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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 15-65263200-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=15&pos=65263200&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "15",
"pos": 65263200,
"ref": "C",
"alt": "T",
"effect": "missense_variant",
"transcript": "NM_017851.6",
"consequences": [
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PARP16",
"gene_hgnc_id": 26040,
"hgvs_c": "c.640G>A",
"hgvs_p": "p.Val214Met",
"transcript": "NM_001316943.2",
"protein_id": "NP_001303872.1",
"transcript_support_level": null,
"aa_start": 214,
"aa_end": null,
"aa_length": 322,
"cds_start": 640,
"cds_end": null,
"cds_length": 969,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000649807.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001316943.2"
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PARP16",
"gene_hgnc_id": 26040,
"hgvs_c": "c.640G>A",
"hgvs_p": "p.Val214Met",
"transcript": "ENST00000649807.2",
"protein_id": "ENSP00000496935.1",
"transcript_support_level": null,
"aa_start": 214,
"aa_end": null,
"aa_length": 322,
"cds_start": 640,
"cds_end": null,
"cds_length": 969,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001316943.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000649807.2"
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PARP16",
"gene_hgnc_id": 26040,
"hgvs_c": "c.640G>A",
"hgvs_p": "p.Val214Met",
"transcript": "ENST00000261888.10",
"protein_id": "ENSP00000261888.6",
"transcript_support_level": 1,
"aa_start": 214,
"aa_end": null,
"aa_length": 323,
"cds_start": 640,
"cds_end": null,
"cds_length": 972,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000261888.10"
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PARP16",
"gene_hgnc_id": 26040,
"hgvs_c": "c.757G>A",
"hgvs_p": "p.Val253Met",
"transcript": "ENST00000906476.1",
"protein_id": "ENSP00000576535.1",
"transcript_support_level": null,
"aa_start": 253,
"aa_end": null,
"aa_length": 361,
"cds_start": 757,
"cds_end": null,
"cds_length": 1086,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906476.1"
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PARP16",
"gene_hgnc_id": 26040,
"hgvs_c": "c.676G>A",
"hgvs_p": "p.Val226Met",
"transcript": "ENST00000966191.1",
"protein_id": "ENSP00000636250.1",
"transcript_support_level": null,
"aa_start": 226,
"aa_end": null,
"aa_length": 334,
"cds_start": 676,
"cds_end": null,
"cds_length": 1005,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000966191.1"
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PARP16",
"gene_hgnc_id": 26040,
"hgvs_c": "c.640G>A",
"hgvs_p": "p.Val214Met",
"transcript": "NM_017851.6",
"protein_id": "NP_060321.3",
"transcript_support_level": null,
"aa_start": 214,
"aa_end": null,
"aa_length": 323,
"cds_start": 640,
"cds_end": null,
"cds_length": 972,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_017851.6"
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PARP16",
"gene_hgnc_id": 26040,
"hgvs_c": "c.583G>A",
"hgvs_p": "p.Val195Met",
"transcript": "ENST00000906477.1",
"protein_id": "ENSP00000576536.1",
"transcript_support_level": null,
"aa_start": 195,
"aa_end": null,
"aa_length": 304,
"cds_start": 583,
"cds_end": null,
"cds_length": 915,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906477.1"
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PARP16",
"gene_hgnc_id": 26040,
"hgvs_c": "c.583G>A",
"hgvs_p": "p.Val195Met",
"transcript": "ENST00000906479.1",
"protein_id": "ENSP00000576538.1",
"transcript_support_level": null,
"aa_start": 195,
"aa_end": null,
"aa_length": 303,
"cds_start": 583,
"cds_end": null,
"cds_length": 912,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906479.1"
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PARP16",
"gene_hgnc_id": 26040,
"hgvs_c": "c.502G>A",
"hgvs_p": "p.Val168Met",
"transcript": "ENST00000906481.1",
"protein_id": "ENSP00000576540.1",
"transcript_support_level": null,
"aa_start": 168,
"aa_end": null,
"aa_length": 277,
"cds_start": 502,
"cds_end": null,
"cds_length": 834,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906481.1"
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PARP16",
"gene_hgnc_id": 26040,
"hgvs_c": "c.502G>A",
"hgvs_p": "p.Val168Met",
"transcript": "ENST00000906478.1",
"protein_id": "ENSP00000576537.1",
"transcript_support_level": null,
"aa_start": 168,
"aa_end": null,
"aa_length": 276,
"cds_start": 502,
"cds_end": null,
"cds_length": 831,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906478.1"
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PARP16",
"gene_hgnc_id": 26040,
"hgvs_c": "c.433G>A",
"hgvs_p": "p.Val145Met",
"transcript": "ENST00000906483.1",
"protein_id": "ENSP00000576542.1",
