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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 15-50459061-C-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=15&pos=50459061&ref=C&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "15",
"pos": 50459061,
"ref": "C",
"alt": "A",
"effect": "synonymous_variant",
"transcript": "NM_005154.5",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP8",
"gene_hgnc_id": 12631,
"hgvs_c": "c.397C>A",
"hgvs_p": "p.Arg133Arg",
"transcript": "NM_005154.5",
"protein_id": "NP_005145.3",
"transcript_support_level": null,
"aa_start": 133,
"aa_end": null,
"aa_length": 1118,
"cds_start": 397,
"cds_end": null,
"cds_length": 3357,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000307179.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_005154.5"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP8",
"gene_hgnc_id": 12631,
"hgvs_c": "c.397C>A",
"hgvs_p": "p.Arg133Arg",
"transcript": "ENST00000307179.9",
"protein_id": "ENSP00000302239.4",
"transcript_support_level": 1,
"aa_start": 133,
"aa_end": null,
"aa_length": 1118,
"cds_start": 397,
"cds_end": null,
"cds_length": 3357,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_005154.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000307179.9"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP8",
"gene_hgnc_id": 12631,
"hgvs_c": "c.397C>A",
"hgvs_p": "p.Arg133Arg",
"transcript": "ENST00000396444.7",
"protein_id": "ENSP00000379721.3",
"transcript_support_level": 1,
"aa_start": 133,
"aa_end": null,
"aa_length": 1118,
"cds_start": 397,
"cds_end": null,
"cds_length": 3357,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000396444.7"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP8",
"gene_hgnc_id": 12631,
"hgvs_c": "n.397C>A",
"hgvs_p": null,
"transcript": "ENST00000559329.5",
"protein_id": "ENSP00000454003.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "non_stop_decay",
"feature": "ENST00000559329.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "USP8",
"gene_hgnc_id": 12631,
"hgvs_c": "n.336-3219C>A",
"hgvs_p": null,
"transcript": "ENST00000560730.5",
"protein_id": "ENSP00000452950.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000560730.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "USP8",
"gene_hgnc_id": 12631,
"hgvs_c": "n.335+9576C>A",
"hgvs_p": null,
"transcript": "ENST00000561330.1",
"protein_id": "ENSP00000453460.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000561330.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP8",
"gene_hgnc_id": 12631,
"hgvs_c": "c.523C>A",
"hgvs_p": "p.Arg175Arg",
"transcript": "ENST00000956759.1",
"protein_id": "ENSP00000626818.1",
"transcript_support_level": null,
"aa_start": 175,
"aa_end": null,
"aa_length": 1160,
"cds_start": 523,
"cds_end": null,
"cds_length": 3483,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000956759.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP8",
"gene_hgnc_id": 12631,
"hgvs_c": "c.523C>A",
"hgvs_p": "p.Arg175Arg",
"transcript": "ENST00000956763.1",
"protein_id": "ENSP00000626822.1",
"transcript_support_level": null,
"aa_start": 175,
"aa_end": null,
"aa_length": 1131,
"cds_start": 523,
"cds_end": null,
"cds_length": 3396,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000956763.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP8",
"gene_hgnc_id": 12631,
"hgvs_c": "c.397C>A",
"hgvs_p": "p.Arg133Arg",
"transcript": "NM_001128610.3",
"protein_id": "NP_001122082.1",
"transcript_support_level": null,
"aa_start": 133,
"aa_end": null,
"aa_length": 1118,
"cds_start": 397,
"cds_end": null,
"cds_length": 3357,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001128610.3"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP8",
"gene_hgnc_id": 12631,
"hgvs_c": "c.397C>A",
"hgvs_p": "p.Arg133Arg",
"transcript": "ENST00000919051.1",
"protein_id": "ENSP00000589110.1",
"transcript_support_level": null,
"aa_start": 133,
"aa_end": null,
"aa_length": 1118,
"cds_start": 397,
"cds_end": null,
"cds_length": 3357,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000919051.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP8",
"gene_hgnc_id": 12631,
"hgvs_c": "c.397C>A",
"hgvs_p": "p.Arg133Arg",
"transcript": "ENST00000919052.1",
"protein_id": "ENSP00000589111.1",
"transcript_support_level": null,
"aa_start": 133,
"aa_end": null,
"aa_length": 1118,
"cds_start": 397,
"cds_end": null,
"cds_length": 3357,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000919052.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP8",
