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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 15-45662024-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=15&pos=45662024&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "15",
"pos": 45662024,
"ref": "C",
"alt": "T",
"effect": "missense_variant",
"transcript": "NM_021199.4",
"consequences": [
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SQOR",
"gene_hgnc_id": 20390,
"hgvs_c": "c.304C>T",
"hgvs_p": "p.Pro102Ser",
"transcript": "NM_021199.4",
"protein_id": "NP_067022.1",
"transcript_support_level": null,
"aa_start": 102,
"aa_end": null,
"aa_length": 450,
"cds_start": 304,
"cds_end": null,
"cds_length": 1353,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000260324.12",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_021199.4"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SQOR",
"gene_hgnc_id": 20390,
"hgvs_c": "c.304C>T",
"hgvs_p": "p.Pro102Ser",
"transcript": "ENST00000260324.12",
"protein_id": "ENSP00000260324.7",
"transcript_support_level": 1,
"aa_start": 102,
"aa_end": null,
"aa_length": 450,
"cds_start": 304,
"cds_end": null,
"cds_length": 1353,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_021199.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000260324.12"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ENSG00000260170",
"gene_hgnc_id": null,
"hgvs_c": "c.304C>T",
"hgvs_p": "p.Pro102Ser",
"transcript": "ENST00000564080.1",
"protein_id": "ENSP00000455047.1",
"transcript_support_level": 3,
"aa_start": 102,
"aa_end": null,
"aa_length": 288,
"cds_start": 304,
"cds_end": null,
"cds_length": 868,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000564080.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SQOR",
"gene_hgnc_id": 20390,
"hgvs_c": "c.304C>T",
"hgvs_p": "p.Pro102Ser",
"transcript": "NM_001271213.2",
"protein_id": "NP_001258142.1",
"transcript_support_level": null,
"aa_start": 102,
"aa_end": null,
"aa_length": 450,
"cds_start": 304,
"cds_end": null,
"cds_length": 1353,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001271213.2"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SQOR",
"gene_hgnc_id": 20390,
"hgvs_c": "c.304C>T",
"hgvs_p": "p.Pro102Ser",
"transcript": "ENST00000568606.5",
"protein_id": "ENSP00000456019.1",
"transcript_support_level": 5,
"aa_start": 102,
"aa_end": null,
"aa_length": 450,
"cds_start": 304,
"cds_end": null,
"cds_length": 1353,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000568606.5"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SQOR",
"gene_hgnc_id": 20390,
"hgvs_c": "c.304C>T",
"hgvs_p": "p.Pro102Ser",
"transcript": "ENST00000888093.1",
"protein_id": "ENSP00000558152.1",
"transcript_support_level": null,
"aa_start": 102,
"aa_end": null,
"aa_length": 450,
"cds_start": 304,
"cds_end": null,
"cds_length": 1353,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000888093.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SQOR",
"gene_hgnc_id": 20390,
"hgvs_c": "c.304C>T",
"hgvs_p": "p.Pro102Ser",
"transcript": "ENST00000888094.1",
"protein_id": "ENSP00000558153.1",
"transcript_support_level": null,
"aa_start": 102,
"aa_end": null,
"aa_length": 450,
"cds_start": 304,
"cds_end": null,
"cds_length": 1353,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000888094.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SQOR",
"gene_hgnc_id": 20390,
"hgvs_c": "c.304C>T",
"hgvs_p": "p.Pro102Ser",
"transcript": "ENST00000888095.1",
"protein_id": "ENSP00000558154.1",
"transcript_support_level": null,
"aa_start": 102,
"aa_end": null,
"aa_length": 450,
"cds_start": 304,
"cds_end": null,
"cds_length": 1353,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000888095.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SQOR",
"gene_hgnc_id": 20390,
"hgvs_c": "c.304C>T",
"hgvs_p": "p.Pro102Ser",
"transcript": "ENST00000888096.1",
"protein_id": "ENSP00000558155.1",
"transcript_support_level": null,
"aa_start": 102,
"aa_end": null,
"aa_length": 450,
"cds_start": 304,
"cds_end": null,
"cds_length": 1353,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000888096.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SQOR",
"gene_hgnc_id": 20390,
"hgvs_c": "c.304C>T",
"hgvs_p": "p.Pro102Ser",
"transcript": "ENST00000888097.1",
"protein_id": "ENSP00000558156.1",
"transcript_support_level": null,
"aa_start": 102,
"aa_end": null,
"aa_length": 450,
"cds_start": 304,
"cds_end": null,
"cds_length": 1353,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000888097.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SQOR",
"gene_hgnc_id": 20390,
"hgvs_c": "c.304C>T",
"hgvs_p": "p.Pro102Ser",
"transcript": "ENST00000888099.1",
"protein_id": "ENSP00000558158.1",
