"
},
{
"aa_ref": "V",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADCK1",
"gene_hgnc_id": 19038,
"hgvs_c": "c.797T>C",
"hgvs_p": "p.Val266Ala",
"transcript": "ENST00000878179.1",
"protein_id": "ENSP00000548238.1",
"transcript_support_level": null,
"aa_start": 266,
"aa_end": null,
"aa_length": 457,
"cds_start": 797,
"cds_end": null,
"cds_length": 1374,
"cdna_start": 882,
"cdna_end": null,
"cdna_length": 3074,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000878179.1"
},
{
"aa_ref": "V",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADCK1",
"gene_hgnc_id": 19038,
"hgvs_c": "c.593T>C",
"hgvs_p": "p.Val198Ala",
"transcript": "NM_001142545.2",
"protein_id": "NP_001136017.1",
"transcript_support_level": null,
"aa_start": 198,
"aa_end": null,
"aa_length": 455,
"cds_start": 593,
"cds_end": null,
"cds_length": 1368,
"cdna_start": 666,
"cdna_end": null,
"cdna_length": 3064,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001142545.2"
},
{
"aa_ref": "V",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADCK1",
"gene_hgnc_id": 19038,
"hgvs_c": "c.593T>C",
"hgvs_p": "p.Val198Ala",
"transcript": "ENST00000341211.5",
"protein_id": "ENSP00000339663.5",
"transcript_support_level": 2,
"aa_start": 198,
"aa_end": null,
"aa_length": 455,
"cds_start": 593,
"cds_end": null,
"cds_length": 1368,
"cdna_start": 636,
"cdna_end": null,
"cdna_length": 1972,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000341211.5"
},
{
"aa_ref": "V",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADCK1",
"gene_hgnc_id": 19038,
"hgvs_c": "c.479T>C",
"hgvs_p": "p.Val160Ala",
"transcript": "ENST00000936822.1",
"protein_id": "ENSP00000606881.1",
"transcript_support_level": null,
"aa_start": 160,
"aa_end": null,
"aa_length": 417,
"cds_start": 479,
"cds_end": null,
"cds_length": 1254,
"cdna_start": 549,
"cdna_end": null,
"cdna_length": 1883,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000936822.1"
},
{
"aa_ref": "V",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADCK1",
"gene_hgnc_id": 19038,
"hgvs_c": "c.797T>C",
"hgvs_p": "p.Val266Ala",
"transcript": "ENST00000936815.1",
"protein_id": "ENSP00000606874.1",
"transcript_support_level": null,
"aa_start": 266,
"aa_end": null,
"aa_length": 407,
"cds_start": 797,
"cds_end": null,
"cds_length": 1224,
"cdna_start": 915,
"cdna_end": null,
"cdna_length": 1902,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000936815.1"
},
{
"aa_ref": "V",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADCK1",
"gene_hgnc_id": 19038,
"hgvs_c": "c.638T>C",
"hgvs_p": "p.Val213Ala",
"transcript": "ENST00000936825.1",
"protein_id": "ENSP00000606884.1",
"transcript_support_level": null,
"aa_start": 213,
"aa_end": null,
"aa_length": 404,
"cds_start": 638,
"cds_end": null,
"cds_length": 1215,
"cdna_start": 649,
"cdna_end": null,
"cdna_length": 1786,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000936825.1"
},
{
"aa_ref": "V",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADCK1",
"gene_hgnc_id": 19038,
"hgvs_c": "c.434T>C",
"hgvs_p": "p.Val145Ala",
"transcript": "ENST00000878180.1",
"protein_id": "ENSP00000548239.1",
"transcript_support_level": null,
"aa_start": 145,
"aa_end": null,
"aa_length": 402,
"cds_start": 434,
"cds_end": null,
"cds_length": 1209,
"cdna_start": 508,
"cdna_end": null,
"cdna_length": 1844,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000878180.1"
},
{
"aa_ref": "V",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADCK1",
"gene_hgnc_id": 19038,
"hgvs_c": "c.434T>C",
"hgvs_p": "p.Val145Ala",
"transcript": "ENST00000936817.1",
"protein_id": "ENSP00000606876.1",
"transcript_support_level": null,
"aa_start": 145,
"aa_end": null,
"aa_length": 402,
"cds_start": 434,
"cds_end": null,
"cds_length": 1209,
"cdna_start": 519,
"cdna_end": null,
"cdna_length": 1860,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000936817.1"
},
{
"aa_ref": "V",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADCK1",
"gene_hgnc_id": 19038,
"hgvs_c": "c.419T>C",
"hgvs_p": "p.Val140Ala",
"transcript": "NM_001366490.2",
"protein_id": "NP_001353419.1",
"transcript_support_level": null,
"aa_start": 140,
"aa_end": null,
"aa_length": 397,
"cds_start": 419,
"cds_end": null,
"cds_length": 1194,
"cdna_start": 988,
"cdna_end": null,
"cdna_length": 3386,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001366490.2"
},
{
"aa_ref": "V",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADCK1",
"gene_hgnc_id": 19038,
"hgvs_c": "c.593T>C",
"hgvs_p": "p.Val198Ala",
"transcript": "ENST00000936816.1",
"protein_id": "ENSP00000606875.1",
"transcript_support_level": null,
"aa_start": 198,
"aa_end": null,
"aa_length": 389,
"cds_start": 593,
"cds_end": null,
"cds_length": 1170,
"cdna_start": 700,
"cdna_end": null,
"cdna_length": 1838,
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}