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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 15-41504231-A-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=15&pos=41504231&ref=A&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "15",
"pos": 41504231,
"ref": "A",
"alt": "C",
"effect": "missense_variant",
"transcript": "NM_002344.6",
"consequences": [
{
"aa_ref": "L",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LTK",
"gene_hgnc_id": 6721,
"hgvs_c": "c.2360T>G",
"hgvs_p": "p.Leu787Arg",
"transcript": "NM_002344.6",
"protein_id": "NP_002335.2",
"transcript_support_level": null,
"aa_start": 787,
"aa_end": null,
"aa_length": 864,
"cds_start": 2360,
"cds_end": null,
"cds_length": 2595,
"cdna_start": 2478,
"cdna_end": null,
"cdna_length": 3072,
"mane_select": "ENST00000263800.11",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_002344.6"
},
{
"aa_ref": "L",
"aa_alt": "R",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LTK",
"gene_hgnc_id": 6721,
"hgvs_c": "c.2360T>G",
"hgvs_p": "p.Leu787Arg",
"transcript": "ENST00000263800.11",
"protein_id": "ENSP00000263800.6",
"transcript_support_level": 1,
"aa_start": 787,
"aa_end": null,
"aa_length": 864,
"cds_start": 2360,
"cds_end": null,
"cds_length": 2595,
"cdna_start": 2478,
"cdna_end": null,
"cdna_length": 3072,
"mane_select": "NM_002344.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000263800.11"
},
{
"aa_ref": "L",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LTK",
"gene_hgnc_id": 6721,
"hgvs_c": "c.2177T>G",
"hgvs_p": "p.Leu726Arg",
"transcript": "ENST00000355166.9",
"protein_id": "ENSP00000347293.5",
"transcript_support_level": 1,
"aa_start": 726,
"aa_end": null,
"aa_length": 803,
"cds_start": 2177,
"cds_end": null,
"cds_length": 2412,
"cdna_start": 2347,
"cdna_end": null,
"cdna_length": 2940,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000355166.9"
},
{
"aa_ref": "L",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LTK",
"gene_hgnc_id": 6721,
"hgvs_c": "c.1454T>G",
"hgvs_p": "p.Leu485Arg",
"transcript": "ENST00000561619.5",
"protein_id": "ENSP00000458111.1",
"transcript_support_level": 1,
"aa_start": 485,
"aa_end": null,
"aa_length": 562,
"cds_start": 1454,
"cds_end": null,
"cds_length": 1689,
"cdna_start": 1541,
"cdna_end": null,
"cdna_length": 1821,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000561619.5"
},
{
"aa_ref": "L",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LTK",
"gene_hgnc_id": 6721,
"hgvs_c": "c.2408T>G",
"hgvs_p": "p.Leu803Arg",
"transcript": "ENST00000953759.1",
"protein_id": "ENSP00000623818.1",
"transcript_support_level": null,
"aa_start": 803,
"aa_end": null,
"aa_length": 880,
"cds_start": 2408,
"cds_end": null,
"cds_length": 2643,
"cdna_start": 2566,
"cdna_end": null,
"cdna_length": 3160,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000953759.1"
},
{
"aa_ref": "L",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LTK",
"gene_hgnc_id": 6721,
"hgvs_c": "c.2348T>G",
"hgvs_p": "p.Leu783Arg",
"transcript": "ENST00000953763.1",
"protein_id": "ENSP00000623822.1",
"transcript_support_level": null,
"aa_start": 783,
"aa_end": null,
"aa_length": 860,
"cds_start": 2348,
"cds_end": null,
"cds_length": 2583,
"cdna_start": 2464,
"cdna_end": null,
"cdna_length": 3061,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000953763.1"
},
{
"aa_ref": "L",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LTK",
"gene_hgnc_id": 6721,
"hgvs_c": "c.2264T>G",
"hgvs_p": "p.Leu755Arg",
"transcript": "ENST00000953760.1",
"protein_id": "ENSP00000623819.1",
"transcript_support_level": null,
"aa_start": 755,
"aa_end": null,
"aa_length": 832,
"cds_start": 2264,
"cds_end": null,
"cds_length": 2499,
