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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 15-44482004-C-G (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=15&pos=44482004&ref=C&alt=G&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 4,
          "criteria": [
            "PM2",
            "BP4_Strong"
          ],
          "effects": [
            "intron_variant"
          ],
          "gene_symbol": "CTDSPL2",
          "hgnc_id": 26936,
          "hgvs_c": "c.187-2220C>G",
          "hgvs_p": null,
          "inheritance_mode": "",
          "pathogenic_score": 2,
          "score": -2,
          "transcript": "NM_016396.3",
          "verdict": "Likely_benign"
        }
      ],
      "acmg_classification": "Likely_benign",
      "acmg_criteria": "PM2,BP4_Strong",
      "acmg_score": -2,
      "allele_count_reference_population": 0,
      "alphamissense_prediction": null,
      "alphamissense_score": null,
      "alt": "G",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": "Benign",
      "bayesdelnoaf_score": -0.9,
      "chr": "15",
      "clinvar_classification": "",
      "clinvar_disease": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "computational_prediction_selected": "Benign",
      "computational_score_selected": -0.8999999761581421,
      "computational_source_selected": "BayesDel_noAF",
      "consequences": [
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 466,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6433,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1401,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 13,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_016396.3",
          "gene_hgnc_id": 26936,
          "gene_symbol": "CTDSPL2",
          "hgvs_c": "c.187-2220C>G",
          "hgvs_p": null,
          "intron_rank": 2,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000260327.9",
          "protein_coding": true,
          "protein_id": "NP_057480.2",
          "strand": true,
          "transcript": "NM_016396.3",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 466,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 6433,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1401,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 13,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000260327.9",
          "gene_hgnc_id": 26936,
          "gene_symbol": "CTDSPL2",
          "hgvs_c": "c.187-2220C>G",
          "hgvs_p": null,
          "intron_rank": 2,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_016396.3",
          "protein_coding": true,
          "protein_id": "ENSP00000260327.4",
          "strand": true,
          "transcript": "ENST00000260327.9",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 466,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1895,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1401,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 13,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000558966.5",
          "gene_hgnc_id": 26936,
          "gene_symbol": "CTDSPL2",
          "hgvs_c": "c.187-2220C>G",
          "hgvs_p": null,
          "intron_rank": 2,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000452837.1",
          "strand": true,
          "transcript": "ENST00000558966.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 394,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4255,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1185,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 11,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000558373.5",
          "gene_hgnc_id": 26936,
          "gene_symbol": "CTDSPL2",
          "hgvs_c": "c.187-2220C>G",
          "hgvs_p": null,
          "intron_rank": 1,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000453051.1",
          "strand": true,
          "transcript": "ENST00000558373.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 466,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4621,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1401,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 13,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000872548.1",
          "gene_hgnc_id": 26936,
          "gene_symbol": "CTDSPL2",
          "hgvs_c": "c.187-2220C>G",
          "hgvs_p": null,
          "intron_rank": 2,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000542607.1",
          "strand": true,
          "transcript": "ENST00000872548.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 465,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4654,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1398,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 13,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000872547.1",
          "gene_hgnc_id": 26936,
          "gene_symbol": "CTDSPL2",
          "hgvs_c": "c.187-2220C>G",
          "hgvs_p": null,
          "intron_rank": 2,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000542606.1",
          "strand": true,
          "transcript": "ENST00000872547.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 465,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4639,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1398,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 13,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000937565.1",
          "gene_hgnc_id": 26936,
          "gene_symbol": "CTDSPL2",
          "hgvs_c": "c.187-2220C>G",
          "hgvs_p": null,
          "intron_rank": 2,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000607624.1",
          "strand": true,
          "transcript": "ENST00000937565.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 463,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3565,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1392,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 13,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000872549.1",
          "gene_hgnc_id": 26936,
          "gene_symbol": "CTDSPL2",
          "hgvs_c": "c.187-2220C>G",
          "hgvs_p": null,
          "intron_rank": 2,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000542608.1",
          "strand": true,
          "transcript": "ENST00000872549.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 445,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3279,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1338,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 12,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000872550.1",
          "gene_hgnc_id": 26936,
          "gene_symbol": "CTDSPL2",
          "hgvs_c": "c.187-2220C>G",
          "hgvs_p": null,
          "intron_rank": 2,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000542609.1",
          "strand": true,
          "transcript": "ENST00000872550.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 434,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3238,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1305,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 12,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000872551.1",
          "gene_hgnc_id": 26936,
          "gene_symbol": "CTDSPL2",
          "hgvs_c": "c.187-2220C>G",
