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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 15-58771610-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=15&pos=58771610&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "15",
"pos": 58771610,
"ref": "C",
"alt": "T",
"effect": "missense_variant",
"transcript": "NM_001040450.3",
"consequences": [
{
"aa_ref": "S",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MINDY2",
"gene_hgnc_id": 26954,
"hgvs_c": "c.215C>T",
"hgvs_p": "p.Ser72Phe",
"transcript": "NM_001040450.3",
"protein_id": "NP_001035540.1",
"transcript_support_level": null,
"aa_start": 72,
"aa_end": null,
"aa_length": 621,
"cds_start": 215,
"cds_end": null,
"cds_length": 1866,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000559228.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001040450.3"
},
{
"aa_ref": "S",
"aa_alt": "F",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MINDY2",
"gene_hgnc_id": 26954,
"hgvs_c": "c.215C>T",
"hgvs_p": "p.Ser72Phe",
"transcript": "ENST00000559228.6",
"protein_id": "ENSP00000452885.1",
"transcript_support_level": 2,
"aa_start": 72,
"aa_end": null,
"aa_length": 621,
"cds_start": 215,
"cds_end": null,
"cds_length": 1866,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001040450.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000559228.6"
},
{
"aa_ref": "S",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MINDY2",
"gene_hgnc_id": 26954,
"hgvs_c": "c.215C>T",
"hgvs_p": "p.Ser72Phe",
"transcript": "ENST00000450403.3",
"protein_id": "ENSP00000393231.2",
"transcript_support_level": 1,
"aa_start": 72,
"aa_end": null,
"aa_length": 620,
"cds_start": 215,
"cds_end": null,
"cds_length": 1863,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000450403.3"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MINDY2",
"gene_hgnc_id": 26954,
"hgvs_c": "n.215C>T",
"hgvs_p": null,
"transcript": "ENST00000316848.9",
"protein_id": "ENSP00000326194.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000316848.9"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MINDY2",
"gene_hgnc_id": 26954,
"hgvs_c": "n.215C>T",
"hgvs_p": null,
"transcript": "ENST00000560289.5",
"protein_id": "ENSP00000453425.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000560289.5"
},
{
"aa_ref": "S",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MINDY2",
"gene_hgnc_id": 26954,
"hgvs_c": "c.215C>T",
"hgvs_p": "p.Ser72Phe",
"transcript": "ENST00000877343.1",
"protein_id": "ENSP00000547402.1",
"transcript_support_level": null,
"aa_start": 72,
"aa_end": null,
"aa_length": 639,
"cds_start": 215,
"cds_end": null,
"cds_length": 1920,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000877343.1"
},
{
"aa_ref": "S",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MINDY2",
"gene_hgnc_id": 26954,
"hgvs_c": "c.215C>T",
"hgvs_p": "p.Ser72Phe",
"transcript": "ENST00000963693.1",
"protein_id": "ENSP00000633752.1",
"transcript_support_level": null,
"aa_start": 72,
"aa_end": null,
"aa_length": 638,
"cds_start": 215,
"cds_end": null,
"cds_length": 1917,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000963693.1"
},
{
"aa_ref": "S",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MINDY2",
"gene_hgnc_id": 26954,
"hgvs_c": "c.215C>T",
"hgvs_p": "p.Ser72Phe",
"transcript": "NM_001040453.3",
"protein_id": "NP_001035543.1",
"transcript_support_level": null,
"aa_start": 72,
"aa_end": null,
"aa_length": 620,
"cds_start": 215,
"cds_end": null,
"cds_length": 1863,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001040453.3"
},
{
"aa_ref": "S",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MINDY2",
"gene_hgnc_id": 26954,
"hgvs_c": "c.215C>T",
"hgvs_p": "p.Ser72Phe",
"transcript": "ENST00000963692.1",
"protein_id": "ENSP00000633751.1",
"transcript_support_level": null,
"aa_start": 72,
"aa_end": null,
"aa_length": 609,
"cds_start": 215,
"cds_end": null,
"cds_length": 1830,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000963692.1"
},
{
"aa_ref": "S",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MINDY2",
"gene_hgnc_id": 26954,
"hgvs_c": "c.215C>T",
"hgvs_p": "p.Ser72Phe",
"transcript": "ENST00000933140.1",
"protein_id": "ENSP00000603199.1",
"transcript_support_level": null,
"aa_start": 72,
"aa_end": null,
"aa_length": 605,
"cds_start": 215,
"cds_end": null,
"cds_length": 1818,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000933140.1"
},
{
"aa_ref": "S",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MINDY2",
"gene_hgnc_id": 26954,
"hgvs_c": "c.215C>T",
"hgvs_p": "p.Ser72Phe",
"transcript": "ENST00000933141.1",
"protein_id": "ENSP00000603200.1",
"transcript_support_level": null,
"aa_start": 72,
"aa_end": null,
"aa_length": 604,
"cds_start": 215,
"cds_end": null,
"cds_length": 1815,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000933141.1"
},
{