"transcript_support_level": null,
"aa_start": 145,
"aa_end": null,
"aa_length": 254,
"cds_start": 433,
"cds_end": null,
"cds_length": 765,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906483.1"
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PARP16",
"gene_hgnc_id": 26040,
"hgvs_c": "c.376G>A",
"hgvs_p": "p.Val126Met",
"transcript": "ENST00000906482.1",
"protein_id": "ENSP00000576541.1",
"transcript_support_level": null,
"aa_start": 126,
"aa_end": null,
"aa_length": 234,
"cds_start": 376,
"cds_end": null,
"cds_length": 705,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906482.1"
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PARP16",
"gene_hgnc_id": 26040,
"hgvs_c": "c.295G>A",
"hgvs_p": "p.Val99Met",
"transcript": "ENST00000906480.1",
"protein_id": "ENSP00000576539.1",
"transcript_support_level": null,
"aa_start": 99,
"aa_end": null,
"aa_length": 208,
"cds_start": 295,
"cds_end": null,
"cds_length": 627,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906480.1"
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PARP16",
"gene_hgnc_id": 26040,
"hgvs_c": "c.295G>A",
"hgvs_p": "p.Val99Met",
"transcript": "NM_001316944.2",
"protein_id": "NP_001303873.1",
"transcript_support_level": null,
"aa_start": 99,
"aa_end": null,
"aa_length": 207,
"cds_start": 295,
"cds_end": null,
"cds_length": 624,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001316944.2"
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PARP16",
"gene_hgnc_id": 26040,
"hgvs_c": "c.295G>A",
"hgvs_p": "p.Val99Met",
"transcript": "ENST00000444347.2",
"protein_id": "ENSP00000396118.2",
"transcript_support_level": 2,
"aa_start": 99,
"aa_end": null,
"aa_length": 207,
"cds_start": 295,
"cds_end": null,
"cds_length": 624,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000444347.2"
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PARP16",
"gene_hgnc_id": 26040,
"hgvs_c": "c.640G>A",
"hgvs_p": "p.Val214Met",
"transcript": "XM_006720589.4",
"protein_id": "XP_006720652.1",
"transcript_support_level": null,
"aa_start": 214,
"aa_end": null,
"aa_length": 311,
"cds_start": 640,
"cds_end": null,
"cds_length": 936,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_006720589.4"
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PARP16",
"gene_hgnc_id": 26040,
"hgvs_c": "c.640G>A",
"hgvs_p": "p.Val214Met",
"transcript": "XM_006720590.4",
"protein_id": "XP_006720653.1",
"transcript_support_level": null,
"aa_start": 214,
"aa_end": null,
"aa_length": 310,
"cds_start": 640,
"cds_end": null,
"cds_length": 933,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_006720590.4"
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PARP16",
"gene_hgnc_id": 26040,
"hgvs_c": "c.640G>A",
"hgvs_p": "p.Val214Met",
"transcript": "XM_047432775.1",
"protein_id": "XP_047288731.1",
"transcript_support_level": null,
"aa_start": 214,
"aa_end": null,
"aa_length": 309,
"cds_start": 640,
"cds_end": null,
"cds_length": 930,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047432775.1"
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PARP16",
"gene_hgnc_id": 26040,
"hgvs_c": "c.640G>A",
"hgvs_p": "p.Val214Met",
"transcript": "XM_047432776.1",
"protein_id": "XP_047288732.1",
"transcript_support_level": null,
"aa_start": 214,
"aa_end": null,
"aa_length": 308,
"cds_start": 640,
"cds_end": null,
"cds_length": 927,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047432776.1"
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PARP16",
"gene_hgnc_id": 26040,
"hgvs_c": "c.583G>A",
"hgvs_p": "p.Val195Met",
"transcript": "XM_006720592.4",
"protein_id": "XP_006720655.1",
"transcript_support_level": null,
"aa_start": 195,
"aa_end": null,
"aa_length": 304,
"cds_start": 583,
"cds_end": null,
"cds_length": 915,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_006720592.4"
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PARP16",
"gene_hgnc_id": 26040,
"hgvs_c": "c.583G>A",
"hgvs_p": "p.Val195Met",
"transcript": "XM_017022386.3",
"protein_id": "XP_016877875.1",
"transcript_support_level": null,
"aa_start": 195,
"aa_end": null,
"aa_length": 303,
"cds_start": 583,
"cds_end": null,
"cds_length": 912,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017022386.3"
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PARP16",
"gene_hgnc_id": 26040,
"hgvs_c": "c.583G>A",
"hgvs_p": "p.Val195Met",
"transcript": "XM_047432777.1",
"protein_id": "XP_047288733.1",
"transcript_support_level": null,
"aa_start": 195,
"aa_end": null,
"aa_length": 291,
"cds_start": 583,
"cds_end": null,
"cds_length": 876,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047432777.1"
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}
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}