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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 15-27951891-T-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=15&pos=27951891&ref=T&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "15",
"pos": 27951891,
"ref": "T",
"alt": "A",
"effect": "missense_variant,splice_region_variant",
"transcript": "NM_000275.3",
"consequences": [
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OCA2",
"gene_hgnc_id": 8101,
"hgvs_c": "c.1844A>T",
"hgvs_p": "p.His615Leu",
"transcript": "NM_000275.3",
"protein_id": "NP_000266.2",
"transcript_support_level": null,
"aa_start": 615,
"aa_end": null,
"aa_length": 838,
"cds_start": 1844,
"cds_end": null,
"cds_length": 2517,
"cdna_start": 1957,
"cdna_end": null,
"cdna_length": 3143,
"mane_select": "ENST00000354638.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_000275.3"
},
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OCA2",
"gene_hgnc_id": 8101,
"hgvs_c": "c.1844A>T",
"hgvs_p": "p.His615Leu",
"transcript": "ENST00000354638.8",
"protein_id": "ENSP00000346659.3",
"transcript_support_level": 1,
"aa_start": 615,
"aa_end": null,
"aa_length": 838,
"cds_start": 1844,
"cds_end": null,
"cds_length": 2517,
"cdna_start": 1957,
"cdna_end": null,
"cdna_length": 3143,
"mane_select": "NM_000275.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000354638.8"
},
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OCA2",
"gene_hgnc_id": 8101,
"hgvs_c": "c.1772A>T",
"hgvs_p": "p.His591Leu",
"transcript": "ENST00000353809.9",
"protein_id": "ENSP00000261276.8",
"transcript_support_level": 1,
"aa_start": 591,
"aa_end": null,
"aa_length": 814,
"cds_start": 1772,
"cds_end": null,
"cds_length": 2445,
"cdna_start": 1882,
"cdna_end": null,
"cdna_length": 3068,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000353809.9"
},
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OCA2",
"gene_hgnc_id": 8101,
"hgvs_c": "c.1844A>T",
"hgvs_p": "p.His615Leu",
"transcript": "ENST00000910120.1",
"protein_id": "ENSP00000580179.1",
"transcript_support_level": null,
"aa_start": 615,
"aa_end": null,
"aa_length": 920,
"cds_start": 1844,
"cds_end": null,
"cds_length": 2763,
"cdna_start": 1957,
"cdna_end": null,
"cdna_length": 3389,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000910120.1"
},
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OCA2",
"gene_hgnc_id": 8101,
"hgvs_c": "c.1997A>T",
"hgvs_p": "p.His666Leu",
"transcript": "ENST00000943942.1",
"protein_id": "ENSP00000614001.1",
"transcript_support_level": null,
"aa_start": 666,
"aa_end": null,
"aa_length": 889,
"cds_start": 1997,
"cds_end": null,
"cds_length": 2670,
"cdna_start": 2356,
"cdna_end": null,
"cdna_length": 3538,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000943942.1"
},
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OCA2",
"gene_hgnc_id": 8101,
"hgvs_c": "c.1844A>T",
"hgvs_p": "p.His615Leu",
"transcript": "ENST00000943940.1",
"protein_id": "ENSP00000613999.1",
"transcript_support_level": null,
"aa_start": 615,
"aa_end": null,
"aa_length": 852,
"cds_start": 1844,
"cds_end": null,
"cds_length": 2559,
"cdna_start": 1996,
"cdna_end": null,
"cdna_length": 3224,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000943940.1"
},
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OCA2",
"gene_hgnc_id": 8101,
"hgvs_c": "c.1772A>T",
"hgvs_p": "p.His591Leu",
"transcript": "NM_001300984.2",
"protein_id": "NP_001287913.1",
"transcript_support_level": null,
"aa_start": 591,
"aa_end": null,
"aa_length": 814,
"cds_start": 1772,
"cds_end": null,
"cds_length": 2445,
"cdna_start": 1885,
"cdna_end": null,
"cdna_length": 3071,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001300984.2"
},
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OCA2",
"gene_hgnc_id": 8101,
"hgvs_c": "c.1772A>T",
"hgvs_p": "p.His591Leu",
"transcript": "ENST00000943939.1",
"protein_id": "ENSP00000613998.1",
"transcript_support_level": null,
"aa_start": 591,
"aa_end": null,
"aa_length": 814,
"cds_start": 1772,
"cds_end": null,
"cds_length": 2445,
"cdna_start": 1843,
"cdna_end": null,
"cdna_length": 3025,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000943939.1"
},
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OCA2",
"gene_hgnc_id": 8101,
"hgvs_c": "c.1844A>T",
"hgvs_p": "p.His615Leu",
"transcript": "ENST00000910119.1",
"protein_id": "ENSP00000580178.1",
"transcript_support_level": null,
"aa_start": 615,
"aa_end": null,
"aa_length": 783,
"cds_start": 1844,
"cds_end": null,
"cds_length": 2352,
"cdna_start": 1957,
"cdna_end": null,
"cdna_length": 2979,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000910119.1"
},
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OCA2",
"gene_hgnc_id": 8101,
"hgvs_c": "c.1772A>T",
"hgvs_p": "p.His591Leu",
"transcript": "ENST00000943941.1",
"protein_id": "ENSP00000614000.1",
"transcript_support_level": null,
"aa_start": 591,
"aa_end": null,
"aa_length": 759,
"cds_start": 1772,
"cds_end": null,
"cds_length": 2280,
"cdna_start": 1879,
"cdna_end": null,
"cdna_length": 2895,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000943941.1"
},
