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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 15-59672705-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=15&pos=59672705&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "15",
"pos": 59672705,
"ref": "C",
"alt": "T",
"effect": "synonymous_variant",
"transcript": "NM_001320674.2",
"consequences": [
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BNIP2",
"gene_hgnc_id": 1083,
"hgvs_c": "c.507G>A",
"hgvs_p": "p.Val169Val",
"transcript": "NM_004330.4",
"protein_id": "NP_004321.3",
"transcript_support_level": null,
"aa_start": 169,
"aa_end": null,
"aa_length": 314,
"cds_start": 507,
"cds_end": null,
"cds_length": 945,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000607373.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_004330.4"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BNIP2",
"gene_hgnc_id": 1083,
"hgvs_c": "c.507G>A",
"hgvs_p": "p.Val169Val",
"transcript": "ENST00000607373.6",
"protein_id": "ENSP00000475320.1",
"transcript_support_level": 1,
"aa_start": 169,
"aa_end": null,
"aa_length": 314,
"cds_start": 507,
"cds_end": null,
"cds_length": 945,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_004330.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000607373.6"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BNIP2",
"gene_hgnc_id": 1083,
"hgvs_c": "c.507G>A",
"hgvs_p": "p.Val169Val",
"transcript": "NM_001320674.2",
"protein_id": "NP_001307603.2",
"transcript_support_level": null,
"aa_start": 169,
"aa_end": null,
"aa_length": 326,
"cds_start": 507,
"cds_end": null,
"cds_length": 981,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001320674.2"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BNIP2",
"gene_hgnc_id": 1083,
"hgvs_c": "c.507G>A",
"hgvs_p": "p.Val169Val",
"transcript": "ENST00000439052.6",
"protein_id": "ENSP00000393644.2",
"transcript_support_level": 2,
"aa_start": 169,
"aa_end": null,
"aa_length": 326,
"cds_start": 507,
"cds_end": null,
"cds_length": 981,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000439052.6"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BNIP2",
"gene_hgnc_id": 1083,
"hgvs_c": "c.507G>A",
"hgvs_p": "p.Val169Val",
"transcript": "ENST00000897502.1",
"protein_id": "ENSP00000567561.1",
"transcript_support_level": null,
"aa_start": 169,
"aa_end": null,
"aa_length": 326,
"cds_start": 507,
"cds_end": null,
"cds_length": 981,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000897502.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BNIP2",
"gene_hgnc_id": 1083,
"hgvs_c": "c.525G>A",
"hgvs_p": "p.Val175Val",
"transcript": "ENST00000897499.1",
"protein_id": "ENSP00000567558.1",
"transcript_support_level": null,
"aa_start": 175,
"aa_end": null,
"aa_length": 320,
"cds_start": 525,
"cds_end": null,
"cds_length": 963,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000897499.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BNIP2",
"gene_hgnc_id": 1083,
"hgvs_c": "c.507G>A",
"hgvs_p": "p.Val169Val",
"transcript": "NM_001320675.4",
"protein_id": "NP_001307604.2",
"transcript_support_level": null,
"aa_start": 169,
"aa_end": null,
"aa_length": 314,
"cds_start": 507,
"cds_end": null,
"cds_length": 945,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001320675.4"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BNIP2",
"gene_hgnc_id": 1083,
"hgvs_c": "c.507G>A",
"hgvs_p": "p.Val169Val",
"transcript": "ENST00000415213.7",
"protein_id": "ENSP00000412767.3",
"transcript_support_level": 2,
"aa_start": 169,
"aa_end": null,
"aa_length": 314,
"cds_start": 507,
"cds_end": null,
"cds_length": 945,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000415213.7"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BNIP2",
"gene_hgnc_id": 1083,
"hgvs_c": "c.498G>A",
"hgvs_p": "p.Val166Val",
"transcript": "ENST00000921900.1",
"protein_id": "ENSP00000591959.1",
"transcript_support_level": null,
"aa_start": 166,
"aa_end": null,
"aa_length": 311,
"cds_start": 498,
"cds_end": null,
"cds_length": 936,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000921900.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BNIP2",
"gene_hgnc_id": 1083,
"hgvs_c": "c.507G>A",
"hgvs_p": "p.Val169Val",
"transcript": "ENST00000897501.1",
"protein_id": "ENSP00000567560.1",
"transcript_support_level": null,
"aa_start": 169,
"aa_end": null,
"aa_length": 308,
"cds_start": 507,
"cds_end": null,
"cds_length": 927,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000897501.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BNIP2",
"gene_hgnc_id": 1083,
"hgvs_c": "c.507G>A",
"hgvs_p": "p.Val169Val",
"transcript": "ENST00000921901.1",
"protein_id": "ENSP00000591960.1",
"transcript_support_level": null,
"aa_start": 169,
"aa_end": null,
"aa_length": 285,
"cds_start": 507,
"cds_end": null,
"cds_length": 858,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000921901.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BNIP2",
"gene_hgnc_id": 1083,
"hgvs_c": "c.507G>A",
"hgvs_p": "p.Val169Val",
"transcript": "NM_001368057.1",
"protein_id": "NP_001354986.1",
"transcript_support_level": null,
"aa_start": 169,
"aa_end": null,
"aa_length": 282,
"cds_start": 507,
"cds_end": null,
"cds_length": 849,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001368057.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BNIP2",
