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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 15-41710993-C-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=15&pos=41710993&ref=C&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "15",
"pos": 41710993,
"ref": "C",
"alt": "A",
"effect": "synonymous_variant",
"transcript": "NM_001400225.1",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MGA",
"gene_hgnc_id": 14010,
"hgvs_c": "c.2728C>A",
"hgvs_p": "p.Arg910Arg",
"transcript": "NM_001400225.1",
"protein_id": "NP_001387154.1",
"transcript_support_level": null,
"aa_start": 910,
"aa_end": null,
"aa_length": 3114,
"cds_start": 2728,
"cds_end": null,
"cds_length": 9345,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000703841.1",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001400225.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MGA",
"gene_hgnc_id": 14010,
"hgvs_c": "c.2728C>A",
"hgvs_p": "p.Arg910Arg",
"transcript": "ENST00000703841.1",
"protein_id": "ENSP00000515495.1",
"transcript_support_level": null,
"aa_start": 910,
"aa_end": null,
"aa_length": 3114,
"cds_start": 2728,
"cds_end": null,
"cds_length": 9345,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001400225.1",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000703841.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MGA",
"gene_hgnc_id": 14010,
"hgvs_c": "c.2728C>A",
"hgvs_p": "p.Arg910Arg",
"transcript": "ENST00000566586.6",
"protein_id": "ENSP00000456141.1",
"transcript_support_level": 1,
"aa_start": 910,
"aa_end": null,
"aa_length": 2856,
"cds_start": 2728,
"cds_end": null,
"cds_length": 8571,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000566586.6"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MGA",
"gene_hgnc_id": 14010,
"hgvs_c": "c.2728C>A",
"hgvs_p": "p.Arg910Arg",
"transcript": "ENST00000916432.1",
"protein_id": "ENSP00000586491.1",
"transcript_support_level": null,
"aa_start": 910,
"aa_end": null,
"aa_length": 3114,
"cds_start": 2728,
"cds_end": null,
"cds_length": 9345,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000916432.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MGA",
"gene_hgnc_id": 14010,
"hgvs_c": "c.2728C>A",
"hgvs_p": "p.Arg910Arg",
"transcript": "NM_001164273.2",
"protein_id": "NP_001157745.1",
"transcript_support_level": null,
"aa_start": 910,
"aa_end": null,
"aa_length": 3065,
"cds_start": 2728,
"cds_end": null,
"cds_length": 9198,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001164273.2"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MGA",
"gene_hgnc_id": 14010,
"hgvs_c": "c.2728C>A",
"hgvs_p": "p.Arg910Arg",
"transcript": "ENST00000219905.13",
"protein_id": "ENSP00000219905.7",
"transcript_support_level": 5,
"aa_start": 910,
"aa_end": null,
"aa_length": 3065,
"cds_start": 2728,
"cds_end": null,
"cds_length": 9198,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000219905.13"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MGA",
"gene_hgnc_id": 14010,
"hgvs_c": "c.2728C>A",
"hgvs_p": "p.Arg910Arg",
"transcript": "ENST00000916430.1",
"protein_id": "ENSP00000586489.1",
"transcript_support_level": null,
"aa_start": 910,
"aa_end": null,
"aa_length": 2955,
"cds_start": 2728,
"cds_end": null,
"cds_length": 8868,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000916430.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MGA",
"gene_hgnc_id": 14010,
"hgvs_c": "c.2728C>A",
"hgvs_p": "p.Arg910Arg",
"transcript": "ENST00000916431.1",
"protein_id": "ENSP00000586490.1",
"transcript_support_level": null,
"aa_start": 910,
"aa_end": null,
"aa_length": 2905,
"cds_start": 2728,
"cds_end": null,
"cds_length": 8718,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000916431.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MGA",
"gene_hgnc_id": 14010,
"hgvs_c": "c.2728C>A",
"hgvs_p": "p.Arg910Arg",
"transcript": "NM_001080541.3",
"protein_id": "NP_001074010.2",
"transcript_support_level": null,
"aa_start": 910,
"aa_end": null,
"aa_length": 2856,
"cds_start": 2728,
"cds_end": null,
"cds_length": 8571,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001080541.3"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MGA",
"gene_hgnc_id": 14010,
"hgvs_c": "c.2728C>A",
"hgvs_p": "p.Arg910Arg",
"transcript": "ENST00000916428.1",
"protein_id": "ENSP00000586487.1",
"transcript_support_level": null,
"aa_start": 910,
"aa_end": null,
"aa_length": 2856,
"cds_start": 2728,
"cds_end": null,
"cds_length": 8571,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000916428.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MGA",
"gene_hgnc_id": 14010,
"hgvs_c": "c.2728C>A",
"hgvs_p": "p.Arg910Arg",
"transcript": "ENST00000916429.1",
"protein_id": "ENSP00000586488.1",
"transcript_support_level": null,
