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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 15-41504849-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=15&pos=41504849&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "15",
"pos": 41504849,
"ref": "G",
"alt": "T",
"effect": "synonymous_variant",
"transcript": "NM_002344.6",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LTK",
"gene_hgnc_id": 6721,
"hgvs_c": "c.2044C>A",
"hgvs_p": "p.Arg682Arg",
"transcript": "NM_002344.6",
"protein_id": "NP_002335.2",
"transcript_support_level": null,
"aa_start": 682,
"aa_end": null,
"aa_length": 864,
"cds_start": 2044,
"cds_end": null,
"cds_length": 2595,
"cdna_start": 2162,
"cdna_end": null,
"cdna_length": 3072,
"mane_select": "ENST00000263800.11",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_002344.6"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LTK",
"gene_hgnc_id": 6721,
"hgvs_c": "c.2044C>A",
"hgvs_p": "p.Arg682Arg",
"transcript": "ENST00000263800.11",
"protein_id": "ENSP00000263800.6",
"transcript_support_level": 1,
"aa_start": 682,
"aa_end": null,
"aa_length": 864,
"cds_start": 2044,
"cds_end": null,
"cds_length": 2595,
"cdna_start": 2162,
"cdna_end": null,
"cdna_length": 3072,
"mane_select": "NM_002344.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000263800.11"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LTK",
"gene_hgnc_id": 6721,
"hgvs_c": "c.1861C>A",
"hgvs_p": "p.Arg621Arg",
"transcript": "ENST00000355166.9",
"protein_id": "ENSP00000347293.5",
"transcript_support_level": 1,
"aa_start": 621,
"aa_end": null,
"aa_length": 803,
"cds_start": 1861,
"cds_end": null,
"cds_length": 2412,
"cdna_start": 2031,
"cdna_end": null,
"cdna_length": 2940,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000355166.9"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LTK",
"gene_hgnc_id": 6721,
"hgvs_c": "c.1138C>A",
"hgvs_p": "p.Arg380Arg",
"transcript": "ENST00000561619.5",
"protein_id": "ENSP00000458111.1",
"transcript_support_level": 1,
"aa_start": 380,
"aa_end": null,
"aa_length": 562,
"cds_start": 1138,
"cds_end": null,
"cds_length": 1689,
"cdna_start": 1225,
"cdna_end": null,
"cdna_length": 1821,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000561619.5"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LTK",
"gene_hgnc_id": 6721,
"hgvs_c": "c.2092C>A",
"hgvs_p": "p.Arg698Arg",
"transcript": "ENST00000953759.1",
"protein_id": "ENSP00000623818.1",
"transcript_support_level": null,
"aa_start": 698,
"aa_end": null,
"aa_length": 880,
"cds_start": 2092,
"cds_end": null,
"cds_length": 2643,
"cdna_start": 2250,
"cdna_end": null,
"cdna_length": 3160,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000953759.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LTK",
"gene_hgnc_id": 6721,
"hgvs_c": "c.2032C>A",
"hgvs_p": "p.Arg678Arg",
"transcript": "ENST00000953763.1",
"protein_id": "ENSP00000623822.1",
"transcript_support_level": null,
"aa_start": 678,
"aa_end": null,
"aa_length": 860,
"cds_start": 2032,
"cds_end": null,
"cds_length": 2583,
"cdna_start": 2148,
"cdna_end": null,
"cdna_length": 3061,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000953763.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LTK",
"gene_hgnc_id": 6721,
"hgvs_c": "c.1948C>A",
"hgvs_p": "p.Arg650Arg",
"transcript": "ENST00000953760.1",
"protein_id": "ENSP00000623819.1",
"transcript_support_level": null,
"aa_start": 650,
"aa_end": null,
"aa_length": 832,
"cds_start": 1948,
"cds_end": null,
"cds_length": 2499,
"cdna_start": 2093,
"cdna_end": null,