"aa_ref": "S",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MINDY2",
"gene_hgnc_id": 26954,
"hgvs_c": "c.215C>T",
"hgvs_p": "p.Ser72Phe",
"transcript": "ENST00000877340.1",
"protein_id": "ENSP00000547399.1",
"transcript_support_level": null,
"aa_start": 72,
"aa_end": null,
"aa_length": 587,
"cds_start": 215,
"cds_end": null,
"cds_length": 1764,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000877340.1"
},
{
"aa_ref": "S",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MINDY2",
"gene_hgnc_id": 26954,
"hgvs_c": "c.215C>T",
"hgvs_p": "p.Ser72Phe",
"transcript": "ENST00000877347.1",
"protein_id": "ENSP00000547406.1",
"transcript_support_level": null,
"aa_start": 72,
"aa_end": null,
"aa_length": 586,
"cds_start": 215,
"cds_end": null,
"cds_length": 1761,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000877347.1"
},
{
"aa_ref": "S",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MINDY2",
"gene_hgnc_id": 26954,
"hgvs_c": "c.215C>T",
"hgvs_p": "p.Ser72Phe",
"transcript": "ENST00000963691.1",
"protein_id": "ENSP00000633750.1",
"transcript_support_level": null,
"aa_start": 72,
"aa_end": null,
"aa_length": 573,
"cds_start": 215,
"cds_end": null,
"cds_length": 1722,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000963691.1"
},
{
"aa_ref": "S",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MINDY2",
"gene_hgnc_id": 26954,
"hgvs_c": "c.215C>T",
"hgvs_p": "p.Ser72Phe",
"transcript": "ENST00000877342.1",
"protein_id": "ENSP00000547401.1",
"transcript_support_level": null,
"aa_start": 72,
"aa_end": null,
"aa_length": 556,
"cds_start": 215,
"cds_end": null,
"cds_length": 1671,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000877342.1"
},
{
"aa_ref": "S",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MINDY2",
"gene_hgnc_id": 26954,
"hgvs_c": "c.215C>T",
"hgvs_p": "p.Ser72Phe",
"transcript": "ENST00000877345.1",
"protein_id": "ENSP00000547404.1",
"transcript_support_level": null,
"aa_start": 72,
"aa_end": null,
"aa_length": 555,
"cds_start": 215,
"cds_end": null,
"cds_length": 1668,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000877345.1"
},
{
"aa_ref": "S",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MINDY2",
"gene_hgnc_id": 26954,
"hgvs_c": "c.215C>T",
"hgvs_p": "p.Ser72Phe",
"transcript": "ENST00000877344.1",
"protein_id": "ENSP00000547403.1",
"transcript_support_level": null,
"aa_start": 72,
"aa_end": null,
"aa_length": 539,
"cds_start": 215,
"cds_end": null,
"cds_length": 1620,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000877344.1"
},
{
"aa_ref": "S",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MINDY2",
"gene_hgnc_id": 26954,
"hgvs_c": "c.215C>T",
"hgvs_p": "p.Ser72Phe",
"transcript": "ENST00000877341.1",
"protein_id": "ENSP00000547400.1",
"transcript_support_level": null,
"aa_start": 72,
"aa_end": null,
"aa_length": 538,
"cds_start": 215,
"cds_end": null,
"cds_length": 1617,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000877341.1"
},
{
"aa_ref": "S",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MINDY2",
"gene_hgnc_id": 26954,
"hgvs_c": "c.215C>T",
"hgvs_p": "p.Ser72Phe",
"transcript": "ENST00000877346.1",
"protein_id": "ENSP00000547405.1",
"transcript_support_level": null,
"aa_start": 72,
"aa_end": null,
"aa_length": 505,
"cds_start": 215,
"cds_end": null,
"cds_length": 1518,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000877346.1"
},
{
"aa_ref": "S",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MINDY2",
"gene_hgnc_id": 26954,
"hgvs_c": "c.215C>T",
"hgvs_p": "p.Ser72Phe",
"transcript": "XM_011521687.3",
"protein_id": "XP_011519989.1",
"transcript_support_level": null,
"aa_start": 72,
"aa_end": null,
"aa_length": 639,
"cds_start": 215,
"cds_end": null,
"cds_length": 1920,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011521687.3"
},
{
"aa_ref": "S",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MINDY2",
"gene_hgnc_id": 26954,
"hgvs_c": "c.215C>T",
"hgvs_p": "p.Ser72Phe",
"transcript": "XM_011521688.3",
"protein_id": "XP_011519990.1",
"transcript_support_level": null,
"aa_start": 72,
"aa_end": null,
"aa_length": 638,
"cds_start": 215,
"cds_end": null,
"cds_length": 1917,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011521688.3"
},
{
"aa_ref": "S",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MINDY2",
"gene_hgnc_id": 26954,
"hgvs_c": "c.215C>T",
"hgvs_p": "p.Ser72Phe",
"transcript": "XM_011521689.3",
"protein_id": "XP_011519991.1",
"transcript_support_level": null,
"aa_start": 72,
"aa_end": null,
"aa_length": 605,
"cds_start": 215,
"cds_end": null,
"cds_length": 1818,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011521689.3"
},
{
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{
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],
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}
],
"message": null
}