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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 15-32131649-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=15&pos=32131649&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "15",
"pos": 32131649,
"ref": "A",
"alt": "G",
"effect": "intron_variant",
"transcript": "ENST00000306901.9",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "CHRNA7",
"gene_hgnc_id": 1960,
"hgvs_c": "c.350+19750A>G",
"hgvs_p": null,
"transcript": "NM_000746.6",
"protein_id": "NP_000737.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 502,
"cds_start": -4,
"cds_end": null,
"cds_length": 1509,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6149,
"mane_select": "ENST00000306901.9",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "CHRNA7",
"gene_hgnc_id": 1960,
"hgvs_c": "c.350+19750A>G",
"hgvs_p": null,
"transcript": "ENST00000306901.9",
"protein_id": "ENSP00000303727.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 502,
"cds_start": -4,
"cds_end": null,
"cds_length": 1509,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6149,
"mane_select": "NM_000746.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "CHRNA7",
"gene_hgnc_id": 1960,
"hgvs_c": "c.437+19750A>G",
"hgvs_p": null,
"transcript": "NM_001190455.3",
"protein_id": "NP_001177384.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 531,
"cds_start": -4,
"cds_end": null,
"cds_length": 1596,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6236,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "CHRNA7",
"gene_hgnc_id": 1960,
"hgvs_c": "c.437+19750A>G",
"hgvs_p": null,
"transcript": "ENST00000454250.7",
"protein_id": "ENSP00000407546.3",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 531,
"cds_start": -4,
"cds_end": null,
"cds_length": 1596,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2093,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "CHRNA7",
"gene_hgnc_id": 1960,
"hgvs_c": "c.437+19750A>G",
"hgvs_p": null,
"transcript": "ENST00000675428.1",
"protein_id": "ENSP00000502560.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 531,
"cds_start": -4,
"cds_end": null,
"cds_length": 1596,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2093,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "CHRNA7",
"gene_hgnc_id": 1960,
"hgvs_c": "c.164+19750A>G",
"hgvs_p": null,
"transcript": "ENST00000636603.1",
"protein_id": "ENSP00000490513.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 440,
"cds_start": -4,
"cds_end": null,
"cds_length": 1323,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2012,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "CHRNA7",
"gene_hgnc_id": 1960,
"hgvs_c": "c.164+19750A>G",
"hgvs_p": null,
"transcript": "ENST00000637033.1",
"protein_id": "ENSP00000490227.1",
"transcript_support_level": 5,
"aa_start": null,
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"aa_length": 440,
"cds_start": -4,
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"cds_length": 1323,
"cdna_start": null,
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"cdna_length": 3204,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "CHRNA7",
"gene_hgnc_id": 1960,
"hgvs_c": "c.113+19750A>G",
"hgvs_p": null,
"transcript": "ENST00000637183.1",
"protein_id": "ENSP00000490365.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 423,
"cds_start": -4,
"cds_end": null,
"cds_length": 1272,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2912,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "CHRNA7",
"gene_hgnc_id": 1960,
"hgvs_c": "c.164+19750A>G",
"hgvs_p": null,
"transcript": "ENST00000635884.1",
"protein_id": "ENSP00000489834.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 318,
"cds_start": -4,
"cds_end": null,
"cds_length": 957,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1975,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 9,
"intron_rank": 4,
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"gene_symbol": "CHRNA7",
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"hgvs_c": "c.371+19750A>G",
"hgvs_p": null,
"transcript": "ENST00000636440.1",
"protein_id": "ENSP00000490366.1",
"transcript_support_level": 5,
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"cds_start": -4,
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"cdna_start": null,
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 9,
"intron_rank": 4,
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"gene_symbol": "CHRNA7",
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"hgvs_c": "c.350+19750A>G",
"hgvs_p": null,
"transcript": "ENST00000637552.1",
"protein_id": "ENSP00000490773.1",
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},
{
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],
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"gene_symbol": "CHRNA7",
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},
{
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],
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"gene_symbol": "CHRNA7",
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"hgvs_c": "c.113+19750A>G",
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"transcript": "ENST00000635978.1",
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},
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],
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"gene_symbol": "CHRNA7",
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"hgvs_c": "n.241-25959A>G",
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},
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],
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},
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],
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},
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},
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],
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"gene_symbol": "CHRNA7",
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"hgvs_c": "n.720+19750A>G",
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"transcript": "ENST00000636292.1",
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},
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],
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"intron_rank": 3,
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"gene_symbol": "CHRNA7",
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],
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],
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],
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"gene_symbol": "CHRNA7",
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},
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"strand": true,
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],
"exon_rank": null,
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"exon_count": 11,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "CHRNA7",
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"hgvs_c": "n.477+19286A>G",
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"transcript": "ENST00000637971.1",
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}
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}