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OCA2",
"gene_hgnc_id": 8101,
"hgvs_c": "c.1868A>T",
"hgvs_p": "p.His623Leu",
"transcript": "XM_017022255.2",
"protein_id": "XP_016877744.1",
"transcript_support_level": null,
"aa_start": 623,
"aa_end": null,
"aa_length": 860,
"cds_start": 1868,
"cds_end": null,
"cds_length": 2583,
"cdna_start": 3210,
"cdna_end": null,
"cdna_length": 4438,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017022255.2"
},
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OCA2",
"gene_hgnc_id": 8101,
"hgvs_c": "c.1844A>T",
"hgvs_p": "p.His615Leu",
"transcript": "XM_011521640.3",
"protein_id": "XP_011519942.1",
"transcript_support_level": null,
"aa_start": 615,
"aa_end": null,
"aa_length": 852,
"cds_start": 1844,
"cds_end": null,
"cds_length": 2559,
"cdna_start": 1957,
"cdna_end": null,
"cdna_length": 3185,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011521640.3"
},
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OCA2",
"gene_hgnc_id": 8101,
"hgvs_c": "c.1868A>T",
"hgvs_p": "p.His623Leu",
"transcript": "XM_017022256.2",
"protein_id": "XP_016877745.1",
"transcript_support_level": null,
"aa_start": 623,
"aa_end": null,
"aa_length": 846,
"cds_start": 1868,
"cds_end": null,
"cds_length": 2541,
"cdna_start": 4162,
"cdna_end": null,
"cdna_length": 5348,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017022256.2"
},
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OCA2",
"gene_hgnc_id": 8101,
"hgvs_c": "c.1796A>T",
"hgvs_p": "p.His599Leu",
"transcript": "XM_017022257.2",
"protein_id": "XP_016877746.1",
"transcript_support_level": null,
"aa_start": 599,
"aa_end": null,
"aa_length": 836,
"cds_start": 1796,
"cds_end": null,
"cds_length": 2511,
"cdna_start": 4091,
"cdna_end": null,
"cdna_length": 5319,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017022257.2"
},
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OCA2",
"gene_hgnc_id": 8101,
"hgvs_c": "c.1868A>T",
"hgvs_p": "p.His623Leu",
"transcript": "XM_017022258.2",
"protein_id": "XP_016877747.1",
"transcript_support_level": null,
"aa_start": 623,
"aa_end": null,
"aa_length": 835,
"cds_start": 1868,
"cds_end": null,
"cds_length": 2508,
"cdna_start": 4165,
"cdna_end": null,
"cdna_length": 5074,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017022258.2"
},
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OCA2",
"gene_hgnc_id": 8101,
"hgvs_c": "c.1772A>T",
"hgvs_p": "p.His591Leu",
"transcript": "XM_047432605.1",
"protein_id": "XP_047288561.1",
"transcript_support_level": null,
"aa_start": 591,
"aa_end": null,
"aa_length": 828,
"cds_start": 1772,
"cds_end": null,
"cds_length": 2487,
"cdna_start": 1885,
"cdna_end": null,
"cdna_length": 3113,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047432605.1"
},
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OCA2",
"gene_hgnc_id": 8101,
"hgvs_c": "c.1844A>T",
"hgvs_p": "p.His615Leu",
"transcript": "XM_047432606.1",
"protein_id": "XP_047288562.1",
"transcript_support_level": null,
"aa_start": 615,
"aa_end": null,
"aa_length": 827,
"cds_start": 1844,
"cds_end": null,
"cds_length": 2484,
"cdna_start": 1957,
"cdna_end": null,
"cdna_length": 2866,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047432606.1"
},
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OCA2",
"gene_hgnc_id": 8101,
"hgvs_c": "c.1796A>T",
"hgvs_p": "p.His599Leu",
"transcript": "XM_017022259.2",
"protein_id": "XP_016877748.1",
"transcript_support_level": null,
"aa_start": 599,
"aa_end": null,
"aa_length": 822,
"cds_start": 1796,
"cds_end": null,
"cds_length": 2469,
"cdna_start": 4089,
"cdna_end": null,
"cdna_length": 5275,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017022259.2"
},
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OCA2",
"gene_hgnc_id": 8101,
"hgvs_c": "c.1730A>T",
"hgvs_p": "p.His577Leu",
"transcript": "XM_017022260.2",
"protein_id": "XP_016877749.1",
"transcript_support_level": null,
"aa_start": 577,
"aa_end": null,
"aa_length": 814,
"cds_start": 1730,
"cds_end": null,
"cds_length": 2445,
"cdna_start": 4026,
"cdna_end": null,
"cdna_length": 5254,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017022260.2"
},
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OCA2",
"gene_hgnc_id": 8101,
"hgvs_c": "c.1796A>T",
"hgvs_p": "p.His599Leu",
"transcript": "XM_047432607.1",
"protein_id": "XP_047288563.1",
"transcript_support_level": null,
"aa_start": 599,
"aa_end": null,
"aa_length": 811,
"cds_start": 1796,
"cds_end": null,
"cds_length": 2436,
"cdna_start": 4092,
"cdna_end": null,
"cdna_length": 5001,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047432607.1"
},
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OCA2",
"gene_hgnc_id": 8101,
"hgvs_c": "c.1706A>T",
"hgvs_p": "p.His569Leu",
"transcript": "XM_047432608.1",
"protein_id": "XP_047288564.1",
"transcript_support_level": null,
"aa_start": 569,
"aa_end": null,
"aa_length": 806,
"cds_start": 1706,
"cds_end": null,
"cds_length": 2421,
"cdna_start": 1819,
"cdna_end": null,
"cdna_length": 3047,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047432608.1"
},
{
"aa_ref": "H",
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}