"gene_hgnc_id": 1083,
"hgvs_c": "c.507G>A",
"hgvs_p": "p.Val169Val",
"transcript": "ENST00000897496.1",
"protein_id": "ENSP00000567555.1",
"transcript_support_level": null,
"aa_start": 169,
"aa_end": null,
"aa_length": 282,
"cds_start": 507,
"cds_end": null,
"cds_length": 849,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000897496.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BNIP2",
"gene_hgnc_id": 1083,
"hgvs_c": "c.507G>A",
"hgvs_p": "p.Val169Val",
"transcript": "ENST00000950839.1",
"protein_id": "ENSP00000620898.1",
"transcript_support_level": null,
"aa_start": 169,
"aa_end": null,
"aa_length": 281,
"cds_start": 507,
"cds_end": null,
"cds_length": 846,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000950839.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BNIP2",
"gene_hgnc_id": 1083,
"hgvs_c": "c.525G>A",
"hgvs_p": "p.Val175Val",
"transcript": "ENST00000921902.1",
"protein_id": "ENSP00000591961.1",
"transcript_support_level": null,
"aa_start": 175,
"aa_end": null,
"aa_length": 276,
"cds_start": 525,
"cds_end": null,
"cds_length": 831,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000921902.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BNIP2",
"gene_hgnc_id": 1083,
"hgvs_c": "c.348G>A",
"hgvs_p": "p.Val116Val",
"transcript": "NM_001368058.1",
"protein_id": "NP_001354987.1",
"transcript_support_level": null,
"aa_start": 116,
"aa_end": null,
"aa_length": 273,
"cds_start": 348,
"cds_end": null,
"cds_length": 822,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001368058.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BNIP2",
"gene_hgnc_id": 1083,
"hgvs_c": "c.507G>A",
"hgvs_p": "p.Val169Val",
"transcript": "NM_001368059.1",
"protein_id": "NP_001354988.1",
"transcript_support_level": null,
"aa_start": 169,
"aa_end": null,
"aa_length": 270,
"cds_start": 507,
"cds_end": null,
"cds_length": 813,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001368059.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BNIP2",
"gene_hgnc_id": 1083,
"hgvs_c": "c.507G>A",
"hgvs_p": "p.Val169Val",
"transcript": "ENST00000897497.1",
"protein_id": "ENSP00000567556.1",
"transcript_support_level": null,
"aa_start": 169,
"aa_end": null,
"aa_length": 270,
"cds_start": 507,
"cds_end": null,
"cds_length": 813,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000897497.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BNIP2",
"gene_hgnc_id": 1083,
"hgvs_c": "c.348G>A",
"hgvs_p": "p.Val116Val",
"transcript": "NM_001368060.1",
"protein_id": "NP_001354989.1",
"transcript_support_level": null,
"aa_start": 116,
"aa_end": null,
"aa_length": 261,
"cds_start": 348,
"cds_end": null,
"cds_length": 786,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001368060.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BNIP2",
"gene_hgnc_id": 1083,
"hgvs_c": "c.330G>A",
"hgvs_p": "p.Val110Val",
"transcript": "ENST00000897498.1",
"protein_id": "ENSP00000567557.1",
"transcript_support_level": null,
"aa_start": 110,
"aa_end": null,
"aa_length": 255,
"cds_start": 330,
"cds_end": null,
"cds_length": 768,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000897498.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BNIP2",
"gene_hgnc_id": 1083,
"hgvs_c": "c.507G>A",
"hgvs_p": "p.Val169Val",
"transcript": "NM_001368061.1",
"protein_id": "NP_001354990.1",
"transcript_support_level": null,
"aa_start": 169,
"aa_end": null,
"aa_length": 252,
"cds_start": 507,
"cds_end": null,
"cds_length": 759,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001368061.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BNIP2",
"gene_hgnc_id": 1083,
"hgvs_c": "c.507G>A",
"hgvs_p": "p.Val169Val",
"transcript": "ENST00000897500.1",
"protein_id": "ENSP00000567559.1",
"transcript_support_level": null,
"aa_start": 169,
"aa_end": null,
"aa_length": 252,
"cds_start": 507,
"cds_end": null,
"cds_length": 759,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000897500.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
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"computational_prediction_selected": "Benign",
"computational_source_selected": "BayesDel_noAF",
"splice_score_selected": 0,
"splice_prediction_selected": "Benign",
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"bayesdelnoaf_score": -0.27,
"bayesdelnoaf_prediction": "Benign",
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"phylop100way_prediction": "Benign",
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"acmg_classification": "Benign",
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"acmg_by_gene": [
{
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"criteria": [
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"BP7",
"BS1",
"BS2"
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"verdict": "Benign",
"transcript": "NM_001320674.2",
"gene_symbol": "BNIP2",
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"effects": [
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"inheritance_mode": "AR",
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],
"clinvar_disease": "",
"clinvar_classification": "",
"clinvar_review_status": "",
"clinvar_submissions_summary": "",
"phenotype_combined": null,
"pathogenicity_classification_combined": null,
"custom_annotations": null
}
],
"message": null
}