"cdna_length": 3002,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000953760.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LTK",
"gene_hgnc_id": 6721,
"hgvs_c": "c.1909C>A",
"hgvs_p": "p.Arg637Arg",
"transcript": "ENST00000897467.1",
"protein_id": "ENSP00000567526.1",
"transcript_support_level": null,
"aa_start": 637,
"aa_end": null,
"aa_length": 819,
"cds_start": 1909,
"cds_end": null,
"cds_length": 2460,
"cdna_start": 2027,
"cdna_end": null,
"cdna_length": 2937,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000897467.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LTK",
"gene_hgnc_id": 6721,
"hgvs_c": "c.1861C>A",
"hgvs_p": "p.Arg621Arg",
"transcript": "NM_206961.4",
"protein_id": "NP_996844.1",
"transcript_support_level": null,
"aa_start": 621,
"aa_end": null,
"aa_length": 803,
"cds_start": 1861,
"cds_end": null,
"cds_length": 2412,
"cdna_start": 1979,
"cdna_end": null,
"cdna_length": 2889,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_206961.4"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LTK",
"gene_hgnc_id": 6721,
"hgvs_c": "c.1837C>A",
"hgvs_p": "p.Arg613Arg",
"transcript": "ENST00000953761.1",
"protein_id": "ENSP00000623820.1",
"transcript_support_level": null,
"aa_start": 613,
"aa_end": null,
"aa_length": 795,
"cds_start": 1837,
"cds_end": null,
"cds_length": 2388,
"cdna_start": 1980,
"cdna_end": null,
"cdna_length": 2890,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000953761.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LTK",
"gene_hgnc_id": 6721,
"hgvs_c": "c.1741C>A",
"hgvs_p": "p.Arg581Arg",
"transcript": "ENST00000953762.1",
"protein_id": "ENSP00000623821.1",
"transcript_support_level": null,
"aa_start": 581,
"aa_end": null,
"aa_length": 763,
"cds_start": 1741,
"cds_end": null,
"cds_length": 2292,
"cdna_start": 1884,
"cdna_end": null,
"cdna_length": 2788,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000953762.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LTK",
"gene_hgnc_id": 6721,
"hgvs_c": "c.1654C>A",
"hgvs_p": "p.Arg552Arg",
"transcript": "NM_001135685.2",
"protein_id": "NP_001129157.1",
"transcript_support_level": null,
"aa_start": 552,
"aa_end": null,
"aa_length": 734,
"cds_start": 1654,
"cds_end": null,
"cds_length": 2205,
"cdna_start": 1772,
"cdna_end": null,
"cdna_length": 2682,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001135685.2"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LTK",
"gene_hgnc_id": 6721,
"hgvs_c": "c.1654C>A",
"hgvs_p": "p.Arg552Arg",
"transcript": "ENST00000453182.2",
"protein_id": "ENSP00000392196.2",
"transcript_support_level": 2,
"aa_start": 552,
"aa_end": null,
"aa_length": 734,
"cds_start": 1654,
"cds_end": null,
"cds_length": 2205,
"cdna_start": 1832,
"cdna_end": null,
"cdna_length": 2412,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000453182.2"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LTK",
"gene_hgnc_id": 6721,
"hgvs_c": "c.1558C>A",
"hgvs_p": "p.Arg520Arg",
"transcript": "ENST00000897466.1",
"protein_id": "ENSP00000567525.1",
"transcript_support_level": null,
"aa_start": 520,
"aa_end": null,
"aa_length": 702,
"cds_start": 1558,
"cds_end": null,
"cds_length": 2109,
"cdna_start": 1709,
"cdna_end": null,
"cdna_length": 2619,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000897466.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LTK",
"gene_hgnc_id": 6721,
"hgvs_c": "c.1153C>A",
"hgvs_p": "p.Arg385Arg",
"transcript": "ENST00000953765.1",
"protein_id": "ENSP00000623824.1",
"transcript_support_level": null,
"aa_start": 385,
"aa_end": null,
"aa_length": 567,
"cds_start": 1153,
"cds_end": null,
"cds_length": 1704,
