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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 15-64974732-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=15&pos=64974732&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "15",
"pos": 64974732,
"ref": "C",
"alt": "T",
"effect": "missense_variant",
"transcript": "NM_016630.7",
"consequences": [
{
"aa_ref": "A",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SPG21",
"gene_hgnc_id": 20373,
"hgvs_c": "c.322G>A",
"hgvs_p": "p.Ala108Thr",
"transcript": "NM_016630.7",
"protein_id": "NP_057714.1",
"transcript_support_level": null,
"aa_start": 108,
"aa_end": null,
"aa_length": 308,
"cds_start": 322,
"cds_end": null,
"cds_length": 927,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000204566.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_016630.7"
},
{
"aa_ref": "A",
"aa_alt": "T",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SPG21",
"gene_hgnc_id": 20373,
"hgvs_c": "c.322G>A",
"hgvs_p": "p.Ala108Thr",
"transcript": "ENST00000204566.7",
"protein_id": "ENSP00000204566.2",
"transcript_support_level": 1,
"aa_start": 108,
"aa_end": null,
"aa_length": 308,
"cds_start": 322,
"cds_end": null,
"cds_length": 927,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_016630.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000204566.7"
},
{
"aa_ref": "A",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SPG21",
"gene_hgnc_id": 20373,
"hgvs_c": "c.322G>A",
"hgvs_p": "p.Ala108Thr",
"transcript": "ENST00000433215.6",
"protein_id": "ENSP00000404111.2",
"transcript_support_level": 1,
"aa_start": 108,
"aa_end": null,
"aa_length": 308,
"cds_start": 322,
"cds_end": null,
"cds_length": 927,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000433215.6"
},
{
"aa_ref": "A",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SPG21",
"gene_hgnc_id": 20373,
"hgvs_c": "c.322G>A",
"hgvs_p": "p.Ala108Thr",
"transcript": "NM_001127889.5",
"protein_id": "NP_001121361.1",
"transcript_support_level": null,
"aa_start": 108,
"aa_end": null,
"aa_length": 308,
"cds_start": 322,
"cds_end": null,
"cds_length": 927,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001127889.5"
},
{
"aa_ref": "A",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SPG21",
"gene_hgnc_id": 20373,
"hgvs_c": "c.322G>A",
"hgvs_p": "p.Ala108Thr",
"transcript": "ENST00000854124.1",
"protein_id": "ENSP00000524183.1",
"transcript_support_level": null,
"aa_start": 108,
"aa_end": null,
"aa_length": 308,
"cds_start": 322,
"cds_end": null,
"cds_length": 927,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854124.1"
},
{
"aa_ref": "A",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SPG21",
"gene_hgnc_id": 20373,
"hgvs_c": "c.322G>A",
"hgvs_p": "p.Ala108Thr",
"transcript": "ENST00000854125.1",
"protein_id": "ENSP00000524184.1",
"transcript_support_level": null,
"aa_start": 108,
"aa_end": null,
"aa_length": 308,
"cds_start": 322,
"cds_end": null,
"cds_length": 927,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854125.1"
},
{
"aa_ref": "A",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SPG21",
"gene_hgnc_id": 20373,
"hgvs_c": "c.322G>A",
"hgvs_p": "p.Ala108Thr",
"transcript": "ENST00000854126.1",
"protein_id": "ENSP00000524185.1",
"transcript_support_level": null,
"aa_start": 108,
"aa_end": null,
"aa_length": 308,
"cds_start": 322,
"cds_end": null,
"cds_length": 927,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854126.1"
},
{
"aa_ref": "A",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SPG21",
"gene_hgnc_id": 20373,
"hgvs_c": "c.322G>A",
"hgvs_p": "p.Ala108Thr",
"transcript": "ENST00000854127.1",
"protein_id": "ENSP00000524186.1",
"transcript_support_level": null,
"aa_start": 108,
"aa_end": null,
"aa_length": 308,
"cds_start": 322,
"cds_end": null,
"cds_length": 927,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854127.1"
},
{
"aa_ref": "A",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SPG21",
"gene_hgnc_id": 20373,
"hgvs_c": "c.322G>A",
"hgvs_p": "p.Ala108Thr",
"transcript": "ENST00000854129.1",
"protein_id": "ENSP00000524188.1",
"transcript_support_level": null,
"aa_start": 108,
"aa_end": null,
"aa_length": 308,
"cds_start": 322,
"cds_end": null,
"cds_length": 927,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854129.1"
},
{
"aa_ref": "A",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SPG21",
"gene_hgnc_id": 20373,
"hgvs_c": "c.322G>A",
"hgvs_p": "p.Ala108Thr",
"transcript": "ENST00000854130.1",
"protein_id": "ENSP00000524189.1",
"transcript_support_level": null,
"aa_start": 108,
"aa_end": null,
"aa_length": 308,
"cds_start": 322,
"cds_end": null,
"cds_length": 927,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854130.1"
},
{
"aa_ref": "A",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SPG21",
"gene_hgnc_id": 20373,
"hgvs_c": "c.322G>A",
"hgvs_p": "p.Ala108Thr",
"transcript": "ENST00000854133.1",
"protein_id": "ENSP00000524192.1",
"transcript_support_level": null,