          "hgvs_p": null,
          "intron_rank": 2,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000542610.1",
          "strand": true,
          "transcript": "ENST00000872551.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 164,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 591,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 496,
          "cds_start": null,
          "consequences": [
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          ],
          "exon_count": 5,
          "exon_rank": null,
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          "feature": "ENST00000558791.5",
          "gene_hgnc_id": 26936,
          "gene_symbol": "CTDSPL2",
          "hgvs_c": "c.187-2220C>G",
          "hgvs_p": null,
          "intron_rank": 2,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000453612.1",
          "strand": true,
          "transcript": "ENST00000558791.5",
          "transcript_support_level": 4
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 116,
          "aa_ref": null,
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          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 575,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 353,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 4,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000559793.5",
          "gene_hgnc_id": 26936,
          "gene_symbol": "CTDSPL2",
          "hgvs_c": "c.187-2220C>G",
          "hgvs_p": null,
          "intron_rank": 2,
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          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000454187.1",
          "strand": true,
          "transcript": "ENST00000559793.5",
          "transcript_support_level": 5
        },
        {
          "aa_alt": null,
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          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 583,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 277,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 3,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000558968.1",
          "gene_hgnc_id": 26936,
          "gene_symbol": "CTDSPL2",
          "hgvs_c": "c.187-2220C>G",
          "hgvs_p": null,
          "intron_rank": 2,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000454154.1",
          "strand": true,
          "transcript": "ENST00000558968.1",
          "transcript_support_level": 5
        },
        {
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          "aa_ref": null,
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          "cdna_length": 6554,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1401,
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          "consequences": [
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          ],
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          "feature": "XM_005254441.3",
          "gene_hgnc_id": 26936,
          "gene_symbol": "CTDSPL2",
          "hgvs_c": "c.187-2220C>G",
          "hgvs_p": null,
          "intron_rank": 2,
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          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "XP_005254498.1",
          "strand": true,
          "transcript": "XM_005254441.3",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
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          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6353,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1401,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 13,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "XM_006720565.3",
          "gene_hgnc_id": 26936,
          "gene_symbol": "CTDSPL2",
          "hgvs_c": "c.187-2220C>G",
          "hgvs_p": null,
          "intron_rank": 2,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "XP_006720628.1",
          "strand": true,
          "transcript": "XM_006720565.3",
          "transcript_support_level": null
        },
        {
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          "aa_ref": null,
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          "biotype": "protein_coding",
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          "cdna_end": null,
          "cdna_length": 6430,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1398,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 13,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "XM_011521665.3",
          "gene_hgnc_id": 26936,
          "gene_symbol": "CTDSPL2",
          "hgvs_c": "c.187-2220C>G",
          "hgvs_p": null,
          "intron_rank": 2,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "XP_011519967.1",
          "strand": true,
          "transcript": "XM_011521665.3",
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        },
        {
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          "biotype": "protein_coding",
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          "cdna_length": 6350,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1398,
          "cds_start": null,
          "consequences": [
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          ],
          "exon_count": 13,
          "exon_rank": null,
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          "feature": "XM_017022306.3",
          "gene_hgnc_id": 26936,
          "gene_symbol": "CTDSPL2",
          "hgvs_c": "c.187-2220C>G",
          "hgvs_p": null,
          "intron_rank": 2,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "XP_016877795.1",
          "strand": true,
          "transcript": "XM_017022306.3",
          "transcript_support_level": null
        },
        {
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          "aa_ref": null,
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          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1287,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1029,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 10,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "XM_047432652.1",
          "gene_hgnc_id": 26936,
          "gene_symbol": "CTDSPL2",
          "hgvs_c": "c.187-2220C>G",
          "hgvs_p": null,
          "intron_rank": 2,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "XP_047288608.1",
          "strand": true,
          "transcript": "XM_047432652.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 342,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1207,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1029,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 10,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "XM_047432653.1",
          "gene_hgnc_id": 26936,
          "gene_symbol": "CTDSPL2",
          "hgvs_c": "c.187-2220C>G",
          "hgvs_p": null,
          "intron_rank": 2,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "XP_047288609.1",
          "strand": true,
          "transcript": "XM_047432653.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
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          "aa_ref": null,
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For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.