"gene_hgnc_id": 12631,
"hgvs_c": "c.397C>A",
"hgvs_p": "p.Arg133Arg",
"transcript": "ENST00000919048.1",
"protein_id": "ENSP00000589107.1",
"transcript_support_level": null,
"aa_start": 133,
"aa_end": null,
"aa_length": 1117,
"cds_start": 397,
"cds_end": null,
"cds_length": 3354,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000919048.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP8",
"gene_hgnc_id": 12631,
"hgvs_c": "c.397C>A",
"hgvs_p": "p.Arg133Arg",
"transcript": "ENST00000919050.1",
"protein_id": "ENSP00000589109.1",
"transcript_support_level": null,
"aa_start": 133,
"aa_end": null,
"aa_length": 1117,
"cds_start": 397,
"cds_end": null,
"cds_length": 3354,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000919050.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP8",
"gene_hgnc_id": 12631,
"hgvs_c": "c.397C>A",
"hgvs_p": "p.Arg133Arg",
"transcript": "ENST00000882495.1",
"protein_id": "ENSP00000552554.1",
"transcript_support_level": null,
"aa_start": 133,
"aa_end": null,
"aa_length": 1091,
"cds_start": 397,
"cds_end": null,
"cds_length": 3276,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000882495.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP8",
"gene_hgnc_id": 12631,
"hgvs_c": "c.397C>A",
"hgvs_p": "p.Arg133Arg",
"transcript": "ENST00000919049.1",
"protein_id": "ENSP00000589108.1",
"transcript_support_level": null,
"aa_start": 133,
"aa_end": null,
"aa_length": 1088,
"cds_start": 397,
"cds_end": null,
"cds_length": 3267,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000919049.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP8",
"gene_hgnc_id": 12631,
"hgvs_c": "c.397C>A",
"hgvs_p": "p.Arg133Arg",
"transcript": "ENST00000956762.1",
"protein_id": "ENSP00000626821.1",
"transcript_support_level": null,
"aa_start": 133,
"aa_end": null,
"aa_length": 1088,
"cds_start": 397,
"cds_end": null,
"cds_length": 3267,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000956762.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP8",
"gene_hgnc_id": 12631,
"hgvs_c": "c.166C>A",
"hgvs_p": "p.Arg56Arg",
"transcript": "ENST00000919053.1",
"protein_id": "ENSP00000589112.1",
"transcript_support_level": null,
"aa_start": 56,
"aa_end": null,
"aa_length": 1041,
"cds_start": 166,
"cds_end": null,
"cds_length": 3126,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000919053.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP8",
"gene_hgnc_id": 12631,
"hgvs_c": "c.166C>A",
"hgvs_p": "p.Arg56Arg",
"transcript": "ENST00000956760.1",
"protein_id": "ENSP00000626819.1",
"transcript_support_level": null,
"aa_start": 56,
"aa_end": null,
"aa_length": 1041,
"cds_start": 166,
"cds_end": null,
"cds_length": 3126,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000956760.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP8",
"gene_hgnc_id": 12631,
"hgvs_c": "c.166C>A",
"hgvs_p": "p.Arg56Arg",
"transcript": "NM_001283049.2",
"protein_id": "NP_001269978.1",
"transcript_support_level": null,
"aa_start": 56,
"aa_end": null,
"aa_length": 1012,
"cds_start": 166,
"cds_end": null,
"cds_length": 3039,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001283049.2"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP8",
"gene_hgnc_id": 12631,
"hgvs_c": "c.166C>A",
"hgvs_p": "p.Arg56Arg",
"transcript": "ENST00000425032.7",
"protein_id": "ENSP00000412682.3",
"transcript_support_level": 2,
"aa_start": 56,
"aa_end": null,
"aa_length": 1012,
"cds_start": 166,
"cds_end": null,
"cds_length": 3039,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000425032.7"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP8",
"gene_hgnc_id": 12631,
"hgvs_c": "c.397C>A",
"hgvs_p": "p.Arg133Arg",
"transcript": "ENST00000956758.1",
"protein_id": "ENSP00000626817.1",
"transcript_support_level": null,
"aa_start": 133,
"aa_end": null,
"aa_length": 894,
"cds_start": 397,
"cds_end": null,
"cds_length": 2685,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000956758.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP8",
"gene_hgnc_id": 12631,
"hgvs_c": "c.397C>A",
"hgvs_p": "p.Arg133Arg",
"transcript": "ENST00000956761.1",
"protein_id": "ENSP00000626820.1",
"transcript_support_level": null,
"aa_start": 133,
"aa_end": null,
"aa_length": 894,
"cds_start": 397,
"cds_end": null,
"cds_length": 2685,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000956761.1"
},
{
"aa_ref": "R",
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}
],
"message": null
}