"aa_start": 108,
"aa_end": null,
"aa_length": 308,
"cds_start": 322,
"cds_end": null,
"cds_length": 927,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854133.1"
},
{
"aa_ref": "A",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SPG21",
"gene_hgnc_id": 20373,
"hgvs_c": "c.322G>A",
"hgvs_p": "p.Ala108Thr",
"transcript": "ENST00000854134.1",
"protein_id": "ENSP00000524193.1",
"transcript_support_level": null,
"aa_start": 108,
"aa_end": null,
"aa_length": 308,
"cds_start": 322,
"cds_end": null,
"cds_length": 927,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854134.1"
},
{
"aa_ref": "A",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SPG21",
"gene_hgnc_id": 20373,
"hgvs_c": "c.322G>A",
"hgvs_p": "p.Ala108Thr",
"transcript": "ENST00000854135.1",
"protein_id": "ENSP00000524194.1",
"transcript_support_level": null,
"aa_start": 108,
"aa_end": null,
"aa_length": 308,
"cds_start": 322,
"cds_end": null,
"cds_length": 927,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854135.1"
},
{
"aa_ref": "A",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SPG21",
"gene_hgnc_id": 20373,
"hgvs_c": "c.322G>A",
"hgvs_p": "p.Ala108Thr",
"transcript": "ENST00000854136.1",
"protein_id": "ENSP00000524195.1",
"transcript_support_level": null,
"aa_start": 108,
"aa_end": null,
"aa_length": 308,
"cds_start": 322,
"cds_end": null,
"cds_length": 927,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854136.1"
},
{
"aa_ref": "A",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SPG21",
"gene_hgnc_id": 20373,
"hgvs_c": "c.322G>A",
"hgvs_p": "p.Ala108Thr",
"transcript": "ENST00000854137.1",
"protein_id": "ENSP00000524196.1",
"transcript_support_level": null,
"aa_start": 108,
"aa_end": null,
"aa_length": 308,
"cds_start": 322,
"cds_end": null,
"cds_length": 927,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854137.1"
},
{
"aa_ref": "A",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SPG21",
"gene_hgnc_id": 20373,
"hgvs_c": "c.322G>A",
"hgvs_p": "p.Ala108Thr",
"transcript": "ENST00000854139.1",
"protein_id": "ENSP00000524198.1",
"transcript_support_level": null,
"aa_start": 108,
"aa_end": null,
"aa_length": 308,
"cds_start": 322,
"cds_end": null,
"cds_length": 927,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854139.1"
},
{
"aa_ref": "A",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SPG21",
"gene_hgnc_id": 20373,
"hgvs_c": "c.322G>A",
"hgvs_p": "p.Ala108Thr",
"transcript": "ENST00000854141.1",
"protein_id": "ENSP00000524200.1",
"transcript_support_level": null,
"aa_start": 108,
"aa_end": null,
"aa_length": 308,
"cds_start": 322,
"cds_end": null,
"cds_length": 927,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854141.1"
},
{
"aa_ref": "A",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SPG21",
"gene_hgnc_id": 20373,
"hgvs_c": "c.322G>A",
"hgvs_p": "p.Ala108Thr",
"transcript": "ENST00000854142.1",
"protein_id": "ENSP00000524201.1",
"transcript_support_level": null,
"aa_start": 108,
"aa_end": null,
"aa_length": 308,
"cds_start": 322,
"cds_end": null,
"cds_length": 927,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854142.1"
},
{
"aa_ref": "A",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SPG21",
"gene_hgnc_id": 20373,
"hgvs_c": "c.322G>A",
"hgvs_p": "p.Ala108Thr",
"transcript": "ENST00000854143.1",
"protein_id": "ENSP00000524202.1",
"transcript_support_level": null,
"aa_start": 108,
"aa_end": null,
"aa_length": 308,
"cds_start": 322,
"cds_end": null,
"cds_length": 927,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854143.1"
},
{
"aa_ref": "A",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SPG21",
"gene_hgnc_id": 20373,
"hgvs_c": "c.322G>A",
"hgvs_p": "p.Ala108Thr",
"transcript": "ENST00000854144.1",
"protein_id": "ENSP00000524203.1",
"transcript_support_level": null,
"aa_start": 108,
"aa_end": null,
"aa_length": 308,
"cds_start": 322,
"cds_end": null,
"cds_length": 927,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854144.1"
},
{
"aa_ref": "A",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SPG21",
"gene_hgnc_id": 20373,
"hgvs_c": "c.322G>A",
"hgvs_p": "p.Ala108Thr",
"transcript": "ENST00000854145.1",
"protein_id": "ENSP00000524204.1",
"transcript_support_level": null,
"aa_start": 108,
"aa_end": null,
"aa_length": 308,
"cds_start": 322,
"cds_end": null,
"cds_length": 927,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854145.1"
},
{
"aa_ref": "A",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SPG21",
"gene_hgnc_id": 20373,
"hgvs_c": "c.322G>A",
"hgvs_p": "p.Ala108Thr",
"transcript": "ENST00000854146.1",
"protein_id": "ENSP00000524205.1",
"transcript_support_level": null,
"aa_start": 108,
"aa_end": null,
"aa_length": 308,
"cds_start": 322,
"cds_end": null,
"cds_length": 927,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854146.1"
},
{
"aa_ref": "A",
"aa_alt": "T",
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}
],
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}