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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 14-92732735-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=14&pos=92732735&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "14",
"pos": 92732735,
"ref": "C",
"alt": "T",
"effect": "missense_variant",
"transcript": "ENST00000334869.9",
"consequences": [
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LGMN",
"gene_hgnc_id": 9472,
"hgvs_c": "c.52G>A",
"hgvs_p": "p.Val18Ile",
"transcript": "NM_005606.7",
"protein_id": "NP_005597.3",
"transcript_support_level": null,
"aa_start": 18,
"aa_end": null,
"aa_length": 433,
"cds_start": 52,
"cds_end": null,
"cds_length": 1302,
"cdna_start": 220,
"cdna_end": null,
"cdna_length": 1980,
"mane_select": "ENST00000334869.9",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LGMN",
"gene_hgnc_id": 9472,
"hgvs_c": "c.52G>A",
"hgvs_p": "p.Val18Ile",
"transcript": "ENST00000334869.9",
"protein_id": "ENSP00000334052.4",
"transcript_support_level": 1,
"aa_start": 18,
"aa_end": null,
"aa_length": 433,
"cds_start": 52,
"cds_end": null,
"cds_length": 1302,
"cdna_start": 220,
"cdna_end": null,
"cdna_length": 1980,
"mane_select": "NM_005606.7",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LGMN",
"gene_hgnc_id": 9472,
"hgvs_c": "c.52G>A",
"hgvs_p": "p.Val18Ile",
"transcript": "ENST00000393218.6",
"protein_id": "ENSP00000376911.2",
"transcript_support_level": 1,
"aa_start": 18,
"aa_end": null,
"aa_length": 433,
"cds_start": 52,
"cds_end": null,
"cds_length": 1302,
"cdna_start": 390,
"cdna_end": null,
"cdna_length": 2115,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LGMN",
"gene_hgnc_id": 9472,
"hgvs_c": "c.52G>A",
"hgvs_p": "p.Val18Ile",
"transcript": "NM_001008530.3",
"protein_id": "NP_001008530.1",
"transcript_support_level": null,
"aa_start": 18,
"aa_end": null,
"aa_length": 433,
"cds_start": 52,
"cds_end": null,
"cds_length": 1302,
"cdna_start": 338,
"cdna_end": null,
"cdna_length": 2098,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LGMN",
"gene_hgnc_id": 9472,
"hgvs_c": "c.52G>A",
"hgvs_p": "p.Val18Ile",
"transcript": "NM_001437394.1",
"protein_id": "NP_001424323.1",
"transcript_support_level": null,
"aa_start": 18,
"aa_end": null,
"aa_length": 429,
"cds_start": 52,
"cds_end": null,
"cds_length": 1290,
"cdna_start": 220,
"cdna_end": null,
"cdna_length": 1912,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LGMN",
"gene_hgnc_id": 9472,
"hgvs_c": "c.52G>A",
"hgvs_p": "p.Val18Ile",
"transcript": "NM_001363696.2",
"protein_id": "NP_001350625.1",
"transcript_support_level": null,
"aa_start": 18,
"aa_end": null,
"aa_length": 376,
"cds_start": 52,
"cds_end": null,
"cds_length": 1131,
"cdna_start": 338,
"cdna_end": null,
"cdna_length": 1927,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LGMN",
"gene_hgnc_id": 9472,
"hgvs_c": "c.52G>A",
"hgvs_p": "p.Val18Ile",
"transcript": "NM_001437397.1",
"protein_id": "NP_001424326.1",
"transcript_support_level": null,
"aa_start": 18,
"aa_end": null,
"aa_length": 376,
"cds_start": 52,
"cds_end": null,
"cds_length": 1131,
"cdna_start": 220,
"cdna_end": null,
"cdna_length": 1809,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LGMN",
"gene_hgnc_id": 9472,
"hgvs_c": "c.52G>A",
"hgvs_p": "p.Val18Ile",
"transcript": "ENST00000557434.5",
"protein_id": "ENSP00000452572.1",
"transcript_support_level": 5,
"aa_start": 18,
"aa_end": null,
"aa_length": 376,
"cds_start": 52,
"cds_end": null,
"cds_length": 1131,
"cdna_start": 238,
"cdna_end": null,
"cdna_length": 1797,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LGMN",
"gene_hgnc_id": 9472,
"hgvs_c": "c.52G>A",
"hgvs_p": "p.Val18Ile",
"transcript": "NM_001363699.2",
"protein_id": "NP_001350628.1",
"transcript_support_level": null,
"aa_start": 18,
"aa_end": null,
"aa_length": 372,
"cds_start": 52,
"cds_end": null,
"cds_length": 1119,
"cdna_start": 338,
"cdna_end": null,
"cdna_length": 1859,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LGMN",
"gene_hgnc_id": 9472,
"hgvs_c": "c.52G>A",
"hgvs_p": "p.Val18Ile",
"transcript": "NM_001437403.1",
"protein_id": "NP_001424332.1",
"transcript_support_level": null,
"aa_start": 18,
"aa_end": null,
"aa_length": 372,
"cds_start": 52,
"cds_end": null,
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"cdna_start": 220,
"cdna_end": null,
"cdna_length": 1741,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LGMN",
"gene_hgnc_id": 9472,
