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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 15-47770879-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=15&pos=47770879&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "15",
"pos": 47770879,
"ref": "T",
"alt": "C",
"effect": "synonymous_variant",
"transcript": "NM_001358352.2",
"consequences": [
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SEMA6D",
"gene_hgnc_id": 16770,
"hgvs_c": "c.2316T>C",
"hgvs_p": "p.Pro772Pro",
"transcript": "NM_001358351.3",
"protein_id": "NP_001345280.1",
"transcript_support_level": null,
"aa_start": 772,
"aa_end": null,
"aa_length": 1073,
"cds_start": 2316,
"cds_end": null,
"cds_length": 3222,
"cdna_start": 2558,
"cdna_end": null,
"cdna_length": 5907,
"mane_select": "ENST00000536845.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001358351.3"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SEMA6D",
"gene_hgnc_id": 16770,
"hgvs_c": "c.2316T>C",
"hgvs_p": "p.Pro772Pro",
"transcript": "ENST00000536845.7",
"protein_id": "ENSP00000446152.3",
"transcript_support_level": 2,
"aa_start": 772,
"aa_end": null,
"aa_length": 1073,
"cds_start": 2316,
"cds_end": null,
"cds_length": 3222,
"cdna_start": 2558,
"cdna_end": null,
"cdna_length": 5907,
"mane_select": "NM_001358351.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000536845.7"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SEMA6D",
"gene_hgnc_id": 16770,
"hgvs_c": "c.2316T>C",
"hgvs_p": "p.Pro772Pro",
"transcript": "ENST00000316364.9",
"protein_id": "ENSP00000324857.5",
"transcript_support_level": 1,
"aa_start": 772,
"aa_end": null,
"aa_length": 1073,
"cds_start": 2316,
"cds_end": null,
"cds_length": 3222,
"cdna_start": 2755,
"cdna_end": null,
"cdna_length": 6099,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000316364.9"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SEMA6D",
"gene_hgnc_id": 16770,
"hgvs_c": "c.2148T>C",
"hgvs_p": "p.Pro716Pro",
"transcript": "ENST00000354744.8",
"protein_id": "ENSP00000346786.4",
"transcript_support_level": 1,
"aa_start": 716,
"aa_end": null,
"aa_length": 1017,
"cds_start": 2148,
"cds_end": null,
"cds_length": 3054,
"cdna_start": 2587,
"cdna_end": null,
"cdna_length": 5931,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000354744.8"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SEMA6D",
"gene_hgnc_id": 16770,
"hgvs_c": "c.2130T>C",
"hgvs_p": "p.Pro710Pro",
"transcript": "ENST00000358066.8",
"protein_id": "ENSP00000350770.4",
"transcript_support_level": 1,
"aa_start": 710,
"aa_end": null,
"aa_length": 1011,
"cds_start": 2130,
"cds_end": null,
"cds_length": 3036,
"cdna_start": 2569,
"cdna_end": null,
"cdna_length": 5913,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000358066.8"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SEMA6D",
"gene_hgnc_id": 16770,
"hgvs_c": "c.2130T>C",
"hgvs_p": "p.Pro710Pro",
"transcript": "ENST00000558014.5",
"protein_id": "ENSP00000452815.1",
"transcript_support_level": 1,
"aa_start": 710,
"aa_end": null,
"aa_length": 1011,
"cds_start": 2130,
"cds_end": null,
"cds_length": 3036,
"cdna_start": 2686,
"cdna_end": null,
"cdna_length": 6028,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000558014.5"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SEMA6D",
"gene_hgnc_id": 16770,
"hgvs_c": "c.2091T>C",
"hgvs_p": "p.Pro697Pro",
"transcript": "ENST00000389428.7",
"protein_id": "ENSP00000374079.3",
"transcript_support_level": 1,
"aa_start": 697,
"aa_end": null,