"transcript_support_level": null,
"aa_start": 102,
"aa_end": null,
"aa_length": 450,
"cds_start": 304,
"cds_end": null,
"cds_length": 1353,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000888099.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SQOR",
"gene_hgnc_id": 20390,
"hgvs_c": "c.304C>T",
"hgvs_p": "p.Pro102Ser",
"transcript": "ENST00000888100.1",
"protein_id": "ENSP00000558159.1",
"transcript_support_level": null,
"aa_start": 102,
"aa_end": null,
"aa_length": 450,
"cds_start": 304,
"cds_end": null,
"cds_length": 1353,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000888100.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SQOR",
"gene_hgnc_id": 20390,
"hgvs_c": "c.304C>T",
"hgvs_p": "p.Pro102Ser",
"transcript": "ENST00000888101.1",
"protein_id": "ENSP00000558160.1",
"transcript_support_level": null,
"aa_start": 102,
"aa_end": null,
"aa_length": 450,
"cds_start": 304,
"cds_end": null,
"cds_length": 1353,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000888101.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SQOR",
"gene_hgnc_id": 20390,
"hgvs_c": "c.304C>T",
"hgvs_p": "p.Pro102Ser",
"transcript": "ENST00000888104.1",
"protein_id": "ENSP00000558163.1",
"transcript_support_level": null,
"aa_start": 102,
"aa_end": null,
"aa_length": 450,
"cds_start": 304,
"cds_end": null,
"cds_length": 1353,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000888104.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SQOR",
"gene_hgnc_id": 20390,
"hgvs_c": "c.304C>T",
"hgvs_p": "p.Pro102Ser",
"transcript": "ENST00000888107.1",
"protein_id": "ENSP00000558166.1",
"transcript_support_level": null,
"aa_start": 102,
"aa_end": null,
"aa_length": 450,
"cds_start": 304,
"cds_end": null,
"cds_length": 1353,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000888107.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SQOR",
"gene_hgnc_id": 20390,
"hgvs_c": "c.304C>T",
"hgvs_p": "p.Pro102Ser",
"transcript": "ENST00000888108.1",
"protein_id": "ENSP00000558167.1",
"transcript_support_level": null,
"aa_start": 102,
"aa_end": null,
"aa_length": 450,
"cds_start": 304,
"cds_end": null,
"cds_length": 1353,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000888108.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SQOR",
"gene_hgnc_id": 20390,
"hgvs_c": "c.304C>T",
"hgvs_p": "p.Pro102Ser",
"transcript": "ENST00000888109.1",
"protein_id": "ENSP00000558168.1",
"transcript_support_level": null,
"aa_start": 102,
"aa_end": null,
"aa_length": 450,
"cds_start": 304,
"cds_end": null,
"cds_length": 1353,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000888109.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SQOR",
"gene_hgnc_id": 20390,
"hgvs_c": "c.304C>T",
"hgvs_p": "p.Pro102Ser",
"transcript": "ENST00000888110.1",
"protein_id": "ENSP00000558169.1",
"transcript_support_level": null,
"aa_start": 102,
"aa_end": null,
"aa_length": 450,
"cds_start": 304,
"cds_end": null,
"cds_length": 1353,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000888110.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SQOR",
"gene_hgnc_id": 20390,
"hgvs_c": "c.304C>T",
"hgvs_p": "p.Pro102Ser",
"transcript": "ENST00000888111.1",
"protein_id": "ENSP00000558170.1",
"transcript_support_level": null,
"aa_start": 102,
"aa_end": null,
"aa_length": 450,
"cds_start": 304,
"cds_end": null,
"cds_length": 1353,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000888111.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SQOR",
"gene_hgnc_id": 20390,
"hgvs_c": "c.304C>T",
"hgvs_p": "p.Pro102Ser",
"transcript": "ENST00000888112.1",
"protein_id": "ENSP00000558171.1",
"transcript_support_level": null,
"aa_start": 102,
"aa_end": null,
"aa_length": 450,
"cds_start": 304,
"cds_end": null,
"cds_length": 1353,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000888112.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SQOR",
"gene_hgnc_id": 20390,
"hgvs_c": "c.304C>T",
"hgvs_p": "p.Pro102Ser",
"transcript": "ENST00000888113.1",
"protein_id": "ENSP00000558172.1",
"transcript_support_level": null,
"aa_start": 102,
"aa_end": null,
"aa_length": 450,
"cds_start": 304,
"cds_end": null,
"cds_length": 1353,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000888113.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SQOR",
"gene_hgnc_id": 20390,
"hgvs_c": "c.304C>T",
"hgvs_p": "p.Pro102Ser",
"transcript": "ENST00000888114.1",
"protein_id": "ENSP00000558173.1",
"transcript_support_level": null,
"aa_start": 102,
"aa_end": null,
"aa_length": 450,
"cds_start": 304,
"cds_end": null,
"cds_length": 1353,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000888114.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
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}