"hgvs_c": "c.52G>A",
"hgvs_p": "p.Val18Ile",
"transcript": "ENST00000555699.5",
"protein_id": "ENSP00000451861.1",
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"cds_start": 52,
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"cdna_start": 205,
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"feature": null
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
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"exon_count": 6,
"intron_rank": null,
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"gene_symbol": "LGMN",
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},
{
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],
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"exon_count": 4,
"intron_rank": null,
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"gene_symbol": "LGMN",
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"hgvs_c": "c.52G>A",
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"transcript": "ENST00000554397.5",
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},
{
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],
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},
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"transcript": "ENST00000554080.5",
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},
{
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],
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"intron_rank": null,
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"gene_symbol": "LGMN",
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"hgvs_c": "c.52G>A",
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},
{
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],
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"hgvs_c": "c.52G>A",
"hgvs_p": "p.Val18Ile",
"transcript": "ENST00000553918.1",
"protein_id": "ENSP00000450619.1",
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},
{
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"consequences": [
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],
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"exon_count": 14,
"intron_rank": null,
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"gene_symbol": "LGMN",
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"hgvs_c": "c.52G>A",
"hgvs_p": "p.Val18Ile",
"transcript": "XM_017021463.2",
"protein_id": "XP_016876952.1",
"transcript_support_level": null,
"aa_start": 18,
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"cds_start": 52,
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"cdna_start": 99,
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},
{
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"gene_symbol": "LGMN",
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"hgvs_c": "c.52G>A",
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},
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"strand": false,
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],
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"intron_rank": null,
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"gene_symbol": "LGMN",
"gene_hgnc_id": 9472,
"hgvs_c": "c.52G>A",
"hgvs_p": "p.Val18Ile",
"transcript": "XM_047431597.1",
"protein_id": "XP_047287553.1",
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"aa_end": null,
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},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": 2,
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"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LGMN",
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"hgvs_c": "c.52G>A",
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"cdna_start": 199,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LGMN",
"gene_hgnc_id": 9472,
"hgvs_c": "n.52G>A",
"hgvs_p": null,
"transcript": "ENST00000554189.5",
"protein_id": "ENSP00000450483.1",
"transcript_support_level": 4,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 570,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LGMN",
"gene_hgnc_id": 9472,
"hgvs_c": "n.52G>A",
"hgvs_p": null,
"transcript": "ENST00000556097.5",
"protein_id": "ENSP00000451746.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
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{
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"clinvar_disease": "",
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}
],
"message": null
}