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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 14-91126957-A-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=14&pos=91126957&ref=A&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "14",
"pos": 91126957,
"ref": "A",
"alt": "T",
"effect": "intron_variant",
"transcript": "ENST00000256324.15",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "DGLUCY",
"gene_hgnc_id": 20498,
"hgvs_c": "c.-82+12674A>T",
"hgvs_p": null,
"transcript": "NM_001102368.3",
"protein_id": "NP_001095838.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 621,
"cds_start": -4,
"cds_end": null,
"cds_length": 1866,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2957,
"mane_select": "ENST00000256324.15",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "DGLUCY",
"gene_hgnc_id": 20498,
"hgvs_c": "c.-82+12674A>T",
"hgvs_p": null,
"transcript": "ENST00000256324.15",
"protein_id": "ENSP00000256324.9",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 621,
"cds_start": -4,
"cds_end": null,
"cds_length": 1866,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2957,
"mane_select": "NM_001102368.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "DGLUCY",
"gene_hgnc_id": 20498,
"hgvs_c": "c.-175+11963A>T",
"hgvs_p": null,
"transcript": "ENST00000522322.5",
"protein_id": "ENSP00000427953.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 616,
"cds_start": -4,
"cds_end": null,
"cds_length": 1851,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2856,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "DGLUCY",
"gene_hgnc_id": 20498,
"hgvs_c": "c.-82+11736A>T",
"hgvs_p": null,
"transcript": "ENST00000523771.5",
"protein_id": "ENSP00000429655.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 616,
"cds_start": -4,
"cds_end": null,
"cds_length": 1851,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2976,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "DGLUCY",
"gene_hgnc_id": 20498,
"hgvs_c": "c.-253+12429A>T",
"hgvs_p": null,
"transcript": "ENST00000523816.5",
"protein_id": "ENSP00000428974.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 616,
"cds_start": -4,
"cds_end": null,
"cds_length": 1851,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2764,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "DGLUCY",
"gene_hgnc_id": 20498,
"hgvs_c": "c.-253+12674A>T",
"hgvs_p": null,
"transcript": "ENST00000521077.6",
"protein_id": "ENSP00000430137.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 581,
"cds_start": -4,
"cds_end": null,
"cds_length": 1746,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2719,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "DGLUCY",
"gene_hgnc_id": 20498,
"hgvs_c": "c.-175+12429A>T",
"hgvs_p": null,
"transcript": "ENST00000517518.5",
"protein_id": "ENSP00000428652.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 430,
"cds_start": -4,
"cds_end": null,
"cds_length": 1295,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1597,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "DGLUCY",
"gene_hgnc_id": 20498,
"hgvs_c": "c.-253+12674A>T",
"hgvs_p": null,
"transcript": "ENST00000518665.6",
"protein_id": "ENSP00000429098.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 159,
"cds_start": -4,
"cds_end": null,
"cds_length": 480,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 959,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "DGLUCY",
"gene_hgnc_id": 20498,
"hgvs_c": "c.-82+11963A>T",
"hgvs_p": null,
"transcript": "ENST00000523894.5",
"protein_id": "ENSP00000429459.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 151,
"cds_start": -4,
"cds_end": null,
"cds_length": 456,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 862,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 8,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "DGLUCY",
"gene_hgnc_id": 20498,
"hgvs_c": "n.-30+12674A>T",
"hgvs_p": null,
"transcript": "ENST00000519994.5",
"protein_id": "ENSP00000429967.1",
"transcript_support_level": 1,
"aa_start": null,
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"aa_length": null,
"cds_start": -4,
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"cdna_start": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 17,
"intron_rank": 1,
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"gene_symbol": "DGLUCY",
"gene_hgnc_id": 20498,
"hgvs_c": "c.-532+12429A>T",
"hgvs_p": null,
"transcript": "NM_001286470.2",
"protein_id": "NP_001273399.1",
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},
{
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"consequences": [
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],
"exon_rank": null,
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"gene_symbol": "DGLUCY",
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"hgvs_c": "c.-81-30682A>T",
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"transcript": "NM_001358310.2",
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},
{
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],
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"gene_symbol": "DGLUCY",
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"hgvs_c": "c.-81-30682A>T",
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"transcript": "NM_001358312.2",
"protein_id": "NP_001345241.1",
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},
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],
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"gene_symbol": "DGLUCY",
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},
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],
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},
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],
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},
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],
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"gene_symbol": "DGLUCY",
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"hgvs_c": "c.-81-30682A>T",
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"transcript": "NM_001358311.2",
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],
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"gene_symbol": "DGLUCY",
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"transcript": "NM_024952.8",
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],
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"gene_symbol": "DGLUCY",
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"hgvs_c": "c.-253+12674A>T",
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"transcript": "NM_001102369.3",
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},
{
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"consequences": [
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],
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"gene_symbol": "DGLUCY",
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"hgvs_c": "c.-253+12674A>T",
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