"cdna_start": 2409,
"cdna_end": null,
"cdna_length": 3002,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000953760.1"
},
{
"aa_ref": "L",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LTK",
"gene_hgnc_id": 6721,
"hgvs_c": "c.2225T>G",
"hgvs_p": "p.Leu742Arg",
"transcript": "ENST00000897467.1",
"protein_id": "ENSP00000567526.1",
"transcript_support_level": null,
"aa_start": 742,
"aa_end": null,
"aa_length": 819,
"cds_start": 2225,
"cds_end": null,
"cds_length": 2460,
"cdna_start": 2343,
"cdna_end": null,
"cdna_length": 2937,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000897467.1"
},
{
"aa_ref": "L",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LTK",
"gene_hgnc_id": 6721,
"hgvs_c": "c.2177T>G",
"hgvs_p": "p.Leu726Arg",
"transcript": "NM_206961.4",
"protein_id": "NP_996844.1",
"transcript_support_level": null,
"aa_start": 726,
"aa_end": null,
"aa_length": 803,
"cds_start": 2177,
"cds_end": null,
"cds_length": 2412,
"cdna_start": 2295,
"cdna_end": null,
"cdna_length": 2889,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_206961.4"
},
{
"aa_ref": "L",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LTK",
"gene_hgnc_id": 6721,
"hgvs_c": "c.2153T>G",
"hgvs_p": "p.Leu718Arg",
"transcript": "ENST00000953761.1",
"protein_id": "ENSP00000623820.1",
"transcript_support_level": null,
"aa_start": 718,
"aa_end": null,
"aa_length": 795,
"cds_start": 2153,
"cds_end": null,
"cds_length": 2388,
"cdna_start": 2296,
"cdna_end": null,
"cdna_length": 2890,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000953761.1"
},
{
"aa_ref": "L",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LTK",
"gene_hgnc_id": 6721,
"hgvs_c": "c.2075T>G",
"hgvs_p": "p.Leu692Arg",
"transcript": "ENST00000953764.1",
"protein_id": "ENSP00000623823.1",
"transcript_support_level": null,
"aa_start": 692,
"aa_end": null,
"aa_length": 769,
"cds_start": 2075,
"cds_end": null,
"cds_length": 2310,
"cdna_start": 2195,
"cdna_end": null,
"cdna_length": 2788,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000953764.1"
},
{
"aa_ref": "L",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LTK",
"gene_hgnc_id": 6721,
"hgvs_c": "c.2057T>G",
"hgvs_p": "p.Leu686Arg",
"transcript": "ENST00000953762.1",
"protein_id": "ENSP00000623821.1",
"transcript_support_level": null,
"aa_start": 686,
"aa_end": null,
"aa_length": 763,
"cds_start": 2057,
"cds_end": null,
"cds_length": 2292,
"cdna_start": 2200,
"cdna_end": null,
"cdna_length": 2788,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000953762.1"
},
{
"aa_ref": "L",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LTK",
"gene_hgnc_id": 6721,
"hgvs_c": "c.1970T>G",
"hgvs_p": "p.Leu657Arg",
"transcript": "NM_001135685.2",
"protein_id": "NP_001129157.1",
"transcript_support_level": null,
"aa_start": 657,
"aa_end": null,
"aa_length": 734,
"cds_start": 1970,
"cds_end": null,
"cds_length": 2205,
"cdna_start": 2088,
"cdna_end": null,
"cdna_length": 2682,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001135685.2"
},
{
"aa_ref": "L",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LTK",
"gene_hgnc_id": 6721,
"hgvs_c": "c.1970T>G",
"hgvs_p": "p.Leu657Arg",
"transcript": "ENST00000453182.2",
"protein_id": "ENSP00000392196.2",
"transcript_support_level": 2,
"aa_start": 657,
"aa_end": null,
"aa_length": 734,
"cds_start": 1970,
"cds_end": null,
"cds_length": 2205,
"cdna_start": 2148,
"cdna_end": null,
"cdna_length": 2412,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000453182.2"
},
{
"aa_ref": "L",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LTK",
"gene_hgnc_id": 6721,
"hgvs_c": "c.1874T>G",
"hgvs_p": "p.Leu625Arg",
"transcript": "ENST00000897466.1",
