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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 14-94582891-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=14&pos=94582891&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "14",
"pos": 94582891,
"ref": "G",
"alt": "T",
"effect": "intron_variant",
"transcript": "NM_000624.6",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "SERPINA5",
"gene_hgnc_id": 8723,
"hgvs_c": "c.-18+1181G>T",
"hgvs_p": null,
"transcript": "NM_000624.6",
"protein_id": "NP_000615.3",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 406,
"cds_start": null,
"cds_end": null,
"cds_length": 1221,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000329597.12",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_000624.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "SERPINA5",
"gene_hgnc_id": 8723,
"hgvs_c": "c.-18+1181G>T",
"hgvs_p": null,
"transcript": "ENST00000329597.12",
"protein_id": "ENSP00000333203.7",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 406,
"cds_start": null,
"cds_end": null,
"cds_length": 1221,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_000624.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000329597.12"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "SERPINA5",
"gene_hgnc_id": 8723,
"hgvs_c": "c.-18+1181G>T",
"hgvs_p": null,
"transcript": "ENST00000554276.1",
"protein_id": "ENSP00000451610.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 406,
"cds_start": null,
"cds_end": null,
"cds_length": 1221,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000554276.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "SERPINA5",
"gene_hgnc_id": 8723,
"hgvs_c": "c.-18+2361G>T",
"hgvs_p": null,
"transcript": "ENST00000553780.5",
"protein_id": "ENSP00000450837.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 406,
"cds_start": null,
"cds_end": null,
"cds_length": 1221,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000553780.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "SERPINA5",
"gene_hgnc_id": 8723,
"hgvs_c": "c.-18+1401G>T",
"hgvs_p": null,
"transcript": "ENST00000554866.5",
"protein_id": "ENSP00000451126.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 406,
"cds_start": null,
"cds_end": null,
"cds_length": 1221,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000554866.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "SERPINA5",
"gene_hgnc_id": 8723,
"hgvs_c": "c.-156+1181G>T",
"hgvs_p": null,
"transcript": "ENST00000884744.1",
"protein_id": "ENSP00000554803.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 406,
"cds_start": null,
"cds_end": null,
"cds_length": 1221,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000884744.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "SERPINA5",
"gene_hgnc_id": 8723,
"hgvs_c": "c.-191+1181G>T",
"hgvs_p": null,
"transcript": "ENST00000884745.1",
"protein_id": "ENSP00000554804.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 406,
"cds_start": null,
"cds_end": null,
"cds_length": 1221,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000884745.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "SERPINA5",
"gene_hgnc_id": 8723,
"hgvs_c": "c.-156+1401G>T",
"hgvs_p": null,
"transcript": "ENST00000884746.1",
"protein_id": "ENSP00000554805.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 406,
"cds_start": null,
"cds_end": null,
"cds_length": 1221,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000884746.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "SERPINA5",
"gene_hgnc_id": 8723,
"hgvs_c": "c.-18+1181G>T",
"hgvs_p": null,
"transcript": "ENST00000884747.1",
"protein_id": "ENSP00000554806.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 406,
"cds_start": null,
"cds_end": null,
"cds_length": 1221,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000884747.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "SERPINA5",
"gene_hgnc_id": 8723,
"hgvs_c": "c.-18+1253G>T",
"hgvs_p": null,
"transcript": "ENST00000884749.1",
"protein_id": "ENSP00000554808.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 406,
"cds_start": null,
"cds_end": null,
"cds_length": 1221,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000884749.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "SERPINA5",
"gene_hgnc_id": 8723,
"hgvs_c": "c.-191+1401G>T",
"hgvs_p": null,
"transcript": "ENST00000884751.1",
"protein_id": "ENSP00000554810.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 406,
"cds_start": null,
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"cds_length": 1221,
"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000884751.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "SERPINA5",
"gene_hgnc_id": 8723,
"hgvs_c": "c.-11+1401G>T",
"hgvs_p": null,
"transcript": "ENST00000884752.1",
"protein_id": "ENSP00000554811.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 406,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000884752.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "SERPINA5",
"gene_hgnc_id": 8723,
"hgvs_c": "c.-156+1253G>T",
"hgvs_p": null,
"transcript": "ENST00000884753.1",
"protein_id": "ENSP00000554812.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 406,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000884753.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 5,
"intron_rank": 1,
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"gene_symbol": "SERPINA5",
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"hgvs_c": "c.-39+1401G>T",
"hgvs_p": null,
"transcript": "ENST00000884754.1",
"protein_id": "ENSP00000554813.1",
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"biotype": "protein_coding",
"feature": "ENST00000884754.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "SERPINA5",
"gene_hgnc_id": 8723,
"hgvs_c": "c.-18+171G>T",
"hgvs_p": null,
"transcript": "ENST00000884755.1",
"protein_id": "ENSP00000554814.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": null,
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"feature": "ENST00000884755.1"
},
{
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"strand": true,
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],
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"exon_count": 6,
"intron_rank": 1,
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"gene_symbol": "SERPINA5",
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"biotype": "protein_coding",
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "SERPINA5",
"gene_hgnc_id": 8723,
"hgvs_c": "c.-18+1401G>T",
"hgvs_p": null,
"transcript": "ENST00000884748.1",
"protein_id": "ENSP00000554807.1",
"transcript_support_level": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000884748.1"
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "SERPINA5",
"gene_hgnc_id": 8723,
"hgvs_c": "c.-18+1181G>T",
"hgvs_p": null,
"transcript": "ENST00000884750.1",
"protein_id": "ENSP00000554809.1",
"transcript_support_level": null,
"aa_start": null,
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"biotype": "protein_coding",
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},
{
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"strand": true,
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],
"exon_rank": null,
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"exon_count": 4,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "SERPINA5",
"gene_hgnc_id": 8723,
"hgvs_c": "c.-18+1253G>T",
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"transcript": "ENST00000556775.5",
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 2,
"intron_rank": 1,
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"gene_symbol": "SERPINA5",
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"hgvs_c": "c.-17-4455G>T",
"hgvs_p": null,
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},
{
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"strand": true,
"consequences": [
"intron_variant"
],
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"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "SERPINA5",
"gene_hgnc_id": 8723,
"hgvs_c": "c.-18+893G>T",
"hgvs_p": null,
"transcript": "ENST00000557598.1",
"protein_id": "ENSP00000450485.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
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"cds_start": null,
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"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000557598.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "SERPINA5",
"gene_hgnc_id": 8723,
"hgvs_c": "c.-18+1253G>T",
"hgvs_p": null,
"transcript": "ENST00000555681.1",
"protein_id": "ENSP00000451650.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 143,
"cds_start": null,
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"cds_length": 433,
"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000555681.1"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
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{
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}
],
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}