"aa_start": 910,
"aa_end": null,
"aa_length": 2795,
"cds_start": 2728,
"cds_end": null,
"cds_length": 8388,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000916429.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MGA",
"gene_hgnc_id": 14010,
"hgvs_c": "c.2728C>A",
"hgvs_p": "p.Arg910Arg",
"transcript": "ENST00000570161.6",
"protein_id": "ENSP00000457035.2",
"transcript_support_level": 5,
"aa_start": 910,
"aa_end": null,
"aa_length": 2573,
"cds_start": 2728,
"cds_end": null,
"cds_length": 7723,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000570161.6"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MGA",
"gene_hgnc_id": 14010,
"hgvs_c": "c.2728C>A",
"hgvs_p": "p.Arg910Arg",
"transcript": "NM_001400242.1",
"protein_id": "NP_001387171.1",
"transcript_support_level": null,
"aa_start": 910,
"aa_end": null,
"aa_length": 2097,
"cds_start": 2728,
"cds_end": null,
"cds_length": 6294,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001400242.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MGA",
"gene_hgnc_id": 14010,
"hgvs_c": "c.2728C>A",
"hgvs_p": "p.Arg910Arg",
"transcript": "ENST00000566718.6",
"protein_id": "ENSP00000455155.2",
"transcript_support_level": 2,
"aa_start": 910,
"aa_end": null,
"aa_length": 1096,
"cds_start": 2728,
"cds_end": null,
"cds_length": 3293,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000566718.6"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MGA",
"gene_hgnc_id": 14010,
"hgvs_c": "c.616C>A",
"hgvs_p": "p.Arg206Arg",
"transcript": "ENST00000703842.1",
"protein_id": "ENSP00000515496.1",
"transcript_support_level": null,
"aa_start": 206,
"aa_end": null,
"aa_length": 428,
"cds_start": 616,
"cds_end": null,
"cds_length": 1287,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000703842.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MGA",
"gene_hgnc_id": 14010,
"hgvs_c": "c.2728C>A",
"hgvs_p": "p.Arg910Arg",
"transcript": "XM_005254243.4",
"protein_id": "XP_005254300.1",
"transcript_support_level": null,
"aa_start": 910,
"aa_end": null,
"aa_length": 3115,
"cds_start": 2728,
"cds_end": null,
"cds_length": 9348,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_005254243.4"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MGA",
"gene_hgnc_id": 14010,
"hgvs_c": "c.2728C>A",
"hgvs_p": "p.Arg910Arg",
"transcript": "XM_005254246.4",
"protein_id": "XP_005254303.1",
"transcript_support_level": null,
"aa_start": 910,
"aa_end": null,
"aa_length": 3115,
"cds_start": 2728,
"cds_end": null,
"cds_length": 9348,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_005254246.4"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MGA",
"gene_hgnc_id": 14010,
"hgvs_c": "c.2728C>A",
"hgvs_p": "p.Arg910Arg",
"transcript": "XM_006720443.5",
"protein_id": "XP_006720506.1",
"transcript_support_level": null,
"aa_start": 910,
"aa_end": null,
"aa_length": 3115,
"cds_start": 2728,
"cds_end": null,
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"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_006720443.5"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MGA",
"gene_hgnc_id": 14010,
"hgvs_c": "c.2728C>A",
"hgvs_p": "p.Arg910Arg",
"transcript": "XM_047432276.1",
"protein_id": "XP_047288232.1",
"transcript_support_level": null,
"aa_start": 910,
"aa_end": null,
"aa_length": 3114,
"cds_start": 2728,
"cds_end": null,
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"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047432276.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MGA",
"gene_hgnc_id": 14010,
"hgvs_c": "c.2728C>A",
"hgvs_p": "p.Arg910Arg",
"transcript": "XM_047432278.1",
"protein_id": "XP_047288234.1",
"transcript_support_level": null,
"aa_start": 910,
"aa_end": null,
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"cds_start": 2728,
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"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047432278.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MGA",
"gene_hgnc_id": 14010,
"hgvs_c": "c.2728C>A",
"hgvs_p": "p.Arg910Arg",
"transcript": "XM_005254249.4",
"protein_id": "XP_005254306.1",
"transcript_support_level": null,
"aa_start": 910,
"aa_end": null,
"aa_length": 3066,
"cds_start": 2728,
"cds_end": null,
"cds_length": 9201,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_005254249.4"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MGA",
"gene_hgnc_id": 14010,
"hgvs_c": "c.2728C>A",
"hgvs_p": "p.Arg910Arg",
"transcript": "XM_047432279.1",
"protein_id": "XP_047288235.1",
"transcript_support_level": null,
"aa_start": 910,
"aa_end": null,
"aa_length": 3066,
"cds_start": 2728,
"cds_end": null,
"cds_length": 9201,
"cdna_start": null,
"cdna_end": null,
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}