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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 15-37072053-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=15&pos=37072053&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "15",
"pos": 37072053,
"ref": "G",
"alt": "A",
"effect": "intron_variant",
"transcript": "ENST00000561208.6",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "MEIS2",
"gene_hgnc_id": 7001,
"hgvs_c": "c.754+11718C>T",
"hgvs_p": null,
"transcript": "NM_170675.5",
"protein_id": "NP_733775.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 477,
"cds_start": -4,
"cds_end": null,
"cds_length": 1434,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5486,
"mane_select": "ENST00000561208.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "MEIS2",
"gene_hgnc_id": 7001,
"hgvs_c": "c.754+11718C>T",
"hgvs_p": null,
"transcript": "ENST00000561208.6",
"protein_id": "ENSP00000453793.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 477,
"cds_start": -4,
"cds_end": null,
"cds_length": 1434,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5486,
"mane_select": "NM_170675.5",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "MEIS2",
"gene_hgnc_id": 7001,
"hgvs_c": "c.754+11718C>T",
"hgvs_p": null,
"transcript": "ENST00000338564.9",
"protein_id": "ENSP00000341400.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 470,
"cds_start": -4,
"cds_end": null,
"cds_length": 1413,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4829,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "MEIS2",
"gene_hgnc_id": 7001,
"hgvs_c": "c.754+11718C>T",
"hgvs_p": null,
"transcript": "ENST00000424352.6",
"protein_id": "ENSP00000404185.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 401,
"cds_start": -4,
"cds_end": null,
"cds_length": 1206,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2917,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "MEIS2",
"gene_hgnc_id": 7001,
"hgvs_c": "c.715+11718C>T",
"hgvs_p": null,
"transcript": "ENST00000340545.9",
"protein_id": "ENSP00000339549.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 381,
"cds_start": -4,
"cds_end": null,
"cds_length": 1146,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3056,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "MEIS2",
"gene_hgnc_id": 7001,
"hgvs_c": "c.754+11718C>T",
"hgvs_p": null,
"transcript": "NM_001220482.2",
"protein_id": "NP_001207411.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 470,
"cds_start": -4,
"cds_end": null,
"cds_length": 1413,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4935,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "MEIS2",
"gene_hgnc_id": 7001,
"hgvs_c": "c.754+11718C>T",
"hgvs_p": null,
"transcript": "NM_170676.5",
"protein_id": "NP_733776.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 470,
"cds_start": -4,
"cds_end": null,
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"cdna_start": null,
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"cdna_length": 5465,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "MEIS2",
"gene_hgnc_id": 7001,
"hgvs_c": "c.715+11718C>T",
"hgvs_p": null,
"transcript": "ENST00000699904.1",
"protein_id": "ENSP00000514680.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 435,
"cds_start": -4,
"cds_end": null,
"cds_length": 1308,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2534,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "MEIS2",
"gene_hgnc_id": 7001,
"hgvs_c": "c.754+11718C>T",
"hgvs_p": null,
"transcript": "NM_170677.5",
"protein_id": "NP_733777.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 401,
"cds_start": -4,
"cds_end": null,
"cds_length": 1206,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5582,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 13,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "MEIS2",
"gene_hgnc_id": 7001,
"hgvs_c": "c.754+11718C>T",
"hgvs_p": null,
"transcript": "NM_170674.5",
"protein_id": "NP_733774.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 12,
"intron_rank": 7,
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"gene_symbol": "MEIS2",
"gene_hgnc_id": 7001,
"hgvs_c": "c.754+11718C>T",
"hgvs_p": null,
"transcript": "ENST00000559561.5",
"protein_id": "ENSP00000453497.1",
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},
{
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"strand": false,
"consequences": [
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],
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"transcript": "NM_172315.3",
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},
{
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"strand": false,
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],
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"gene_symbol": "MEIS2",
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},
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],
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"gene_symbol": "MEIS2",
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"hgvs_c": "c.715+11718C>T",
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],
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},
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],
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"gene_symbol": "MEIS2",
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],
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"gene_symbol": "MEIS2",
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"hgvs_c": "c.316+11718C>T",
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},
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],
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"intron_rank": 7,
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"gene_symbol": "MEIS2",
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"hgvs_c": "c.490+11718C>T",
"hgvs_p": null,
"transcript": "NM_172316.3",
"protein_id": "NP_758527.1",
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},
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"strand": false,
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],
"exon_rank": null,
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"exon_count": 8,
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"gene_symbol": "MEIS2",
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"hgvs_c": "c.331+11718C>T",
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"transcript": "ENST00000607277.5",
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},
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],
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},
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"consequences": [
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],
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"gene_symbol": "MEIS2",
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"hgvs_c": "n.*473+11718C>T",
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"transcript": "ENST00000397620.6",
"protein_id": "ENSP00000380745.3",
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 12,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "MEIS2",
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"hgvs_c": "n.*473+11718C>T",
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"transcript": "ENST00000397624.7",
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}