"aa_length": 998,
"cds_start": 2091,
"cds_end": null,
"cds_length": 2997,
"cdna_start": 2530,
"cdna_end": null,
"cdna_length": 5874,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000389428.7"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SEMA6D",
"gene_hgnc_id": 16770,
"hgvs_c": "c.2355T>C",
"hgvs_p": "p.Pro785Pro",
"transcript": "NM_001358352.2",
"protein_id": "NP_001345281.1",
"transcript_support_level": null,
"aa_start": 785,
"aa_end": null,
"aa_length": 1086,
"cds_start": 2355,
"cds_end": null,
"cds_length": 3261,
"cdna_start": 2597,
"cdna_end": null,
"cdna_length": 5939,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001358352.2"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SEMA6D",
"gene_hgnc_id": 16770,
"hgvs_c": "c.2316T>C",
"hgvs_p": "p.Pro772Pro",
"transcript": "NM_153618.2",
"protein_id": "NP_705871.1",
"transcript_support_level": null,
"aa_start": 772,
"aa_end": null,
"aa_length": 1073,
"cds_start": 2316,
"cds_end": null,
"cds_length": 3222,
"cdna_start": 3152,
"cdna_end": null,
"cdna_length": 6494,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_153618.2"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SEMA6D",
"gene_hgnc_id": 16770,
"hgvs_c": "c.2316T>C",
"hgvs_p": "p.Pro772Pro",
"transcript": "ENST00000864678.1",
"protein_id": "ENSP00000534737.1",
"transcript_support_level": null,
"aa_start": 772,
"aa_end": null,
"aa_length": 1073,
"cds_start": 2316,
"cds_end": null,
"cds_length": 3222,
"cdna_start": 3021,
"cdna_end": null,
"cdna_length": 5047,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000864678.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SEMA6D",
"gene_hgnc_id": 16770,
"hgvs_c": "c.2316T>C",
"hgvs_p": "p.Pro772Pro",
"transcript": "ENST00000864681.1",
"protein_id": "ENSP00000534740.1",
"transcript_support_level": null,
"aa_start": 772,
"aa_end": null,
"aa_length": 1073,
"cds_start": 2316,
"cds_end": null,
"cds_length": 3222,
"cdna_start": 2825,
"cdna_end": null,
"cdna_length": 4834,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000864681.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SEMA6D",
"gene_hgnc_id": 16770,
"hgvs_c": "c.2298T>C",
"hgvs_p": "p.Pro766Pro",
"transcript": "ENST00000864674.1",
"protein_id": "ENSP00000534733.1",
"transcript_support_level": null,
"aa_start": 766,
"aa_end": null,
"aa_length": 1067,
"cds_start": 2298,
"cds_end": null,
"cds_length": 3204,
"cdna_start": 2606,
"cdna_end": null,
"cdna_length": 5948,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000864674.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SEMA6D",
"gene_hgnc_id": 16770,
"hgvs_c": "c.2298T>C",
"hgvs_p": "p.Pro766Pro",
"transcript": "ENST00000864683.1",
"protein_id": "ENSP00000534742.1",
"transcript_support_level": null,
"aa_start": 766,
"aa_end": null,
"aa_length": 1067,
"cds_start": 2298,
"cds_end": null,
"cds_length": 3204,
"cdna_start": 3123,
"cdna_end": null,
"cdna_length": 5148,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000864683.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SEMA6D",
"gene_hgnc_id": 16770,
"hgvs_c": "c.2259T>C",
"hgvs_p": "p.Pro753Pro",
"transcript": "ENST00000864677.1",
"protein_id": "ENSP00000534736.1",
"transcript_support_level": null,
"aa_start": 753,
"aa_end": null,
"aa_length": 1054,
"cds_start": 2259,
"cds_end": null,
"cds_length": 3165,
"cdna_start": 2655,
"cdna_end": null,
"cdna_length": 4680,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000864677.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SEMA6D",