"protein_id": "ENSP00000567525.1",
"transcript_support_level": null,
"aa_start": 625,
"aa_end": null,
"aa_length": 702,
"cds_start": 1874,
"cds_end": null,
"cds_length": 2109,
"cdna_start": 2025,
"cdna_end": null,
"cdna_length": 2619,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000897466.1"
},
{
"aa_ref": "L",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LTK",
"gene_hgnc_id": 6721,
"hgvs_c": "c.1469T>G",
"hgvs_p": "p.Leu490Arg",
"transcript": "ENST00000953765.1",
"protein_id": "ENSP00000623824.1",
"transcript_support_level": null,
"aa_start": 490,
"aa_end": null,
"aa_length": 567,
"cds_start": 1469,
"cds_end": null,
"cds_length": 1704,
"cdna_start": 1586,
"cdna_end": null,
"cdna_length": 2177,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000953765.1"
},
{
"aa_ref": "L",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LTK",
"gene_hgnc_id": 6721,
"hgvs_c": "c.1406T>G",
"hgvs_p": "p.Leu469Arg",
"transcript": "ENST00000897468.1",
"protein_id": "ENSP00000567527.1",
"transcript_support_level": null,
"aa_start": 469,
"aa_end": null,
"aa_length": 546,
"cds_start": 1406,
"cds_end": null,
"cds_length": 1641,
"cdna_start": 1419,
"cdna_end": null,
"cdna_length": 2010,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000897468.1"
},
{
"aa_ref": "L",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LTK",
"gene_hgnc_id": 6721,
"hgvs_c": "c.2240T>G",
"hgvs_p": "p.Leu747Arg",
"transcript": "XM_011521557.3",
"protein_id": "XP_011519859.1",
"transcript_support_level": null,
"aa_start": 747,
"aa_end": null,
"aa_length": 824,
"cds_start": 2240,
"cds_end": null,
"cds_length": 2475,
"cdna_start": 2358,
"cdna_end": null,
"cdna_length": 2952,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011521557.3"
},
{
"aa_ref": "L",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LTK",
"gene_hgnc_id": 6721,
"hgvs_c": "c.2225T>G",
"hgvs_p": "p.Leu742Arg",
"transcript": "XM_047432499.1",
"protein_id": "XP_047288455.1",
"transcript_support_level": null,
"aa_start": 742,
"aa_end": null,
"aa_length": 819,
"cds_start": 2225,
"cds_end": null,
"cds_length": 2460,
"cdna_start": 2343,
"cdna_end": null,
"cdna_length": 2937,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047432499.1"
},
{
"aa_ref": "L",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LTK",
"gene_hgnc_id": 6721,
"hgvs_c": "c.2192T>G",
"hgvs_p": "p.Leu731Arg",
"transcript": "XM_047432500.1",
"protein_id": "XP_047288456.1",
"transcript_support_level": null,
"aa_start": 731,
"aa_end": null,
"aa_length": 808,
"cds_start": 2192,
"cds_end": null,
"cds_length": 2427,
"cdna_start": 2310,
"cdna_end": null,
"cdna_length": 2904,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047432500.1"
},
{
"aa_ref": "L",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LTK",
"gene_hgnc_id": 6721,
"hgvs_c": "c.2096T>G",
"hgvs_p": "p.Leu699Arg",
"transcript": "XM_047432501.1",
"protein_id": "XP_047288457.1",
"transcript_support_level": null,
"aa_start": 699,
"aa_end": null,
"aa_length": 776,
"cds_start": 2096,
"cds_end": null,
"cds_length": 2331,
"cdna_start": 2214,
"cdna_end": null,
"cdna_length": 2808,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047432501.1"
},
{
"aa_ref": "L",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LTK",
"gene_hgnc_id": 6721,
"hgvs_c": "c.1985T>G",
"hgvs_p": "p.Leu662Arg",
"transcript": "XM_047432502.1",
"protein_id": "XP_047288458.1",
"transcript_support_level": null,
"aa_start": 662,
"aa_end": null,
"aa_length": 739,
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"clinvar_review_status": "",
"clinvar_submissions_summary": "",
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"custom_annotations": null
}
],
"message": null
}