"cdna_start": 1270,
"cdna_end": null,
"cdna_length": 2177,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000953765.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LTK",
"gene_hgnc_id": 6721,
"hgvs_c": "c.1090C>A",
"hgvs_p": "p.Arg364Arg",
"transcript": "ENST00000897468.1",
"protein_id": "ENSP00000567527.1",
"transcript_support_level": null,
"aa_start": 364,
"aa_end": null,
"aa_length": 546,
"cds_start": 1090,
"cds_end": null,
"cds_length": 1641,
"cdna_start": 1103,
"cdna_end": null,
"cdna_length": 2010,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000897468.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LTK",
"gene_hgnc_id": 6721,
"hgvs_c": "c.1924C>A",
"hgvs_p": "p.Arg642Arg",
"transcript": "XM_011521557.3",
"protein_id": "XP_011519859.1",
"transcript_support_level": null,
"aa_start": 642,
"aa_end": null,
"aa_length": 824,
"cds_start": 1924,
"cds_end": null,
"cds_length": 2475,
"cdna_start": 2042,
"cdna_end": null,
"cdna_length": 2952,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011521557.3"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LTK",
"gene_hgnc_id": 6721,
"hgvs_c": "c.1909C>A",
"hgvs_p": "p.Arg637Arg",
"transcript": "XM_047432499.1",
"protein_id": "XP_047288455.1",
"transcript_support_level": null,
"aa_start": 637,
"aa_end": null,
"aa_length": 819,
"cds_start": 1909,
"cds_end": null,
"cds_length": 2460,
"cdna_start": 2027,
"cdna_end": null,
"cdna_length": 2937,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047432499.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LTK",
"gene_hgnc_id": 6721,
"hgvs_c": "c.1876C>A",
"hgvs_p": "p.Arg626Arg",
"transcript": "XM_047432500.1",
"protein_id": "XP_047288456.1",
"transcript_support_level": null,
"aa_start": 626,
"aa_end": null,
"aa_length": 808,
"cds_start": 1876,
"cds_end": null,
"cds_length": 2427,
"cdna_start": 1994,
"cdna_end": null,
"cdna_length": 2904,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047432500.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LTK",
"gene_hgnc_id": 6721,
"hgvs_c": "c.1780C>A",
"hgvs_p": "p.Arg594Arg",
"transcript": "XM_047432501.1",
"protein_id": "XP_047288457.1",
"transcript_support_level": null,
"aa_start": 594,
"aa_end": null,
"aa_length": 776,
"cds_start": 1780,
"cds_end": null,
"cds_length": 2331,
"cdna_start": 1898,
"cdna_end": null,
"cdna_length": 2808,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047432501.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LTK",
"gene_hgnc_id": 6721,
"hgvs_c": "c.1669C>A",
"hgvs_p": "p.Arg557Arg",
"transcript": "XM_047432502.1",
"protein_id": "XP_047288458.1",
"transcript_support_level": null,
"aa_start": 557,
"aa_end": null,
"aa_length": 739,
"cds_start": 1669,
"cds_end": null,
"cds_length": 2220,
"cdna_start": 1787,
"cdna_end": null,
"cdna_length": 2697,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047432502.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LTK",
"gene_hgnc_id": 6721,
"hgvs_c": "c.877C>A",
"hgvs_p": "p.Arg293Arg",
"transcript": "XM_024449919.2",
"protein_id": "XP_024305687.2",
"transcript_support_level": null,
"aa_start": 293,
"aa_end": null,
"aa_length": 475,
"cds_start": 877,
"cds_end": null,
"cds_length": 1428,
"cdna_start": 1355,
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{
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"BP7"
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"verdict": "Likely_benign",
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"clinvar_review_status": "",
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"custom_annotations": null
}
],
"message": null
}