"gene_hgnc_id": 16770,
"hgvs_c": "c.2259T>C",
"hgvs_p": "p.Pro753Pro",
"transcript": "ENST00000962907.1",
"protein_id": "ENSP00000632966.1",
"transcript_support_level": null,
"aa_start": 753,
"aa_end": null,
"aa_length": 1054,
"cds_start": 2259,
"cds_end": null,
"cds_length": 3165,
"cdna_start": 2792,
"cdna_end": null,
"cdna_length": 4197,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000962907.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SEMA6D",
"gene_hgnc_id": 16770,
"hgvs_c": "c.2187T>C",
"hgvs_p": "p.Pro729Pro",
"transcript": "ENST00000864671.1",
"protein_id": "ENSP00000534730.1",
"transcript_support_level": null,
"aa_start": 729,
"aa_end": null,
"aa_length": 1030,
"cds_start": 2187,
"cds_end": null,
"cds_length": 3093,
"cdna_start": 2649,
"cdna_end": null,
"cdna_length": 5988,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000864671.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SEMA6D",
"gene_hgnc_id": 16770,
"hgvs_c": "c.2187T>C",
"hgvs_p": "p.Pro729Pro",
"transcript": "ENST00000864685.1",
"protein_id": "ENSP00000534744.1",
"transcript_support_level": null,
"aa_start": 729,
"aa_end": null,
"aa_length": 1030,
"cds_start": 2187,
"cds_end": null,
"cds_length": 3093,
"cdna_start": 2686,
"cdna_end": null,
"cdna_length": 4025,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000864685.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SEMA6D",
"gene_hgnc_id": 16770,
"hgvs_c": "c.2187T>C",
"hgvs_p": "p.Pro729Pro",
"transcript": "ENST00000962906.1",
"protein_id": "ENSP00000632965.1",
"transcript_support_level": null,
"aa_start": 729,
"aa_end": null,
"aa_length": 1030,
"cds_start": 2187,
"cds_end": null,
"cds_length": 3093,
"cdna_start": 3035,
"cdna_end": null,
"cdna_length": 5010,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000962906.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SEMA6D",
"gene_hgnc_id": 16770,
"hgvs_c": "c.2148T>C",
"hgvs_p": "p.Pro716Pro",
"transcript": "NM_153617.2",
"protein_id": "NP_705870.1",
"transcript_support_level": null,
"aa_start": 716,
"aa_end": null,
"aa_length": 1017,
"cds_start": 2148,
"cds_end": null,
"cds_length": 3054,
"cdna_start": 2984,
"cdna_end": null,
"cdna_length": 6326,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_153617.2"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SEMA6D",
"gene_hgnc_id": 16770,
"hgvs_c": "c.2148T>C",
"hgvs_p": "p.Pro716Pro",
"transcript": "ENST00000864672.1",
"protein_id": "ENSP00000534731.1",
"transcript_support_level": null,
"aa_start": 716,
"aa_end": null,
"aa_length": 1017,
"cds_start": 2148,
"cds_end": null,
"cds_length": 3054,
"cdna_start": 2573,
"cdna_end": null,
"cdna_length": 5915,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000864672.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SEMA6D",
"gene_hgnc_id": 16770,
"hgvs_c": "c.2148T>C",
"hgvs_p": "p.Pro716Pro",
"transcript": "ENST00000864673.1",
"protein_id": "ENSP00000534732.1",
"transcript_support_level": null,
"aa_start": 716,
"aa_end": null,
"aa_length": 1017,
"cds_start": 2148,
"cds_end": null,
"cds_length": 3054,
"cdna_start": 2912,
"cdna_end": null,
"cdna_length": 6248,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000864673.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SEMA6D",
"gene_hgnc_id": 16770,
"hgvs_c": "c.2148T>C",
"hgvs_p": "p.Pro716Pro",
"transcript": "ENST00000864675.1",
"protein_id": "ENSP00000534734.1",
"transcript_support_level": null,
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